Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in Parkinson’s disease models

Journal of Neuroscience

Volumn 34, Issue 45, 2014, Pages 15123-15131

  Choi, Min Sik ^a   Nakamura, Tomohiro ^a   Cho, Seung Je ^a   Han, Xuemei ^b   Holland, Emily A ^a   Qu, Jing ^a   Petsko, Gregory A ^c   Yates, John R ^b   Liddington, Robert C ^a   Lipton, Stuart A ^a  

^a BURNHAM INSTITUTE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c FEIL FAMILY BRAIN AND MIND RESEARCH INSTITUTE   (United States)

Author keywords

DJ 1; Nitric oxide; Parkinson s disease; PTEN; S nitrosylation; Transnitrosylation

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL) [2, 5' BI 1H BENZIMIDAZOL] 2' YL] PHENOL; APOPTOSIS REGULATORY PROTEIN; BACTERIAL VECTOR; CALCIMYCIN; COMPLEMENTARY DNA; DJ 1 PROTEIN; MONOCLONAL ANTIBODY; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; POLYCLONAL ANTIBODY; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ONCOPROTEIN; PARK7 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, HUMAN; SIGNAL PEPTIDE;

APOPTOSIS ASSAY; ARTICLE; BIOTIN SWITCH ASSAY; CELL DEATH; CELL LYSATE; CELL SURVIVAL; CONTROLLED STUDY; CRYSTALLIZATION; DISEASE MODEL; DOWN REGULATION; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE MUTATION; GENETIC TRANSFECTION; HEK293 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NERVE CELL; NEUROBLASTOMA CELL LINE; NEUROPROTECTION; NITROSYLATION; PARKINSON DISEASE; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS REGULATION; S NITROSYLATION; SITE DIRECTED MUTAGENESIS; TANDEM MASS SPECTROMETRY; TRANSNITROSYLATION; X RAY CRYSTALLOGRAPHY; AGED; AMINO ACID SEQUENCE; APOPTOSIS; CASE CONTROL STUDY; CHEMISTRY; FEMALE; GENETICS; MALE; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN MOTIF; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; APOPTOSIS; CASE-CONTROL STUDIES; FEMALE; HEK293 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MOLECULAR SEQUENCE DATA; MUTATION; NEURONS; NITRIC OXIDE; ONCOGENE PROTEINS; PARKINSON DISEASE; PTEN PHOSPHOHYDROLASE;

EID: 84908518890     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4751-13.2014     Document Type: Article

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