Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration

Science Signaling

Volumn 3, Issue 110, 2010, Pages

  Li, Fang ^a   Huang, Qian ^a,b   Chen, Jiang ^a   Peng, Yuanlin ^c   Roop, Dennis R ^a   Bedford, Joel S ^c   Li, Chuan Yuan ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; ARACHIDONIC ACID; PRIMER DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; LIVER REGENERATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SKIN INJURY; STEM CELL; TISSUE REGENERATION; WOUND HEALING; ANIMAL; C57BL MOUSE; CELL LINE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

MUS;

ANIMALS; APOPTOSIS; ARACHIDONIC ACID; CASPASE 3; CASPASE 7; CELL LINE; CELL PROLIFERATION; DINOPROSTONE; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; LIVER REGENERATION; MICE; MICE, INBRED C57BL; PHOSPHOLIPASES A2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS; WOUND HEALING;

EID: 77949847250     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000634     Document Type: Article

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54. Acknowledgments: We thank R. Flavell of Yale University for providing the MEFs with caspase 3 and 7 deficiencies. We also thank the anonymous reviewers for the excellent suggestions and criticisms. Funding: This study was supported in part by grants EB001882 from the U. S. National Institute of Bioimaging and Bioengineering, CA131408 and CA CA136748 from the U. S. National Cancer Institute, and grant NNX09AH19G from NASA Space Radiation Biology Research Program (all to C.-Y. L.). It was also supported by US NIH grants AR052263 and AR057212 to D. R. R. Q. H. was supported by grant 2010CB529900 from the National Basic Research Project of China and Outstanding Young Scientist grants 30325043 and 30428015 from China National Natural Science Foundation. Author contributions: F. L., Q. H., J. C., and Y. P. performed the experiments; F. L., C.-Y. L., D. R., and J. S. B. designed the experiments and analyzed the data; C.-Y. L. analyzed the data and wrote the paper. Competing interests: The University of Colorado has filed a provisional patent related to this work. The authors declare no personal financial interest in the published study.