Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway

Geriatrics and Gerontology International

Volumn 11, Issue 4, 2011, Pages 510-516

  Maekawa, Yoshihiro ^a   Ohishi, Mitsuru ^a   Ikushima, Masashi ^a   Yamamoto, Koichi ^a   Yasuda, Osamu ^a   Oguro, Ryosuke ^a   Yamamoto Hanasaki, Hiroko ^a   Tatara, Yuji ^a   Takeya, Yasushi ^a   Rakugi, Hiromi ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Endothelial cell; Extracellular signal regulated kinase phosphorylation; Klotho protein; Senescence

Indexed keywords

BETA GALACTOSIDASE; CASPASE 3; CASPASE 9; KLOTHO PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PROTEIN P21; PROTEIN P53; RECOMBINANT PROTEIN;

APOPTOSIS; ARTICLE; CELL AGING; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; APOPTOSIS; BETA-GALACTOSIDASE; BLOTTING, WESTERN; CASPASES; CELL AGING; CELLS, CULTURED; ENDOTHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUCURONIDASE; HUMANS; P21-ACTIVATED KINASES; PHOSPHORYLATION; TUMOR SUPPRESSOR PROTEIN P53; UMBILICAL VEINS;

EID: 80053274845     PISSN: 14441586     EISSN: 14470594     Source Type: Journal    
DOI: 10.1111/j.1447-0594.2011.00699.x     Document Type: Article

References (28)

1. Kawaguchi H, Manabe N, Chikuda H, Nakamura K, Kuroo M. Cellular and molecular mechanism of low-turnover osteopenia in the klotho-deficient mouse. Cell Mol Life Sci 2000; 57: 731-737.
2. Kuro-o M, Matsumura Y, Aizawa H etal. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997; 390 (6655): 45-51.
3. Mori K, Yahata K, Mukoyama M etal. Disruption of klotho gene causes an abnormal energy homeostasis in mice. Biochem Biophys Res Commun 2000; 278 (3): 665-670.
4. Suga T, Kurabayashi M, Sando Y etal. Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life. Am J Respir Cell Mol Biol 2000; 22 (1): 26-33.
5. Kurosu H, Ogawa Y, Miyoshi M etal. Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 2006; 281 (10): 6120-6123.
6. Yamamoto M, Clark JD, Pastor JV etal. Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem 2005; 280 (45): 38029-38034.
7. Imura A, Iwano A, Tohyama O etal. Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett 2004; 565: 143-147.
8. Li SA, Watanabe M, Yamada H, Nagai A, Kinuta M, Takei K. Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice. Cell Struct Funct 2004; 29 (4): 91-99.
9. Brandes RP, Fleming I, Busse R. Endothelial aging. Cardiovasc Res 2005; 66: 286-294.
10. Dimmeler S, Hermann C, Zeiher AM. Apoptosis of endothelial cells. Contribution to the pathophysiology of atherosclerosis? Eur Cytokine Netw 1998; 9: 697-698.
11. Oguro R, Kamide K, Kokubo Y etal. Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertension. Geriatr Gerontol Int 2010; 10: 311-318.
12. Ikushima M, Rakugi H, Ishikawa K etal. Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem Biophys Res Commun 2006; 339 (3): 827-832.
13. Safirstein R, DiMari J, Megyesi J, Price P. Mechanisms of renal repair and survival following acute injury. Semin Nephrol 1998; 18: 519-522.
14. Cross TG, Scheel-Toellner D, Henriquez NV, Deacon E, Salmon M, Lord JM. Serine/threonine protein kinases and apoptosis. Exp Cell Res 2000; 256 (1): 34-41.
15. Pearson G, Robinson F, Beers Gibson T etal. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 2001; 22: 153-183.
16. Cobb MH. MAP kinase pathways. Prog Biophys Mol Biol 1999; 71: 479-500.
17. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995; 270 (5240): 1326-1331.
18. Steelman LS, Bertrand FE, McCubrey JA. The complexity of PTEN: mutation, marker and potential target for therapeutic intervention. Expert Opin Ther Targets 2004; 8 (6): 537-550.
19. Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA. JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 2004; 18: 189-218.
20. Niwa H, Yamamura K, Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 1991; 108: 193-199.
21. Kato Y, Arakawa E, Kinoshita S etal. Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys. Biochem Biophys Res Commun 2000; 267 (2): 597-602.
22. Mitobe M, Yoshida T, Sugiura H, Shirota S, Tsuchiya K, Nihei H. Oxidative stress decreases klotho expression in a mouse kidney cell line. Nephron Exp Nephrol 2005; 101 (2): e67-e74.
23. Killilea DW, Wong SL, Cahaya HS, Atamna H, Ames BN. Iron accumulation during cellular senescence. Ann N Y Acad Sci 2004; 1019: 365-367.
24. Wang W, Passaniti A. Extracellular matrix inhibits apoptosis and enhances endothelial cell differentiation by a NfkappaB-dependent mechanism. J Cell Biochem 1999; 73: 321-331.
25. Haendeler J, Hoffmann J, Diehl JF etal. Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ Res 2004; 94: 768-775.
26. Miyauchi H, Minamino T, Tateno K, Kunieda T, Toko H, Komuro I. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J 2004; 23 (1): 212-220.
27. Manya H, Akasaka-Manya K, Endo T. Klotho protein deficiency and aging. Geriatr Gerontol Int 2010; 10 (Suppl 1): S80-S87.
28. Kurosu H, Yamamoto M, Clark JD etal. Suppression of aging in mice by the hormone Klotho. Science 2005; 309 (5742): 1829-1833.