Reduced expression of the chaperone-mediated autophagy carrier hsc70 protein in lymphomonocytes of patients with Parkinson's disease

Brain Research

Volumn 1546, Issue , 2014, Pages 46-52

  Sala, Gessica ^a   Stefanoni, Giovanni ^a,b   Arosio, Alessandro ^a   Riva, Chiara ^a   Melchionda, Laura ^a   Saracchi, Enrico ^a,b   Fermi, Silvia ^a,b   Brighina, Laura ^b   Ferrarese, Carlo ^a,b  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b SAN GERARDO HOSPITAL   (Italy)

Author keywords

Chaperone mediated autophagy; Hsc70; Lamp2a; MEF2D; Parkinson's disease; Peripheral blood mononuclear cell

Indexed keywords

HEAT SHOCK COGNATE PROTEIN 70; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2A; MEMBRANE PROTEIN; MYOCYTE ENHANCER FACTOR 2D; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AGED; ARTICLE; CELL SURVIVAL; CHAPERONE-MEDIATED AUTOPHAGY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MONOCYTE; NERVE CELL; PARKINSON DISEASE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

CHAPERONE-MEDIATED AUTOPHAGY; HSC70; LAMP2A; MEF2D; PARKINSON'S DISEASE; PERIPHERAL BLOOD MONONUCLEAR CELL;

AGED; AUTOPHAGY; CELL SURVIVAL; FEMALE; HSC70 HEAT-SHOCK PROTEINS; HUMANS; LEUKOCYTES, MONONUCLEAR; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; MALE; MEF2 TRANSCRIPTION FACTORS; MIDDLE AGED; PARKINSON DISEASE;

EID: 84892795290     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.12.017     Document Type: Article

References (23)

1. L. Alvarez-Erviti, M.C. Rodriguez-Oroz, J.M. Cooper, C. Caballero, I. Ferrer, J.A. Obeso, and A.H. Schapira Chaperone-mediated autophagy markers in Parkinson disease brains Arch. Neurol. 67 2010 1464 1472
2. L. Brighina, A. Prigione, B. Begni, A. Galbussera, S. Andreoni, R. Piolti, and C. Ferrarese Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease Neurobiol. Aging 31 2010 884 885
3. K.Y. Chong, C.C. Lai, and C.Y. Su Inducible and constitutive HSP70s confer synergistic resistance against metabolic challenges Biochem. Biophys. Res. Commun. 430 2013 774 779
4. J.F. Dice Peptide sequences that target cytosolic proteins for lysosomal proteolysis Trends Biochem. Sci. 15 1990 305 309
5. D.J. Gelb, E. Oliver, and S. Gilman Diagnostic criteria for Parkinson disease Arch. Neurol. 56 1999 33 39
6. M.M. Hoehn, and M.D. Yahr Parkinsonism: onset, progression and mortality Neurology 17 1967 427 442
7. R. Kiffin, C. Christian, E. Knecht, and A.M. Cuervo Activation of chaperone-mediated autophagy during oxidative stress Mol. Biol. Cell 15 2004 4829 4840
8. K.A. Malkus, and H. Ischiropoulos Regional deficiencies in chaperone-mediated autophagy underlie α-synuclein aggregation and neurodegeneration Neurobiol. Dis. 46 2012 732 744
9. S. Mandel, E. Grunblatt, P. Riederer, N. Amariglio, J. Jacob-Hirsch, G. Rechavi, and M.B. Youdim Gene expression profiling of sporadic Parkinson's disease substantia nigra pars compacta reveals impairment of ubiquitin-proteasome subunits, SKP1A, aldehyde dehydrogenase, and chaperone HSC-70 Ann. N. Y. Acad. Sci. 1053 2005 356 375
10. Movement Disorder Society Task Force on Rating Scales for Parkinson's Disease The Unified Parkinson's Disease Rating Scale (UPDRS): status and recommendations Mov. Disord. 18 2003 738 750
11. S. Pemberton, and R. Melki The interaction of Hsc70 protein with fibrillar α-Synuclein and its therapeutic potential in Parkinson's disease Commun. Integr. Biol. 5 2012 94 95
12. A. Prigione, B. Begni, A. Galbussera, S. Beretta, L. Brighina, R. Garofalo, S. Andreoni, R. Piolti, and C. Ferrarese Oxidative stress in peripheral blood mononuclear cells from patients with Parkinson's disease: negative correlation with levodopa dosage Neurobiol. Dis. 23 2006 36 43
13. A. Prigione, I.U. Isaias, A. Galbussera, L. Brighina, B. Begni, S. Andreoni, G. Pezzoli, A. Antonini, and C. Ferrarese Increased oxidative stress in lymphocytes from untreated Parkinson's disease patients Parkinsonism Relat. Disord. 15 2009 327 328
14. A. Prigione, F. Piazza, L. Brighina, B. Begni, A. Galbussera, J.C. Difrancesco, S. Andreoni, R. Piolti, and C. Ferrarese Alpha-synuclein nitration and autophagy response are induced in peripheral blood cells from patients with Parkinson disease Neurosci. Lett. 477 2010 6 10
15. G. Sala, A. Arosio, G. Stefanoni, L. Melchionda, C. Riva, D. Marinig, L. Brighina, and C. Ferrarese Rotenone upregulates alpha-synuclein and myocyte enhancer factor 2D independently from lysosomal degradation inhibition Biomed. Res. Int. 2013 2013 846725
16. G. Sala, L. Brighina, E. Saracchi, S. Fermi, C. Riva, V. Carrozza, M. Pirovano, and C. Ferrarese Vesicular monoamine transporter 2 mRNA levels are reduced in platelets from patients with Parkinson's disease J. Neural Transm. 117 2010 1093 1098
17. T.N. Tombaugh, and N.J. McIntyre The mini-mental state examination: a comprehensive review J. Am. Geriatr. Soc. 40 1992 922 935
18. T. Vogiatzi, M. Xilouri, K. Vekrellis, and L. Stefanis Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells J. Biol. Chem. 283 2008 23542 23556
19. B.S. Wang, Y. Yang, H. Yang, Y.Z. Liu, J.J. Hao, Y. Zhang, Z.Z. Shi, X.M. Jia, Q.M. Zhan, and M.R. Wang PKCι counteracts oxidative stress by regulating Hsc70 in an esophageal cancer cell line Cell Stress Chaperones 18 2013 359 366
20. J.L. Webb, B. Ravikumar, J. Atkins, J.N. Skepper, and D.C. Rubinsztein Alpha-Synuclein is degraded by both autophagy and the proteasome J. Biol. Chem. 278 2003 25009 25013
21. G. Wu, X. Wang, X. Feng, A. Zhang, J. Li, K. Gu, J. Huang, S. Pang, H. Dong, H. Gao, and B. Yan Altered expression of autophagic genes in the peripheral leukocytes of patients with sporadic Parkinson's disease Brain Res. 1394 2011 105 111
22. M. Xilouri, T. Vogiatzi, K. Vekrellis, D. Park, and L. Stefanis Aberrant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy PLoS One 4 2009 e5515
23. Q. Yang, H. She, M. Gearing, E. Colla, M. Lee, J.J. Shacka, and Z. Mao Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy Science 323 2009 124 127