Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression

FEBS Letters

Volumn 586, Issue 11, 2012, Pages 1584-1591

  Abrahamsen, Hilde ^a,b   Stenmark, Harald ^a,b   Platta, Harald W ^c  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

BCL 2; Beclin 1; Cancer; NEDD4; Phosphatidylinositol 3 kinase (PI3K); TRAF6; Ubiquitin protein ligase (E3); Ubiquitination; VPS15; VPS34

Indexed keywords

BECLIN 1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 5; DEATH ASSOCIATED PROTEIN KINASE; PARKIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 2; PROTEIN SERINE THREONINE KINASE VPS15; STRESS ACTIVATED PROTEIN KINASE; THREONINE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE NEDD4;

AUTOPHAGY; CANCER INHIBITION; CATALYSIS; COMPLEX FORMATION; CYTOKINESIS; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME REGULATION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; RNA INTERFERENCE; UBIQUITINATION;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CLASS III PHOSPHATIDYLINOSITOL 3-KINASES; GENES, TUMOR SUPPRESSOR; HUMANS; MEMBRANE PROTEINS; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; UBIQUITINATION;

EID: 84861614439     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.04.046     Document Type: Review

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