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Volumn 38, Issue 2, 2010, Pages 265-279

The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy

Author keywords

HUMDISEASE; PROTEINS

Indexed keywords

AUTOPHAGY LINKED FYVE PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; POLYGLUTAMINE; UNCLASSIFIED DRUG;

EID: 77950903972     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2010.04.007     Document Type: Article
Times cited : (360)

References (59)
  • 1
    • 7244236320 scopus 로고    scopus 로고
    • Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
    • Arrasate M., Mitra S., Schweitzer E.S., Segal M.R., and Finkbeiner S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 431 (2004) 805-810
    • (2004) Nature , vol.431 , pp. 805-810
    • Arrasate, M.1    Mitra, S.2    Schweitzer, E.S.3    Segal, M.R.4    Finkbeiner, S.5
  • 2
    • 50249084987 scopus 로고    scopus 로고
    • Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
    • Axe E.L., Walker S.A., Manifava M., Chandra P., Roderick H.L., Habermann A., Griffiths G., and Ktistakis N.T. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J. Cell Biol. 182 (2008) 685-701
    • (2008) J. Cell Biol. , vol.182 , pp. 685-701
    • Axe, E.L.1    Walker, S.A.2    Manifava, M.3    Chandra, P.4    Roderick, H.L.5    Habermann, A.6    Griffiths, G.7    Ktistakis, N.T.8
  • 3
    • 0036501074 scopus 로고    scopus 로고
    • Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy
    • Bailey C.K., Andriola I.F., Kampinga H.H., and Merry D.E. Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy. Hum. Mol. Genet. 11 (2002) 515-523
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 515-523
    • Bailey, C.K.1    Andriola, I.F.2    Kampinga, H.H.3    Merry, D.E.4
  • 4
    • 0032555641 scopus 로고    scopus 로고
    • Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes
    • Berg T.O., Fengsrud M., Strømhaug P.E., Berg T., and Seglen P.O. Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes. J. Biol. Chem. 273 (1998) 21883-21892
    • (1998) J. Biol. Chem. , vol.273 , pp. 21883-21892
    • Berg, T.O.1    Fengsrud, M.2    Strømhaug, P.E.3    Berg, T.4    Seglen, P.O.5
  • 5
    • 29444455075 scopus 로고    scopus 로고
    • Drosophila as a model for human neurodegenerative disease
    • Bilen J., and Bonini N.M. Drosophila as a model for human neurodegenerative disease. Annu. Rev. Genet. 39 (2005) 153-171
    • (2005) Annu. Rev. Genet. , vol.39 , pp. 153-171
    • Bilen, J.1    Bonini, N.M.2
  • 6
    • 27944504351 scopus 로고    scopus 로고
    • p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • Bjørkøy G., Lamark T., Brech A., Outzen H., Perander M., Overvatn A., Stenmark H., and Johansen T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 171 (2005) 603-614
    • (2005) J. Cell Biol. , vol.171 , pp. 603-614
    • Bjørkøy, G.1    Lamark, T.2    Brech, A.3    Outzen, H.4    Perander, M.5    Overvatn, A.6    Stenmark, H.7    Johansen, T.8
  • 7
    • 33749074277 scopus 로고    scopus 로고
    • Neuronal macroautophagy: from development to degeneration
    • Boland B., and Nixon R.A. Neuronal macroautophagy: from development to degeneration. Mol. Aspects Med. 27 (2006) 503-519
    • (2006) Mol. Aspects Med. , vol.27 , pp. 503-519
    • Boland, B.1    Nixon, R.A.2
  • 10
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    • Cuervo A.M., Stefanis L., Fredenburg R., Lansbury P.T., and Sulzer D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305 (2004) 1292-1295
    • (2004) Science , vol.305 , pp. 1292-1295
    • Cuervo, A.M.1    Stefanis, L.2    Fredenburg, R.3    Lansbury, P.T.4    Sulzer, D.5
  • 12
    • 0030752709 scopus 로고    scopus 로고
    • Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
    • DiFiglia M., Sapp E., Chase K.O., Davies S.W., Bates G.P., Vonsattel J.P., and Aronin N. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277 (1997) 1990-1993
    • (1997) Science , vol.277 , pp. 1990-1993
    • DiFiglia, M.1    Sapp, E.2    Chase, K.O.3    Davies, S.W.4    Bates, G.P.5    Vonsattel, J.P.6    Aronin, N.7
  • 15
    • 43949143804 scopus 로고    scopus 로고
    • The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy
    • Fujita N., Itoh T., Omori H., Fukuda M., Noda T., and Yoshimori T. The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol. Biol. Cell 19 (2008) 2092-2100
    • (2008) Mol. Biol. Cell , vol.19 , pp. 2092-2100
    • Fujita, N.1    Itoh, T.2    Omori, H.3    Fukuda, M.4    Noda, T.5    Yoshimori, T.6
  • 18
    • 33646204392 scopus 로고    scopus 로고
    • Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size
    • Hosokawa N., Hara Y., and Mizushima N. Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett. 580 (2006) 2623-2629
    • (2006) FEBS Lett. , vol.580 , pp. 2623-2629
    • Hosokawa, N.1    Hara, Y.2    Mizushima, N.3
  • 20
    • 28844475400 scopus 로고    scopus 로고
    • HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin
    • Iwata A., Riley B.E., Johnston J.A., and Kopito R.R. HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J. Biol. Chem. 280 (2005) 40282-40292
    • (2005) J. Biol. Chem. , vol.280 , pp. 40282-40292
    • Iwata, A.1    Riley, B.E.2    Johnston, J.A.3    Kopito, R.R.4
  • 21
    • 0032576605 scopus 로고    scopus 로고
    • Aggresomes: a cellular response to misfolded proteins
    • Johnston J.A., Ward C.L., and Kopito R.R. Aggresomes: a cellular response to misfolded proteins. J. Cell Biol. 143 (1998) 1883-1898
    • (1998) J. Cell Biol. , vol.143 , pp. 1883-1898
    • Johnston, J.A.1    Ward, C.L.2    Kopito, R.R.3
  • 23
    • 67650264633 scopus 로고    scopus 로고
    • Atg32 is a mitochondrial protein that confers selectivity during mitophagy
    • Kanki T., Wang K., Cao Y., Baba M., and Klionsky D.J. Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev. Cell 17 (2009) 98-109
    • (2009) Dev. Cell , vol.17 , pp. 98-109
    • Kanki, T.1    Wang, K.2    Cao, Y.3    Baba, M.4    Klionsky, D.J.5
  • 24
    • 0346020435 scopus 로고    scopus 로고
    • The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
    • Kawaguchi Y., Kovacs J.J., McLaurin A., Vance J.M., Ito A., and Yao T.P. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 115 (2003) 727-738
    • (2003) Cell , vol.115 , pp. 727-738
    • Kawaguchi, Y.1    Kovacs, J.J.2    McLaurin, A.3    Vance, J.M.4    Ito, A.5    Yao, T.P.6
  • 25
    • 0034629073 scopus 로고    scopus 로고
    • Genetic suppression of polyglutamine toxicity in Drosophila
    • Kazemi-Esfarjani P., and Benzer S. Genetic suppression of polyglutamine toxicity in Drosophila. Science 287 (2000) 1837-1840
    • (2000) Science , vol.287 , pp. 1837-1840
    • Kazemi-Esfarjani, P.1    Benzer, S.2
  • 29
    • 33645120442 scopus 로고    scopus 로고
    • Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes
    • Köchl R., Hu X.W., Chan E.Y., and Tooze S.A. Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes. Traffic 7 (2006) 129-145
    • (2006) Traffic , vol.7 , pp. 129-145
    • Köchl, R.1    Hu, X.W.2    Chan, E.Y.3    Tooze, S.A.4
  • 31
    • 33744914606 scopus 로고    scopus 로고
    • A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body
    • Lindmo K., Simonsen A., Brech A., Finley K., Rusten T.E., and Stenmark H. A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body. Exp. Cell Res. 312 (2006) 2018-2027
    • (2006) Exp. Cell Res. , vol.312 , pp. 2018-2027
    • Lindmo, K.1    Simonsen, A.2    Brech, A.3    Finley, K.4    Rusten, T.E.5    Stenmark, H.6
  • 32
    • 0020085949 scopus 로고
    • Isolation of autophagic vacuoles from rat liver: morphological and biochemical characterization
    • Marzella L., Ahlberg J., and Glaumann H. Isolation of autophagic vacuoles from rat liver: morphological and biochemical characterization. J. Cell Biol. 93 (1982) 144-154
    • (1982) J. Cell Biol. , vol.93 , pp. 144-154
    • Marzella, L.1    Ahlberg, J.2    Glaumann, H.3
  • 34
    • 29644435706 scopus 로고    scopus 로고
    • Molecular mechanisms and regulation of specific and nonspecific autophagy pathways in yeast
    • Nair U., and Klionsky D.J. Molecular mechanisms and regulation of specific and nonspecific autophagy pathways in yeast. J. Biol. Chem. 280 (2005) 41785-41788
    • (2005) J. Biol. Chem. , vol.280 , pp. 41785-41788
    • Nair, U.1    Klionsky, D.J.2
  • 36
    • 67650246357 scopus 로고    scopus 로고
    • Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy
    • Okamoto K., Kondo-Okamoto N., and Ohsumi Y. Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev. Cell 17 (2009) 87-97
    • (2009) Dev. Cell , vol.17 , pp. 87-97
    • Okamoto, K.1    Kondo-Okamoto, N.2    Ohsumi, Y.3
  • 39
    • 0034284565 scopus 로고    scopus 로고
    • Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis
    • Passani L.A., Bedford M.T., Faber P.W., McGinnis K.M., Sharp A.H., Gusella J.F., Vonsattel J.P., and MacDonald M.E. Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis. Hum. Mol. Genet. 9 (2000) 2175-2182
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 2175-2182
    • Passani, L.A.1    Bedford, M.T.2    Faber, P.W.3    McGinnis, K.M.4    Sharp, A.H.5    Gusella, J.F.6    Vonsattel, J.P.7    MacDonald, M.E.8
  • 40
    • 0036566266 scopus 로고    scopus 로고
    • Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
    • Ravikumar B., Duden R., and Rubinsztein D.C. Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum. Mol. Genet. 11 (2002) 1107-1117
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 1107-1117
    • Ravikumar, B.1    Duden, R.2    Rubinsztein, D.C.3
  • 42
    • 29244480602 scopus 로고    scopus 로고
    • Proteasomes degrade proteins in focal subdomains of the human cell nucleus
    • Rockel T.D., Stuhlmann D., and von Mikecz A. Proteasomes degrade proteins in focal subdomains of the human cell nucleus. J. Cell Sci. 118 (2005) 5231-5242
    • (2005) J. Cell Sci. , vol.118 , pp. 5231-5242
    • Rockel, T.D.1    Stuhlmann, D.2    von Mikecz, A.3
  • 43
    • 4344608793 scopus 로고    scopus 로고
    • Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway
    • Rusten T.E., Lindmo K., Juhász G., Sass M., Seglen P.O., Brech A., and Stenmark H. Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev. Cell 7 (2004) 179-192
    • (2004) Dev. Cell , vol.7 , pp. 179-192
    • Rusten, T.E.1    Lindmo, K.2    Juhász, G.3    Sass, M.4    Seglen, P.O.5    Brech, A.6    Stenmark, H.7
  • 46
    • 4344563878 scopus 로고    scopus 로고
    • Role and regulation of starvation-induced autophagy in the Drosophila fat body
    • Scott R.C., Schuldiner O., and Neufeld T.P. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev. Cell 7 (2004) 167-178
    • (2004) Dev. Cell , vol.7 , pp. 167-178
    • Scott, R.C.1    Schuldiner, O.2    Neufeld, T.P.3
  • 48
    • 34250728186 scopus 로고    scopus 로고
    • Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles
    • Simonsen A., Cumming R.C., Lindmo K., Galaviz V., Cheng S., Rusten T.E., and Finley K.D. Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles. Genetics 176 (2007) 1283-1297
    • (2007) Genetics , vol.176 , pp. 1283-1297
    • Simonsen, A.1    Cumming, R.C.2    Lindmo, K.3    Galaviz, V.4    Cheng, S.5    Rusten, T.E.6    Finley, K.D.7
  • 49
    • 38949099761 scopus 로고    scopus 로고
    • Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
    • Simonsen A., Cumming R.C., Brech A., Isakson P., Schubert D.R., and Finley K.D. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 4 (2008) 176-184
    • (2008) Autophagy , vol.4 , pp. 176-184
    • Simonsen, A.1    Cumming, R.C.2    Brech, A.3    Isakson, P.4    Schubert, D.R.5    Finley, K.D.6
  • 51
    • 0032532323 scopus 로고    scopus 로고
    • Purification and characterization of autophagosomes from rat hepatocytes
    • Strømhaug P.E., Berg T.O., Fengsrud M., and Seglen P.O. Purification and characterization of autophagosomes from rat hepatocytes. Biochem. J. 335 (1998) 217-224
    • (1998) Biochem. J. , vol.335 , pp. 217-224
    • Strømhaug, P.E.1    Berg, T.O.2    Fengsrud, M.3    Seglen, P.O.4
  • 53
    • 70350450808 scopus 로고    scopus 로고
    • The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria
    • Thurston T.L., Ryzhakov G., Bloor S., von Muhlinen N., and Randow F. The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat. Immunol. 10 (2009) 1215-1221
    • (2009) Nat. Immunol. , vol.10 , pp. 1215-1221
    • Thurston, T.L.1    Ryzhakov, G.2    Bloor, S.3    von Muhlinen, N.4    Randow, F.5
  • 54
    • 53049098471 scopus 로고    scopus 로고
    • Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    • Vogiatzi T., Xilouri M., Vekrellis K., and Stefanis L. Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J. Biol. Chem. 283 (2008) 23542-23556
    • (2008) J. Biol. Chem. , vol.283 , pp. 23542-23556
    • Vogiatzi, T.1    Xilouri, M.2    Vekrellis, K.3    Stefanis, L.4
  • 55
    • 0032879437 scopus 로고    scopus 로고
    • Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates
    • Wanker E.E., Scherzinger E., Heiser V., Sittler A., Eickhoff H., and Lehrach H. Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates. Methods Enzymol. 309 (1999) 375-386
    • (1999) Methods Enzymol. , vol.309 , pp. 375-386
    • Wanker, E.E.1    Scherzinger, E.2    Heiser, V.3    Sittler, A.4    Eickhoff, H.5    Lehrach, H.6
  • 56
    • 0034737299 scopus 로고    scopus 로고
    • Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
    • Yamamoto A., Lucas J.J., and Hen R. Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease. Cell 101 (2000) 57-66
    • (2000) Cell , vol.101 , pp. 57-66
    • Yamamoto, A.1    Lucas, J.J.2    Hen, R.3
  • 57
    • 33644540193 scopus 로고    scopus 로고
    • Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway
    • Yamamoto A., Cremona M.L., and Rothman J.E. Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J. Cell Biol. 172 (2006) 719-731
    • (2006) J. Cell Biol. , vol.172 , pp. 719-731
    • Yamamoto, A.1    Cremona, M.L.2    Rothman, J.E.3
  • 58
    • 71649112895 scopus 로고    scopus 로고
    • 3D tomography reveals connections between the phagophore and endoplasmic reticulum
    • Ylä-Anttila P., Vihinen H., Jokitalo E., and Eskelinen E.L. 3D tomography reveals connections between the phagophore and endoplasmic reticulum. Autophagy 5 (2009) 1180-1185
    • (2009) Autophagy , vol.5 , pp. 1180-1185
    • Ylä-Anttila, P.1    Vihinen, H.2    Jokitalo, E.3    Eskelinen, E.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.