Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1H46R-expressing mouse ALS model by disturbing endolysosomal trafficking

PLoS ONE

Volumn 5, Issue 3, 2010, Pages

  Hadano, Shinji ^a,b,c   Otomo, Asako ^b   Kunita, Ryota ^b   Suzuki Utsunomiya, Kyoko ^b   Akatsuka, Akira ^c   Koike, Masato ^d   Aoki, Masashi ^e   Uchiyama, Yasuo ^d   Itoyama, Yasuto ^e   Ikeda, Joh E ^a,b,c,f  

^a TOKAI UNIVERSITY   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOKAI UNIVERSITY   (Japan)

^d JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALSIN PROTEIN, MOUSE; COPPER ZINC SUPEROXIDE DISMUTASE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PROTEASOME; SUPEROXIDE DISMUTASE;

ANIMAL; ARTICLE; AUTOPHAGY; DISEASE MODEL; ENDOSOME; FEMALE; GENETICS; HELA CELL; HUMAN; LYSOSOME; MALE; METABOLISM; MOTONEURON; MOUSE; NERVE FIBER; NEURITE; PHYSIOLOGY; SPINAL CORD; TRANSGENIC MOUSE;

ANIMALS; AUTOPHAGY; AXONS; DISEASE MODELS, ANIMAL; ENDOSOMES; FEMALE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HELA CELLS; HUMANS; LYSOSOMES; MALE; MICE; MICE, TRANSGENIC; MOTOR NEURONS; NEURITES; PROTEASOME ENDOPEPTIDASE COMPLEX; SPINAL CORD; SUPEROXIDE DISMUTASE;

EID: 77956274512     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009805     Document Type: Article

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