Cysteine-based regulation of the CUL3 adaptor protein Keap1

Toxicology and Applied Pharmacology

Volumn 244, Issue 1, 2010, Pages 21-26

  Sekhar, Konjeti R ^a   Rachakonda, Girish ^a   Freeman, Michael L ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

CULLIN3; Cysteine adduction oxidation; Detoxification; Keap1; Nrf2; Oxidative stress; Phase II gene expression; Proteomics

Indexed keywords

CYSTEINE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PROTEASOME; THIOL; TRANSCRIPTION FACTOR NRF2;

AMINO ACID SEQUENCE; ANTIOXIDANT RESPONSIVE ELEMENT; CONFORMATIONAL TRANSITION; GENE EXPRESSION; GENE TARGETING; HUMAN; NONHUMAN; OXIDATION REDUCTION REACTION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEIN TRANSPORT; REGULATORY MECHANISM; REVIEW; SITE DIRECTED MUTAGENESIS; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; ANIMALS; CULLIN PROTEINS; CYSTEINE; CYTOSKELETAL PROTEINS; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; TRANSCRIPTIONAL ACTIVATION; UBIQUITINATION;

EID: 77949262414     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.06.016     Document Type: Review

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