-
1
-
-
84861614439
-
Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression
-
Abrahamsen, H., Stenmark, H., and Platta, H.W. (2012). Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression. FEBS Lett. 586, 1584-1591.
-
(2012)
FEBS Lett
, vol.586
, pp. 1584-1591
-
-
Abrahamsen, H.1
Stenmark, H.2
Platta, H.W.3
-
2
-
-
77957043835
-
Frequency of known mutations in early-onset Parkinson disease: Implication for genetic counseling: The consortium on risk for early onset Parkinson disease study
-
Alcalay, R.N., Caccappolo, E., Mejia-Santana, H., Tang, M.X., Rosado, L., Ross, B.M., Verbitsky, M., Kisselev, S., Louis, E.D., Comella, C., et al. (2010). Frequency of known mutations in early-onset Parkinson disease: implication for genetic counseling: the consortium on risk for early onset Parkinson disease study. Arch. Neurol. 67, 1116-1122.
-
(2010)
Arch. Neurol
, vol.67
, pp. 1116-1122
-
-
Alcalay, R.N.1
Caccappolo, E.2
Mejia-Santana, H.3
Tang, M.X.4
Rosado, L.5
Ross, B.M.6
Verbitsky, M.7
Kisselev, S.8
Louis, E.D.9
Comella, C.10
-
3
-
-
70349991886
-
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
-
Alegre-Abarrategui, J., Christian, H., Lufino, M.M., Mutihac, R., Venda, L.L., Ansorge, O., and Wade-Martins, R. (2009). LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum. Mol. Genet. 18, 4022-4034.
-
(2009)
Hum. Mol. Genet
, vol.18
, pp. 4022-4034
-
-
Alegre-Abarrategui, J.1
Christian, H.2
Lufino, M.M.3
Mutihac, R.4
Venda, L.L.5
Ansorge, O.6
Wade-Martins, R.7
-
4
-
-
80755133370
-
Clinical genetics of amyotrophic lateral sclerosis: What do we really know? Nat
-
Andersen, P.M., and Al-Chalabi, A. (2011). Clinical genetics of amyotrophic lateral sclerosis: what do we really know? Nat. Rev. Neurol. 7, 603-615.
-
(2011)
Rev. Neurol
, vol.7
, pp. 603-615
-
-
Andersen, P.M.1
Al-Chalabi, A.2
-
5
-
-
0031036896
-
Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
-
Anglade, P., Vyas, S., Javoy-Agid, F., Herrero, M.T., Michel, P.P., Marquez, J., Mouatt-Prigent, A., Ruberg, M., Hirsch, E.C., and Agid, Y. (1997). Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol. Histopathol. 12, 25-31.
-
(1997)
Histol. Histopathol
, vol.12
, pp. 25-31
-
-
Anglade, P.1
Vyas, S.2
Javoy-Agid, F.3
Herrero, M.T.4
Michel, P.P.5
Marquez, J.6
Mouatt-Prigent, A.7
Ruberg, M.8
Hirsch, E.C.9
Agid, Y.10
-
6
-
-
84904729990
-
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
-
Barmada, S.J., Serio, A., Arjun, A., Bilican, B., Daub, A., Ando, D.M., Tsvetkov, A., Pleiss, M., Li, X., Peisach, D., et al. (2014). Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models. Nat. Chem. Biol. 10, 677-685.
-
(2014)
Nat. Chem. Biol
, vol.10
, pp. 677-685
-
-
Barmada, S.J.1
Serio, A.2
Arjun, A.3
Bilican, B.4
Daub, A.5
Ando, D.M.6
Tsvetkov, A.7
Pleiss, M.8
Li, X.9
Peisach, D.10
-
7
-
-
33748876153
-
Parkinson's disease: The LRRK2-G2019S mutation: Opening a novel era in Parkinson's disease genetics
-
Bonifati, V. (2006). Parkinson's disease: the LRRK2-G2019S mutation: opening a novel era in Parkinson's disease genetics. Eur. J. Hum. Genet. 14, 1061-1062.
-
(2006)
Eur. J. Hum. Genet
, vol.14
, pp. 1061-1062
-
-
Bonifati, V.1
-
8
-
-
84880376355
-
Emerging regulation and functions of autophagy
-
Boya, P., Reggiori, F., and Codogno, P. (2013). Emerging regulation and functions of autophagy. Nat. Cell Biol. 15, 713-720.
-
(2013)
Nat. Cell Biol
, vol.15
, pp. 713-720
-
-
Boya, P.1
Reggiori, F.2
Codogno, P.3
-
9
-
-
84891304904
-
Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease
-
Bürli, R.W., Luckhurst, C.A., Aziz, O., Matthews, K.L., Yates, D., Lyons, K.A., Beconi, M., McAllister, G., Breccia, P., Stott, A.J., et al. (2013). Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. J. Med. Chem. 56, 9934-9954.
-
(2013)
J. Med. Chem
, vol.56
, pp. 9934-9954
-
-
Bürli, R.W.1
Luckhurst, C.A.2
Aziz, O.3
Matthews, K.L.4
Yates, D.5
Lyons, K.A.6
Beconi, M.7
McAllister, G.8
Breccia, P.9
Stott, A.J.10
-
10
-
-
77951227122
-
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: Effects on cognitive impairments
-
Caccamo, A., Majumder, S., Richardson, A., Strong, R., and Oddo, S. (2010). Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J. Biol. Chem. 285, 13107-13120.
-
(2010)
J. Biol. Chem
, vol.285
, pp. 13107-13120
-
-
Caccamo, A.1
Majumder, S.2
Richardson, A.3
Strong, R.4
Oddo, S.5
-
11
-
-
84862777210
-
A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate
-
Chen, D., Fan, W., Lu, Y., Ding, X., Chen, S., and Zhong, Q. (2012). A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. Mol. Cell. 45, 629-641.
-
(2012)
Mol. Cell
, vol.45
, pp. 629-641
-
-
Chen, D.1
Fan, W.2
Lu, Y.3
Ding, X.4
Chen, S.5
Zhong, Q.6
-
12
-
-
44149124887
-
Autophagy in neuroprotection and neurodegeneration: A question of balance
-
Cherra, S.J. 3rd, and Chu, C.T. (2008). Autophagy in neuroprotection and neurodegeneration: A question of balance. Future Neurol. 3, 309-323.
-
(2008)
Future Neurol
, vol.3
, pp. 309-323
-
-
Cherra, S.J.1
Chu, C.T.2
-
13
-
-
84877330289
-
Rapamycin-induced autophagy aggravates pathology and weakness in a mouse model of VCPassociated myopathy
-
Ching, J.K., and Weihl, C.C. (2013). Rapamycin-induced autophagy aggravates pathology and weakness in a mouse model of VCPassociated myopathy. Autophagy 9, 799-800.
-
(2013)
Autophagy
, vol.9
, pp. 799-800
-
-
Ching, J.K.1
Weihl, C.C.2
-
14
-
-
84903770556
-
The many faces of autophagy dysfunction in Huntington's disease: From mechanism to therapy
-
Cortes, C.J, and La Spada, A.R. (2014). The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy. Drug Discov. Today 19, 963-971.
-
(2014)
Drug Discov. Today
, vol.19
, pp. 963-971
-
-
Cortes, C.J.1
La Spada, A.R.2
-
15
-
-
84857834456
-
Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alphasynuclein based rat model of Parkinson's disease
-
Coune, P.G., Bensadoun, J.C., Aebischer, P., and Schneider, B.L. (2011). Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alphasynuclein based rat model of Parkinson's disease. J. Parkinsons Dis. 1, 373-387.
-
(2011)
J. Parkinsons Dis
, vol.1
, pp. 373-387
-
-
Coune, P.G.1
Bensadoun, J.C.2
Aebischer, P.3
Schneider, B.L.4
-
16
-
-
77955365630
-
The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)
-
Crippa, V., Sau, D., Rusmini, P., Boncoraglio, A., Onesto, E., Bolzoni, E., Galbiati, M., Fontana, E., Marino, M., Carra, S., et al. (2010). The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). Hum. Mol. Genet. 19, 3440-3456.
-
(2010)
Hum. Mol. Genet
, vol.19
, pp. 3440-3456
-
-
Crippa, V.1
Sau, D.2
Rusmini, P.3
Boncoraglio, A.4
Onesto, E.5
Bolzoni, E.6
Galbiati, M.7
Fontana, E.8
Marino, M.9
Carra, S.10
-
17
-
-
84877351078
-
TFEB-mediated autophagy rescues midbrain dopamine neurons from m-synuclein toxicity
-
Decressac, M., Mattsson, B., Weikop, P., Lundblad, M., Jakobsson, J., and Björklund, A. (2013). TFEB-mediated autophagy rescues midbrain dopamine neurons from m-synuclein toxicity. Proc. Natl. Acad. Sci. USA 110, E1817-1826.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 1817-1826
-
-
Decressac, M.1
Mattsson, B.2
Weikop, P.3
Lundblad, M.4
Jakobsson, J.5
Björklund, A.6
-
18
-
-
84877589314
-
Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy
-
Deng, Y.N., Shi, J., Liu, J., and Qu, Q.M. (2013). Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy. Neurochem. Int. 63, 1-9.
-
(2013)
Neurochem. Int
, vol.63
, pp. 1-9
-
-
Deng, Y.N.1
Shi, J.2
Liu, J.3
Qu, Q.M.4
-
19
-
-
77954571538
-
A caspase cleaved form of tau is preferentially degraded through the autophagy pathway
-
Dolan, P.J., and Johnson, G.V. (2010). A caspase cleaved form of tau is preferentially degraded through the autophagy pathway. J. Biol. Chem. 285, 21978-21987.
-
(2010)
J. Biol. Chem
, vol.285
, pp. 21978-21987
-
-
Dolan, P.J.1
Johnson, G.V.2
-
20
-
-
77954208049
-
Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation
-
Du, G., Liu, X., Chen, X., Song, M., Yan, Y., Jiao, R., and Wang, C.C. (2010). Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation. Mol. Biol. Cell 21, 2128-2137.
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 2128-2137
-
-
Du, G.1
Liu, X.2
Chen, X.3
Song, M.4
Yan, Y.5
Jiao, R.6
Wang, C.C.7
-
21
-
-
0029082383
-
Inactivation of the mouse Huntington's disease gene homolog Hdh
-
Duyao, M.P., Auerbach, A.B., Ryan, A., Persichetti, F., Barnes, G.T., McNeil, S.M., Ge, P., Vonsattel, J.P., Gusella, J.F., Joyner, A.L., et al. (1995). Inactivation of the mouse Huntington's disease gene homolog Hdh. Science 269, 407-410.
-
(1995)
Science
, vol.269
, pp. 407-410
-
-
Duyao, M.P.1
Auerbach, A.B.2
Ryan, A.3
Persichetti, F.4
Barnes, G.T.5
McNeil, S.M.6
Ge, P.7
Vonsattel, J.P.8
Gusella, J.F.9
Joyner, A.L.10
-
22
-
-
80054026084
-
Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of a-synuclein
-
Ebrahimi-Fakhari, D., Cantuti-Castelvetri, I., Fan, Z., Rockenstein, E., Masliah, E., Hyman, B.T., McLean, P.J., and Unni, V.K. (2011). Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of a-synuclein. J. Neurosci. 31, 14508-14520.
-
(2011)
J. Neurosci
, vol.31
, pp. 14508-14520
-
-
Ebrahimi-Fakhari, D.1
Cantuti-Castelvetri, I.2
Fan, Z.3
Rockenstein, E.4
Masliah, E.5
Hyman, B.T.6
McLean, P.J.7
Unni, V.K.8
-
23
-
-
77950903972
-
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy
-
Filimonenko, M., Isakson, P., Finley, K.D., Anderson, M., Jeong, H., Melia, T.J., Bartlett, B.J., Myers, K.M., Birkeland, H.C., Lamark, T. et al. (2010). The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol. Cell 38, 265-279.
-
(2010)
Mol. Cell
, vol.38
, pp. 265-279
-
-
Filimonenko, M.1
Isakson, P.2
Finley, K.D.3
Anderson, M.4
Jeong, H.5
Melia, T.J.6
Bartlett, B.J.7
Myers, K.M.8
Birkeland, H.C.9
Lamark, T.10
-
24
-
-
84856975752
-
Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: Possible implications for Parkinson's disease
-
Filomeni, G., Graziani, I., De Zio, D., Dini, L., Centonze, D., Rotilio, G., and Ciriolo, M.R. (2012). Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease. Neurobiol. Aging 33, 767-785.
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 767-785
-
-
Filomeni, G.1
Graziani, I.2
De Zio, D.3
Dini, L.4
Centonze, D.5
Rotilio, G.6
Ciriolo, M.R.7
-
25
-
-
84860553281
-
Does lithium prevent Alzheimer's disease?
-
Forlenza, O.V., de Paula, V.J., Machado-Vieira, R., Diniz, B.S., and Gattaz, W.F. (2012). Does lithium prevent Alzheimer's disease? Drugs Aging 29, 335-342.
-
(2012)
Drugs Aging
, vol.29
, pp. 335-342
-
-
Forlenza, O.V.1
de Paula, V.J.2
Machado-Vieira, R.3
Diniz, B.S.4
Gattaz, W.F.5
-
26
-
-
41149124406
-
Lithium delays progression of amyotrophic lateral sclerosis
-
Fornai, F., Longone, P., Cafaro, L., Kastsiuchenka, O., Ferrucci, M., Manca, M.L., Lazzeri, G., Spalloni, A., Bellio, N., Lenzi, P., et al. (2008). Lithium delays progression of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA 105, 2052-2057.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 2052-2057
-
-
Fornai, F.1
Longone, P.2
Cafaro, L.3
Kastsiuchenka, O.4
Ferrucci, M.5
Manca, M.L.6
Lazzeri, G.7
Spalloni, A.8
Bellio, N.9
Lenzi, P.10
-
27
-
-
0041689948
-
Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease
-
Gamblin, T.C., Chen, F., Zambrano, A., Abraha, A., Lagalwar, S., Guillozet, A.L., Lu, M., Fu, Y., Garcia-Sierra, F., LaPointe, N., et al. (2003). Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 100, 10032-10037.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 10032-10037
-
-
Gamblin, T.C.1
Chen, F.2
Zambrano, A.3
Abraha, A.4
Lagalwar, S.5
Guillozet, A.L.6
Lu, M.7
Fu, Y.8
Garcia-Sierra, F.9
LaPointe, N.10
-
28
-
-
84892163616
-
Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease
-
Giordano, S., Darley-Usmar, V., and Zhang, J. (2014). Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease. Redox Biol. 2, 82-90.
-
(2014)
Redox Biol
, vol.2
, pp. 82-90
-
-
Giordano, S.1
Darley-Usmar, V.2
Zhang, J.3
-
29
-
-
77956274512
-
Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking
-
Hadano, S., Otomo, A., Kunita, R., Suzuki-Utsunomiya, K., Akatsuka, A., Koike, M., Aoki, M., Uchiyama, Y., Itoyama, Y., and Ikeda, J.E. (2010). Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking. PLoS One 5, e9805.
-
(2010)
PLoS One
, vol.5
-
-
Hadano, S.1
Otomo, A.2
Kunita, R.3
Suzuki-Utsunomiya, K.4
Akatsuka, A.5
Koike, M.6
Aoki, M.7
Uchiyama, Y.8
Itoyama, Y.9
Ikeda, J.E.10
-
30
-
-
41149085729
-
Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression
-
Hamano, T., Gendron, T.F., Causevic, E., Yen, S.H., Lin, W.L., Isidoro, C., Deture, M., and Ko, L.W. (2008). Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression. Eur. J. Neurosci. 27, 1119-1130.
-
(2008)
Eur. J. Neurosci
, vol.27
, pp. 1119-1130
-
-
Hamano, T.1
Gendron, T.F.2
Causevic, E.3
Yen, S.H.4
Lin, W.L.5
Isidoro, C.6
Deture, M.7
Ko, L.W.8
-
31
-
-
84946432668
-
Autophagy-linked FYVE protein (Alfy) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)
-
[Epub ahead of print]
-
Han, H., Wei, W., Duan, W., Guo, Y., Li, Y., Wang, J., Bi, Y., and Li, C. (2014). Autophagy-linked FYVE protein (Alfy) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). In Vitro Cell. Dev. Biol. Anim. [Epub ahead of print]
-
(2014)
In Vitro Cell. Dev. Biol. Anim
-
-
Han, H.1
Wei, W.2
Duan, W.3
Guo, Y.4
Li, Y.5
Wang, J.6
Bi, Y.7
Li, C.8
-
32
-
-
70349627027
-
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
-
Hetz, C., Thielen, P., Matus, S., Nassif, M., Court, F., Kiffin, R., Martinez, G., Cuervo, A.M., Brown, R.H., and Glimcher, L.H. (2009). XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev. 23, 2294-2306.
-
(2009)
Genes Dev
, vol.23
, pp. 2294-2306
-
-
Hetz, C.1
Thielen, P.2
Matus, S.3
Nassif, M.4
Court, F.5
Kiffin, R.6
Martinez, G.7
Cuervo, A.M.8
Brown, R.H.9
Glimcher, L.H.10
-
33
-
-
84871903696
-
Maturation of autophagosomes and endosomes: A key role for Rab7
-
Hyttinen, J.M., Niittykoski, M., Salminen, A., and Kaarniranta, K. (2013). Maturation of autophagosomes and endosomes: a key role for Rab7. Biochim. Biophys. Acta 1833, 503-510.
-
(2013)
Biochim. Biophys. Acta
, vol.1833
, pp. 503-510
-
-
Hyttinen, J.M.1
Niittykoski, M.2
Salminen, A.3
Kaarniranta, K.4
-
34
-
-
77956215864
-
Regulation of amyloid precursor protein processing by the Beclin 1 complex
-
Jaeger, P.A., Pickford, F., Sun, C.H., Lucin, K.M., Masliah, E., and Wyss-Coray, T. (2010). Regulation of amyloid precursor protein processing by the Beclin 1 complex. PLoS One 5, e11102.
-
(2010)
PLoS One
, vol.5
-
-
Jaeger, P.A.1
Pickford, F.2
Sun, C.H.3
Lucin, K.M.4
Masliah, E.5
Wyss-Coray, T.6
-
35
-
-
84870378784
-
Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: Implications for the ubiquitinproteasomal and autophagy systems
-
Jia, H., Kast, R.J., Steffan, J.S., and Thomas, E.A. (2012). Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitinproteasomal and autophagy systems. Hum. Mol. Genet. 21, 5280-5293.
-
(2012)
Hum. Mol. Genet
, vol.21
, pp. 5280-5293
-
-
Jia, H.1
Kast, R.J.2
Steffan, J.S.3
Thomas, E.A.4
-
36
-
-
84874645362
-
Curcumin ameliorates the neurodegenerative pathology in A53T e-synuclein cell model of Parkinson's disease through the downregulation of mTOR/ p70S6K signaling and the recovery of macroautophagy
-
Jiang, T.F., Zhang, Y.J., Zhou, H.Y., Wang, H.M., Tian, L.P., Liu, J., Ding, J.Q., and Chen, S.D. (2013). Curcumin ameliorates the neurodegenerative pathology in A53T e-synuclein cell model of Parkinson's disease through the downregulation of mTOR/ p70S6K signaling and the recovery of macroautophagy. J. Neuroimmune Pharmacol. 8, 356-669.
-
(2013)
J. Neuroimmune Pharmacol
, vol.8
, pp. 356-669
-
-
Jiang, T.F.1
Zhang, Y.J.2
Zhou, H.Y.3
Wang, H.M.4
Tian, L.P.5
Liu, J.6
Ding, J.Q.7
Chen, S.D.8
-
37
-
-
84884567375
-
Expanded polyglutaminecontaining N-terminal huntingtin fragments are entirely degraded by mammalian proteasomes
-
Juenemann, K., Schipper-Krom, S., Wiemhoefer, A., Kloss, A., Sanz Sanz, A., and Reits, E.A. (2013). Expanded polyglutaminecontaining N-terminal huntingtin fragments are entirely degraded by mammalian proteasomes. J. Biol. Chem. 288, 27068-27084.
-
(2013)
J. Biol. Chem
, vol.288
, pp. 27068-27084
-
-
Juenemann, K.1
Schipper-Krom, S.2
Wiemhoefer, A.3
Kloss, A.4
Sanz Sanz, A.5
Reits, E.A.6
-
38
-
-
84864318195
-
Chaperone-mediated autophagy: A unique way to enter the lysosome world
-
Kaushik, S., and Cuervo, A.M. (2012). Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol. 22, 407-417.
-
(2012)
Trends Cell Biol
, vol.22
, pp. 407-417
-
-
Kaushik, S.1
Cuervo, A.M.2
-
39
-
-
84886707662
-
Autophagy and neurodegenerative disorders
-
Kesidou, E., Lagoudaki, R., Touloumi, O., Poulatsidou, K.N., and Simeonidou, C. (2013). Autophagy and neurodegenerative disorders. Neural Regen. Res. 8, 2275-2283.
-
(2013)
Neural Regen. Res
, vol.8
, pp. 2275-2283
-
-
Kesidou, E.1
Lagoudaki, R.2
Touloumi, O.3
Poulatsidou, K.N.4
Simeonidou, C.5
-
40
-
-
78650746798
-
Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
-
Kickstein, E., Krauss, S., Thornhill, P., Rutschow, D., Zeller, R., Sharkey, J., Williamson, R., Fuchs, M., Köhler, A., Glossmann, H., et al. (2010). Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proc. Natl. Acad. Sci. USA 107, 21830-21835.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 21830-21835
-
-
Kickstein, E.1
Krauss, S.2
Thornhill, P.3
Rutschow, D.4
Zeller, R.5
Sharkey, J.6
Williamson, R.7
Fuchs, M.8
Köhler, A.9
Glossmann, H.10
-
41
-
-
79952486262
-
Amyotrophic lateral sclerosis
-
Kiernan, M.C., Vucic, S., Cheah, B.C., Turner, M.R., Eisen, A., Hardiman, O., Burrell, J.R., and Zoing, M.C. (2011). Amyotrophic lateral sclerosis. Lancet 377, 942-955.
-
(2011)
Lancet
, vol.377
, pp. 942-955
-
-
Kiernan, M.C.1
Vucic, S.2
Cheah, B.C.3
Turner, M.R.4
Eisen, A.5
Hardiman, O.6
Burrell, J.R.7
Zoing, M.C.8
-
42
-
-
83455199097
-
Constitutive upregulation of chaperone-mediated autophagy in Huntington's disease
-
Koga, H., Martinez-Vicente, M., Arias, E., Kaushik, S., Sulzer, D., and Cuervo, A.M. (2011). Constitutive upregulation of chaperone-mediated autophagy in Huntington's disease. J. Neurosci. 31, 18492-18505.
-
(2011)
J. Neurosci
, vol.31
, pp. 18492-18505
-
-
Koga, H.1
Martinez-Vicente, M.2
Arias, E.3
Kaushik, S.4
Sulzer, D.5
Cuervo, A.M.6
-
43
-
-
77955964664
-
Selective autophagy regulates various cellular functions
-
Komatsu, M., and Ichimura, Y. (2010). Selective autophagy regulates various cellular functions. Genes Cells 15, 923-933.
-
(2010)
Genes Cells
, vol.15
, pp. 923-933
-
-
Komatsu, M.1
Ichimura, Y.2
-
44
-
-
84866155363
-
Neuronal autophagy: A housekeeper or a fighter in neuronal cell survival?
-
Lee, J.A. (2012). Neuronal autophagy: a housekeeper or a fighter in neuronal cell survival? Exp. Neurobiol. 21, 1-8.
-
(2012)
Exp Neurobiol
, vol.21
, pp. 1-8
-
-
Lee, J.A.1
-
45
-
-
77953913051
-
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
-
Lee, J.H., Yu, W.H., Kumar, A., Lee, S., Mohan, P.S., Peterhoff, C.M., Wolfe, D.M., Martinez-Vicente, M., Massey, A.C., Sovak, G., et al. (2010). Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 141, 1146-1158.
-
(2010)
Cell
, vol.141
, pp. 1146-1158
-
-
Lee, J.H.1
Yu, W.H.2
Kumar, A.3
Lee, S.4
Mohan, P.S.5
Peterhoff, C.M.6
Wolfe, D.M.7
Martinez-Vicente, M.8
Massey, A.C.9
Sovak, G.10
-
46
-
-
41449113885
-
Altered macroautophagy in the spinal cord of SOD1 mutant mice
-
Li, L., Zhang, X., and Le, W. (2008). Altered macroautophagy in the spinal cord of SOD1 mutant mice. Autophagy 4, 290-293.
-
(2008)
Autophagy
, vol.4
, pp. 290-293
-
-
Li, L.1
Zhang, X.2
Le, W.3
-
47
-
-
84859161154
-
Microautophagy: Lesserknown self-eating
-
Li, W.W., Li, J., and Bao, J.K. (2012). Microautophagy: lesserknown self-eating. Cell. Mol. Life Sci. 69, 1125-1136.
-
(2012)
Cell. Mol. Life Sci
, vol.69
, pp. 1125-1136
-
-
Li, W.W.1
Li, J.2
Bao, J.K.3
-
48
-
-
84896703719
-
Resveratrol partially prevents rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through induction of heme oxygenase-1 dependent autophagy
-
Lin, T.K., Chen, S.D., Chuang, Y.C., Lin, H.Y., Huang, C.R., Chuang, J.H., Wang, P.W., Huang, S.T., Tiao, M.M., Chen, J.B., et al. (2014). Resveratrol partially prevents rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through induction of heme oxygenase-1 dependent autophagy. Int. J. Mol. Sci. 15, 1625-1646.
-
(2014)
Int. J. Mol. Sci
, vol.15
, pp. 1625-1646
-
-
Lin, T.K.1
Chen, S.D.2
Chuang, Y.C.3
Lin, H.Y.4
Huang, C.R.5
Chuang, J.H.6
Wang, P.W.7
Huang, S.T.8
Tiao, M.M.9
Chen, J.B.10
-
49
-
-
84875257081
-
Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: Evidence for improved neuronal bioenergetics and autophagy procession
-
Liu, D., Pitta, M., Jiang, H., Lee, J.H., Zhang, G., Chen, X., Kawamoto, E.M., and Mattson, M.P. (2013). Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession. Neurobiol. Aging 34, 1564-1580.
-
(2013)
Neurobiol. Aging
, vol.34
, pp. 1564-1580
-
-
Liu, D.1
Pitta, M.2
Jiang, H.3
Lee, J.H.4
Zhang, G.5
Chen, X.6
Kawamoto, E.M.7
Mattson, M.P.8
-
50
-
-
84884185631
-
Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease
-
Lucin, K.M., O'Brien, C.E., Bieri, G., Czirr, E., Mosher,. KI., Abbey, R.J., Mastroeni, D.F., Rogers, J., Spencer, B., Masliah, E., et al. (2013). Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. Neuron 79, 873-886.
-
(2013)
Neuron
, vol.79
, pp. 873-886
-
-
Lucin, K.M.1
O'Brien, C.E.2
Bieri, G.3
Czirr, E.4
Mosher, K.I.5
Abbey, R.J.6
Mastroeni, D.F.7
Rogers, J.8
Spencer, B.9
Masliah, E.10
-
51
-
-
84882754673
-
Inhibition of LRRK2 kinase activity stimulates macroautophagy
-
Manzoni, C., Mamais, A., Dihanich, S., Abeti, R., Soutar, M.P., Plun-Favreau, H., Giunti, P., Tooze, S.A., Bandopadhyay, R., and Lewis, P.A. (2013). Inhibition of LRRK2 kinase activity stimulates macroautophagy. Biochim. Biophys. Acta 1833, 2900-2910.
-
(2013)
Biochim. Biophys. Acta
, vol.1833
, pp. 2900-2910
-
-
Manzoni, C.1
Mamais, A.2
Dihanich, S.3
Abeti, R.4
Soutar, M.P.5
Plun-Favreau, H.6
Giunti, P.7
Tooze, S.A.8
Bandopadhyay, R.9
Lewis, P.A.10
-
52
-
-
84922359207
-
Autophagy in Huntington disease and huntingtin in autophagy
-
Martin, D.D., Ladha, S., Ehrnhoefer, D.E., and Hayden, M.R. (2015). Autophagy in Huntington disease and huntingtin in autophagy. Trends Neurosci. 38, 26-35.
-
(2015)
Trends Neurosci
, vol.38
, pp. 26-35
-
-
Martin, D.D.1
Ladha, S.2
Ehrnhoefer, D.E.3
Hayden, M.R.4
-
53
-
-
38849174979
-
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
-
Martinez-Vicente, M., Talloczy, Z., Kaushik, S., Massey, A.C., Mazzulli, J., Mosharov, E.V., Hodara, R., Fredenburg R., Wu, D.C., Follenzi, A., et al. (2008). Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J. Clin. Invest. 118, 777-788.
-
(2008)
J. Clin. Invest
, vol.118
, pp. 777-788
-
-
Martinez-Vicente, M.1
Talloczy, Z.2
Kaushik, S.3
Massey, A.C.4
Mazzulli, J.5
Mosharov, E.V.6
Hodara, R.7
Fredenburg, R.8
Wu, D.C.9
Follenzi, A.10
-
54
-
-
77951665859
-
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
-
Martinez-Vicente, M., Talloczy, Z., Wong, E., Tang, G., Koga, H., Kaushik, S., de Vries, R., Arias, E., Harris, S., Sulzer, D., et al. (2010). Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat. Neurosci. 13, 567-576.
-
(2010)
Nat. Neurosci
, vol.13
, pp. 567-576
-
-
Martinez-Vicente, M.1
Talloczy, Z.2
Wong, E.3
Tang, G.4
Koga, H.5
Kaushik, S.6
de Vries, R.7
Arias, E.8
Harris, S.9
Sulzer, D.10
-
55
-
-
84875443717
-
Axonal transport deficits and neurodegenerative diseases
-
Millecamps, S., and Julien, J.P. (2013). Axonal transport deficits and neurodegenerative diseases. Nat. Rev. Neurosci. 14, 161-176.
-
(2013)
Nat. Rev. Neurosci
, vol.14
, pp. 161-176
-
-
Millecamps, S.1
Julien, J.P.2
-
56
-
-
80054025654
-
The role of Atg proteins in autophagosome formation
-
Mizushima, N., Yoshimori, T., and Ohsumi, Y. (2011). The role of Atg proteins in autophagosome formation. Annu. Rev. Cell Dev. Biol. 27, 107-132.
-
(2011)
Annu. Rev. Cell Dev. Biol
, vol.27
, pp. 107-132
-
-
Mizushima, N.1
Yoshimori, T.2
Ohsumi, Y.3
-
57
-
-
77951221542
-
The role of the Atg1/ULK1 complex in autophagy regulation
-
Mizushima, N. (2010). The role of the Atg1/ULK1 complex in autophagy regulation. Curr. Opin. Cell Biol. 22, 132-139.
-
(2010)
Curr. Opin. Cell Biol
, vol.22
, pp. 132-139
-
-
Mizushima, N.1
-
58
-
-
34548125010
-
Increased autophagy in transgenic mice with a G93A mutant SOD1 gene
-
Morimoto, N., Nagai, M., Ohta, Y., Miyazaki, K., Kurata, T., Morimoto, M., Murakami, T., Takehisa, Y., Ikeda, Y., Kamiya, T., et al. (2007). Increased autophagy in transgenic mice with a G93A mutant SOD1 gene. Brain Res. 1167, 112-117.
-
(2007)
Brain Res
, vol.1167
, pp. 112-117
-
-
Morimoto, N.1
Nagai, M.2
Ohta, Y.3
Miyazaki, K.4
Kurata, T.5
Morimoto, M.6
Murakami, T.7
Takehisa, Y.8
Ikeda, Y.9
Kamiya, T.10
-
59
-
-
2942527227
-
Autophagosome-like vacuole formation in Huntington's disease lymphoblasts
-
Nagata, E., Sawa, A., Ross, C.A., and Snyder, SH. (2004). Autophagosome-like vacuole formation in Huntington's disease lymphoblasts. Neuroreport 15, 1325-1328.
-
(2004)
Neuroreport
, vol.15
, pp. 1325-1328
-
-
Nagata, E.1
Sawa, A.2
Ross, C.A.3
Snyder, S.H.4
-
60
-
-
84890833205
-
BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid tt42
-
Nah, J., Pyo, J.O., Jung, S., Yoo, S.M., Kam, T.I., Chang, J., Han, J., Soo A An, S., Onodera, T., and Jung, Y.K. (2013). BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid tt42. Autophagy 9, 2009-2021.
-
(2013)
Autophagy
, vol.9
, pp. 2009-2021
-
-
Nah, J.1
Pyo, J.O.2
Jung, S.3
Yoo, S.M.4
Kam, T.I.5
Chang, J.6
Han, J.7
Soo A An, S.8
Onodera, T.9
Jung, Y.K.10
-
61
-
-
79960798816
-
SNARE proteins are required for macroautophagy
-
Nair, U., Jotwani, A., Geng, J., Gammoh, N., Richerson, D., Yen, W.L., Griffith, J., Nag, S., Wang, K., Moss, T., et al. (2011). SNARE proteins are required for macroautophagy. Cell 146, 290-302.
-
(2011)
Cell
, vol.146
, pp. 290-302
-
-
Nair, U.1
Jotwani, A.2
Geng, J.3
Gammoh, N.4
Richerson, D.5
Yen, W.L.6
Griffith, J.7
Nag, S.8
Wang, K.9
Moss, T.10
-
62
-
-
67649467294
-
Dynamics and diversity in autophagy mechanisms: Lessons from yeast
-
Nakatogawa, H., Suzuki, K., Kamada, Y., and Ohsumi, Y. (2009). Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat. Rev. Mol. Cell Biol. 10, 458-467.
-
(2009)
Nat. Rev. Mol. Cell Biol
, vol.10
, pp. 458-467
-
-
Nakatogawa, H.1
Suzuki, K.2
Kamada, Y.3
Ohsumi, Y.4
-
63
-
-
58149314211
-
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
-
Narendra, D., Tanaka, A., Suen, D.F., and Youle, R.J. (2008). Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183, 795-803.
-
(2008)
J. Cell Biol
, vol.183
, pp. 795-803
-
-
Narendra, D.1
Tanaka, A.2
Suen, D.F.3
Youle, R.J.4
-
64
-
-
84898463603
-
Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis
-
Nassif, M., Valenzuela, V., Rojas-Rivera, D., Vidal, R., Matus, S., Castillo, K., Fuentealba, Y., Kroemer, G., Levine, B., and Hetz, C. (2014). Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis. Autophagy 10, 1256-1271.
-
(2014)
Autophagy
, vol.10
, pp. 1256-1271
-
-
Nassif, M.1
Valenzuela, V.2
Rojas-Rivera, D.3
Vidal, R.4
Matus, S.5
Castillo, K.6
Fuentealba, Y.7
Kroemer, G.8
Levine, B.9
Hetz, C.10
-
65
-
-
14844303381
-
Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study
-
Nixon, R.A., Wegiel, J., Kumar, A., Yu, W.H., Peterhoff, C., Cataldo, A., and Cuervo, A.M. (2005). Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J. Neuropathol. Exp. Neurol. 64, 113-122.
-
(2005)
J. Neuropathol. Exp. Neurol
, vol.64
, pp. 113-122
-
-
Nixon, R.A.1
Wegiel, J.2
Kumar, A.3
Yu, W.H.4
Peterhoff, C.5
Cataldo, A.6
Cuervo, A.M.7
-
66
-
-
84875640261
-
Interplay of LRRK2 with chaperone-mediated autophagy
-
Orenstein, S.J., Kuo, S.H., Tasset, I., Arias, E., Koga, H., Fernandez-Carasa, I., Cortes, E., Honig, L.S., Dauer, W., Consiglio, A., et al. (2013). Interplay of LRRK2 with chaperone-mediated autophagy. Nat. Neurosci. 16, 394-406.
-
(2013)
Nat. Neurosci
, vol.16
, pp. 394-406
-
-
Orenstein, S.J.1
Kuo, S.H.2
Tasset, I.3
Arias, E.4
Koga, H.5
Fernandez-Carasa, I.6
Cortes, E.7
Honig, L.S.8
Dauer, W.9
Consiglio, A.10
-
67
-
-
84887963355
-
Genetic causes of Parkinson's disease and their links to autophagy regulation
-
Pan, P.Y., and Yue, Z. (2014). Genetic causes of Parkinson's disease and their links to autophagy regulation. Parkinsonism Relat. Disord. 20 Suppl 1, S154-157.
-
(2014)
Parkinsonism Relat. Disord
, vol.1
, Issue.20
, pp. 154-157
-
-
Pan, P.Y.1
Yue, Z.2
-
68
-
-
34250183177
-
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
-
Pandey, U.B., Nie, Z., Batlevi, Y., McCray, B.A., Ritson, G.P., Nedelsky, N.B., Schwartz, S.L., DiProspero, N.A., Knight, M.A., Schuldiner, O., et al. (2007). HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447, 859-863.
-
(2007)
Nature
, vol.447
, pp. 859-863
-
-
Pandey, U.B.1
Nie, Z.2
Batlevi, Y.3
McCray, B.A.4
Ritson, G.P.5
Nedelsky, N.B.6
Schwartz, S.L.7
DiProspero, N.A.8
Knight, M.A.9
Schuldiner, O.10
-
69
-
-
45749114895
-
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
-
Pickford, F., Masliah, E., Britschgi, M., Lucin, K., Narasimhan, R., Jaeger, P.A., Small, S., Spencer, B., Rockenstein, E., Levine, B., et al. (2008). The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J. Clin. Invest. 118, 2190-2199.
-
(2008)
J. Clin. Invest
, vol.118
, pp. 2190-2199
-
-
Pickford, F.1
Masliah, E.2
Britschgi, M.3
Lucin, K.4
Narasimhan, R.5
Jaeger, P.A.6
Small, S.7
Spencer, B.8
Rockenstein, E.9
Levine, B.10
-
70
-
-
68149100027
-
Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice
-
Pizzasegola, C., Caron, I., Daleno, C., Ronchi, A., Minoia, C., Carrì, M.T., and Bendotti, C. (2009). Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice. Amyotroph. Lateral Scler. 10, 221-228.
-
(2009)
Amyotroph. Lateral Scler
, vol.10
, pp. 221-228
-
-
Pizzasegola, C.1
Caron, I.2
Daleno, C.3
Ronchi, A.4
Minoia, C.5
Carrì, M.T.6
Bendotti, C.7
-
71
-
-
84893228727
-
Role of chaperone-mediated autophagy in degrading Huntington's disease-associated huntingtin protein
-
(Shanghai)
-
Qi, L., and Zhang, X.D. (2014). Role of chaperone-mediated autophagy in degrading Huntington's disease-associated huntingtin protein. Acta Biochim. Biophys. Sin. (Shanghai) 46, 83-91.
-
(2014)
Acta Biochim. Biophys. Sin
, vol.46
, pp. 83-91
-
-
Qi, L.1
Zhang, X.D.2
-
73
-
-
2642586352
-
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
-
Ravikumar, B., Vacher, C., Berger, Z., Davies, J.E., Luo, S., Oroz, L.G., Scaravilli, F., Easton, D.F., Duden, R., O'Kane, C.J., et al. (2004). Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat. Genet. 36, 585-595.
-
(2004)
Nat. Genet
, vol.36
, pp. 585-595
-
-
Ravikumar, B.1
Vacher, C.2
Berger, Z.3
Davies, J.E.4
Luo, S.5
Oroz, L.G.6
Scaravilli, F.7
Easton, D.F.8
Duden, R.9
O'Kane, C.J.10
-
74
-
-
84878945608
-
Tau phosphorylation affects its axonal transport and degradation
-
Rodríguez-Martín, T., Cuchillo-Ibáñez, I., Noble, W., Nyenya, F., Anderton, B.H., and Hanger, D.P. (2013). Tau phosphorylation affects its axonal transport and degradation. Neurobiol. Aging 34, 2146-2157.
-
(2013)
Neurobiol. Aging
, vol.34
, pp. 2146-2157
-
-
Rodríguez-Martín, T.1
Cuchillo-Ibáñez, I.2
Noble, W.3
Nyenya, F.4
Anderton, B.H.5
Hanger, D.P.6
-
75
-
-
79955964504
-
Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain
-
Rohn, T.T., Wirawan, E., Brown, R.J., Harris, J.R., Masliah, E., and Vandenabeele, P. (2011). Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain. Neurobiol. Dis. 43, 68-78.
-
(2011)
Neurobiol. Dis
, vol.43
, pp. 68-78
-
-
Rohn, T.T.1
Wirawan, E.2
Brown, R.J.3
Harris, J.R.4
Masliah, E.5
Vandenabeele, P.6
-
76
-
-
77953486943
-
Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease
-
Rose, C., Menzies, F.M., Renna, M., Acevedo-Arozena, A., Corrochano, S., Sadiq, O., Brown, S.D., and Rubinsztein, D.C. (2010). Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum. Mol. Genet. 19, 2144-2153.
-
(2010)
Hum. Mol. Genet
, vol.19
, pp. 2144-2153
-
-
Rose, C.1
Menzies, F.M.2
Renna, M.3
Acevedo-Arozena, A.4
Corrochano, S.5
Sadiq, O.6
Brown, S.D.7
Rubinsztein, D.C.8
-
77
-
-
84880331368
-
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
-
Russell, R.C., Tian, Y., Yuan, H., Park, H.W., Chang, Y.Y., Kim, J., Kim, H., Neufeld, T.P., Dillin, A., and Guan, K.L. (2013). ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat. Cell Biol. 15, 741-750.
-
(2013)
Nat. Cell Biol
, vol.15
, pp. 741-750
-
-
Russell, R.C.1
Tian, Y.2
Yuan, H.3
Park, H.W.4
Chang, Y.Y.5
Kim, J.6
Kim, H.7
Neufeld, T.P.8
Dillin, A.9
Guan, K.L.10
-
78
-
-
84892795290
-
Reduced expression of the chaperone-mediated autophagy carrier hsc70 protein in lymphomonocytes of patients with Parkinson's disease
-
Sala, G., Stefanoni, G., Arosio, A., Riva, C., Melchionda, L., Saracchi, E., Fermi, S., Brighina, L., and Ferrarese, C. (2014). Reduced expression of the chaperone-mediated autophagy carrier hsc70 protein in lymphomonocytes of patients with Parkinson's disease. Brain Res. 1546, 46-52.
-
(2014)
Brain Res
, vol.1546
, pp. 46-52
-
-
Sala, G.1
Stefanoni, G.2
Arosio, A.3
Riva, C.4
Melchionda, L.5
Saracchi, E.6
Fermi, S.7
Brighina, L.8
Ferrarese, C.9
-
79
-
-
79955522014
-
Autophagy in spinal cord motor neurons in sporadic amyotrophic lateral sclerosis
-
Sasaki, S. (2011). Autophagy in spinal cord motor neurons in sporadic amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 70, 349-359.
-
(2011)
J. Neuropathol. Exp. Neurol
, vol.70
, pp. 349-359
-
-
Sasaki, S.1
-
80
-
-
84901639801
-
Parkin and PINK1: Much more than mitophagy
-
Scarffe, L.A., Stevens, D.A., Dawson, V.L., and Dawson, T.M. (2014). Parkin and PINK1: much more than mitophagy. Trends Neurosci. 37, 315-324.
-
(2014)
Trends Neurosci
, vol.37
, pp. 315-324
-
-
Scarffe, L.A.1
Stevens, D.A.2
Dawson, V.L.3
Dawson, T.M.4
-
81
-
-
33744916798
-
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1
-
Shibata, M., Lu, T., Furuya, T., Degterev, A., Mizushima, N., Yoshimori, T., MacDonald, M., Yankner, B., and Yuan, J. (2006). Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J. Biol. Chem. 281, 14474-14485.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 14474-14485
-
-
Shibata, M.1
Lu, T.2
Furuya, T.3
Degterev, A.4
Mizushima, N.5
Yoshimori, T.6
MacDonald, M.7
Yankner, B.8
Yuan, J.9
-
82
-
-
84891748139
-
A current perspective of autophagosome biogenesis
-
Shibutani, S.T., and Yoshimori, T. (2014) A current perspective of autophagosome biogenesis. Cell Res. 24, 58-68.
-
(2014)
Cell Res
, vol.24
, pp. 58-68
-
-
Shibutani, S.T.1
Yoshimori, T.2
-
83
-
-
8344242220
-
utophagy in health and disease: A double-edged sword
-
Shintani, T., and Klionsky, D.J. (2004). utophagy in health and disease: a double-edged sword. Science 306, 990-995.
-
(2004)
Science
, vol.306
, pp. 990-995
-
-
Shintani, T.1
Klionsky, D.J.2
-
84
-
-
84873709314
-
Identification of a candidate therapeutic autophagyinducing peptide
-
Shoji-Kawata, S., Sumpter, R., Leveno, M., Campbell, G.R., Zou, Z., Kinch, L., Wilkins, A.D., Sun, Q., Pallauf, K., MacDuff, D., et al. (2013). Identification of a candidate therapeutic autophagyinducing peptide. Nature 494, 201-206.
-
(2013)
Nature
, vol.494
, pp. 201-206
-
-
Shoji-Kawata, S.1
Sumpter, R.2
Leveno, M.3
Campbell, G.R.4
Zou, Z.5
Kinch, L.6
Wilkins, A.D.7
Sun, Q.8
Pallauf, K.9
MacDuff, D.10
-
85
-
-
84864809503
-
Ubiquitin-like proteins and autophagy at a glance
-
Shpilka, T., Mizushima, N., and Elazar, Z. (2012). Ubiquitin-like proteins and autophagy at a glance. J. Cell Sci. 125, 2343-2348.
-
(2012)
J. Cell Sci
, vol.125
, pp. 2343-2348
-
-
Shpilka, T.1
Mizushima, N.2
Elazar, Z.3
-
86
-
-
84858336588
-
AA-induced formation of autophagosomes is mediated by RAGECaMKK A-AMPK signaling
-
1006
-
Son, S.M., Jung, E.S., Shin, H.J., Byun, J., and Mook-Jung, I. (2012). AA-induced formation of autophagosomes is mediated by RAGECaMKK A-AMPK signaling. Neurobiol. Aging 33, 1006.e11-23.
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 11-23
-
-
Son, S.M.1
Jung, E.S.2
Shin, H.J.3
Byun, J.4
Mook-Jung, I.5
-
87
-
-
84869742069
-
Autophagy and Its Comprehensive Impact on ALS
-
Song, C.Y., Guo, J.F., Liu, Y., and Tang, B.S. (2012). Autophagy and Its Comprehensive Impact on ALS. Int. J. Neurosci. 122, 695-703.
-
(2012)
Int. J. Neurosci
, vol.122
, pp. 695-703
-
-
Song, C.Y.1
Guo, J.F.2
Liu, Y.3
Tang, B.S.4
-
88
-
-
70350550208
-
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases
-
Spencer, B., Potkar, R., Trejo, M., Rockenstein, E., Patrick, C., Gindi, R., Adame, A., Wyss-Coray, T., and Masliah, E. (2009). Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J. Neurosci. 29, 13578-13588.
-
(2009)
J. Neurosci
, vol.29
, pp. 13578-13588
-
-
Spencer, B.1
Potkar, R.2
Trejo, M.3
Rockenstein, E.4
Patrick, C.5
Gindi, R.6
Adame, A.7
Wyss-Coray, T.8
Masliah, E.9
-
89
-
-
84883637335
-
Rapamycin increases survival in ALS mice lacking mature lymphocytes
-
Staats, K.A., Hernandez, S., Schönefeldt, S., Bento-Abreu, A., Dooley, J., Van Damme P., Liston, A., Robberecht, W., and Van Den Bosch, L. (2013). Rapamycin increases survival in ALS mice lacking mature lymphocytes. Mol. Neurodegener 8, 31.
-
(2013)
Mol. Neurodegener
, vol.8
, pp. 31
-
-
Staats, K.A.1
Hernandez, S.2
Schönefeldt, S.3
Bento-Abreu, A.4
Dooley, J.5
Van Damme, P.6
Liston, A.7
Robberecht, W.8
Van Den Bosch, L.9
-
90
-
-
84877333097
-
Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model
-
Steele, J.W., and Gandy, S. (2013). Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model. Autophagy 9, 617-618.
-
(2013)
Autophagy
, vol.9
, pp. 617-618
-
-
Steele, J.W.1
Gandy, S.2
-
91
-
-
78049348191
-
Parkinson's disease: Oxidative stress and therapeutic approaches
-
Surendran, S., and Rajasankar, S. (2010). Parkinson's disease: oxidative stress and therapeutic approaches. Neurol. Sci. 31, 531-540.
-
(2010)
Neurol. Sci
, vol.31
, pp. 531-540
-
-
Surendran, S.1
Rajasankar, S.2
-
92
-
-
84893714992
-
Autophagy in aging and neurodegenerative diseases: Implications for pathogenesis and therapy
-
Tan, C.C., Yu, J.T., Tan, M.S., Jiang, T., Zhu, X.C., and Tan, L. (2014). Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy. Neurobiol. Aging 35, 941-957.
-
(2014)
Neurobiol. Aging
, vol.35
, pp. 941-957
-
-
Tan, C.C.1
Yu, J.T.2
Tan, M.S.3
Jiang, T.4
Zhu, X.C.5
Tan, L.6
-
93
-
-
1642633757
-
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease
-
Tanaka, M., Machida, Y., Niu, S., Ikeda, T., Jana, N.R., Doi, H., Kurosawa, M., Nekooki, M., and Nukina, N. (2004). Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. Nat. Med. 10, 148-154.
-
(2004)
Nat. Med
, vol.10
, pp. 148-154
-
-
Tanaka, M.1
Machida, Y.2
Niu, S.3
Ikeda, T.4
Jana, N.R.5
Doi, H.6
Kurosawa, M.7
Nekooki, M.8
Nukina, N.9
-
94
-
-
72149124383
-
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
-
Thompson, L,M., Aiken, C,T., Kaltenbach, L.S., Agrawal, N., Illes, K., Khoshnan, A., Martinez-Vincente, M., Arrasate, M., O'Rourke, J.G., Khashwji, H., et al. (2009). IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J. Cell Biol. 187, 1083-1099.
-
(2009)
J. Cell Biol
, vol.187
, pp. 1083-1099
-
-
Thompson, L.M.1
Aiken, C.T.2
Kaltenbach, L.S.3
Agrawal, N.4
Illes, K.5
Khoshnan, A.6
Martinez-Vincente, M.7
Arrasate, M.8
O'Rourke, J.G.9
Khashwji, H.10
-
95
-
-
79957917512
-
A smallmolecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway
-
Tian, Y., Bustos, V., Flajolet, M., and Greengard, P. (2011). A smallmolecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 25, 1934-1942.
-
(2011)
FASEB J
, vol.25
, pp. 1934-1942
-
-
Tian, Y.1
Bustos, V.2
Flajolet, M.3
Greengard, P.4
-
96
-
-
78049231804
-
A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model
-
Tsvetkov, A.S., Miller, J., Arrasate, M., Wong, J.S., Pleiss, M.A., and Finkbeiner, S. (2010). A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model. Proc. Natl. Acad. Sci. USA. 107, 16982-16987.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 16982-16987
-
-
Tsvetkov, A.S.1
Miller, J.2
Arrasate, M.3
Wong, J.S.4
Pleiss, M.A.5
Finkbeiner, S.6
-
97
-
-
84881481931
-
Neuronal autophagy: Self-eating or self-cannibalism in Alzheimer's disease
-
Ułamek-Kozioł, M., Furmaga-Jabłońska, W., Januszewski, S., Brzozowska, J., Sciślewska, M., Jabłoński, M., and Pluta, R. (2013). Neuronal autophagy: self-eating or self-cannibalism in Alzheimer's disease. Neurochem. Res. 38, 1769-1773.
-
(2013)
Neurochem. Res
, vol.38
, pp. 1769-1773
-
-
Ułamek-Kozioł, M.1
Furmaga-Jabłońska, W.2
Januszewski, S.3
Brzozowska, J.4
Sciślewska, M.5
Jabłoński, M.6
Pluta, R.7
-
98
-
-
77950575506
-
AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism
-
Vingtdeux, V., Giliberto, L., Zhao, H., Chandakkar, P., Wu, Q., Simon, J.E., Janle, E.M., Lobo, J., Ferruzzi. M.G., Davies. P., et al. (2010). AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J. Biol. Chem. 285, 9100-9113.
-
(2010)
J. Biol. Chem
, vol.285
, pp. 9100-9113
-
-
Vingtdeux, V.1
Giliberto, L.2
Zhao, H.3
Chandakkar, P.4
Wu, Q.5
Simon, J.E.6
Janle, E.M.7
Lobo, J.8
Ferruzzi, M.G.9
Davies, P.10
-
99
-
-
16544383250
-
Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer
-
Wacker, J.L., Zareie, M.H., Fong, H., Sarikaya, M., and Muchowski, P.J. (2004). Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer. Nat. Struct. Mol. Biol. 11, 1215-1222.
-
(2004)
Nat. Struct. Mol. Biol
, vol.11
, pp. 1215-1222
-
-
Wacker, J.L.1
Zareie, M.H.2
Fong, H.3
Sarikaya, M.4
Muchowski, P.J.5
-
100
-
-
33846179357
-
Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline
-
Waldemar, G., Dubois, B., Emre, M., Georges, J., McKeith, I.G., Rossor, M., Scheltens, P., Tariska, P., and Winblad, B. (2007). Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline. Eur. J. Neurol. 14, e1-26.
-
(2007)
Eur. J. Neurol
, vol.14
, pp. 1-26
-
-
Waldemar, G.1
Dubois, B.2
Emre, M.3
Georges, J.4
McKeith, I.G.5
Rossor, M.6
Scheltens, P.7
Tariska, P.8
Winblad, B.9
-
101
-
-
84877980134
-
Abnormal hyperphosphorylation of tau: Sites, regulation, and molecular mechanism of neurofibrillary degeneration
-
Wang, J.Z., Xia, Y.Y., Grundke-Iqbal, I., and Iqbal, K. (2013). Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration. J. Alzheimers Dis. 33 Suppl 1, S123-139.
-
(2013)
J. Alzheimers Dis
, vol.1
, Issue.33
, pp. 123-139
-
-
Wang, J.Z.1
Xia, Y.Y.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
102
-
-
79959415069
-
Biogenesis and cargo selectivity of autophagosomes
-
Weidberg, H., Shvets, E., and Elazar, Z. (2011). Biogenesis and cargo selectivity of autophagosomes. Annu. Rev. Biochem. 80, 125-156.
-
(2011)
Annu. Rev. Biochem
, vol.80
, pp. 125-156
-
-
Weidberg, H.1
Shvets, E.2
Elazar, Z.3
-
103
-
-
26444587508
-
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease
-
Yu, W.H., Cuervo, A.M., Kumar, A., Peterhoff, C.M., Schmidt, S.D., Lee, J.H., Mohan, P.S., Mercken, M., Farmery, M.R., Tjernberg, L.O., et al. (2005). Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J. Cell Biol. 171, 87-98.
-
(2005)
J. Cell Biol
, vol.171
, pp. 87-98
-
-
Yu, W.H.1
Cuervo, A.M.2
Kumar, A.3
Peterhoff, C.M.4
Schmidt, S.D.5
Lee, J.H.6
Mohan, P.S.7
Mercken, M.8
Farmery, M.R.9
Tjernberg, L.O.10
-
104
-
-
79953647105
-
Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis
-
Zhang, X., Li, L., Chen, S., Yang, D., Wang, Y., Zhang, X., Wang, Z., and Le, W. (2011). Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Autophagy 7, 412-425.
-
(2011)
Autophagy
, vol.7
, pp. 412-425
-
-
Zhang, X.1
Li, L.2
Chen, S.3
Yang, D.4
Wang, Y.5
Zhang, X.6
Wang, Z.7
Le, W.8
-
105
-
-
84898465382
-
MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis
-
Zhang, X., Chen, S., Song, L., Tang, Y., Shen, Y., Jia, L., and Le, W. (2014). MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis. Autophagy 10, 588-602.
-
(2014)
Autophagy
, vol.10
, pp. 588-602
-
-
Zhang, X.1
Chen, S.2
Song, L.3
Tang, Y.4
Shen, Y.5
Jia, L.6
Le, W.7
|