Identification of two reactive cysteine residues in the tumor suppressor protein p53 using top-down FTICR mass spectrometry

Journal of the American Society for Mass Spectrometry

Volumn 22, Issue 5, 2011, Pages 888-897

  Scotcher, Jenna ^a   Clarke, David J ^a   Weidt, Stefan K ^a   Mackay, C Logan ^a   Hupp, Ted R ^a   Sadler, Peter J ^b   Langridge Smith, Pat R R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Cysteine reactivity; FTICR mass spectrometry; Middle down fragmentation; P53; Top down fragmentation; Tumor suppressor

Indexed keywords

CYSTEINE REACTIVITY; FTICR MASS SPECTROMETRY; MIDDLE-DOWN FRAGMENTATION; P53; TOPDOWN; TUMOR-SUPPRESSOR;

CELL DEATH; CHEMICAL ANALYSIS; MASS SPECTROMETRY; TRANSCRIPTION FACTORS; TUMORS;

AMINO ACIDS;

CYSTEINE; N ETHYLMALEIMIDE; PROTEIN P53;

ALKYLATION; ARTICLE; BODY TEMPERATURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; OXIDATION REDUCTION REACTION; PROTEIN FOLDING; PROTEIN MODIFICATION; SITE DIRECTED MUTAGENESIS;

ALKYLATING AGENTS; AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; ETHYLMALEIMIDE; FOURIER ANALYSIS; HUMANS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PEPTIDE FRAGMENTS; PROTEIN UNFOLDING; TEMPERATURE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79955780678     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-011-0088-x     Document Type: Article

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