Effect of renin-angiotensin system blockade on soluble Klotho in patients with type 2 diabetes, systolic hypertension, and albuminuria

Clinical Journal of the American Society of Nephrology

Volumn 8, Issue 11, 2013, Pages 1899-1905

  Karalliedde, Janaka ^a   Maltese, Giuseppe ^a   Hill, Benjamin ^a   Viberti, Giancarlo ^a   Gnudi, Luigi ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMLODIPINE; CREATININE; FIBROBLAST GROWTH FACTOR 23; HYDROCHLOROTHIAZIDE PLUS VALSARTAN; KLOTHO PROTEIN; MOXONIDINE; VALSARTAN;

ADULT; ALBUMINURIA; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PHOSPHATE BLOOD LEVEL; PULSE PRESSURE; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC HYPERTENSION; TONOMETRY;

AGED; ALBUMINURIA; AMLODIPINE; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; BIOLOGICAL MARKERS; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DIURETICS; FEMALE; GLUCURONIDASE; HOSPITALS, UNIVERSITY; HUMANS; HYDROCHLOROTHIAZIDE; HYPERTENSION; LONDON; MALE; MIDDLE AGED; PHOSPHATES; PULSE WAVE ANALYSIS; RENIN-ANGIOTENSIN SYSTEM; SYSTOLE; TETRAZOLES; TIME FACTORS; TREATMENT OUTCOME; VALINE;

EID: 84887302965     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.02700313     Document Type: Article

References (32)

1. Maltese G, Karalliedde J: The putative role of the antiageing protein klotho in cardiovascular and renal disease. Int J Hypertens 2012: 757469, 2012
2. Kuro-o M: Klotho in health and disease. Curr Opin Nephrol Hypertens 21: 362-368, 2012
3. BernheimJ, Benchetrit S: The potential roles of FGF23 and Klotho in the prognosis of renal and cardiovascular diseases. Nephrol Dial Transplant 26: 2433-2438, 2011
4. Hu MC, Shiizaki K, Kuro-o M, MoeOW: Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism. Annu Rev Physiol 75: 503-533, 2013
5. Yoon HE, Ghee JY, Piao S, Song JH, Han DH, Kim S, Ohashi N, Kobori H, Kuro-o M, Yang CW: Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy. Nephrol Dial Transplan 26: 800-813, 2011
6. MitaniH, IshizakaN, Aizawa T, Ohno M, Usui S, Suzuki T, Amaki T, Mori I, Nakamura Y, Sato M, Nangaku M, Hirata Y, Nagai R: In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension 39: 838-843, 2002
7. Karalliedde J, Smith A, DeAngelis L, Mirenda V, Kandra A, Botha J, Ferber P, VibertiG: Valsartan improves arterial stiffness in type 2 diabetes independently of blood pressure lowering. Hypertension 51: 1617-1623, 2008
8. Törnig J, Amann K, Ritz E, Nichols C, Zeier M, Mall G: Arteriolar wall thickening, capillary rarefaction and interstitial fibrosis in the heart of rats with renal failure: The effects of ramipril, nifedipine and moxonidine. J Am Soc Nephrol 7: 667-675, 1996
9. Asmar RG, Benetos A, Chaouche-Teyara K, Raveau-Landon CM, Safar ME: Comparison of effects of felodipine versus hydrochlorothiazide on arterial diameter and pulse-wave velocity in essential hypertension. Am J Cardiol 72: 794-798, 1993
10. Yamazaki Y, Imura A, Urakawa I, Shimada T, Murakami J, Aono Y, Hasegawa H, Yamashita T, Nakatani K, Saito Y, Okamoto N, KurumataniN, NambaN, Kitaoka T, Ozono K, Sakai T, HatayaH, Ichikawa S, Imel EA, Econs MJ, Nabeshima Y: Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Agedependent change of soluble alpha-Klotho levels in healthy subjects. Biochem Biophys Res Commun 398: 513-518, 2010
11. Kitagawa M, SugiyamaH, MorinagaH, Inoue T, Takiue K, Ogawa A, Yamanari T, Kikumoto Y, Uchida HA, Kitamura S, Maeshima Y, Nakamura K, Ito H, Makino H: A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease. PLoS ONE 8: e56695, 2013
12. Shimamura Y, Hamada K, Inoue K, Ogata K, Ishihara M, Kagawa T, Inoue M, Fujimoto S, Ikebe M, Yuasa K, Yamanaka S, Sugiura T, Terada Y: Serum levels of soluble secreted a-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis. Clin Exp Nephrol 16: 722-729, 2012
13. Semba RD, Cappola AR, Sun K, Bandinelli S, Dalal M, Crasto C, Guralnik JM, Ferrucci L: Plasma klotho andmortality risk in older community-dwelling adults. J Gerontol A Biol Sci Med Sci 66: 794-800, 2011
14. Zhou Q, Lin S, Tang R, Veeraragoo P, Peng W, Wu R: Role of fosinopril and valsartan on Klotho gene expression induced by angiotensin II in rat renal tubular epithelial cells. Kidney Blood Press Res 33: 186-192, 2010
15. Lim SC, Liu JJ, Subramaniam T, Sum CF: Elevated circulating alpha-klotho by angiotensin II receptor blocker losartan is associated with reduction of albuminuria in type 2 diabetic patients [published online ahead of print February 4, 2013]. J Renin Angiotensin Aldosterone Syst doi:10.1177/1470320313475905
16. Dominguez LJ, Barbagallo M, Kattah W, Garcia D, Sowers JR: Quinapril reduces microalbuminuria in essential hypertensive and in diabetic hypertensive subjects. Am J Hypertens 8: 808-814, 1995
17. Akimoto T, Yoshizawa H, Watanabe Y, Numata A, Yamazaki T, Takeshima E, Iwazu K, Komada T, Otani N, Morishita Y, Ito C, Shiizaki K, Ando Y, Muto S, Kuro-o M, Kusano E: Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease. BMC Nephrol 13: 155, 2012
18. Devaraj S, Syed B, Chien A, Jialal I: Validation of an immunoassay for soluble Klotho protein: decreased levels in diabetes and increased levels in chronic kidney disease. Am J Clin Pathol 137: 479-485, 2012
19. Chen TH, Kuro O M, Chen CH, Sue YM, Chen YC, Wu HH, Cheng CY: The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice. Eur J Pharmacol 698: 67-73, 2013
20. Zoccali C, Ruggenenti P, Perna A, Leonardis D, Tripepi R, Tripepi G, Mallamaci F, Remuzzi G; REIN Study Group: Phosphate may promote CKD progression and attenuate renoprotective effect of ACE inhibition. J Am Soc Nephrol 22: 1923-1930, 2011
21. Shroff R: Phosphate is a vascular toxin. Pediatr Nephrol 28: 583-593, 2013
22. Leiter LA, Lewanczuk RZ: Of the renin-angiotensin system and reactive oxygen species type 2 diabetes and angiotensin II inhibition. Am J Hypertens 18: 121-128, 2005
23. Middler S, Pak CY, Murad F, Bartter FC: Thiazide diuretics and calcium metabolism. Metabolism 22: 139-146, 1973
24. Kool MJ, Lustermans FA, Breed JG, Struyker Boudier HA, Hoeks AP, Reneman RS, Van Bortel LM: The influence of perindopril and the diuretic combination amiloride+hydrochlorothiazide on the vessel wall properties of large arteries in hypertensive patients. J Hypertens 13: 839-848, 1995
25. Zhou MS, Schulman IH, Jaimes EA, Raij L: Thiazide diuretics, endothelial function, and vascular oxidative stress. J Hypertens 26: 494-500, 2008
26. Safar ME, London GM: The arterial system in human hypertension. In: Textbook of Hypertension, edited by Swales JS, London, Blackwell Scientific Publications, 1994, pp 85-102
27. de Borst MH, Vervloet MG, ter Wee PM, Navis G: Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease. J Am Soc Nephrol 22: 1603-1609, 2011
28. Lau WL, Leaf EM, Hu MC, Takeno MM, Kuro-o M, Moe OW, Giachelli CM: Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet. Kidney Int 82: 1261-1270, 2012
29. Grant FD, Mandel SJ, Brown EM, Williams GH, Seely EW: Interrelationships between the renin-angiotensin-aldosterone and calcium homeostatic systems. J Clin Endocrinol Metab 75: 988-992, 1992
30. Yüksel H, Darcan S, Kabasakal C, Cura A, Mir S, Mavi E: Effect of enalapril on proteinuria, phosphaturia, and calciuria in insulin-dependent diabetes. Pediatr Nephrol 12: 648-650, 1998
31. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker-Boudier H; European Network for Non-invasive Investigation of Large Arteries: Expert consensus document on arterial stiffness: Methodological issues and clinical applications. Eur Heart J 27: 2588-2605, 2006
32. Karalliedde J, Viberti G: Evidence for renoprotection by blockade of the renin-angiotensin-aldosterone system in hypertension and diabetes. J Hum Hypertens 20: 239-253, 2006