-
1
-
-
67349284051
-
Non-genetic heterogeneity: a mutation-independent driving force for the somatic evolution of tumours
-
Brock A., et al. Non-genetic heterogeneity: a mutation-independent driving force for the somatic evolution of tumours. Nat. Rev. Genet. 2009, 10:336-342.
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 336-342
-
-
Brock, A.1
-
2
-
-
77956520011
-
Functional roles for noise in genetic circuits
-
Eldar A., Elowitz M.B. Functional roles for noise in genetic circuits. Nature 2010, 467:167-173.
-
(2010)
Nature
, vol.467
, pp. 167-173
-
-
Eldar, A.1
Elowitz, M.B.2
-
3
-
-
53549123008
-
Nature, nurture, or chance: stochastic gene expression and its consequences
-
Raj A., van Oudenaarden A. Nature, nurture, or chance: stochastic gene expression and its consequences. Cell 2008, 135:216-226.
-
(2008)
Cell
, vol.135
, pp. 216-226
-
-
Raj, A.1
van Oudenaarden, A.2
-
4
-
-
26444495615
-
Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways
-
Beere H.M. Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways. J. Clin. Invest. 2005, 115:2633-2639.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 2633-2639
-
-
Beere, H.M.1
-
5
-
-
84877574804
-
Another fork in the road: life or death decisions by the tumour suppressor p53
-
Carvajal L.A., Manfredi J.J. Another fork in the road: life or death decisions by the tumour suppressor p53. EMBO Rep. 2013, 14:414-421.
-
(2013)
EMBO Rep.
, vol.14
, pp. 414-421
-
-
Carvajal, L.A.1
Manfredi, J.J.2
-
6
-
-
84894565195
-
Self-consumption: the interplay of autophagy and apoptosis
-
Marino G., et al. Self-consumption: the interplay of autophagy and apoptosis. Nat. Rev. 2014, 15:81-94.
-
(2014)
Nat. Rev.
, vol.15
, pp. 81-94
-
-
Marino, G.1
-
7
-
-
33745513015
-
Divergence from a dedicated cellular suicide mechanism: exploring the evolution of cell death
-
Yuan J. Divergence from a dedicated cellular suicide mechanism: exploring the evolution of cell death. Mol. Cell 2006, 23:1-12.
-
(2006)
Mol. Cell
, vol.23
, pp. 1-12
-
-
Yuan, J.1
-
8
-
-
84859871133
-
Signaling pathways that regulate life and cell death: evolution of apoptosis in the context of self-defense
-
Munoz-Pinedo C. Signaling pathways that regulate life and cell death: evolution of apoptosis in the context of self-defense. Adv. Exp. Med. Biol. 2012, 738:124-143.
-
(2012)
Adv. Exp. Med. Biol.
, vol.738
, pp. 124-143
-
-
Munoz-Pinedo, C.1
-
9
-
-
79951831808
-
Caspase signaling in animal development
-
Kuranaga E. Caspase signaling in animal development. Dev. Growth Differ. 2011, 53:137-148.
-
(2011)
Dev. Growth Differ.
, vol.53
, pp. 137-148
-
-
Kuranaga, E.1
-
10
-
-
84868140124
-
Driving apoptosis-relevant proteins toward neural differentiation
-
Sola S., et al. Driving apoptosis-relevant proteins toward neural differentiation. Mol. Neurobiol. 2012, 46:316-331.
-
(2012)
Mol. Neurobiol.
, vol.46
, pp. 316-331
-
-
Sola, S.1
-
11
-
-
41749107942
-
Stochasticity and cell fate
-
Losick R., Desplan C. Stochasticity and cell fate. Science 2008, 320:65-68.
-
(2008)
Science
, vol.320
, pp. 65-68
-
-
Losick, R.1
Desplan, C.2
-
12
-
-
44749085513
-
Targeting the extrinsic apoptosis pathway in cancer
-
Ashkenazi A. Targeting the extrinsic apoptosis pathway in cancer. Cytokine Growth Factor Rev. 2008, 19:325-331.
-
(2008)
Cytokine Growth Factor Rev.
, vol.19
, pp. 325-331
-
-
Ashkenazi, A.1
-
13
-
-
67649386107
-
Life and death by death receptors
-
Guicciardi M.E., Gores G.J. Life and death by death receptors. FASEB J. 2009, 23:1625-1637.
-
(2009)
FASEB J.
, vol.23
, pp. 1625-1637
-
-
Guicciardi, M.E.1
Gores, G.J.2
-
14
-
-
33751006615
-
TRAIL resistance results in cancer progression: a TRAIL to perdition?
-
Malhi H., Gores G.J. TRAIL resistance results in cancer progression: a TRAIL to perdition?. Oncogene 2006, 25:7333-7335.
-
(2006)
Oncogene
, vol.25
, pp. 7333-7335
-
-
Malhi, H.1
Gores, G.J.2
-
15
-
-
62849093368
-
Death receptor signal transducers: nodes of coordination in immune signaling networks
-
Wilson N.S., et al. Death receptor signal transducers: nodes of coordination in immune signaling networks. Nat. Immunol. 2009, 10:348-355.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 348-355
-
-
Wilson, N.S.1
-
16
-
-
33846247103
-
Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling
-
Feig C., et al. Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling. EMBO J. 2007, 26:221-231.
-
(2007)
EMBO J.
, vol.26
, pp. 221-231
-
-
Feig, C.1
-
17
-
-
84857048734
-
Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells
-
Mazurek N., et al. Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells. Cell Death Differ. 2011, 19:523-533.
-
(2011)
Cell Death Differ.
, vol.19
, pp. 523-533
-
-
Mazurek, N.1
-
18
-
-
62749084512
-
Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling
-
Rossin A., et al. Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling. Biochem. J. 2009, 419:185-192.
-
(2009)
Biochem. J.
, vol.419
, pp. 185-192
-
-
Rossin, A.1
-
19
-
-
34948894931
-
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
-
Wagner K.W., et al. Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat. Med. 2007, 13:1070-1077.
-
(2007)
Nat. Med.
, vol.13
, pp. 1070-1077
-
-
Wagner, K.W.1
-
20
-
-
77956170550
-
New insights into apoptosis signaling by Apo2L/TRAIL
-
Gonzalvez F., Ashkenazi A. New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene 2010, 29:4752-4765.
-
(2010)
Oncogene
, vol.29
, pp. 4752-4765
-
-
Gonzalvez, F.1
Ashkenazi, A.2
-
21
-
-
84903577507
-
E-cadherin couples death receptors to the cytoskeleton to regulate apoptosis
-
Lu M., et al. E-cadherin couples death receptors to the cytoskeleton to regulate apoptosis. Mol. Cell 2014, 54:987-998.
-
(2014)
Mol. Cell
, vol.54
, pp. 987-998
-
-
Lu, M.1
-
22
-
-
33749164762
-
Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2
-
Merino D., et al. Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol. Cell. Biol. 2006, 26:7046-7055.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 7046-7055
-
-
Merino, D.1
-
23
-
-
5644222552
-
Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction
-
Muppidi J.R., et al. Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction. Immunity 2004, 21:461-465.
-
(2004)
Immunity
, vol.21
, pp. 461-465
-
-
Muppidi, J.R.1
-
24
-
-
77949405660
-
Dynamics within the CD95 death-inducing signaling complex decide life and death of cells
-
Neumann L., et al. Dynamics within the CD95 death-inducing signaling complex decide life and death of cells. Mol. Syst. Biol. 2010, 6:352.
-
(2010)
Mol. Syst. Biol.
, vol.6
, pp. 352
-
-
Neumann, L.1
-
26
-
-
0037160117
-
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex
-
Micheau O., et al. The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J. Biol. Chem. 2002, 277:45162-45171.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45162-45171
-
-
Micheau, O.1
-
27
-
-
0037099678
-
C-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis
-
Chang D.W., et al. c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. EMBO J. 2002, 21:3704-3714.
-
(2002)
EMBO J.
, vol.21
, pp. 3704-3714
-
-
Chang, D.W.1
-
28
-
-
41149152733
-
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
-
Chipuk J.E., Green D.R. How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?. Trends Cell Biol. 2008, 18:157-164.
-
(2008)
Trends Cell Biol.
, vol.18
, pp. 157-164
-
-
Chipuk, J.E.1
Green, D.R.2
-
29
-
-
0036728834
-
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
-
Letai A., et al. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2002, 2:183-192.
-
(2002)
Cancer Cell
, vol.2
, pp. 183-192
-
-
Letai, A.1
-
30
-
-
41549132691
-
Quantitative analysis of pathways controlling extrinsic apoptosis in single cells
-
Albeck J.G., et al. Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol. Cell 2008, 30:11-25.
-
(2008)
Mol. Cell
, vol.30
, pp. 11-25
-
-
Albeck, J.G.1
-
31
-
-
82155170633
-
Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis
-
Aldridge B.B., et al. Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis. Mol. Syst. Biol. 2011, 7:553.
-
(2011)
Mol. Syst. Biol.
, vol.7
, pp. 553
-
-
Aldridge, B.B.1
-
32
-
-
69249208481
-
XIAP discriminates between type I and type II FAS-induced apoptosis
-
Jost P.J., et al. XIAP discriminates between type I and type II FAS-induced apoptosis. Nature 2009, 460:1035-1039.
-
(2009)
Nature
, vol.460
, pp. 1035-1039
-
-
Jost, P.J.1
-
33
-
-
84861133687
-
Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis
-
Gaudet S., et al. Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis. PLoS Comput. Biol. 2012, 8:e1002482.
-
(2012)
PLoS Comput. Biol.
, vol.8
, pp. e1002482
-
-
Gaudet, S.1
-
34
-
-
84885419088
-
Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells
-
Passante E., et al. Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells. Cell Death Differ. 2013, 20:1521-1531.
-
(2013)
Cell Death Differ.
, vol.20
, pp. 1521-1531
-
-
Passante, E.1
-
35
-
-
84891656477
-
Death receptor-ligand systems in cancer, cell death, and inflammation
-
Walczak H. Death receptor-ligand systems in cancer, cell death, and inflammation. Cold Spring Harb. Perspect. Biol. 2013, 5:a008698.
-
(2013)
Cold Spring Harb. Perspect. Biol.
, vol.5
, pp. a008698
-
-
Walczak, H.1
-
36
-
-
33750370438
-
Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis
-
Jin Z., El-Deiry W.S. Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis. Mol. Cell. Biol. 2006, 26:8136-8148.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 8136-8148
-
-
Jin, Z.1
El-Deiry, W.S.2
-
37
-
-
28844441555
-
Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand
-
Varfolomeev E., et al. Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. J. Biol. Chem. 2005, 280:40599-40608.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 40599-40608
-
-
Varfolomeev, E.1
-
38
-
-
0037299282
-
Non-apoptotic Fas signaling
-
Wajant H., et al. Non-apoptotic Fas signaling. Cytokine Growth Factor Rev. 2003, 14:53-66.
-
(2003)
Cytokine Growth Factor Rev.
, vol.14
, pp. 53-66
-
-
Wajant, H.1
-
39
-
-
4143108125
-
CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells
-
Barnhart B.C., et al. CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells. EMBO J. 2004, 23:3175-3185.
-
(2004)
EMBO J.
, vol.23
, pp. 3175-3185
-
-
Barnhart, B.C.1
-
40
-
-
84880401580
-
Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes
-
Flusberg D.A., et al. Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes. Mol. Biol. Cell 2013, 24:2186-2200.
-
(2013)
Mol. Biol. Cell
, vol.24
, pp. 2186-2200
-
-
Flusberg, D.A.1
-
41
-
-
0032697485
-
Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways
-
Hu W.H., et al. Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways. J. Biol. Chem. 1999, 274:30603-30610.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 30603-30610
-
-
Hu, W.H.1
-
42
-
-
33644801980
-
Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells
-
Ishimura N., et al. Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2006, 290:G129-G136.
-
(2006)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.290
, pp. G129-G136
-
-
Ishimura, N.1
-
43
-
-
84872438072
-
The multilevel regulation of CD95 signaling outcome
-
Yurchenko M., et al. The multilevel regulation of CD95 signaling outcome. Exp. Oncol. 2012, 34:153-159.
-
(2012)
Exp. Oncol.
, vol.34
, pp. 153-159
-
-
Yurchenko, M.1
-
44
-
-
0033835065
-
Fas engagement accelerates liver regeneration after partial hepatectomy
-
Desbarats J., Newell M.K. Fas engagement accelerates liver regeneration after partial hepatectomy. Nat. Med. 2000, 6:920-923.
-
(2000)
Nat. Med.
, vol.6
, pp. 920-923
-
-
Desbarats, J.1
Newell, M.K.2
-
45
-
-
33645006173
-
Control of neuronal branching by the death receptor CD95 (Fas/Apo-1)
-
Zuliani C., et al. Control of neuronal branching by the death receptor CD95 (Fas/Apo-1). Cell Death Differ. 2006, 13:31-40.
-
(2006)
Cell Death Differ.
, vol.13
, pp. 31-40
-
-
Zuliani, C.1
-
46
-
-
70350233206
-
Non-canonical role for the TRAIL receptor DR5/FADD/caspase pathway in the regulation of MyoD expression and skeletal myoblast differentiation
-
Freer-Prokop M., et al. Non-canonical role for the TRAIL receptor DR5/FADD/caspase pathway in the regulation of MyoD expression and skeletal myoblast differentiation. Differentiation 2009, 78:205-212.
-
(2009)
Differentiation
, vol.78
, pp. 205-212
-
-
Freer-Prokop, M.1
-
47
-
-
31944445326
-
Involvement of TRAIL/TRAIL-receptors in human intestinal cell differentiation
-
Rimondi E., et al. Involvement of TRAIL/TRAIL-receptors in human intestinal cell differentiation. J. Cell. Physiol. 2006, 206:647-654.
-
(2006)
J. Cell. Physiol.
, vol.206
, pp. 647-654
-
-
Rimondi, E.1
-
48
-
-
36549083012
-
Tumor-necrosis-factor-related apoptosis-inducing ligand and the regulation of hematopoiesis
-
Secchiero P., Zauli G. Tumor-necrosis-factor-related apoptosis-inducing ligand and the regulation of hematopoiesis. Curr. Opin. Hematol. 2008, 15:42-48.
-
(2008)
Curr. Opin. Hematol.
, vol.15
, pp. 42-48
-
-
Secchiero, P.1
Zauli, G.2
-
49
-
-
0038414629
-
TRAIL promotes the survival and proliferation of primary human vascular endothelial cells by activating the Akt and ERK pathways
-
Secchiero P., et al. TRAIL promotes the survival and proliferation of primary human vascular endothelial cells by activating the Akt and ERK pathways. Circulation 2003, 107:2250-2256.
-
(2003)
Circulation
, vol.107
, pp. 2250-2256
-
-
Secchiero, P.1
-
50
-
-
4143082567
-
TRAIL promotes the survival, migration and proliferation of vascular smooth muscle cells
-
Secchiero P., et al. TRAIL promotes the survival, migration and proliferation of vascular smooth muscle cells. Cell. Mol. Life Sci. 2004, 61:1965-1974.
-
(2004)
Cell. Mol. Life Sci.
, vol.61
, pp. 1965-1974
-
-
Secchiero, P.1
-
51
-
-
84895500549
-
Involvement of caspase 8 and c-FLIPL in the proangiogenic effects of the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)
-
Cantarella G., et al. Involvement of caspase 8 and c-FLIPL in the proangiogenic effects of the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL). FEBS J. 2014, 281:1505-1513.
-
(2014)
FEBS J.
, vol.281
, pp. 1505-1513
-
-
Cantarella, G.1
-
52
-
-
40149099894
-
Yes and PI3K bind CD95 to signal invasion of glioblastoma
-
Kleber S., et al. Yes and PI3K bind CD95 to signal invasion of glioblastoma. Cancer Cell 2008, 13:235-248.
-
(2008)
Cancer Cell
, vol.13
, pp. 235-248
-
-
Kleber, S.1
-
53
-
-
77952973860
-
CD95 promotes tumour growth
-
Chen L., et al. CD95 promotes tumour growth. Nature 2010, 465:492-496.
-
(2010)
Nature
, vol.465
, pp. 492-496
-
-
Chen, L.1
-
54
-
-
0038339094
-
TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB
-
Ehrhardt H., et al. TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB. Oncogene 2003, 22:3842-3852.
-
(2003)
Oncogene
, vol.22
, pp. 3842-3852
-
-
Ehrhardt, H.1
-
55
-
-
54449083955
-
TRAIL induces MMP-9 expression via ERK activation in human astrocytoma cells
-
Kim J.H., et al. TRAIL induces MMP-9 expression via ERK activation in human astrocytoma cells. Biochem. Biophys. Res. Commun. 2008, 377:195-199.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.377
, pp. 195-199
-
-
Kim, J.H.1
-
56
-
-
84957565443
-
Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells
-
Pavet V., et al. Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells. Cell Death Dis. 2014, 5:e1043.
-
(2014)
Cell Death Dis.
, vol.5
, pp. e1043
-
-
Pavet, V.1
-
57
-
-
33845221022
-
TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma
-
Trauzold A., et al. TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma. Oncogene 2006, 25:7434-7439.
-
(2006)
Oncogene
, vol.25
, pp. 7434-7439
-
-
Trauzold, A.1
-
58
-
-
42149165564
-
The potential molecular mechanism of overexpression of uPA, IL-8, MMP-7 and MMP-9 induced by TRAIL in pancreatic cancer cell
-
Zhou D.H., et al. The potential molecular mechanism of overexpression of uPA, IL-8, MMP-7 and MMP-9 induced by TRAIL in pancreatic cancer cell. Hepatobiliary Pancreat. Dis. Int. 2008, 7:201-209.
-
(2008)
Hepatobiliary Pancreat. Dis. Int.
, vol.7
, pp. 201-209
-
-
Zhou, D.H.1
-
59
-
-
84880271502
-
Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family
-
Azijli K., et al. Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family. Cell Death Differ. 2013, 20:858-868.
-
(2013)
Cell Death Differ.
, vol.20
, pp. 858-868
-
-
Azijli, K.1
-
60
-
-
84894115526
-
Control of life-or-death decisions by RIP1 kinase
-
Christofferson D.E., et al. Control of life-or-death decisions by RIP1 kinase. Annu. Rev. Physiol. 2014, 76:129-150.
-
(2014)
Annu. Rev. Physiol.
, vol.76
, pp. 129-150
-
-
Christofferson, D.E.1
-
61
-
-
84861653411
-
The 'complexities' of life and death: death receptor signalling platforms
-
Dickens L.S., et al. The 'complexities' of life and death: death receptor signalling platforms. Exp. Cell Res. 2012, 318:1269-1277.
-
(2012)
Exp. Cell Res.
, vol.318
, pp. 1269-1277
-
-
Dickens, L.S.1
-
62
-
-
0041853690
-
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
-
Micheau O., Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003, 114:181-190.
-
(2003)
Cell
, vol.114
, pp. 181-190
-
-
Micheau, O.1
Tschopp, J.2
-
63
-
-
5944233768
-
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
-
Holler N., et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat. Immunol. 2000, 1:489-495.
-
(2000)
Nat. Immunol.
, vol.1
, pp. 489-495
-
-
Holler, N.1
-
64
-
-
33745928465
-
Death-receptor activation halts clathrin-dependent endocytosis
-
Austin C.D., et al. Death-receptor activation halts clathrin-dependent endocytosis. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:10283-10288.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 10283-10288
-
-
Austin, C.D.1
-
65
-
-
34250331231
-
Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis
-
Kohlhaas S.L., et al. Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. J. Biol. Chem. 2007, 282:12831-12841.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 12831-12841
-
-
Kohlhaas, S.L.1
-
66
-
-
34547123570
-
Lipid rafts and nonrafts mediate tumor necrosis factor related apoptosis-inducing ligand induced apoptotic and nonapoptotic signals in non small cell lung carcinoma cells
-
Song J.H., et al. Lipid rafts and nonrafts mediate tumor necrosis factor related apoptosis-inducing ligand induced apoptotic and nonapoptotic signals in non small cell lung carcinoma cells. Cancer Res. 2007, 67:6946-6955.
-
(2007)
Cancer Res.
, vol.67
, pp. 6946-6955
-
-
Song, J.H.1
-
67
-
-
34250346095
-
Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling
-
Lavrik I.N., et al. Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling. J. Biol. Chem. 2007, 282:13664-13671.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 13664-13671
-
-
Lavrik, I.N.1
-
68
-
-
10044232636
-
Induction of apoptosis and activation of NF-kappaB by CD95 require different signalling thresholds
-
Legembre P., et al. Induction of apoptosis and activation of NF-kappaB by CD95 require different signalling thresholds. EMBO Rep. 2004, 5:1084-1089.
-
(2004)
EMBO Rep.
, vol.5
, pp. 1084-1089
-
-
Legembre, P.1
-
69
-
-
70349694386
-
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
-
LA O.R., et al. Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature 2009, 461:659-663.
-
(2009)
Nature
, vol.461
, pp. 659-663
-
-
La, O.R.1
-
70
-
-
77955465116
-
Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL
-
Fricker N., et al. Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL. J. Cell Biol. 2010, 190:377-389.
-
(2010)
J. Cell Biol.
, vol.190
, pp. 377-389
-
-
Fricker, N.1
-
71
-
-
84878729789
-
MAPK p38 and JNK have opposing activities on TRAIL-induced apoptosis activation in NSCLC H460 cells that involves RIP1 and caspase-8 and is mediated by Mcl-1
-
Azijli K., et al. MAPK p38 and JNK have opposing activities on TRAIL-induced apoptosis activation in NSCLC H460 cells that involves RIP1 and caspase-8 and is mediated by Mcl-1. Apoptosis 2013, 18:851-860.
-
(2013)
Apoptosis
, vol.18
, pp. 851-860
-
-
Azijli, K.1
-
72
-
-
77954659814
-
TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1
-
Son J.K., et al. TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1. Cell Death Differ. 2010, 17:1288-1301.
-
(2010)
Cell Death Differ.
, vol.17
, pp. 1288-1301
-
-
Son, J.K.1
-
73
-
-
84871679702
-
TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer
-
Gonzalvez F., et al. TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer. Mol. Cell 2012, 48:888-899.
-
(2012)
Mol. Cell
, vol.48
, pp. 888-899
-
-
Gonzalvez, F.1
-
74
-
-
65549085701
-
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
-
Jin Z., et al. Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 2009, 137:721-735.
-
(2009)
Cell
, vol.137
, pp. 721-735
-
-
Jin, Z.1
-
75
-
-
84864318803
-
A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death
-
Dickens L.S., et al. A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death. Mol. Cell 2012, 47:291-305.
-
(2012)
Mol. Cell
, vol.47
, pp. 291-305
-
-
Dickens, L.S.1
-
76
-
-
84864294821
-
Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model
-
Schleich K., et al. Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model. Mol. Cell 2012, 47:306-319.
-
(2012)
Mol. Cell
, vol.47
, pp. 306-319
-
-
Schleich, K.1
-
77
-
-
68349154339
-
Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival
-
Hughes M.A., et al. Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival. Mol. Cell 2009, 35:265-279.
-
(2009)
Mol. Cell
, vol.35
, pp. 265-279
-
-
Hughes, M.A.1
-
78
-
-
84896070517
-
Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis
-
Kallenberger S.M., et al. Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis. Sci. Signal. 2014, 7:ra23.
-
(2014)
Sci. Signal.
, vol.7
, pp. ra23
-
-
Kallenberger, S.M.1
-
79
-
-
66249136447
-
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
-
Spencer S.L., et al. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 2009, 459:428-432.
-
(2009)
Nature
, vol.459
, pp. 428-432
-
-
Spencer, S.L.1
-
80
-
-
34447094000
-
TRAIL signalling: decisions between life and death
-
Falschlehner C., et al. TRAIL signalling: decisions between life and death. Int. J. Biochem. Cell Biol. 2007, 39:1462-1475.
-
(2007)
Int. J. Biochem. Cell Biol.
, vol.39
, pp. 1462-1475
-
-
Falschlehner, C.1
-
81
-
-
84860214990
-
Intra-tumour heterogeneity: a looking glass for cancer?
-
Marusyk A., et al. Intra-tumour heterogeneity: a looking glass for cancer?. Nat. Rev. Cancer 2012, 12:323-334.
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 323-334
-
-
Marusyk, A.1
-
82
-
-
70849090419
-
Determinism and divergence of apoptosis susceptibility in mammalian cells
-
Bhola P.D., Simon S.M. Determinism and divergence of apoptosis susceptibility in mammalian cells. J. Cell Sci. 2009, 122:4296-4302.
-
(2009)
J. Cell Sci.
, vol.122
, pp. 4296-4302
-
-
Bhola, P.D.1
Simon, S.M.2
-
83
-
-
62849098695
-
Dynamics of outer mitochondrial membrane permeabilization during apoptosis
-
Rehm M., et al. Dynamics of outer mitochondrial membrane permeabilization during apoptosis. Cell Death Differ. 2009, 16:613-623.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 613-623
-
-
Rehm, M.1
-
84
-
-
84878887369
-
Modulating cell-to-cell variability and sensitivity to death ligands by co-drugging
-
Flusberg D.A., Sorger P.K. Modulating cell-to-cell variability and sensitivity to death ligands by co-drugging. Phys. Biol. 2013, 10:035002.
-
(2013)
Phys. Biol.
, vol.10
, pp. 035002
-
-
Flusberg, D.A.1
Sorger, P.K.2
-
85
-
-
84908336319
-
Modeling dynamics of cell-to-cell variability in TRAIL-induced apoptosis explains fractional killing and predicts reversible resistance
-
Bertaux F., et al. Modeling dynamics of cell-to-cell variability in TRAIL-induced apoptosis explains fractional killing and predicts reversible resistance. PLoS Comput. Biol. 2014, 10:e1003893.
-
(2014)
PLoS Comput. Biol.
, vol.10
, pp. e1003893
-
-
Bertaux, F.1
-
86
-
-
58149154792
-
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced chemokine release in both TRAIL-resistant and TRAIL-sensitive cells via nuclear factor kappa B
-
Tang W., et al. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced chemokine release in both TRAIL-resistant and TRAIL-sensitive cells via nuclear factor kappa B. FEBS J. 2009, 276:581-593.
-
(2009)
FEBS J.
, vol.276
, pp. 581-593
-
-
Tang, W.1
-
87
-
-
12944333065
-
PI-3K/Akt and NF-kappaB/IkappaBalpha pathways are activated in Jurkat T cells in response to TRAIL treatment
-
Zauli G., et al. PI-3K/Akt and NF-kappaB/IkappaBalpha pathways are activated in Jurkat T cells in response to TRAIL treatment. J. Cell. Physiol. 2005, 202:900-911.
-
(2005)
J. Cell. Physiol.
, vol.202
, pp. 900-911
-
-
Zauli, G.1
-
88
-
-
57349097152
-
Dynamic proteomics of individual cancer cells in response to a drug
-
Cohen A.A., et al. Dynamic proteomics of individual cancer cells in response to a drug. Science 2008, 322:1511-1516.
-
(2008)
Science
, vol.322
, pp. 1511-1516
-
-
Cohen, A.A.1
-
89
-
-
84856989746
-
Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells
-
Muranen T., et al. Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell 2012, 21:227-239.
-
(2012)
Cancer Cell
, vol.21
, pp. 227-239
-
-
Muranen, T.1
-
90
-
-
84905726946
-
Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells
-
Lee H.J., et al. Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells. Cancer Cell 2014, 26:207-221.
-
(2014)
Cancer Cell
, vol.26
, pp. 207-221
-
-
Lee, H.J.1
-
91
-
-
85047688749
-
The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation
-
Raha D., et al. The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation. Cancer Res. 2014, 74:3579-3590.
-
(2014)
Cancer Res.
, vol.74
, pp. 3579-3590
-
-
Raha, D.1
-
92
-
-
77952502408
-
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
-
Roesch A., et al. A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell 2010, 141:583-594.
-
(2010)
Cell
, vol.141
, pp. 583-594
-
-
Roesch, A.1
-
93
-
-
49649112223
-
Stopping treatment can reverse acquired resistance to letrozole
-
Sabnis G.J., et al. Stopping treatment can reverse acquired resistance to letrozole. Cancer Res. 2008, 68:4518-4524.
-
(2008)
Cancer Res.
, vol.68
, pp. 4518-4524
-
-
Sabnis, G.J.1
-
94
-
-
77950809059
-
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
-
Sharma S.V., et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 2010, 141:69-80.
-
(2010)
Cell
, vol.141
, pp. 69-80
-
-
Sharma, S.V.1
-
95
-
-
84897531613
-
Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma
-
Sun C., et al. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma. Nature 2014, 508:118-122.
-
(2014)
Nature
, vol.508
, pp. 118-122
-
-
Sun, C.1
-
96
-
-
34249113550
-
Resistance of melanoma cells to TRAIL does not result from upregulation of antiapoptotic proteins by NF-kappaB but is related to downregulation of initiator caspases and DR4
-
Kurbanov B.M., et al. Resistance of melanoma cells to TRAIL does not result from upregulation of antiapoptotic proteins by NF-kappaB but is related to downregulation of initiator caspases and DR4. Oncogene 2007, 26:3364-3377.
-
(2007)
Oncogene
, vol.26
, pp. 3364-3377
-
-
Kurbanov, B.M.1
-
97
-
-
33846969909
-
Evidence for two modes of development of acquired tumor necrosis factor-related apoptosis-inducing ligand resistance. Involvement of Bcl-Xl
-
Song J.J., et al. Evidence for two modes of development of acquired tumor necrosis factor-related apoptosis-inducing ligand resistance. Involvement of Bcl-Xl. J. Biol. Chem. 2007, 282:319-328.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 319-328
-
-
Song, J.J.1
-
98
-
-
71349087492
-
C-Cbl acts as a mediator of Src-induced activation of the PI3K-Akt signal transduction pathway during TRAIL treatment
-
Song J.J., et al. c-Cbl acts as a mediator of Src-induced activation of the PI3K-Akt signal transduction pathway during TRAIL treatment. Cell Signal. 2009, 22:377-385.
-
(2009)
Cell Signal.
, vol.22
, pp. 377-385
-
-
Song, J.J.1
-
99
-
-
84891646475
-
Reversible adaptive plasticity: a mechanism for neuroblastoma cell heterogeneity and chemo-resistance
-
Chakrabarti L., et al. Reversible adaptive plasticity: a mechanism for neuroblastoma cell heterogeneity and chemo-resistance. Front. Oncol. 2012, 2:82.
-
(2012)
Front. Oncol.
, vol.2
, pp. 82
-
-
Chakrabarti, L.1
-
100
-
-
84886509950
-
Metrics other than potency reveal systematic variation in responses to cancer drugs
-
Fallahi-Sichani M., et al. Metrics other than potency reveal systematic variation in responses to cancer drugs. Nat. Chem. Biol. 2013, 9:708-714.
-
(2013)
Nat. Chem. Biol.
, vol.9
, pp. 708-714
-
-
Fallahi-Sichani, M.1
-
101
-
-
84864286442
-
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
-
Wilson T.R., et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 2012, 487:505-509.
-
(2012)
Nature
, vol.487
, pp. 505-509
-
-
Wilson, T.R.1
-
102
-
-
84901032309
-
Cell-to-cell variability in cell death: can systems biology help us make sense of it all?
-
Xia X., et al. Cell-to-cell variability in cell death: can systems biology help us make sense of it all?. Cell Death Dis. 2014, 5:e1261.
-
(2014)
Cell Death Dis.
, vol.5
, pp. e1261
-
-
Xia, X.1
-
103
-
-
18744361871
-
Enhancement of cellular memory by reducing stochastic transitions
-
Acar M., et al. Enhancement of cellular memory by reducing stochastic transitions. Nature 2005, 435:228-232.
-
(2005)
Nature
, vol.435
, pp. 228-232
-
-
Acar, M.1
-
104
-
-
84866096861
-
Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators
-
Bodenmiller B., et al. Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators. Nat. Biotechnol. 2012, 30:858-867.
-
(2012)
Nat. Biotechnol.
, vol.30
, pp. 858-867
-
-
Bodenmiller, B.1
-
105
-
-
84897399093
-
Noise genetics: inferring protein function by correlating phenotype with protein levels and localization in individual human cells
-
Farkash-Amar S., et al. Noise genetics: inferring protein function by correlating phenotype with protein levels and localization in individual human cells. PLoS Genet. 2014, 10:e1004176.
-
(2014)
PLoS Genet.
, vol.10
, pp. e1004176
-
-
Farkash-Amar, S.1
-
106
-
-
77951643590
-
Identifying single-cell molecular programs by stochastic profiling
-
Janes K.A., et al. Identifying single-cell molecular programs by stochastic profiling. Nat. Methods 2010, 7:311-317.
-
(2010)
Nat. Methods
, vol.7
, pp. 311-317
-
-
Janes, K.A.1
-
107
-
-
33845257870
-
Variability and memory of protein levels in human cells
-
Sigal A., et al. Variability and memory of protein levels in human cells. Nature 2006, 444:643-646.
-
(2006)
Nature
, vol.444
, pp. 643-646
-
-
Sigal, A.1
-
108
-
-
14944380128
-
Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance
-
Marriott H.M., et al. Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance. J. Clin. Invest. 2005, 115:359-368.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 359-368
-
-
Marriott, H.M.1
-
109
-
-
0348014686
-
DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells
-
Cuconati A., et al. DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. Genes Dev. 2003, 17:2922-2932.
-
(2003)
Genes Dev.
, vol.17
, pp. 2922-2932
-
-
Cuconati, A.1
-
110
-
-
33845975986
-
Is caspase-dependent apoptosis only cell differentiation taken to the extreme?
-
Fernando P., Megeney L.A. Is caspase-dependent apoptosis only cell differentiation taken to the extreme?. FASEB J. 2007, 21:8-17.
-
(2007)
FASEB J.
, vol.21
, pp. 8-17
-
-
Fernando, P.1
Megeney, L.A.2
-
111
-
-
41149144611
-
Preconditioning with death ligands FasL and TNF-alpha protects the cirrhotic mouse liver against ischaemic injury
-
Jang J.H., et al. Preconditioning with death ligands FasL and TNF-alpha protects the cirrhotic mouse liver against ischaemic injury. Gut 2008, 57:492-499.
-
(2008)
Gut
, vol.57
, pp. 492-499
-
-
Jang, J.H.1
-
112
-
-
84857538593
-
Disease tolerance as a defense strategy
-
Medzhitov R., et al. Disease tolerance as a defense strategy. Science 2012, 335:936-941.
-
(2012)
Science
, vol.335
, pp. 936-941
-
-
Medzhitov, R.1
-
113
-
-
3543047947
-
Effects of tumor necrosis factor-alpha (TNF alpha) in epidermal keratinocytes revealed using global transcriptional profiling
-
Banno T., et al. Effects of tumor necrosis factor-alpha (TNF alpha) in epidermal keratinocytes revealed using global transcriptional profiling. J. Biol. Chem. 2004, 279:32633-32642.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 32633-32642
-
-
Banno, T.1
-
114
-
-
79952767986
-
TRAIL-induced keratinocyte differentiation requires caspase activation and p63 expression
-
Wu N.L., et al. TRAIL-induced keratinocyte differentiation requires caspase activation and p63 expression. J. Invest. Dermatol. 2011, 131:874-883.
-
(2011)
J. Invest. Dermatol.
, vol.131
, pp. 874-883
-
-
Wu, N.L.1
-
115
-
-
77949847250
-
Apoptotic cells activate the 'phoenix rising' pathway to promote wound healing and tissue regeneration
-
Li F., et al. Apoptotic cells activate the 'phoenix rising' pathway to promote wound healing and tissue regeneration. Sci. Signal. 2010, 3:ra13.
-
(2010)
Sci. Signal.
, vol.3
, pp. ra13
-
-
Li, F.1
-
116
-
-
1542294200
-
Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression
-
Clarkson R.W., et al. Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression. Breast Cancer Res. 2004, 6:R92-R109.
-
(2004)
Breast Cancer Res.
, vol.6
, pp. R92-R109
-
-
Clarkson, R.W.1
-
117
-
-
79959870486
-
Apoptotic and non-apoptotic caspase functions in neural development
-
Miura M. Apoptotic and non-apoptotic caspase functions in neural development. Neurochem. Res. 2011, 36:1253-1260.
-
(2011)
Neurochem. Res.
, vol.36
, pp. 1253-1260
-
-
Miura, M.1
-
118
-
-
4644343922
-
Bacterial persistence as a phenotypic switch
-
Balaban N.Q., et al. Bacterial persistence as a phenotypic switch. Science 2004, 305:1622-1625.
-
(2004)
Science
, vol.305
, pp. 1622-1625
-
-
Balaban, N.Q.1
-
119
-
-
84873084388
-
Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer
-
Kreso A., et al. Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science 2013, 339:543-548.
-
(2013)
Science
, vol.339
, pp. 543-548
-
-
Kreso, A.1
-
120
-
-
77952257945
-
Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities
-
Singh D.K., et al. Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities. Mol. Syst. Biol. 2010, 6:369.
-
(2010)
Mol. Syst. Biol.
, vol.6
, pp. 369
-
-
Singh, D.K.1
-
121
-
-
84875884456
-
Cellular heterogeneity and molecular evolution in cancer
-
Almendro V., et al. Cellular heterogeneity and molecular evolution in cancer. Annu. Rev. Pathol. 2013, 8:277-302.
-
(2013)
Annu. Rev. Pathol.
, vol.8
, pp. 277-302
-
-
Almendro, V.1
-
122
-
-
84905831182
-
Evolution of acquired resistance to anti-cancer therapy
-
Foo J., Michor F. Evolution of acquired resistance to anti-cancer therapy. J. Theor. Biol. 2014, 355:10-20.
-
(2014)
J. Theor. Biol.
, vol.355
, pp. 10-20
-
-
Foo, J.1
Michor, F.2
-
123
-
-
84891850975
-
Targeting protein-protein interaction by small molecules
-
Jin L., et al. Targeting protein-protein interaction by small molecules. Annu. Rev. Pharmacol. Toxicol. 2014, 54:435-456.
-
(2014)
Annu. Rev. Pharmacol. Toxicol.
, vol.54
, pp. 435-456
-
-
Jin, L.1
-
124
-
-
84906249332
-
Targeting molecular networks for drug research
-
Pinto J.P., et al. Targeting molecular networks for drug research. Front. Genet. 2014, 5:160.
-
(2014)
Front. Genet.
, vol.5
, pp. 160
-
-
Pinto, J.P.1
-
125
-
-
45849085339
-
Cytochrome c: functions beyond respiration
-
Ow Y.P., et al. Cytochrome c: functions beyond respiration. Nat. Rev. 2008, 9:532-542.
-
(2008)
Nat. Rev.
, vol.9
, pp. 532-542
-
-
Ow, Y.P.1
-
126
-
-
33845497181
-
Inflammatory caspases and inflammasomes: master switches of inflammation
-
Martinon F., Tschopp J. Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ. 2007, 14:10-22.
-
(2007)
Cell Death Differ.
, vol.14
, pp. 10-22
-
-
Martinon, F.1
Tschopp, J.2
-
127
-
-
0037276438
-
Tumor necrosis factor signaling
-
Wajant H., et al. Tumor necrosis factor signaling. Cell Death Differ. 2003, 10:45-65.
-
(2003)
Cell Death Differ.
, vol.10
, pp. 45-65
-
-
Wajant, H.1
-
128
-
-
45149096045
-
Identification of a critical tyrosine residue in caspase 8 that promotes cell migration
-
Barbero S., et al. Identification of a critical tyrosine residue in caspase 8 that promotes cell migration. J. Biol. Chem. 2008, 283:13031-13034.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 13031-13034
-
-
Barbero, S.1
-
129
-
-
77955713683
-
Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation
-
Ehrenschwender M., et al. Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation. Cell Death Differ. 2010, 17:1435-1447.
-
(2010)
Cell Death Differ.
, vol.17
, pp. 1435-1447
-
-
Ehrenschwender, M.1
-
130
-
-
33646264300
-
Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions
-
Helfer B., et al. Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions. Cancer Res. 2006, 66:4273-4278.
-
(2006)
Cancer Res.
, vol.66
, pp. 4273-4278
-
-
Helfer, B.1
-
131
-
-
0033386808
-
Caspase activation is required for T cell proliferation
-
Kennedy N.J., et al. Caspase activation is required for T cell proliferation. J. Exp. Med. 1999, 190:1891-1896.
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1891-1896
-
-
Kennedy, N.J.1
-
132
-
-
63649143438
-
Dynamic expression of epidermal caspase 8 simulates a wound healing response
-
Lee P., et al. Dynamic expression of epidermal caspase 8 simulates a wound healing response. Nature 2009, 458:519-523.
-
(2009)
Nature
, vol.458
, pp. 519-523
-
-
Lee, P.1
-
133
-
-
77957360239
-
Apoptotic caspases regulate induction of iPSCs from human fibroblasts
-
Li F., et al. Apoptotic caspases regulate induction of iPSCs from human fibroblasts. Cell Stem Cell 2010, 7:508-520.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 508-520
-
-
Li, F.1
-
134
-
-
33745808650
-
Identification of proteins cleaved downstream of caspase activation in monocytes undergoing macrophage differentiation
-
Cathelin S., et al. Identification of proteins cleaved downstream of caspase activation in monocytes undergoing macrophage differentiation. J. Biol. Chem. 2006, 281:17779-17788.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 17779-17788
-
-
Cathelin, S.1
-
135
-
-
84900811351
-
Procaspase-3 regulates fibronectin secretion and influences adhesion, migration and survival independent of catalytic function
-
Brentnall M., et al. Procaspase-3 regulates fibronectin secretion and influences adhesion, migration and survival independent of catalytic function. J. Cell Sci. 2014, 127:2217-2226.
-
(2014)
J. Cell Sci.
, vol.127
, pp. 2217-2226
-
-
Brentnall, M.1
-
136
-
-
84894198332
-
Alpha6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation
-
Basu S., et al. alpha6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation. J. Biol. Chem. 2014, 289:3842-3855.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 3842-3855
-
-
Basu, S.1
-
137
-
-
63849169831
-
Various functions of caspases in hematopoiesis
-
Droin N., et al. Various functions of caspases in hematopoiesis. Front. Biosci. (Landmark Ed.) 2009, 14:2358-2371.
-
(2009)
Front. Biosci. (Landmark Ed.)
, vol.14
, pp. 2358-2371
-
-
Droin, N.1
-
138
-
-
0037143626
-
Caspase 3 activity is required for skeletal muscle differentiation
-
Fernando P., et al. Caspase 3 activity is required for skeletal muscle differentiation. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:11025-11030.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 11025-11030
-
-
Fernando, P.1
-
139
-
-
0031894491
-
A role for caspases in lens fiber differentiation
-
Ishizaki Y., et al. A role for caspases in lens fiber differentiation. J. Cell Biol. 1998, 140:153-158.
-
(1998)
J. Cell Biol.
, vol.140
, pp. 153-158
-
-
Ishizaki, Y.1
-
140
-
-
77749298000
-
Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks
-
Larsen B.D., et al. Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:4230-4235.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 4230-4235
-
-
Larsen, B.D.1
-
141
-
-
0037654554
-
Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila
-
Arama E., et al. Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila. Dev. Cell 2003, 4:687-697.
-
(2003)
Dev. Cell
, vol.4
, pp. 687-697
-
-
Arama, E.1
-
142
-
-
33746570157
-
Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs
-
Kuranaga E., et al. Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs. Cell 2006, 126:583-596.
-
(2006)
Cell
, vol.126
, pp. 583-596
-
-
Kuranaga, E.1
-
143
-
-
0032498138
-
Requirement for DCP-1 caspase during Drosophila oogenesis
-
McCall K., Steller H. Requirement for DCP-1 caspase during Drosophila oogenesis. Science 1998, 279:230-234.
-
(1998)
Science
, vol.279
, pp. 230-234
-
-
McCall, K.1
Steller, H.2
-
144
-
-
84862113237
-
Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology
-
Hyman B.T., Yuan J. Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology. Nat. Rev. Neurosci. 2012, 13:395-406.
-
(2012)
Nat. Rev. Neurosci.
, vol.13
, pp. 395-406
-
-
Hyman, B.T.1
Yuan, J.2
-
145
-
-
84860806410
-
Caspases in synaptic plasticity
-
Li Z., Sheng M. Caspases in synaptic plasticity. Mol. Brain 2012, 5:15.
-
(2012)
Mol. Brain
, vol.5
, pp. 15
-
-
Li, Z.1
Sheng, M.2
-
146
-
-
33749000311
-
Local caspase activity directs engulfment of dendrites during pruning
-
Williams D.W., et al. Local caspase activity directs engulfment of dendrites during pruning. Nat. Neurosci. 2006, 9:1234-1236.
-
(2006)
Nat. Neurosci.
, vol.9
, pp. 1234-1236
-
-
Williams, D.W.1
-
147
-
-
77958124651
-
Homeostatic functions of BCL-2 proteins beyond apoptosis
-
Danial N.N., et al. Homeostatic functions of BCL-2 proteins beyond apoptosis. Adv. Exp. Med. Biol. 2010, 687:1-32.
-
(2010)
Adv. Exp. Med. Biol.
, vol.687
, pp. 1-32
-
-
Danial, N.N.1
-
148
-
-
33749846225
-
Role of Bax and Bak in mitochondrial morphogenesis
-
Karbowski M., et al. Role of Bax and Bak in mitochondrial morphogenesis. Nature 2006, 443:658-662.
-
(2006)
Nature
, vol.443
, pp. 658-662
-
-
Karbowski, M.1
-
149
-
-
0348148880
-
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
-
Opferman J.T., et al. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 2003, 426:671-676.
-
(2003)
Nature
, vol.426
, pp. 671-676
-
-
Opferman, J.T.1
-
150
-
-
33847051539
-
RIP1, a kinase on the crossroads of a cell's decision to live or die
-
Festjens N., et al. RIP1, a kinase on the crossroads of a cell's decision to live or die. Cell Death Differ. 2007, 14:400-410.
-
(2007)
Cell Death Differ.
, vol.14
, pp. 400-410
-
-
Festjens, N.1
-
151
-
-
77954620472
-
FADD: a regulator of life and death
-
Tourneur L., Chiocchia G. FADD: a regulator of life and death. Trends Immunol. 2010, 31:260-269.
-
(2010)
Trends Immunol.
, vol.31
, pp. 260-269
-
-
Tourneur, L.1
Chiocchia, G.2
-
152
-
-
84876085177
-
Targeting c-FLIP in cancer
-
Shirley S., Micheau O. Targeting c-FLIP in cancer. Cancer Lett. 2010, 332:141-150.
-
(2010)
Cancer Lett.
, vol.332
, pp. 141-150
-
-
Shirley, S.1
Micheau, O.2
-
153
-
-
84861673635
-
Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions
-
Ozturk S., et al. Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions. Exp. Cell Res. 2012, 318:1324-1331.
-
(2012)
Exp. Cell Res.
, vol.318
, pp. 1324-1331
-
-
Ozturk, S.1
-
154
-
-
84894142926
-
The C-terminal domain of the long form of cellular FLICE-inhibitory protein (c-FLIPL) inhibits the interaction of the caspase 8 prodomain with the receptor-interacting protein 1 (RIP1) death domain and regulates caspase 8-dependent nuclear factor kappaB (NF-kappaB) activation
-
Matsuda I., et al. The C-terminal domain of the long form of cellular FLICE-inhibitory protein (c-FLIPL) inhibits the interaction of the caspase 8 prodomain with the receptor-interacting protein 1 (RIP1) death domain and regulates caspase 8-dependent nuclear factor kappaB (NF-kappaB) activation. J. Biol. Chem. 2014, 289:3876-3887.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 3876-3887
-
-
Matsuda, I.1
-
155
-
-
84861712290
-
Survival function of the FADD-CASPASE-8-cFLIP(L) complex
-
Dillon C.P., et al. Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Rep. 2012, 1:401-407.
-
(2012)
Cell Rep.
, vol.1
, pp. 401-407
-
-
Dillon, C.P.1
-
156
-
-
0032548842
-
Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal
-
Martin D.A., et al. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal. J. Biol. Chem. 1998, 273:4345-4349.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 4345-4349
-
-
Martin, D.A.1
-
157
-
-
0028883850
-
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
-
Kischkel F.C., et al. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 1995, 14:5579-5588.
-
(1995)
EMBO J.
, vol.14
, pp. 5579-5588
-
-
Kischkel, F.C.1
-
158
-
-
0037291871
-
A unified model for apical caspase activation
-
Boatright K.M., et al. A unified model for apical caspase activation. Mol. Cell 2003, 11:529-541.
-
(2003)
Mol. Cell
, vol.11
, pp. 529-541
-
-
Boatright, K.M.1
-
159
-
-
0037291890
-
Insights into the regulatory mechanism for caspase-8 activation
-
Donepudi M., et al. Insights into the regulatory mechanism for caspase-8 activation. Mol. Cell 2003, 11:543-549.
-
(2003)
Mol. Cell
, vol.11
, pp. 543-549
-
-
Donepudi, M.1
-
160
-
-
0042303323
-
The CD95 type I/type II model
-
Barnhart B.C., et al. The CD95 type I/type II model. Semin. Immunol. 2003, 15:185-193.
-
(2003)
Semin. Immunol.
, vol.15
, pp. 185-193
-
-
Barnhart, B.C.1
-
161
-
-
0030810926
-
X-linked IAP is a direct inhibitor of cell-death proteases
-
Deveraux Q.L., et al. X-linked IAP is a direct inhibitor of cell-death proteases. Nature 1997, 388:300-304.
-
(1997)
Nature
, vol.388
, pp. 300-304
-
-
Deveraux, Q.L.1
-
162
-
-
0035902601
-
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
-
Suzuki Y., et al. Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:8662-8667.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 8662-8667
-
-
Suzuki, Y.1
-
163
-
-
0036141029
-
TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO
-
Deng Y., et al. TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. Genes Dev. 2002, 16:33-45.
-
(2002)
Genes Dev.
, vol.16
, pp. 33-45
-
-
Deng, Y.1
-
164
-
-
0037178881
-
Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis
-
Li S., et al. Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis. J. Biol. Chem. 2002, 277:26912-26920.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 26912-26920
-
-
Li, S.1
-
165
-
-
0032555716
-
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
-
Luo X., et al. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998, 94:481-490.
-
(1998)
Cell
, vol.94
, pp. 481-490
-
-
Luo, X.1
-
166
-
-
0030976895
-
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro
-
Han Z., et al. A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro. J. Biol. Chem. 1997, 272:13432-13436.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 13432-13436
-
-
Han, Z.1
-
167
-
-
44349162752
-
Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
-
Chang H.H., et al. Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature 2008, 453:544-547.
-
(2008)
Nature
, vol.453
, pp. 544-547
-
-
Chang, H.H.1
-
168
-
-
50149090966
-
Variability and robustness in T cell activation from regulated heterogeneity in protein levels
-
Feinerman O., et al. Variability and robustness in T cell activation from regulated heterogeneity in protein levels. Science 2008, 321:1081-1084.
-
(2008)
Science
, vol.321
, pp. 1081-1084
-
-
Feinerman, O.1
-
169
-
-
84885614963
-
The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit
-
Spencer S.L., et al. The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell 2013, 155:369-383.
-
(2013)
Cell
, vol.155
, pp. 369-383
-
-
Spencer, S.L.1
-
170
-
-
84859641038
-
Using gene expression noise to understand gene regulation
-
Munsky B., et al. Using gene expression noise to understand gene regulation. Science 2012, 336:183-187.
-
(2012)
Science
, vol.336
, pp. 183-187
-
-
Munsky, B.1
-
171
-
-
78951470515
-
Origins of regulated cell-to-cell variability
-
Snijder B., Pelkmans L. Origins of regulated cell-to-cell variability. Nat. Rev. 2011, 12:119-125.
-
(2011)
Nat. Rev.
, vol.12
, pp. 119-125
-
-
Snijder, B.1
Pelkmans, L.2
-
172
-
-
79952635820
-
Measuring and modeling apoptosis in single cells
-
Spencer S.L., Sorger P.K. Measuring and modeling apoptosis in single cells. Cell 2011, 144:926-939.
-
(2011)
Cell
, vol.144
, pp. 926-939
-
-
Spencer, S.L.1
Sorger, P.K.2
-
173
-
-
15544388848
-
Noise propagation in gene networks
-
Pedraza J.M., van Oudenaarden A. Noise propagation in gene networks. Science 2005, 307:1965-1969.
-
(2005)
Science
, vol.307
, pp. 1965-1969
-
-
Pedraza, J.M.1
van Oudenaarden, A.2
-
174
-
-
33847208871
-
Timescales of genetic and epigenetic inheritance
-
Rando O.J., Verstrepen K.J. Timescales of genetic and epigenetic inheritance. Cell 2007, 128:655-668.
-
(2007)
Cell
, vol.128
, pp. 655-668
-
-
Rando, O.J.1
Verstrepen, K.J.2
-
175
-
-
52049091499
-
Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation
-
Hellwig C.T., et al. Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation. J. Biol. Chem. 2008, 283:21676-21685.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 21676-21685
-
-
Hellwig, C.T.1
-
176
-
-
84862270480
-
P53 dynamics control cell fate
-
Purvis J.E., et al. p53 dynamics control cell fate. Science 2012, 336:1440-1444.
-
(2012)
Science
, vol.336
, pp. 1440-1444
-
-
Purvis, J.E.1
-
177
-
-
7444254365
-
Oscillations in NF-kappaB signaling control the dynamics of gene expression
-
Nelson D.E., et al. Oscillations in NF-kappaB signaling control the dynamics of gene expression. Science 2004, 306:704-708.
-
(2004)
Science
, vol.306
, pp. 704-708
-
-
Nelson, D.E.1
-
178
-
-
64849104716
-
Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription
-
Ashall L., et al. Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription. Science 2009, 324:242-246.
-
(2009)
Science
, vol.324
, pp. 242-246
-
-
Ashall, L.1
-
179
-
-
77954920254
-
Population robustness arising from cellular heterogeneity
-
Paszek P., et al. Population robustness arising from cellular heterogeneity. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:11644-11649.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 11644-11649
-
-
Paszek, P.1
-
180
-
-
84896404575
-
Fold change of nuclear NF-kappaB determines TNF-induced transcription in single cells
-
Lee R.E., et al. Fold change of nuclear NF-kappaB determines TNF-induced transcription in single cells. Mol. Cell 2014, 53:867-879.
-
(2014)
Mol. Cell
, vol.53
, pp. 867-879
-
-
Lee, R.E.1
-
181
-
-
77954541844
-
Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing
-
Tay S., et al. Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature 2010, 466:267-271.
-
(2010)
Nature
, vol.466
, pp. 267-271
-
-
Tay, S.1
-
182
-
-
84872796463
-
Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals
-
Albeck J.G., et al. Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol. Cell 2013, 49:249-261.
-
(2013)
Mol. Cell
, vol.49
, pp. 249-261
-
-
Albeck, J.G.1
-
183
-
-
84856264773
-
A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision
-
Chen J.Y., et al. A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision. Mol. Cell 2012, 45:196-209.
-
(2012)
Mol. Cell
, vol.45
, pp. 196-209
-
-
Chen, J.Y.1
-
184
-
-
71449121678
-
Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor
-
Shankaran H., et al. Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor. Mol. Syst. Biol. 2009, 5:332.
-
(2009)
Mol. Syst. Biol.
, vol.5
, pp. 332
-
-
Shankaran, H.1
-
185
-
-
79651474934
-
Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations
-
Yuan T.L., et al. Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations. Curr. Biol. 2011, 21:173-183.
-
(2011)
Curr. Biol.
, vol.21
, pp. 173-183
-
-
Yuan, T.L.1
|