A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 39, 2010, Pages 16982-16987

  Tsvetkov, Andrey S ^a   Miller, Jason ^a   Arrasate, Montserrat ^a   Wong, Jinny S ^a   Pleiss, Michael A ^a   Finkbeiner, Steven ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Chemistry and Chemical Biology Program University of California ^*  (United States)

Author keywords

Akt; Light chain 3; Neuronal autophagy; Phenoxazine

Indexed keywords

10 [4' (N DIETHYLAMINO)BUTYL] 2 CHLOROPHENOXAZINE; EVEROLIMUS; FLUSPIRILENE; LOPERAMIDE; MAMMALIAN TARGET OF RAPAMYCIN; MEPACRINE; MESORIDAZINE; NORTRIPTYLINE; PHENOXAZINE DERIVATIVE; PIMOZIDE; PROMAZINE; PROMETHAZINE; PROTEIN KINASE B; RAPAMYCIN; SCAFFOLD PROTEIN; THIORIDAZINE; TRIFLUOPERAZINE; UNCLASSIFIED DRUG; 10-(4'-(N-DIETHYLAMINO)BUTYL)-2-CHLOROPHENOXAZINE; MTOR PROTEIN, MOUSE; NEUROPROTECTIVE AGENT; OXAZINE DERIVATIVE; PHENOXAZINE; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ARTICLE; AUTOPHAGY; DRUG MECHANISM; EMBRYO; HUNTINGTON CHOREA; MOUSE; NERVE CELL; NEUROPROTECTION; NEWBORN; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; RAT; STRUCTURE ACTIVITY RELATION; UPREGULATION; ANIMAL; CELL CULTURE; CELL PROTECTION; CHEMISTRY; DRUG APPROVAL; DRUG EFFECTS; METABOLISM; PATHOLOGY;

ANIMALS; AUTOPHAGY; CELLS, CULTURED; CYTOPROTECTION; DRUG APPROVAL; HUNTINGTON DISEASE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NEURONS; NEUROPROTECTIVE AGENTS; OXAZINES; PROTEIN FOLDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; TOR SERINE-THREONINE KINASES;

EID: 78049231804     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1004498107     Document Type: Article

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