-
1
-
-
0019392575
-
Minerals formed by organisms
-
Lowenstam HA. 1981. Minerals formed by organisms. Science 211:1126-31
-
(1981)
Science
, vol.211
, pp. 1126-1131
-
-
Lowenstam, H.A.1
-
4
-
-
0011390728
-
Calcium, phosphorus and the origin of backbones
-
Pautard FG. 1961. Calcium, phosphorus and the origin of backbones. New Sci. 260:364
-
(1961)
New Sci.
, vol.260
, pp. 364
-
-
Pautard, F.G.1
-
6
-
-
80053258367
-
Leptin in human physiology and pathophysiology
-
Mantzoros CS, Magkos F, Brinkoetter M, Sienkiewicz E, Dardeno TA, et al. 2011. Leptin in human physiology and pathophysiology. Am. J. Physiol. Endocrinol. Metab. 301:E567-84
-
(2011)
Am. J. Physiol. Endocrinol. Metab.
, vol.301
-
-
Mantzoros, C.S.1
Magkos, F.2
Brinkoetter, M.3
Sienkiewicz, E.4
Dardeno, T.A.5
-
7
-
-
80052545899
-
The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism
-
Ducy P. 2011. The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism. Diabetologia 54:1291-97
-
(2011)
Diabetologia
, vol.54
, pp. 1291-1297
-
-
Ducy, P.1
-
8
-
-
84855987634
-
The contribution of bone to whole-organism physiology
-
Karsenty G, Ferron M. 2012. The contribution of bone to whole-organism physiology. Nature 481:314-20
-
(2012)
Nature
, vol.481
, pp. 314-320
-
-
Karsenty, G.1
Ferron, M.2
-
11
-
-
38149134409
-
Functional evolutionary history of the mouse Fgf gene family
-
Itoh N, Ornitz DM. 2008. Functional evolutionary history of the mouse Fgf gene family. Dev. Dyn. 237:18-27
-
(2008)
Dev. Dyn.
, vol.237
, pp. 18-27
-
-
Itoh, N.1
Ornitz, D.M.2
-
12
-
-
84859519654
-
The structural biology of the FGF19 subfamily
-
Beenken A, Mohammadi M. 2012. The structural biology of the FGF19 subfamily. Adv. Exp. Med. Biol. 728:1-24
-
(2012)
Adv. Exp. Med. Biol.
, vol.728
, pp. 1-24
-
-
Beenken, A.1
Mohammadi, M.2
-
13
-
-
84859528536
-
Physiology of FGF15/19
-
Jones SA. 2012. Physiology of FGF15/19. Adv. Exp. Med. Biol. 728:171-82
-
(2012)
Adv. Exp. Med. Biol.
, vol.728
, pp. 171-182
-
-
Jones, S.A.1
-
14
-
-
84862144084
-
-
Austin, TX/New York: Landes Biosci./Springer.
-
Kuro-o M. 2012. Endocrine FGFs and Klothos. Austin, TX/New York: Landes Biosci./Springer. 233 pp.
-
(2012)
Endocrine FGFs and Klothos
-
-
Kuro-O, M.1
-
15
-
-
77957376253
-
Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse
-
Fon Tacer K, Bookout AL, Ding X, Kurosu H, John GB, et al. 2010. Research resource: comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Mol. Endocrinol. 24:2050-64
-
(2010)
Mol. Endocrinol.
, vol.24
, pp. 2050-2064
-
-
Fon Tacer, K.1
Bookout, A.L.2
Ding, X.3
Kurosu, H.4
John, G.B.5
-
16
-
-
34247565954
-
Molecular insights into the Klotho-dependent, endocrine mode of action of FGF19 subfamily members
-
Goetz R, Beenken A, Ibrahimi OA, Kalinina J, Olsen SK, et al. 2007. Molecular insights into the Klotho-dependent, endocrine mode of action of FGF19 subfamily members. Mol. Cell. Biol. 27:3417-28
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 3417-3428
-
-
Goetz, R.1
Beenken, A.2
Ibrahimi, O.A.3
Kalinina, J.4
Olsen, S.K.5
-
17
-
-
76249084836
-
Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation
-
Goetz R, Nakada Y, Hu MC, Kurosu H, Wang L, et al. 2010. Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation. Proc. Natl. Acad. Sci. USA 107:407-12
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 407-412
-
-
Goetz, R.1
Nakada, Y.2
Hu, M.C.3
Kurosu, H.4
Wang, L.5
-
18
-
-
0033763097
-
Autosomal dominant hy-pophosphataemic rickets is associated with mutations in FGF23
-
White KE, Evans WE, O'Riordan JLH, Speer MC, Econs MJ, et al. 2000. Autosomal dominant hy-pophosphataemic rickets is associated with mutations in FGF23. Nat. Genet. 26:345-48
-
(2000)
Nat. Genet.
, vol.26
, pp. 345-348
-
-
White, K.E.1
Evans, W.E.2
Jlh, O.3
Speer, M.C.4
Econs, M.J.5
-
19
-
-
14344279878
-
Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
-
Shimada T, Mizutani S, Muto T, Yoneya T, Hino R, et al. 2001. Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc. Natl. Acad. Sci. USA 98:6500-5
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 6500-6505
-
-
Shimada, T.1
Mizutani, S.2
Muto, T.3
Yoneya, T.4
Hino, R.5
-
20
-
-
0035186837
-
Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23
-
White KE, Carn G, Lorenz-Depiereux B, Benet-Pages A, Strom TM, Econs MJ. 2001. Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23. Kidney Int. 60:2079-86
-
(2001)
Kidney Int.
, vol.60
, pp. 2079-2086
-
-
White, K.E.1
Carn, G.2
Lorenz-Depiereux, B.3
Benet-Pages, A.4
Strom, T.M.5
Econs, M.J.6
-
21
-
-
1642416884
-
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism
-
Shimada T, Kakitani M, Yamazaki Y, Hasegawa H, Takeuchi Y, et al. 2004. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J. Clin. Investig. 113:561-68
-
(2004)
J. Clin. Investig.
, vol.113
, pp. 561-568
-
-
Shimada, T.1
Kakitani, M.2
Yamazaki, Y.3
Hasegawa, H.4
Takeuchi, Y.5
-
22
-
-
0030724491
-
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
-
Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, et al. 1997. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390:45-51
-
(1997)
Nature
, vol.390
, pp. 45-51
-
-
Kuro-O, M.1
Matsumura, Y.2
Aizawa, H.3
Kawaguchi, H.4
Suga, T.5
-
23
-
-
33646578195
-
Regulation of fibroblast growth factor-23 signaling by klotho
-
Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, et al. 2006. Regulation of fibroblast growth factor-23 signaling by klotho. J. Biol. Chem. 281:6120-23
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 6120-6123
-
-
Kurosu, H.1
Ogawa, Y.2
Miyoshi, M.3
Yamamoto, M.4
Nandi, A.5
-
24
-
-
80555148939
-
FGF23 induces left ventricular hypertrophy
-
Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, et al. 2011. FGF23 induces left ventricular hypertrophy. J. Clin. Investig. 121:4393-408
-
(2011)
J. Clin. Investig.
, vol.121
, pp. 4393-4408
-
-
Faul, C.1
Amaral, A.P.2
Oskouei, B.3
Hu, M.C.4
Sloan, A.5
-
25
-
-
0032746021
-
Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia
-
Kawaguchi H, Manabe N, Miyaura C, Chikuda H, Nakamura K, Kuro-o M. 1999. Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia. J. Clin. Investig. 104:229-37
-
(1999)
J. Clin. Investig.
, vol.104
, pp. 229-237
-
-
Kawaguchi, H.1
Manabe, N.2
Miyaura, C.3
Chikuda, H.4
Nakamura, K.5
Kuro-O, M.6
-
26
-
-
0034093125
-
Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life
-
Suga T, Kurabayashi M, Sando Y, Ohyama Y, Maeno T, et al. 2000. Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life. Am. J. Respir. Cell Mol. Biol. 22:26-33
-
(2000)
Am. J. Respir. Cell Mol. Biol.
, vol.22
, pp. 26-33
-
-
Suga, T.1
Kurabayashi, M.2
Sando, Y.3
Ohyama, Y.4
Maeno, T.5
-
27
-
-
33845631059
-
Klotho converts canonical FGF receptor into a specific receptor for FGF23
-
Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, et al. 2006. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444:770-74
-
(2006)
Nature
, vol.444
, pp. 770-774
-
-
Urakawa, I.1
Yamazaki, Y.2
Shimada, T.3
Iijima, K.4
Hasegawa, H.5
-
28
-
-
77956642900
-
Klotho: A novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
-
Hu MC, Shi M, Zhang J, Pastor J, Nakatani T, et al. 2010. Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J. 24:3438-50
-
(2010)
FASEB J.
, vol.24
, pp. 3438-3450
-
-
Hu, M.C.1
Shi, M.2
Zhang, J.3
Pastor, J.4
Nakatani, T.5
-
30
-
-
33646367420
-
Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D
-
Liu S, Tang W, Zhou J, Stubbs JR, Luo Q, et al. 2006. Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. J. Am. Soc. Nephrol. 17:1305-15
-
(2006)
J. Am. Soc. Nephrol.
, vol.17
, pp. 1305-1315
-
-
Liu, S.1
Tang, W.2
Zhou, J.3
Stubbs, J.R.4
Luo, Q.5
-
33
-
-
36849017126
-
The parathyroid is a target organ for FGF23 in rats
-
Ben-Dov IZ, Galitzer H, Lavi-Moshayoff V, Goetz R, Kuro-o M, et al. 2007. The parathyroid is a target organ for FGF23 in rats. J. Clin. Investig. 117:4003-8
-
(2007)
J. Clin. Investig.
, vol.117
, pp. 4003-4008
-
-
Ben-Dov, I.Z.1
Galitzer, H.2
Lavi-Moshayoff, V.3
Goetz, R.4
Kuro-O, M.5
-
34
-
-
35848947037
-
Fibroblast growth factor-23 regulates parathyroid hormone and 1α-hydroxylase expression in cultured bovine parathyroid cells
-
Krajisnik T, Bjorklund P, Marsell R, Ljunggren O, Akerstrom G, et al. 2007. Fibroblast growth factor-23 regulates parathyroid hormone and 1α-hydroxylase expression in cultured bovine parathyroid cells. J. Endocrinol. 195:125-31
-
(2007)
J. Endocrinol.
, vol.195
, pp. 125-131
-
-
Krajisnik, T.1
Bjorklund, P.2
Marsell, R.3
Ljunggren, O.4
Akerstrom, G.5
-
35
-
-
24944481544
-
Suppression of aging in mice by the hormone Klotho
-
Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, et al. 2005. Suppression of aging in mice by the hormone Klotho. Science 309:1829-33
-
(2005)
Science
, vol.309
, pp. 1829-1833
-
-
Kurosu, H.1
Yamamoto, M.2
Clark, J.D.3
Pastor, J.V.4
Nandi, A.5
-
36
-
-
0034333526
-
Molecular cloning and expression analyses of mouse βklotho, which encodes a novel Klotho family protein
-
Ito S, Kinoshita S, Shiraishi N, Nakagawa S, Sekine S, et al. 2000. Molecular cloning and expression analyses of mouse βklotho, which encodes a novel Klotho family protein. Mech. Dev. 98:115-19
-
(2000)
Mech. Dev.
, vol.98
, pp. 115-119
-
-
Ito, S.1
Kinoshita, S.2
Shiraishi, N.3
Nakagawa, S.4
Sekine, S.5
-
37
-
-
0037135232
-
Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure
-
Ito S, Fujimori T, Hayashizaki Y, Nabeshima Y. 2002. Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure. Biochim. Biophys. Acta 1576:341-45
-
(2002)
Biochim. Biophys. Acta
, vol.1576
, pp. 341-345
-
-
Ito, S.1
Fujimori, T.2
Hayashizaki, Y.3
Nabeshima, Y.4
-
38
-
-
26844564690
-
Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23
-
Yu X, Ibrahimi OA, Goetz R, Zhang F, Davis SI, et al. 2005. Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23. Endocrinology 146:4647-56
-
(2005)
Endocrinology
, vol.146
, pp. 4647-4656
-
-
Yu, X.1
Ibrahimi, O.A.2
Goetz, R.3
Zhang, F.4
Davis, S.I.5
-
39
-
-
34848869695
-
Tissue-specific expression of βklotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
-
Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, et al. 2007. Tissue-specific expression of βKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J. Biol. Chem. 282:26687-95
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 26687-26695
-
-
Kurosu, H.1
Choi, M.2
Ogawa, Y.3
Dickson, A.S.4
Goetz, R.5
-
40
-
-
34249697012
-
βKlotho is required for metabolic activity of fibroblast growth factor 21
-
Ogawa Y, Kurosu H, Yamamoto M, Nandi A, Rosenblatt KP, et al. 2007. βKlotho is required for metabolic activity of fibroblast growth factor 21. Proc. Natl. Acad. Sci. USA 104:7432-37
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 7432-7437
-
-
Ogawa, Y.1
Kurosu, H.2
Yamamoto, M.3
Nandi, A.4
Rosenblatt, K.P.5
-
41
-
-
27844546989
-
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
-
Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, et al. 2005. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab. 2:217-25
-
(2005)
Cell Metab.
, vol.2
, pp. 217-225
-
-
Inagaki, T.1
Choi, M.2
Moschetta, A.3
Peng, L.4
Cummins, C.L.5
-
42
-
-
23644437321
-
Impaired negative feedback suppression of bile acid synthesis in mice lacking βklotho
-
Ito S, Fujimori T, Furuya A, Satoh J, Nabeshima Y, Nabeshima Y. 2005. Impaired negative feedback suppression of bile acid synthesis in mice lacking βKlotho. J. Clin. Investig. 115:2202-8
-
(2005)
J. Clin. Investig.
, vol.115
, pp. 2202-2208
-
-
Ito, S.1
Fujimori, T.2
Furuya, A.3
Satoh, J.4
Nabeshima, Y.5
Nabeshima, Y.6
-
43
-
-
0034685916
-
Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4
-
Yu C, Wang F, Kan M, Jin C, Jones RB, et al. 2000. Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J. Biol. Chem. 275:15482-89
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 15482-15489
-
-
Yu, C.1
Wang, F.2
Kan, M.3
Jin, C.4
Jones, R.B.5
-
44
-
-
33750698614
-
Identification of a hormonal basis for gallbladder filling
-
Choi M, Moschetta A, Bookout AL, Peng L, Umetani M, et al. 2006. Identification of a hormonal basis for gallbladder filling. Nat. Med. 12:1253-55
-
(2006)
Nat. Med.
, vol.12
, pp. 1253-1255
-
-
Choi, M.1
Moschetta, A.2
Bookout, A.L.3
Peng, L.4
Umetani, M.5
-
45
-
-
79953129095
-
FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis
-
Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, et al. 2011. FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science 331:1621-24
-
(2011)
Science
, vol.331
, pp. 1621-1624
-
-
Kir, S.1
Beddow, S.A.2
Samuel, V.T.3
Miller, P.4
Previs, S.F.5
-
46
-
-
18344394556
-
Transgenic mice expressing human fibro-blast growth factor-19 display increased metabolic rate and decreased adiposity
-
Tomlinson E, Fu L, John L, Hultgren B, Huang X, et al. 2002. Transgenic mice expressing human fibro-blast growth factor-19 display increased metabolic rate and decreased adiposity. Endocrinology 143:1741-47
-
(2002)
Endocrinology
, vol.143
, pp. 1741-1747
-
-
Tomlinson, E.1
Fu, L.2
John, L.3
Hultgren, B.4
Huang, X.5
-
47
-
-
79958066536
-
FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1αpathway
-
Potthoff MJ, Boney-Montoya J, Choi M, He T, Sunny NE, et al. 2011. FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1αpathway. Cell Metab. 13:729-38
-
(2011)
Cell Metab.
, vol.13
, pp. 729-738
-
-
Potthoff, M.J.1
Boney-Montoya, J.2
Choi, M.3
He, T.4
Sunny, N.E.5
-
48
-
-
84857185764
-
Endocrine fibroblast growth factors 15/19 and 21: From feast to famine
-
Potthoff MJ, Kliewer SA, Mangelsdorf DJ. 2012. Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Genes Dev. 26:312-24
-
(2012)
Genes Dev.
, vol.26
, pp. 312-324
-
-
Potthoff, M.J.1
Kliewer, S.A.2
Mangelsdorf, D.J.3
-
49
-
-
74049108945
-
Fibroblast growth factor 21: From pharmacology to physiology
-
Kliewer SA, Mangelsdorf DJ. 2010. Fibroblast growth factor 21: from pharmacology to physiology. Am. J. Clin. Nutr. 91:254S-57S
-
(2010)
Am. J. Clin. Nutr.
, vol.91
-
-
Kliewer, S.A.1
Mangelsdorf, D.J.2
-
50
-
-
67649823642
-
FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
-
Potthoff MJ, Inagaki T, Satapati S, Ding X, He T, et al. 2009. FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc. Natl. Acad. Sci. USA 106:10853-58
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 10853-10858
-
-
Potthoff, M.J.1
Inagaki, T.2
Satapati, S.3
Ding, X.4
He, T.5
-
51
-
-
34249686631
-
Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21
-
Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, et al. 2007. Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21. Cell Metab. 5:415-25
-
(2007)
Cell Metab.
, vol.5
, pp. 415-425
-
-
Inagaki, T.1
Dutchak, P.2
Zhao, G.3
Ding, X.4
Gautron, L.5
-
52
-
-
79960726293
-
Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo
-
Fisher FM, Estall JL, Adams AC, Antonellis PJ, Bina HA, et al. 2011. Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology 152:2996-3004
-
(2011)
Endocrinology
, vol.152
, pp. 2996-3004
-
-
Fisher, F.M.1
Estall, J.L.2
Adams, A.C.3
Antonellis, P.J.4
Bina, H.A.5
-
53
-
-
84863012022
-
FGF21 regulates PGC-1cx and browning of white adipose tissues in adaptive thermogenesis
-
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, et al. 2012. FGF21 regulates PGC-1cx and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 26:271-81
-
(2012)
Genes Dev.
, vol.26
, pp. 271-281
-
-
Fisher, F.M.1
Kleiner, S.2
Douris, N.3
Fox, E.C.4
Mepani, R.J.5
-
54
-
-
34249711964
-
Hepatic fibroblast growth factor 21 is regulated by PPARtx and is a key mediator of hepatic lipid metabolism in ketotic states
-
Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. 2007. Hepatic fibroblast growth factor 21 is regulated by PPARtx and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 5:426-37
-
(2007)
Cell Metab.
, vol.5
, pp. 426-437
-
-
Badman, M.K.1
Pissios, P.2
Kennedy, A.R.3
Koukos, G.4
Flier, J.S.5
Maratos-Flier, E.6
-
55
-
-
0032567647
-
Identification of the human klotho gene and its two transcripts encoding membrane and secreted Klotho protein
-
Matsumura Y, Aizawa H, Shiraki-Iida T, Nagai R, Kuro-o M, Nabeshima Y. 1998. Identification of the human klotho gene and its two transcripts encoding membrane and secreted Klotho protein. Biochem. Biophys. Res. Commun. 242:626-30
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.242
, pp. 626-630
-
-
Matsumura, Y.1
Aizawa, H.2
Shiraki-Iida, T.3
Nagai, R.4
Kuro-O, M.5
Nabeshima, Y.6
-
56
-
-
2342610541
-
Secreted Klotho protein in sera and CSF: Implication for post-translational cleavage in release of Klotho protein from cell membrane
-
Imura A, Iwano A, Tohyama O, Tsuji Y, Nozaki K, et al. 2004. Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett 565:143-47
-
(2004)
FEBS Lett
, vol.565
, pp. 143-147
-
-
Imura, A.1
Iwano, A.2
Tohyama, O.3
Tsuji, Y.4
Nozaki, K.5
-
57
-
-
38049144010
-
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
-
Chen CD, Podvin S, Gillespie E, Leeman SE, Abraham CR. 2007. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc. Natl. Acad. Sci. USA 104:19796-801
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 19796-19801
-
-
Chen, C.D.1
Podvin, S.2
Gillespie, E.3
Leeman, S.E.4
Abraham, C.R.5
-
58
-
-
70349437179
-
Klotho is a substrate for ex-, β3-and y-secretase
-
Bloch L, Sineshchekova O, Reichenbach D, Reiss K, Saftig P, et al. 2009. Klotho is a substrate for ex-, β3-and y-secretase. FEBS Lett. 583:3221-24
-
(2009)
FEBS Lett.
, vol.583
, pp. 3221-3224
-
-
Bloch, L.1
Sineshchekova, O.2
Reichenbach, D.3
Reiss, K.4
Saftig, P.5
-
59
-
-
78651408919
-
Klotho deficiency causes vascular calcification in chronic kidney disease
-
Hu MC, Shi M, Zhang J, Quinones H, Griffith C, et al. 2011. Klotho deficiency causes vascular calcification in chronic kidney disease. J. Am. Soc. Nephrol. 22:124-36
-
(2011)
J. Am. Soc. Nephrol.
, vol.22
, pp. 124-136
-
-
Hu, M.C.1
Shi, M.2
Zhang, J.3
Quinones, H.4
Griffith, C.5
-
60
-
-
47749148805
-
Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1
-
Cha SK, Ortega B, Kurosu H, Rosenblatt KP, Kuro-o M, Huang CL. 2008. Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc. Natl. Acad. Sci. USA 105:9805-10
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 9805-9810
-
-
Cha, S.K.1
Ortega, B.2
Kurosu, H.3
Rosenblatt, K.P.4
Kuro-O, M.5
Huang, C.L.6
-
61
-
-
27144440831
-
The β3-glucuronidase klotho hydrolyzes and activates the TRPV5 channel
-
Chang Q, Hoefs S, van der Kemp AW, Topala CN, Bindels RJ, Hoenderop JG. 2005. The β3-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 310:490-93
-
(2005)
Science
, vol.310
, pp. 490-493
-
-
Chang, Q.1
Hoefs, S.2
Van Der Kemp, A.W.3
Topala, C.N.4
Bindels, R.J.5
Hoenderop, J.G.6
-
62
-
-
34547908461
-
Augmented Wnt signaling in a mammalian model of accelerated aging
-
Liu H, Fergusson MM, Castilho RM, Liu J, Cao L, et al. 2007. Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317:803-6
-
(2007)
Science
, vol.317
, pp. 803-806
-
-
Liu, H.1
Fergusson, M.M.2
Castilho, R.M.3
Liu, J.4
Cao, L.5
-
63
-
-
79953138206
-
Klotho inhibits transforming growth factor-131 (TGF-131) signaling and suppresses renal fibrosis and cancer metastasis in mice
-
Doi S, Zou Y, Togao O, Pastor JV, John GB, et al. 2011. Klotho inhibits transforming growth factor-131 (TGF-131) signaling and suppresses renal fibrosis and cancer metastasis in mice. J. Biol. Chem. 286:8655-65
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 8655-8665
-
-
Doi, S.1
Zou, Y.2
Togao, O.3
Pastor, J.V.4
John, G.B.5
-
65
-
-
1642352496
-
Klotho is a novel β3-glucuronidase capable of hydrolyzing steroid β3-glucuronides
-
Tohyama O, Imura A, Iwano A, Freund JN, Henrissat B, et al. 2004. Klotho is a novel β3-glucuronidase capable of hydrolyzing steroid β3-glucuronides. J. Biol. Chem. 279:9777-84
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 9777-9784
-
-
Tohyama, O.1
Imura, A.2
Iwano, A.3
Freund, J.N.4
Henrissat, B.5
-
66
-
-
84857067427
-
Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo
-
Lopez I, Rodriguez-Ortiz ME, Almaden Y, Guerrero F, de Oca AM, et al. 2011. Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo. Kidney Int. 80:475-82
-
(2011)
Kidney Int.
, vol.80
, pp. 475-482
-
-
Lopez, I.1
Rodriguez-Ortiz, M.E.2
Almaden, Y.3
Guerrero, F.4
De Oca, A.M.5
-
67
-
-
84863506935
-
Calcium deficiency reduces circulating levels of FGF23
-
Rodriguez-Ortiz ME, Lopez I, Munoz-Castaneda JR, Martinez-Moreno JM, Ramirez AP, et al. 2012. Calcium deficiency reduces circulating levels of FGF23. J. Am. Soc. Nephrol. 23:1190-97
-
(2012)
J. Am. Soc. Nephrol.
, vol.23
, pp. 1190-1197
-
-
Rodriguez-Ortiz, M.E.1
Lopez, I.2
Munoz-Castaneda, J.R.3
Martinez-Moreno, J.M.4
Ramirez, A.P.5
-
68
-
-
80052303008
-
Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo
-
Rhee Y, Bivi N, Farrow E, Lezcano V, Plotkin LI, et al. 2011. Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo. Bone 49:636-43
-
(2011)
Bone
, vol.49
, pp. 636-643
-
-
Rhee, Y.1
Bivi, N.2
Farrow, E.3
Lezcano, V.4
Plotkin, L.I.5
-
69
-
-
33845296928
-
Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts
-
Masuyama R, Stockmans I, Torrekens S, Van Looveren R, Maes C, et al. 2006. Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts. J. Clin. Investig. 116:3150-59
-
(2006)
J. Clin. Investig.
, vol.116
, pp. 3150-3159
-
-
Masuyama, R.1
Stockmans, I.2
Torrekens, S.3
Van Looveren, R.4
Maes, C.5
-
70
-
-
84858128980
-
The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis
-
Haussler MR, Whitfield GK, Kaneko I, Forster R, Saini R, et al. 2011. The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis. Rev. Endocr. Metab. Disord. 13:57-69
-
(2011)
Rev. Endocr. Metab. Disord.
, vol.13
, pp. 57-69
-
-
Haussler, M.R.1
Whitfield, G.K.2
Kaneko, I.3
Forster, R.4
Saini, R.5
-
71
-
-
18744371012
-
Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia
-
Yamazaki Y, Okazaki R, Shibata M, Hasegawa Y, Satoh K, et al. 2002. Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia. J. Clin. Endocrinol. Metab. 87:4957-60
-
(2002)
J. Clin. Endocrinol. Metab.
, vol.87
, pp. 4957-4960
-
-
Yamazaki, Y.1
Okazaki, R.2
Shibata, M.3
Hasegawa, Y.4
Satoh, K.5
-
73
-
-
20244368616
-
Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia
-
Jonsson KB, Zahradnik R, Larsson T, White KE, Sugimoto T, et al. 2003. Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. N. Engl. J. Med. 348:1656-63
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 1656-1663
-
-
Jonsson, K.B.1
Zahradnik, R.2
Larsson, T.3
White, K.E.4
Sugimoto, T.5
-
74
-
-
33750454816
-
Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
-
Feng JQ, Ward LM, Liu S, Lu Y, Xie Y, et al. 2006. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat. Genet. 38:1310-15
-
(2006)
Nat. Genet.
, vol.38
, pp. 1310-1315
-
-
Feng, J.Q.1
Ward, L.M.2
Liu, S.3
Lu, Y.4
Xie, Y.5
-
75
-
-
80053211073
-
FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone
-
Wohrle S, Bonny O, Beluch N, Gaulis S, Stamm C, et al. 2011. FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone. J. Bone Miner. Res. 26:2486-97
-
(2011)
J. Bone Miner. Res.
, vol.26
, pp. 2486-2497
-
-
Wohrle, S.1
Bonny, O.2
Beluch, N.3
Gaulis, S.4
Stamm, C.5
-
76
-
-
80051687775
-
Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling
-
Martin A, Liu S, David V, Li H, Karydis A, et al. 2011. Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling. FASEB J. 25:2551-62
-
(2011)
FASEB J.
, vol.25
, pp. 2551-2562
-
-
Martin, A.1
Liu, S.2
David, V.3
Li, H.4
Karydis, A.5
-
77
-
-
77957993384
-
PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: A bone parathyroid feedback loop
-
Lavi-Moshayoff V, Wasserman G, Meir T, Silver J, Naveh-Many T. 2010. PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop. Am. J. Physiol. Ren. Physiol. 299:F882-89
-
(2010)
Am. J. Physiol. Ren. Physiol.
, vol.299
-
-
Lavi-Moshayoff, V.1
Wasserman, G.2
Meir, T.3
Silver, J.4
Naveh-Many, T.5
-
78
-
-
33947365189
-
Phosphatonins and the regulation of phosphate homeostasis
-
Berndt T, Kumar R. 2007. Phosphatonins and the regulation of phosphate homeostasis. Annu. Rev. Physiol. 69:341-59
-
(2007)
Annu. Rev. Physiol.
, vol.69
, pp. 341-359
-
-
Berndt, T.1
Kumar, R.2
-
79
-
-
80051979062
-
FGF-23/Klotho signaling is not essential for the phosphaturic and anabolic functions of PTH
-
Yuan Q, Sato T, Densmore M, Saito H, Schuler C, et al. 2011. FGF-23/Klotho signaling is not essential for the phosphaturic and anabolic functions of PTH. J. Bone Miner. Res. 26:2026-35
-
(2011)
J. Bone Miner. Res.
, vol.26
, pp. 2026-2035
-
-
Yuan, Q.1
Sato, T.2
Densmore, M.3
Saito, H.4
Schuler, C.5
-
80
-
-
33947192418
-
1, 25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism
-
Barthel TK, Mathern DR, Whitfield GK, Haussler CA, Hopper HA 4th, et al. 2007. 1, 25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism. J. Steroid Biochem. Mol. Biol. 103:381-88
-
(2007)
J. Steroid Biochem. Mol. Biol.
, vol.103
, pp. 381-388
-
-
Barthel, T.K.1
Mathern, D.R.2
Whitfield, G.K.3
Haussler, C.A.4
Hopper IV, H.A.5
-
81
-
-
20444404265
-
Genetic dissection of phosphate-and vitamin D-mediated regulation of circulating Fgf23 concentrations
-
Yu X, Sabbagh Y, Davis SI, Demay MB, White KE. 2005. Genetic dissection of phosphate-and vitamin D-mediated regulation of circulating Fgf23 concentrations. Bone 36:971-77
-
(2005)
Bone
, vol.36
, pp. 971-977
-
-
Yu, X.1
Sabbagh, Y.2
Davis, S.I.3
Demay, M.B.4
White, K.E.5
-
82
-
-
35748956817
-
Effect of acute changes of serum phosphate on fibroblast growth factor (FGF)23 levels in humans
-
Ito N, Fukumoto S, Takeuchi Y, Takeda S, Suzuki H, et al. 2007. Effect of acute changes of serum phosphate on fibroblast growth factor (FGF)23 levels in humans. J. Bone Miner. Metab. 25:419-22
-
(2007)
J. Bone Miner. Metab.
, vol.25
, pp. 419-422
-
-
Ito, N.1
Fukumoto, S.2
Takeuchi, Y.3
Takeda, S.4
Suzuki, H.5
-
83
-
-
33746406756
-
Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women
-
Burnett SM, Gunawardene SC, Bringhurst FR, Juppner H, Lee H, Finkelstein JS. 2006. Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women. J. Bone Miner. Res. 21:1187-96
-
(2006)
J. Bone Miner. Res.
, vol.21
, pp. 1187-1196
-
-
Burnett, S.M.1
Gunawardene, S.C.2
Bringhurst, F.R.3
Juppner, H.4
Lee, H.5
Finkelstein, J.S.6
-
84
-
-
34848871595
-
A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis
-
Ichikawa S, Imel EA, Kreiter ML, Yu X, Mackenzie DS, et al. 2007. A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. J. Clin. Investig. 117:2684-91
-
(2007)
J. Clin. Investig.
, vol.117
, pp. 2684-2691
-
-
Ichikawa, S.1
Imel, E.A.2
Kreiter, M.L.3
Yu, X.4
MacKenzie, D.S.5
-
85
-
-
84868364558
-
Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis
-
Shimamura Y, Hamada K, Inoue K, Ogata K, Ishihara M, et al. 2012. Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis. Clin. Exp. Nephrol. 16:722-29
-
(2012)
Clin. Exp. Nephrol.
, vol.16
, pp. 722-729
-
-
Shimamura, Y.1
Hamada, K.2
Inoue, K.3
Ogata, K.4
Ishihara, M.5
-
86
-
-
84857153786
-
Soluble klotho and autosomal dominant polycystic kidney disease
-
Pavik I, Jaeger P, Ebner L, Poster D, Krauer F, et al. 2012. Soluble klotho and autosomal dominant polycystic kidney disease. Clin. J. Am. Soc. Nephrol. 7:248-57
-
(2012)
Clin. J. Am. Soc. Nephrol.
, vol.7
, pp. 248-257
-
-
Pavik, I.1
Jaeger, P.2
Ebner, L.3
Poster, D.4
Krauer, F.5
-
88
-
-
0034810211
-
Severely reduced production of klotho in human chronic renal failure kidney
-
Koh N, Fujimori T, Nishiguchi S, Tamori A, Shiomi S, et al. 2001. Severely reduced production of klotho in human chronic renal failure kidney. Biochem. Biophys. Res. Commun. 280:1015-20
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.280
, pp. 1015-1020
-
-
Koh, N.1
Fujimori, T.2
Nishiguchi, S.3
Tamori, A.4
Shiomi, S.5
-
89
-
-
59649091992
-
In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23)-mediated regulation of systemic phosphate homeostasis
-
Nakatani T, Sarraj B, Ohnishi M, Densmore MJ, Taguchi T, et al. 2009. In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23)-mediated regulation of systemic phosphate homeostasis. FASEB J. 23:433-41
-
(2009)
FASEB J.
, vol.23
, pp. 433-441
-
-
Nakatani, T.1
Sarraj, B.2
Ohnishi, M.3
Densmore, M.J.4
Taguchi, T.5
-
90
-
-
58249095115
-
Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype
-
Bai X, Dinghong Q, Miao D, Goltzman D, Karaplis AC. 2009. Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype. Am. J. Physiol. Endocrinol. Metab. 296:E79-88
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.296
-
-
Bai, X.1
Dinghong, Q.2
Miao, D.3
Goltzman, D.4
Karaplis, A.C.5
-
91
-
-
70350552306
-
Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophos-phatemic (Hyp) mouse model
-
Nakatani T, Ohnishi M, Razzaque MS. 2009. Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophos-phatemic (Hyp) mouse model. FASEB J. 23:3702-11
-
(2009)
FASEB J.
, vol.23
, pp. 3702-3711
-
-
Nakatani, T.1
Ohnishi, M.2
Razzaque, M.S.3
-
92
-
-
78049511826
-
Circulating levelsofsoluble Klotho and FGF23 in X-linked hypophosphatemia: Circadian variance, effects of treatment, and relationship to parathyroid status
-
Carpenter TO, Insogna KL, Zhang JH, Ellis B, Nieman S, et al. 2010. Circulating levelsofsoluble Klotho and FGF23 in X-linked hypophosphatemia: circadian variance, effects of treatment, and relationship to parathyroid status. J. Clin. Endocrinol. Metab. 95:E352-57
-
(2010)
J. Clin. Endocrinol. Metab.
, vol.95
-
-
Carpenter, T.O.1
Insogna, K.L.2
Zhang, J.H.3
Ellis, B.4
Nieman, S.5
-
93
-
-
42449126730
-
Gene expression analysis of kidneys from transgenic mice expressingfibroblast growth factor-23
-
Marsell R, Krajisnik T, Goransson H, Ohlsson C, Ljunggren O, et al. 2008. Gene expression analysis of kidneys from transgenic mice expressingfibroblast growth factor-23. Nephrol. Dial. Transplant. 23:827-33
-
(2008)
Nephrol. Dial. Transplant.
, vol.23
, pp. 827-833
-
-
Marsell, R.1
Krajisnik, T.2
Goransson, H.3
Ohlsson, C.4
Ljunggren, O.5
-
94
-
-
2342599742
-
Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression
-
Takeshita K, Fujimori T, Kurotaki Y, Honjo H, Tsujikawa H, et al. 2004. Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Circulation 109:1776-82
-
(2004)
Circulation
, vol.109
, pp. 1776-1782
-
-
Takeshita, K.1
Fujimori, T.2
Kurotaki, Y.3
Honjo, H.4
Tsujikawa, H.5
-
95
-
-
77954567520
-
FGF23 fails to inhibit uremic parathyroid glands
-
Canalejo R, Canalejo A, Martinez-Moreno JM, Rodriguez-Ortiz ME, Estepa JC, et al. 2010. FGF23 fails to inhibit uremic parathyroid glands. J. Am. Soc. Nephrol. 21:1125-35
-
(2010)
J. Am. Soc. Nephrol.
, vol.21
, pp. 1125-1135
-
-
Canalejo, R.1
Canalejo, A.2
Martinez-Moreno, J.M.3
Rodriguez-Ortiz, M.E.4
Estepa, J.C.5
-
96
-
-
7844250506
-
Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands
-
Tatsumi S, Segawa H, Morita K, Haga H, Kouda T, et al. 1998. Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands. Endocrinology 139:1692-99
-
(1998)
Endocrinology
, vol.139
, pp. 1692-1699
-
-
Tatsumi, S.1
Segawa, H.2
Morita, K.3
Haga, H.4
Kouda, T.5
-
97
-
-
53849118425
-
The discovery of α-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis
-
Nabeshima Y. 2008. The discovery of α-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis. Cell. Mol. Life Sci. 65:3218-30
-
(2008)
Cell. Mol. Life Sci.
, vol.65
, pp. 3218-3230
-
-
Nabeshima, Y.1
-
98
-
-
0036150953
-
Mediation of unusually high concentrations of 1, 25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1α-hydroxylase gene
-
Yoshida T, Fujimori T, Nabeshima Y. 2002. Mediation of unusually high concentrations of 1, 25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1α-hydroxylase gene. Endocrinology 143:683-89
-
(2002)
Endocrinology
, vol.143
, pp. 683-689
-
-
Yoshida, T.1
Fujimori, T.2
Nabeshima, Y.3
-
99
-
-
79955979230
-
Vitamin D-deficient diet rescues hearing loss in Klotho mice
-
Carpinelli MR, Wise AK, Burt RA. 2011. Vitamin D-deficient diet rescues hearing loss in Klotho mice. Hear. Res. 275:105-9
-
(2011)
Hear. Res.
, vol.275
, pp. 105-109
-
-
Carpinelli, M.R.1
Wise, A.K.2
Burt, R.A.3
-
100
-
-
0346849707
-
Klotho, agene related toasyndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system
-
Tsujikawa H, Kurotaki Y, Fujimori T, Fukuda K, Nabeshima Y. 2003. Klotho, agene related toasyndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol. Endocrinol. 17:2393-403
-
(2003)
Mol. Endocrinol.
, vol.17
, pp. 2393-2403
-
-
Tsujikawa, H.1
Kurotaki, Y.2
Fujimori, T.3
Fukuda, K.4
Nabeshima, Y.5
-
101
-
-
80054945714
-
Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells
-
Forster RE, Jurutka PW, Hsieh JC, Haussler CA, Lowmiller CL, et al. 2011. Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells. Biochem. Biophys. Res. Commun. 414:557-62
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.414
, pp. 557-562
-
-
Forster, R.E.1
Jurutka, P.W.2
Hsieh, J.C.3
Haussler, C.A.4
Lowmiller, C.L.5
-
102
-
-
0001068343
-
Renal damage following the ingestion of a diet containing an excess of inorganic phosphate
-
Mackay EM, Oliver J. 1935. Renal damage following the ingestion of a diet containing an excess of inorganic phosphate. J. Exp. Med. 61:319-34
-
(1935)
J. Exp. Med.
, vol.61
, pp. 319-334
-
-
MacKay, E.M.1
Oliver, J.2
-
103
-
-
0018933525
-
Renal toxicity of phosphate in rats
-
Haut LL, Alfrey AC, Guggenheim S, Buddington B, Schrier N. 1980. Renal toxicity of phosphate in rats. Kidney Int. 17:722-31
-
(1980)
Kidney Int.
, vol.17
, pp. 722-731
-
-
Haut, L.L.1
Alfrey, A.C.2
Guggenheim, S.3
Buddington, B.4
Schrier, N.5
-
104
-
-
56049117448
-
Acute phosphate nephropathy-an emerging threat
-
Ori Y, Herman M, Tobar A, Chernin G, Gafter U, et al. 2008. Acute phosphate nephropathy-an emerging threat. Am. J. Med. Sci. 336:309-14
-
(2008)
Am. J. Med. Sci.
, vol.336
, pp. 309-314
-
-
Ori, Y.1
Herman, M.2
Tobar, A.3
Chernin, G.4
Gafter, U.5
-
105
-
-
27444436252
-
Relation between serum phosphate level and cardiovascular event rate in people with coronary disease
-
Tonelli M, Sacks F, Pfeffer M, Gao Z, Curhan G. 2005. Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation 112:2627-33
-
(2005)
Circulation
, vol.112
, pp. 2627-2633
-
-
Tonelli, M.1
Sacks, F.2
Pfeffer, M.3
Gao, Z.4
Curhan, G.5
-
106
-
-
0034836578
-
Association of elevated serum PO(4), Ca × PO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodial-ysis patients
-
Ganesh SK, Stack AG, Levin NW, Hulbert-Shearon T, Port FK. 2001. Association of elevated serum PO(4), Ca × PO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodial-ysis patients. J. Am. Soc. Nephrol. 12:2131-38
-
(2001)
J. Am. Soc. Nephrol.
, vol.12
, pp. 2131-2138
-
-
Ganesh, S.K.1
Stack, A.G.2
Levin, N.W.3
Hulbert-Shearon, T.4
Port, F.K.5
-
107
-
-
79951867511
-
Prevention and control of phosphate retention/hyperphosphatemia in CKD-MBD: What is normal, when to start, and how to treat?
-
Martin KJ, Gonzalez EA. 2011. Prevention and control of phosphate retention/hyperphosphatemia in CKD-MBD: What is normal, when to start, and how to treat? Clin. J. Am. Soc. Nephrol. 6:440-46
-
(2011)
Clin. J. Am. Soc. Nephrol.
, vol.6
, pp. 440-446
-
-
Martin, K.J.1
Gonzalez, E.A.2
-
108
-
-
79952048863
-
-
Home Econ. Res. Rep. No. 58, US Dep. Agric., Washington, DC
-
Hiza H, Bente L, Fungwe T. 2008. Nutrient content of the U. S. food supply, 2005. Home Econ. Res. Rep. No. 58, US Dep. Agric., Washington, DC
-
(2008)
Nutrient Content of the U. S. Food Supply, 2005
-
-
Hiza, H.1
Bente, L.2
Fungwe, T.3
-
109
-
-
70349902634
-
Phosphorus additives in food and their effect in dialysis patients
-
Uribarri J. 2009. Phosphorus additives in food and their effect in dialysis patients. Clin. J. Am. Soc. Nephrol. 4:1290-92
-
(2009)
Clin. J. Am. Soc. Nephrol.
, vol.4
, pp. 1290-1292
-
-
Uribarri, J.1
-
110
-
-
34547163355
-
Phosphorus homeostasis in normal health and in chronic kidney disease patients with special emphasis on dietary phosphorus intake
-
Uribarri J. 2007. Phosphorus homeostasis in normal health and in chronic kidney disease patients with special emphasis on dietary phosphorus intake. Semin. Dial. 20:295-301
-
(2007)
Semin. Dial.
, vol.20
, pp. 295-301
-
-
Uribarri, J.1
-
111
-
-
45949095467
-
All-cause mortality attributable to chronic kidney disease: A prospective cohort study based on 462 293 adults in Taiwan
-
Wen CP, Cheng TY, Tsai MK, Chang YC, Chan HT, et al. 2008. All-cause mortality attributable to chronic kidney disease: a prospective cohort study based on 462 293 adults in Taiwan. Lancet 371:2173-82
-
(2008)
Lancet
, vol.371
, pp. 2173-2182
-
-
Wen, C.P.1
Cheng, T.Y.2
Tsai, M.K.3
Chang, Y.C.4
Chan, H.T.5
-
112
-
-
0017617210
-
Physiological responses of human adults to foods containing phosphate additives
-
Bell RR, Draper HH, Tzeng DY, Shin HK, Schmidt GR. 1977. Physiological responses of human adults to foods containing phosphate additives. J. Nutr. 107:42-50
-
(1977)
J. Nutr.
, vol.107
, pp. 42-50
-
-
Bell, R.R.1
Draper, H.H.2
Tzeng, D.Y.3
Shin, H.K.4
Schmidt, G.R.5
-
113
-
-
80052298245
-
Human nephron number: Implications for health and disease
-
Bertram JF, Douglas-Denton RN, Diouf B, Hughson MD, Hoy WE. 2011. Human nephron number: implications for health and disease. Pediatr. Nephrol. 26:1529-33
-
(2011)
Pediatr. Nephrol.
, vol.26
, pp. 1529-1533
-
-
Bertram, J.F.1
Douglas-Denton, R.N.2
Diouf, B.3
Hughson, M.D.4
Hoy, W.E.5
-
114
-
-
77956823416
-
Effects of aging on glomerular function and number in living kidney donors
-
Tan JC, Busque S, Workeneh B, Ho B, Derby G, et al. 2010. Effects of aging on glomerular function and number in living kidney donors. Kidney Int. 78:686-92
-
(2010)
Kidney Int.
, vol.78
, pp. 686-692
-
-
Tan, J.C.1
Busque, S.2
Workeneh, B.3
Ho, B.4
Derby, G.5
-
115
-
-
0141786880
-
Calcium phosphate-induced renal epithelial injury and stone formation: Involvement of reactive oxygen species
-
Aihara K, Byer KJ, Khan SR. 2003. Calcium phosphate-induced renal epithelial injury and stone formation: involvement of reactive oxygen species. Kidney Int. 64:1283-91
-
(2003)
Kidney Int.
, vol.64
, pp. 1283-1291
-
-
Aihara, K.1
Byer, K.J.2
Khan, S.R.3
-
116
-
-
48249123181
-
Increased inorganic phosphate induces human endothelial cell apoptosis in vitro
-
Di Marco GS, Hausberg M, Hillebrand U, Rustemeyer P, Wittkowski W, et al. 2008. Increased inorganic phosphate induces human endothelial cell apoptosis in vitro. Am. J. Physiol. Ren. Physiol. 294:F1381-87
-
(2008)
Am. J. Physiol. Ren. Physiol.
, vol.294
-
-
Di Marco, G.S.1
Hausberg, M.2
Hillebrand, U.3
Rustemeyer, P.4
Wittkowski, W.5
-
117
-
-
0034730291
-
Phosphate regulation of vascular smooth muscle cell calcification
-
Jono S, McKee MD, Murry CE, Shioi A, Nishizawa Y, et al. 2000. Phosphate regulation of vascular smooth muscle cell calcification. Circ. Res. 87:E10-17
-
(2000)
Circ. Res.
, vol.87
-
-
Jono, S.1
McKee, M.D.2
Murry, C.E.3
Shioi, A.4
Nishizawa, Y.5
-
118
-
-
79551529058
-
Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro
-
Sage AP, Lu J, Tintut Y, Demer LL. 2011. Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro. Kidney Int. 79:414-22
-
(2011)
Kidney Int.
, vol.79
, pp. 414-422
-
-
Sage, A.P.1
Lu, J.2
Tintut, Y.3
Demer, L.L.4
-
119
-
-
65549090151
-
Phosphonoformic acid prevents vascular smooth muscle cell calcification by inhibiting calcium-phosphate deposition
-
Villa-Bellosta R, Sorribas V. 2009. Phosphonoformic acid prevents vascular smooth muscle cell calcification by inhibiting calcium-phosphate deposition. Arterioscler. Thromb. Vasc. Biol. 29:761-66
-
(2009)
Arterioscler. Thromb. Vasc. Biol.
, vol.29
, pp. 761-766
-
-
Villa-Bellosta, R.1
Sorribas, V.2
-
120
-
-
0018181114
-
A micropuncture study of renal phosphate transport in rats with chronic renal failure and secondary hyperparathyroidism
-
Bank N, Su WS, Aynedjian HS. 1978. A micropuncture study of renal phosphate transport in rats with chronic renal failure and secondary hyperparathyroidism. J. Clin. Investig. 61:884-94
-
(1978)
J. Clin. Investig.
, vol.61
, pp. 884-894
-
-
Bank, N.1
Su, W.S.2
Aynedjian, H.S.3
-
121
-
-
3142659602
-
Crystal-induced inflammation of the kidneys: Results from human studies, animal models, and tissue-culture studies
-
Khan SR. 2004. Crystal-induced inflammation of the kidneys: results from human studies, animal models, and tissue-culture studies. Clin. Exp. Nephrol. 8:75-88
-
(2004)
Clin. Exp. Nephrol.
, vol.8
, pp. 75-88
-
-
Khan, S.R.1
-
122
-
-
34250667000
-
Role of hyperphosphatemia and 1, 25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice
-
Stubbs JR, Liu S, Tang W, Zhou J, Wang Y, et al. 2007. Role of hyperphosphatemia and 1, 25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice. J. Am. Soc. Nephrol. 18:2116-24
-
(2007)
J. Am. Soc. Nephrol.
, vol.18
, pp. 2116-2124
-
-
Stubbs, J.R.1
Liu, S.2
Tang, W.3
Zhou, J.4
Wang, Y.5
-
123
-
-
33846566785
-
Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice
-
Hesse M, Frohlich LF, Zeitz U, Lanske B, Erben RG. 2007. Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice. Matrix Biol. 26:75-84
-
(2007)
Matrix Biol.
, vol.26
, pp. 75-84
-
-
Hesse, M.1
Frohlich, L.F.2
Zeitz, U.3
Lanske, B.4
Erben, R.G.5
-
124
-
-
33646238028
-
Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process
-
Razzaque MS, Sitara D, Taguchi T, St-Arnaud R, Lanske B. 2006. Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process. FASEB J. 20:720-22
-
(2006)
FASEB J.
, vol.20
, pp. 720-722
-
-
Razzaque, M.S.1
Sitara, D.2
Taguchi, T.3
St-Arnaud, R.4
Lanske, B.5
-
125
-
-
67349229781
-
Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1α-hydroxylase
-
Ohnishi M, Nakatani T, Lanske B, Razzaque MS. 2009. Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1α-hydroxylase. Kidney Int. 75:1166-72
-
(2009)
Kidney Int.
, vol.75
, pp. 1166-1172
-
-
Ohnishi, M.1
Nakatani, T.2
Lanske, B.3
Razzaque, M.S.4
-
126
-
-
77956637592
-
Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging
-
Ohnishi M, Razzaque MS. 2010. Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. FASEB J. 24:3562-71
-
(2010)
FASEB J.
, vol.24
, pp. 3562-3571
-
-
Ohnishi, M.1
Razzaque, M.S.2
-
127
-
-
68949114585
-
KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD)
-
Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group.
-
Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group. 2009. KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney Int. Suppl. 76(Suppl. 113):1-130
-
(2009)
Kidney Int. Suppl.
, vol.76
, Issue.SUPPL. 113
, pp. 1-130
-
-
-
128
-
-
81755165861
-
CKD-mineral and bone disorder: Core curriculum 2011
-
Moorthi RN, Moe SM. 2011. CKD-mineral and bone disorder: core curriculum 2011. Am. J. Kidney Dis. 58:1022-36
-
(2011)
Am. J. Kidney Dis.
, vol.58
, pp. 1022-1036
-
-
Moorthi, R.N.1
Moe, S.M.2
-
129
-
-
58849160105
-
Metabolic abnormalities in chronic kidney disease that contribute to cardiovascular disease, and nutritional initiatives that may diminish the risk
-
Chmielewski M, Carrero JJ, Stenvinkel P, Lindholm B. 2009. Metabolic abnormalities in chronic kidney disease that contribute to cardiovascular disease, and nutritional initiatives that may diminish the risk. Curr. Opin. Lipidol. 20:3-9
-
(2009)
Curr. Opin. Lipidol.
, vol.20
, pp. 3-9
-
-
Chmielewski, M.1
Carrero, J.J.2
Stenvinkel, P.3
Lindholm, B.4
-
130
-
-
77951253893
-
Cardiovascular risk in chronic kidney disease (CKD): The CKD-mineral bone disorder (CKD-MBD)
-
Hruska KA, Choi ET, Memon I, Davis TK, Mathew S. 2010. Cardiovascular risk in chronic kidney disease (CKD): the CKD-mineral bone disorder (CKD-MBD). Pediatr. Nephrol. 25:769-78
-
(2010)
Pediatr. Nephrol.
, vol.25
, pp. 769-778
-
-
Hruska, K.A.1
Choi, E.T.2
Memon, I.3
Davis, T.K.4
Mathew, S.5
-
131
-
-
4043078575
-
Evidence for increased cardiovascular disease risk in patients with chronic kidney disease
-
Coresh J, Astor B, Sarnak MJ. 2004. Evidence for increased cardiovascular disease risk in patients with chronic kidney disease. Curr. Opin. Nephrol. Hypertens. 13:73-81
-
(2004)
Curr. Opin. Nephrol. Hypertens.
, vol.13
, pp. 73-81
-
-
Coresh, J.1
Astor, B.2
Sarnak, M.J.3
-
132
-
-
56749158017
-
Nontraditional risk factors for cardiovascular disease in patients with chronic kidney disease
-
Kendrick J, Chonchol MB. 2008. Nontraditional risk factors for cardiovascular disease in patients with chronic kidney disease. Nat. Clin. Pract. Nephrol. 4:672-81
-
(2008)
Nat. Clin. Pract. Nephrol.
, vol.4
, pp. 672-681
-
-
Kendrick, J.1
Chonchol, M.B.2
-
133
-
-
39049096394
-
Mechanisms of vascular calcification in chronic kidney disease
-
Moe SM, Chen NX. 2008. Mechanisms of vascular calcification in chronic kidney disease. J. Am. Soc. Nephrol. 19:213-16
-
(2008)
J. Am. Soc. Nephrol.
, vol.19
, pp. 213-216
-
-
Moe, S.M.1
Chen, N.X.2
-
134
-
-
33845274560
-
Vascular calcifications: Pathogenesis, management, and impact on clinical outcomes
-
Cannata-Andia JB, Rodriguez-Garcia M, Carrillo-Lopez N, Naves-Diaz M, Diaz-Lopez B. 2006. Vascular calcifications: pathogenesis, management, and impact on clinical outcomes. J. Am. Soc. Nephrol. 17:S267-73
-
(2006)
J. Am. Soc. Nephrol.
, vol.17
-
-
Cannata-Andia, J.B.1
Rodriguez-Garcia, M.2
Carrillo-Lopez, N.3
Naves-Diaz, M.4
Diaz-Lopez, B.5
-
135
-
-
67649678424
-
Vascular calcification: The killer of patients with chronic kidney disease
-
Mizobuchi M, Towler D, Slatopolsky E. 2009. Vascular calcification: the killer of patients with chronic kidney disease. J. Am. Soc. Nephrol. 20:1453-64
-
(2009)
J. Am. Soc. Nephrol.
, vol.20
, pp. 1453-1464
-
-
Mizobuchi, M.1
Towler, D.2
Slatopolsky, E.3
-
136
-
-
80052081093
-
Vascular calcification is associated with cortical bone loss in chronic renal failure rats with and without ovariectomy: The calcification paradox
-
De Schutter TM, Neven E, Persy VP, Behets GJ, Postnov AA, et al. 2011. Vascular calcification is associated with cortical bone loss in chronic renal failure rats with and without ovariectomy: the calcification paradox. Am. J. Nephrol. 34:356-66
-
(2011)
Am. J. Nephrol.
, vol.34
, pp. 356-366
-
-
De Schutter, T.M.1
Neven, E.2
Persy, V.P.3
Behets, G.J.4
Postnov, A.A.5
-
137
-
-
79952279677
-
Klotho and kidney disease
-
Hu MC, Kuro-o M, Moe OW. 2010. Klotho and kidney disease. J. Nephrol. 23(Suppl. 16):136-44
-
(2010)
J. Nephrol.
, vol.23
, Issue.SUPPL. 16
, pp. 136-144
-
-
Hu, M.C.1
Kuro-O, M.2
Moe, O.W.3
-
138
-
-
33847781131
-
Amelioration of progressive renal injury by genetic manipulation of Klotho gene
-
Haruna Y, Kashihara N, Satoh M, Tomita N, Namikoshi T, et al. 2007. Amelioration of progressive renal injury by genetic manipulation of Klotho gene. Proc. Natl. Acad. Sci. USA 104:2331-36
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 2331-2336
-
-
Haruna, Y.1
Kashihara, N.2
Satoh, M.3
Tomita, N.4
Namikoshi, T.5
-
139
-
-
80052101334
-
Klotho depletion contributestoincreased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation
-
Zhao Y, Banerjee S, Dey N, Le Jeune WS, Sarkar PS, et al. 2011. Klotho depletion contributestoincreased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation. Diabetes 60:1907-16
-
(2011)
Diabetes
, vol.60
, pp. 1907-1916
-
-
Zhao, Y.1
Banerjee, S.2
Dey, N.3
Le Jeune, W.S.4
Sarkar, P.S.5
-
140
-
-
70349659193
-
Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage
-
Wang Y, Sun Z. 2009. Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage. Hypertension 54:810-17
-
(2009)
Hypertension
, vol.54
, pp. 810-817
-
-
Wang, Y.1
Sun, Z.2
-
141
-
-
0032575483
-
Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats
-
Aizawa H, Saito Y, Nakamura T, Inoue M, Imanari T, et al. 1998. Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats. Biochem. Biophys. Res. Commun. 249:865-71
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.249
, pp. 865-871
-
-
Aizawa, H.1
Saito, Y.2
Nakamura, T.3
Inoue, M.4
Imanari, T.5
-
142
-
-
84857784178
-
Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion
-
Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, et al. 2012. Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion. Kidney Int. 81:539-47
-
(2012)
Kidney Int.
, vol.81
, pp. 539-547
-
-
Asai, O.1
Nakatani, K.2
Tanaka, T.3
Sakan, H.4
Imura, A.5
-
143
-
-
77955272026
-
Establishment of sandwich ELISA for soluble α-Klotho measurement: Age-dependent change of soluble α-Klotho levels in healthy subjects
-
Yamazaki Y, Imura A, Urakawa I, Shimada T, Murakami J, et al. 2010. Establishment of sandwich ELISA for soluble α-Klotho measurement: age-dependent change of soluble α-Klotho levels in healthy subjects. Biochem. Biophys. Res. Commun. 398:513-18
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.398
, pp. 513-518
-
-
Yamazaki, Y.1
Imura, A.2
Urakawa, I.3
Shimada, T.4
Murakami, J.5
-
144
-
-
80755188093
-
Circulating levels of soluble α-Klotho in patients with chronic kidney disease
-
Sugiura H, Tsuchiya K, Nitta K. 2011. Circulating levels of soluble α-Klotho in patients with chronic kidney disease. Clin. Exp. Nephrol. 15:795-96
-
(2011)
Clin. Exp. Nephrol.
, vol.15
, pp. 795-796
-
-
Sugiura, H.1
Tsuchiya, K.2
Nitta, K.3
-
145
-
-
78049481921
-
Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients
-
Krajisnik T, Olauson H, Mirza MA, Hellman P, Akerstrom G, et al. 2010. Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients. Kidney Int. 78:1024-32
-
(2010)
Kidney Int.
, vol.78
, pp. 1024-1032
-
-
Krajisnik, T.1
Olauson, H.2
Mirza, M.A.3
Hellman, P.4
Akerstrom, G.5
-
146
-
-
27744545673
-
Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease
-
Gutierrez O, Isakova T, Rhee E, Shah A, Holmes J, et al. 2005. Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease. J. Am. Soc. Nephrol. 16:2205-15
-
(2005)
J. Am. Soc. Nephrol.
, vol.16
, pp. 2205-2215
-
-
Gutierrez, O.1
Isakova, T.2
Rhee, E.3
Shah, A.4
Holmes, J.5
-
147
-
-
32844468124
-
Regulation of plasma fibroblast growth factor 23 by calcium in primary hyperparathyroidism
-
Kobayashi K, Imanishi Y, Miyauchi A, Onoda N, Kawata T, et al. 2006. Regulation of plasma fibroblast growth factor 23 by calcium in primary hyperparathyroidism. Eur. J. Endocrinol. 154:93-99
-
(2006)
Eur. J. Endocrinol.
, vol.154
, pp. 93-99
-
-
Kobayashi, K.1
Imanishi, Y.2
Miyauchi, A.3
Onoda, N.4
Kawata, T.5
-
148
-
-
79957871451
-
Mineral metabolism and vitamin D in chronic kidney disease-more questions than answers
-
Goldsmith DJ, Cunningham J. 2011. Mineral metabolism and vitamin D in chronic kidney disease-more questions than answers. Nat. Rev. Nephrol. 7:341-46
-
(2011)
Nat. Rev. Nephrol.
, vol.7
, pp. 341-346
-
-
Goldsmith, D.J.1
Cunningham, J.2
-
149
-
-
74449094013
-
Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease
-
Galitzer H, Ben-Dov IZ, Silver J, Naveh-Many T. 2010. Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease. Kidney Int. 77:211-18
-
(2010)
Kidney Int.
, vol.77
, pp. 211-218
-
-
Galitzer, H.1
Ben-Dov, I.Z.2
Silver, J.3
Naveh-Many, T.4
-
150
-
-
78349252613
-
Klotho, FGF23, and FGF receptors in chronic kidney disease: A yin-yang situation?
-
Drueke TB. 2010. Klotho, FGF23, and FGF receptors in chronic kidney disease: A yin-yang situation? Kidney Int. 78:1057-60
-
(2010)
Kidney Int.
, vol.78
, pp. 1057-1060
-
-
Drueke, T.B.1
-
151
-
-
76149101238
-
Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active
-
Shimada T, Urakawa I, Isakova T, Yamazaki Y, Epstein M, et al. 2010. Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active. J. Clin. Endocrinol. Metab. 95:578-85
-
(2010)
J. Clin. Endocrinol. Metab.
, vol.95
, pp. 578-585
-
-
Shimada, T.1
Urakawa, I.2
Isakova, T.3
Yamazaki, Y.4
Epstein, M.5
-
152
-
-
76749134283
-
Does the downregulation of the FGF23 signaling pathway in hyperplastic parathyroid glands contribute to refractory secondary hyperparathyroidism in CKD patients?
-
Lafage-Proust MH. 2010. Does the downregulation of the FGF23 signaling pathway in hyperplastic parathyroid glands contribute to refractory secondary hyperparathyroidism in CKD patients? Kidney Int. 77:390-92
-
(2010)
Kidney Int.
, vol.77
, pp. 390-392
-
-
Lafage-Proust, M.H.1
-
153
-
-
67649099265
-
Regulation of fibroblast growth factor 23 production in bone in uremic rats
-
Saji F, Shiizaki K, Shimada S, Okada T, Kunimoto K, et al. 2009. Regulation of fibroblast growth factor 23 production in bone in uremic rats. Nephron. Physiol. 111:59-66
-
(2009)
Nephron. Physiol.
, vol.111
, pp. 59-66
-
-
Saji, F.1
Shiizaki, K.2
Shimada, S.3
Okada, T.4
Kunimoto, K.5
-
154
-
-
0034220058
-
Improvement of multiple pathophysiological phenotypes of klotho (kl/kl) mice by adenovirus-mediated expression of the klotho gene
-
Shiraki-Iida T, Iida A, Nabeshima Y, Anazawa H, Nishikawa S, et al. 2000. Improvement of multiple pathophysiological phenotypes of klotho (kl/kl) mice by adenovirus-mediated expression of the klotho gene. J. Gene Med. 2:233-42
-
(2000)
J. Gene Med.
, vol.2
, pp. 233-242
-
-
Shiraki-Iida, T.1
Iida, A.2
Nabeshima, Y.3
Anazawa, H.4
Nishikawa, S.5
-
155
-
-
77956633892
-
Phosphate and vascular calcification: Emerging role of the sodium-dependent phosphate co-transporter PiT-1
-
Lau WL, Festing MH, Giachelli CM. 2010. Phosphate and vascular calcification: emerging role of the sodium-dependent phosphate co-transporter PiT-1. Thromb. Haemost. 104:464-70
-
(2010)
Thromb. Haemost.
, vol.104
, pp. 464-470
-
-
Lau, W.L.1
Festing, M.H.2
Giachelli, C.M.3
-
156
-
-
33749342012
-
Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway
-
de Oliveira RM. 2006. Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway. FEBS Lett. 580:5753-58
-
(2006)
FEBS Lett.
, vol.580
, pp. 5753-5758
-
-
De Oliveira, R.M.1
-
157
-
-
70350438009
-
Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition
-
Nakano-Kurimoto R, Ikeda K, Uraoka M, Nakagawa Y, Yutaka K, et al. 2009. Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition. Am. J. Physiol. Heart Circ. Physiol. 297:H1673-84
-
(2009)
Am. J. Physiol. Heart Circ. Physiol.
, vol.297
-
-
Nakano-Kurimoto, R.1
Ikeda, K.2
Uraoka, M.3
Nakagawa, Y.4
Yutaka, K.5
-
158
-
-
84860778116
-
Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to FGF-23
-
Lim K, Lu TS, Molostvov G, Lee C, Lam F, et al. 2012. Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to FGF-23. Circulation 125:2243-55
-
(2012)
Circulation
, vol.125
, pp. 2243-2255
-
-
Lim, K.1
Lu, T.S.2
Molostvov, G.3
Lee, C.4
Lam, F.5
-
159
-
-
84876110372
-
Expression of FGF23/KLOTHO system in human vascular tissue
-
In press; doi:10.1016/j.ijcard.2011.08.850
-
Donate-Correa J, Mora-Fernandez C, Martinez-Sanz R, Muros-de-Fuentes M, Perez H, et al. 2011. Expression of FGF23/KLOTHO system in human vascular tissue. Int. J. Cardiol. In press; doi:10.1016/j.ijcard.2011.08.850
-
(2011)
Int. J. Cardiol
-
-
Donate-Correa, J.1
Mora-Fernandez, C.2
Martinez-Sanz, R.3
Muros-De-Fuentes, M.4
Perez, H.5
-
161
-
-
0030982693
-
Angiotensin II receptor antagonists. Potential in elderly patients with cardiovascular disease
-
Burrell LM, Johnston CI. 1997. Angiotensin II receptor antagonists. Potential in elderly patients with cardiovascular disease. Drugs Aging 10:421-34
-
(1997)
Drugs Aging
, vol.10
, pp. 421-434
-
-
Burrell, L.M.1
Johnston, C.I.2
-
162
-
-
24944566874
-
The role of vitamin D in left ventricular hypertrophy and cardiac function
-
Achinger SG, Ayus JC. 2005. The role of vitamin D in left ventricular hypertrophy and cardiac function. Kidney Int. Suppl. 67(Suppl. 95):37-42
-
(2005)
Kidney Int. Suppl.
, vol.67
, Issue.SUPPL. 95
, pp. 37-42
-
-
Achinger, S.G.1
Ayus, J.C.2
-
163
-
-
70450230670
-
Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population
-
Mirza MA, Larsson A, Melhus H, Lind L, Larsson TE. 2009. Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population. Atherosclerosis 207:546-51
-
(2009)
Atherosclerosis
, vol.207
, pp. 546-551
-
-
Mirza, M.A.1
Larsson, A.2
Melhus, H.3
Lind, L.4
Larsson, T.E.5
-
164
-
-
54149083620
-
Bone mineral metabolism and its relationship to kidney disease in a residential care home population: A cross-sectional study
-
Carter JL, O'Riordan SE, Eaglestone GL, Delaney MP, Lamb EJ. 2008. Bone mineral metabolism and its relationship to kidney disease in a residential care home population: a cross-sectional study. Nephrol. Dial. Transplant. 23:3554-65
-
(2008)
Nephrol. Dial. Transplant.
, vol.23
, pp. 3554-3565
-
-
Carter, J.L.1
O'Riordan, S.E.2
Eaglestone, G.L.3
Delaney, M.P.4
Lamb, E.J.5
-
165
-
-
77749334660
-
Early control of PTH and FGF23 in normophosphatemic CKD patients: A new target in CKD-MBD therapy?
-
Oliveira RB, Cancela AL, Graciolli FG, Dos Reis LM, Draibe SA, et al. 2010. Early control of PTH and FGF23 in normophosphatemic CKD patients: a new target in CKD-MBD therapy? Clin. J. Am. Soc. Nephrol. 5:286-91
-
(2010)
Clin. J. Am. Soc. Nephrol.
, vol.5
, pp. 286-291
-
-
Oliveira, R.B.1
Cancela, A.L.2
Graciolli, F.G.3
Dos Reis, L.M.4
Draibe, S.A.5
-
166
-
-
33750993057
-
FGF23: Its role in renal bone disease
-
Fukagawa M, Kazama JJ. 2006. FGF23: its role in renal bone disease. Pediatr. Nephrol. 21:1802-6
-
(2006)
Pediatr. Nephrol.
, vol.21
, pp. 1802-1806
-
-
Fukagawa, M.1
Kazama, J.J.2
-
167
-
-
0031780431
-
Elongation of the epiphyseal trabecular bone in transgenic mice carrying a klotho gene locus mutation that leads to a syndrome resembling aging
-
Yamashita T, Nifuji A, Furuya K, Nabeshima Y, Noda M. 1998. Elongation of the epiphyseal trabecular bone in transgenic mice carrying a klotho gene locus mutation that leads to a syndrome resembling aging. J. Endocrinol. 159:1-8
-
(1998)
J. Endocrinol.
, vol.159
, pp. 1-8
-
-
Yamashita, T.1
Nifuji, A.2
Furuya, K.3
Nabeshima, Y.4
Noda, M.5
-
168
-
-
79960386992
-
Fibroblast growth factor 23 (FGF23)and oc-klotho stimulate osteoblastic MC3T3. E1 cell proliferation and inhibit mineralization
-
Shalhoub V, Ward SC, Sun B, Stevens J, Renshaw L, et al. 2011. Fibroblast growth factor 23 (FGF23)and oc-klotho stimulate osteoblastic MC3T3. E1 cell proliferation and inhibit mineralization. Calcif. Tissue Int. 89:140-50
-
(2011)
Calcif. Tissue Int.
, vol.89
, pp. 140-150
-
-
Shalhoub, V.1
Ward, S.C.2
Sun, B.3
Stevens, J.4
Renshaw, L.5
-
169
-
-
59949084660
-
Phosphorus binders and survival on hemodialysis
-
Isakova T, Gutierrez OM, Chang Y, Shah A, Tamez H, et al. 2009. Phosphorus binders and survival on hemodialysis. J. Am. Soc. Nephrol. 20:388-96
-
(2009)
J. Am. Soc. Nephrol.
, vol.20
, pp. 388-396
-
-
Isakova, T.1
Gutierrez, O.M.2
Chang, Y.3
Shah, A.4
Tamez, H.5
-
170
-
-
79251474745
-
Vitamin D supplementation in chronic kidney disease: A systematic review and meta-analysis of observational studies and randomized controlled trials
-
Kandula P, Dobre M, Schold JD, Schreiber MJ Jr, Mehrotra R, Navaneethan SD. 2011. Vitamin D supplementation in chronic kidney disease: a systematic review and meta-analysis of observational studies and randomized controlled trials. Clin. J. Am. Soc. Nephrol. 6:50-62
-
(2011)
Clin. J. Am. Soc. Nephrol.
, vol.6
, pp. 50-62
-
-
Kandula, P.1
Dobre, M.2
Schold, J.D.3
Schreiber Jr., M.J.4
Mehrotra, R.5
Navaneethan, S.D.6
-
171
-
-
48149102507
-
Impact of activated vitamin D and race on survival among hemodialysis patients
-
Wolf M, Betancourt J, Chang Y, Shah A, Teng M, et al. 2008. Impact of activated vitamin D and race on survival among hemodialysis patients. J. Am. Soc. Nephrol. 19:1379-88
-
(2008)
J. Am. Soc. Nephrol.
, vol.19
, pp. 1379-1388
-
-
Wolf, M.1
Betancourt, J.2
Chang, Y.3
Shah, A.4
Teng, M.5
-
172
-
-
11144353767
-
Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis
-
Block GA, Martin KJ, de Francisco AL, Turner SA, Avram MM, et al. 2004. Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. N. Engl. J. Med. 350:1516-25
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 1516-1525
-
-
Block, G.A.1
Martin, K.J.2
De Francisco, A.L.3
Turner, S.A.4
Avram, M.M.5
-
173
-
-
64049106961
-
Treatment of secondary hyperparathyroidism in CKD patients with cinacalcet and/or vitamin D derivatives
-
Drueke TB, Ritz E. 2009. Treatment of secondary hyperparathyroidism in CKD patients with cinacalcet and/or vitamin D derivatives. Clin. J. Am. Soc. Nephrol. 4:234-41
-
(2009)
Clin. J. Am. Soc. Nephrol.
, vol.4
, pp. 234-241
-
-
Drueke, T.B.1
Ritz, E.2
-
174
-
-
77953778295
-
Therapeutic potential of klotho-FGF23 fusion polypeptides: WO2009095372
-
Razzaque MS. 2010. Therapeutic potential of klotho-FGF23 fusion
-
(2010)
Expert Opin. Ther. Pat.
, vol.20
, pp. 981-985
-
-
Razzaque, M.S.1
-
175
-
-
78049463249
-
Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease
-
Hasegawa H, Nagano N, Urakawa I, Yamazaki Y, Iijima K, et al. 2010. Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease. Kidney Int. 78:975-80
-
(2010)
Kidney Int.
, vol.78
, pp. 975-980
-
-
Hasegawa, H.1
Nagano, N.2
Urakawa, I.3
Yamazaki, Y.4
Iijima, K.5
-
176
-
-
84863550146
-
FGF23 neutralization improves secondary hyperparathyroidism and osteodystrophy parameters yet exacerbates vascular calcification in chronic kidney disease rats
-
Shalhoub V, Shatzen EM, Ward SC, Davis J, Stevens J, et al. 2012. FGF23 neutralization improves secondary hyperparathyroidism and osteodystrophy parameters yet exacerbates vascular calcification in chronic kidney disease rats. J. Clin. Investig. 122:2543-53
-
(2012)
J. Clin. Investig.
, vol.122
, pp. 2543-2553
-
-
Shalhoub, V.1
Shatzen, E.M.2
Ward, S.C.3
Davis, J.4
Stevens, J.5
-
177
-
-
78649642147
-
Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective
-
Hu MC, Shi M, Zhang J, Quinones H, Kuro-o M, Moe OW. 2010. Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective. Kidney Int. 78:1240-51
-
(2010)
Kidney Int.
, vol.78
, pp. 1240-1251
-
-
Hu, M.C.1
Shi, M.2
Zhang, J.3
Quinones, H.4
Kuro-O, M.5
Moe, O.W.6
-
178
-
-
79953138206
-
Klotho inhibits transforming growth factor-131 (TGF-β31) signaling and suppresses renal fibrosis and cancer metastasis in mice
-
Doi S, Zou Y, Togao O, Pastor JV, John GB, et al. 2011. Klotho inhibits transforming growth factor-131 (TGF-β31) signaling and suppresses renal fibrosis and cancer metastasis in mice. J. Biol. Chem. 286:8655-65
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 8655-8665
-
-
Doi, S.1
Zou, Y.2
Togao, O.3
Pastor, J.V.4
John, G.B.5
-
179
-
-
0035208924
-
The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc
-
Morishita K, Shirai A, Kubota M, Katakura Y, Nabeshima Y, et al. 2001. The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc. J. Nutr. 131:3182-88
-
(2001)
J. Nutr.
, vol.131
, pp. 3182-3188
-
-
Morishita, K.1
Shirai, A.2
Kubota, M.3
Katakura, Y.4
Nabeshima, Y.5
-
180
-
-
0036235099
-
In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage
-
Mitani H, Ishizaka N, Aizawa T, Ohno M, Usui S, et al. 2002. In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension 39:838-43
-
(2002)
Hypertension
, vol.39
, pp. 838-843
-
-
Mitani, H.1
Ishizaka, N.2
Aizawa, T.3
Ohno, M.4
Usui, S.5
-
181
-
-
50849091263
-
Klotho is a target gene of PPAR-y
-
Zhang H, Li Y, Fan Y, Wu J, Zhao B, et al. 2008. Klotho is a target gene of PPAR-y. Kdney Int. 74:732-39
-
(2008)
Kdney Int.
, vol.74
, pp. 732-739
-
-
Zhang, H.1
Li, Y.2
Fan, Y.3
Wu, J.4
Zhao, B.5
-
182
-
-
79251501315
-
Fibroblast growth factors: From molecular evolution to roles in development, metabolism and disease
-
Itoh N, Ornitz DM. 2011. Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. J. Biochem. 149:121-30
-
(2011)
J. Biochem.
, vol.149
, pp. 121-130
-
-
Itoh, N.1
Ornitz, D.M.2
-
183
-
-
33750698614
-
Identification of a hormonal basis for gallbladder filling
-
Choi M, Moschetta A, Bookout AL, Peng L, Umetani M, et al. 2006. Identification of a hormonal basis for gallbladder filling. Nat. Med. 12:1253-55
-
(2006)
Nat. Med.
, vol.12
, pp. 1253-1255
-
-
Choi, M.1
Moschetta, A.2
Bookout, A.L.3
Peng, L.4
Umetani, M.5
-
184
-
-
72949100508
-
Decreased expression of klotho gene in uremic atherosclerosis in apolipoprotein E-deficient mice
-
Yu J, Deng M, Zhao J, Huang L. 2010. Decreased expression of klotho gene in uremic atherosclerosis in apolipoprotein E-deficient mice. Biochem. Biophys. Res. Commun. 391:261-66
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.391
, pp. 261-266
-
-
Yu, J.1
Deng, M.2
Zhao, J.3
Huang, L.4
-
185
-
-
77953670159
-
Role of fosinopril and valsartan on klotho gene expression induced by angiotensin II in rat renal tubular epithelial cells
-
Zhou Q, Lin S, Tang R, Veeraragoo P, Peng W, Wu R. 2010. Role of fosinopril and valsartan on klotho gene expression induced by angiotensin II in rat renal tubular epithelial cells. Kidney Blood Press. Res. 33:186-92
-
(2010)
Kidney Blood Press. Res.
, vol.33
, pp. 186-192
-
-
Zhou, Q.1
Lin, S.2
Tang, R.3
Veeraragoo, P.4
Peng, W.5
Wu, R.6
-
186
-
-
84859259028
-
Validation of an immunoassay for soluble klotho protein: Decreased levels in diabetes and increased levels in chronic kidney disease
-
Devaraj S, Syed B, Chien A, Jialal I. 2012. Validation of an immunoassay for soluble klotho protein: decreased levels in diabetes and increased levels in chronic kidney disease. Am. J. Clin. Pathol. 137:479-85
-
(2012)
Am. J. Clin. Pathol.
, vol.137
, pp. 479-485
-
-
Devaraj, S.1
Syed, B.2
Chien, A.3
Jialal, I.4
|