KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity

Biochemical Journal

Volumn 469, Issue 3, 2015, Pages 347-355

  Dodson, Matthew ^a,b   Redmann, Matthew ^a,b   Rajasekaran, Namakkal S ^a,b   Darley Usmar, Victor ^a,b   Zhang, Jianhua ^a,b,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

Antioxidants; Autophagy; KEAP1 NRF2; Mitophagy; p62; Redox signalling

Indexed keywords

CYSTEINE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HYDROGEN PEROXIDE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PROTEASOME; PROTEIN AGGREGATE; PROTEIN P62; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOL; TRANSCRIPTION FACTOR NRF2; UBIQUITIN; UBIQUITINATED PROTEIN; ANTIOXIDANT; KEAP1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANTIOXIDANT ACTIVITY; ANXIETY DISORDER; AUTOPHAGY; CARDIOVASCULAR DISEASE; CELL DAMAGE; CELL FUNCTION; CELL SURVIVAL; CONFORMATIONAL TRANSITION; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; GLUTATHIONYLATION; HUMAN; INSULIN RESISTANCE; KENNEDY DISEASE; MITOPHAGY; NEOPLASM; NERVE DEGENERATION; NEUROPATHOLOGY; NITROSATION; NITROSATIVE STRESS; NONHUMAN; OBESITY; OXIDATION REDUCTION REACTION; PAGET BONE DISEASE; PATHOGENESIS; PATHOPHYSIOLOGY; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEOTOXICITY; REDOX STRESS; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SULFENATION; SULFHYDRATION; UBIQUITINATION; ANIMAL; GENETICS; METABOLISM; OXIDATIVE STRESS;

ANIMALS; ANTIOXIDANTS; AUTOPHAGY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 84938487642     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20150568     Document Type: Review

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