-
1
-
-
0030892234
-
Apoptosis by death factor
-
Nagata, S. (1997) Apoptosis by death factor. Cell 88, 355-365
-
(1997)
Cell
, vol.88
, pp. 355-365
-
-
Nagata, S.1
-
2
-
-
0032575714
-
Death receptors: Signaling and modulation
-
Ashkenazi, A., and Dixit, V. M. (1998) Death receptors: signaling and modulation. Science 281, 1305-1308
-
(1998)
Science
, vol.281
, pp. 1305-1308
-
-
Ashkenazi, A.1
Dixit, V.M.2
-
3
-
-
0035936797
-
The TNF and TNF receptor superfamilies: Integrating mammalian biology
-
DOI 10.1016/S0092-8674(01)00237-9
-
Locksley, R. M., Killeen, N., and Lenardo, M. J. (2001) The TNF and TNF receptor superfamily: integrating mammalian biology. Cell 104, 487-501 (Pubitemid 32201945)
-
(2001)
Cell
, vol.104
, Issue.4
, pp. 487-501
-
-
Locksley, R.M.1
Killeen, N.2
Lenardo, M.J.3
-
4
-
-
0345015844
-
Death receptors
-
Wajant, H. (2003) Death receptors. Essays Biochem. 39, 53-71
-
(2003)
Essays Biochem.
, vol.39
, pp. 53-71
-
-
Wajant, H.1
-
5
-
-
0032550366
-
Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity
-
Schneider, P., Holler, N., Bodmer, J. L., Hahne, M., Frei, K., Fontana, A., and Tschopp, J. (1998) Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J. Exp. Med. 187, 1205-1213
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1205-1213
-
-
Schneider, P.1
Holler, N.2
Bodmer, J.L.3
Hahne, M.4
Frei, K.5
Fontana, A.6
Tschopp, J.7
-
6
-
-
0034850864
-
The membrane-bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity
-
Shudo, K., Kinoshita, K., Imamura, R., Fan, H., Hasumoto, K., Tanaka, M., Nagata, S., and Suda, T. (2001) The membrane-bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity. Eur. J. Immunol. 31, 2504-2511
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 2504-2511
-
-
Shudo, K.1
Kinoshita, K.2
Imamura, R.3
Fan, H.4
Hasumoto, K.5
Tanaka, M.6
Nagata, S.7
Suda, T.8
-
7
-
-
0035811587
-
Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative
-
DOI 10.1038/sj.onc.1204558
-
Wajant, H., Moosmayer, D., Wuest, T., Bartke, T., Gerlach, E., Schonherr, U., Peters, N., Scheurich, P., and Pfizenmaier, K. (2001) Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative. Oncogene 20, 4101-4106 (Pubitemid 32681615)
-
(2001)
Oncogene
, vol.20
, Issue.30
, pp. 4101-4106
-
-
Wajant, H.1
Moosmayer, D.2
Wuest, T.3
Bartke, T.4
Gerlach, E.5
Schonherr, U.6
Peters, N.7
Scheurich, P.8
Pfizenmaier, K.9
-
8
-
-
0031882913
-
The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor
-
Grell, M., Wajant, H., Zimmermann, G., and Scheurich, P. (1998) The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc. Natl. Acad. Sci. U. S. A. 95, 570-575
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 570-575
-
-
Grell, M.1
Wajant, H.2
Zimmermann, G.3
Scheurich, P.4
-
9
-
-
0028985261
-
Self-association of the "death domains" of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 prompts signaling for TNF and Fas/APO1 effects
-
Boldin, M. P., Mett, I. L., Varfolomeev, E. E., Chumakov, I., Shemer-Avni, Y., Camonis, J. H., and Wallach, D. (1995) Self-association of the "death domains" of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 prompts signaling for TNF and Fas/APO1 effects. J. Biol. Chem. 270, 387-391
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 387-391
-
-
Boldin, M.P.1
Mett, I.L.2
Varfolomeev, E.E.3
Chumakov, I.4
Shemer-Avni, Y.5
Camonis, J.H.6
Wallach, D.7
-
10
-
-
0033725002
-
Signaling by the TNF receptor superfamily and T cell homeostasis
-
Chan, K. F., Siegel, M. R., and Lenardo, J. M. (2000) Signaling by the TNF receptor superfamily and T cell homeostasis. Immunity 13, 419-422 (Pubitemid 30951865)
-
(2000)
Immunity
, vol.13
, Issue.4
, pp. 419-422
-
-
Chan, F.K.-M.1
Siegel, R.M.2
Lenardo, M.J.3
-
11
-
-
0034733682
-
A domain in TNF receptors that mediates ligand-independent receptor assembty and signaling
-
DOI 10.1126/science.288.5475.2351
-
Chan, F. K., Chun, H. J., Zheng, L., Siegel, R. M., Bui, K. L., and Lenardo, M. J. (2000) A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 288, 2351-2354 (Pubitemid 30448156)
-
(2000)
Science
, vol.288
, Issue.5475
, pp. 2351-2354
-
-
Chan, F.K.-M.1
Chun, H.J.2
Zheng, L.3
Siegel, R.M.4
Bui, K.L.5
Lenardo, M.J.6
-
12
-
-
29144496895
-
Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis
-
Clancy, L., Mruk, K., Archer, K., Woelfel, M., Mongkolsapaya, J., Screaton, G., Lenardo, M. J., and Chan, F. K. (2005) Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Proc. Natl. Acad. Sci. U. S. A. 102, 18099-18104
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 18099-18104
-
-
Clancy, L.1
Mruk, K.2
Archer, K.3
Woelfel, M.4
Mongkolsapaya, J.5
Screaton, G.6
Lenardo, M.J.7
Chan, F.K.8
-
13
-
-
0034733584
-
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations
-
DOI 10.1126/science.288.5475.2354
-
Siegel, R. M., Frederiksen, J. K., Zacharias, D. A., Chan, F. K., Johnson, M., Lynch, D., Tsien, R. Y., and Lenardo, M. J. (2000) Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science 288, 2354-2357 (Pubitemid 30448157)
-
(2000)
Science
, vol.288
, Issue.5475
, pp. 2354-2357
-
-
Siegel, R.M.1
Frederiksen, J.K.2
Zacharias, D.A.3
Chan, F.K.-M.4
Johnson, M.5
Lynch, D.6
Tsien, R.Y.7
Lenardo, M.J.8
-
14
-
-
0033613143
-
Caspase activation: The induced-proximity model
-
Salvesen, G. S., and Dixit, V. M. (1999) Caspase activation: the induced-proximity model. Proc. Natl. Acad. Sci. U. S. A. 96, 10964-10967
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 10964-10967
-
-
Salvesen, G.S.1
Dixit, V.M.2
-
15
-
-
2942746419
-
Caspase activation: Revisiting the induced proximity model
-
Shi, Y. (2004) Caspase activation: revisiting the induced proximity model. Cell 117, 855-858
-
(2004)
Cell
, vol.117
, pp. 855-858
-
-
Shi, Y.1
-
16
-
-
22744436580
-
Engineering a dimeric caspase-9: A re-evaluation of the induced proximity model for caspase activation
-
Online
-
Chao, Y., Shiozaki, E. N., Srinivasula, S. M., Rigotti, D. J., Fairman, R., and Shi, Y. (2005) Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation. [Online] PLoS Biol. 3, e183
-
(2005)
PLoS Biol.
, vol.3
-
-
Chao, Y.1
Shiozaki, E.N.2
Srinivasula, S.M.3
Rigotti, D.J.4
Fairman, R.5
Shi, Y.6
-
17
-
-
0031726359
-
Inhibition of Fas death signals by FLIPs
-
Tschopp, J., Irmler, M., and Thome, M. (1998) Inhibition of Fas death signals by FLIPs. Curr. Opin. Immunol. 10, 552-558
-
(1998)
Curr. Opin. Immunol.
, vol.10
, pp. 552-558
-
-
Tschopp, J.1
Irmler, M.2
Thome, M.3
-
18
-
-
17644378775
-
c-FLIPR, a new regulator of death receptor-induced apoptosis
-
Golks, A., Brenner, D., Fritsch, C., Krammer, P. H., and Lavrik, I. N. (2005) c-FLIPR, a new regulator of death receptor-induced apoptosis. J. Biol. Chem. 280, 14507-14513
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 14507-14513
-
-
Golks, A.1
Brenner, D.2
Fritsch, C.3
Krammer, P.H.4
Lavrik, I.N.5
-
19
-
-
0037099678
-
c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis
-
Chang, D. W., Xing, Z., Pan, Y., Algeciras-Schimnich, A., Barnhart, B. C., Yaish-Ohad, S., Peter, M. E., and Yang, X. (2002) c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. EMBO J. 21, 3704-3714
-
(2002)
EMBO J.
, vol.21
, pp. 3704-3714
-
-
Chang, D.W.1
Xing, Z.2
Pan, Y.3
Algeciras-Schimnich, A.4
Barnhart, B.C.5
Yaish-Ohad, S.6
Peter, M.E.7
Yang, X.8
-
20
-
-
7344220967
-
Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex
-
Rasper, D. M., Vaillancourt, J. P., Hadano, S., Houtzager, V. M., Seiden, I., Keen, S. L., Tawa, P., Xanthoudakis, S., Nasir, J., Martindale, D., Koop, B. F., Peterson, E. P., Thornberry, N. A., Huang, J., MacPherson, D. P., Black, S. C., Hornung, F., Lenardo, M. J., Hayden, M. R., Roy, S., and Nicholson, D. W. (1998) Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex. Cell Death Differ. 5, 271-288 (Pubitemid 28356540)
-
(1998)
Cell Death and Differentiation
, vol.5
, Issue.4
, pp. 271-288
-
-
Rasper, D.M.1
Vaillancourt, J.P.2
Hadano, S.3
Houtzager, V.M.4
Seiden, I.5
Keen, S.L.C.6
Tawa, P.7
Xanthoudakis, S.8
Nasir, J.9
Martindale, D.10
Koop, B.F.11
Peterson, E.P.12
Thornberry, N.A.13
Huang, J.14
MacPherson, D.P.15
Black, S.C.16
Hornung, F.17
Lenardo, M.J.18
Hayden, M.R.19
Roy, S.20
Nicholson, D.W.21
more..
-
21
-
-
0030800070
-
Inhibition of death receptor signals by cellular FLIP
-
DOI 10.1038/40657
-
Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J. L., Schroter, M., Burns, K., Mattmann, C., Rimoldi, D., French, L. E., and Tschopp, J. (1997) Inhibition of death receptor signals by cellular FLIP. Nature 388, 190-195 (Pubitemid 27297457)
-
(1997)
Nature
, vol.388
, Issue.6638
, pp. 190-195
-
-
Irmler, M.1
Thome, M.2
Hahne, M.3
Schneider, P.4
Hofmann, K.5
Steiner, V.6
Bodmer, J.-L.7
Schroter, M.8
Burns, K.9
Mattmann, C.10
Rimoldi, D.11
French, L.E.12
Tschopp, J.13
-
22
-
-
0035192884
-
FLICE-inhibitory proteins: Regulators of death receptor- Mediated apoptosis
-
Krueger, A., Baumann, S., Krammer, P. H., and Kirchhoff, S. (2001) FLICE-inhibitory proteins: regulators of death receptor- mediated apoptosis. Mol. Cell. Biol. 21, 8247-8254
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 8247-8254
-
-
Krueger, A.1
Baumann, S.2
Krammer, P.H.3
Kirchhoff, S.4
-
23
-
-
0034646478
-
Activation of NF-κB by FADD, Casper, and Caspase-8
-
Hu, W. H., Johnson, H., and Shu, H. B. (2000) Activation of NF-κB by FADD, Casper, and Caspase-8. J. Biol. Chem. 275, 10838-10844
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 10838-10844
-
-
Hu, W.H.1
Johnson, H.2
Shu, H.B.3
-
24
-
-
18744425429
-
The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways
-
Kataoka, T., Budd, R. C., Holler, N., Thome, M., Martinon, F., Irmler, M., Burns, K., Hahne, M., Kennedy, N., Kovacsovics, M., and Tschopp, J. (2000) The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways. Curr. Biol. 10, 640-648
-
(2000)
Curr. Biol.
, vol.10
, pp. 640-648
-
-
Kataoka, T.1
Budd, R.C.2
Holler, N.3
Thome, M.4
Martinon, F.5
Irmler, M.6
Burns, K.7
Hahne, M.8
Kennedy, N.9
Kovacsovics, M.10
Tschopp, J.11
-
25
-
-
0037160117
-
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex
-
Micheau, O., Thome, M., Schneider, P., Holler, N., Tschopp, J., Nicholson, D. W., Briand, C., and Grutter, M. G. (2002) The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J. Biol. Chem. 277, 45162-45171
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45162-45171
-
-
Micheau, O.1
Thome, M.2
Schneider, P.3
Holler, N.4
Tschopp, J.5
Nicholson, D.W.6
Briand, C.7
Grutter, M.G.8
-
26
-
-
21244449877
-
Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8
-
Dohrman, A., Russell, J. Q., Cuenin, S., Fortner, K., Tschopp, J., and Budd, R. C. (2005) Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8. J. Immunol. 175, 311-318 (Pubitemid 40884333)
-
(2005)
Journal of Immunology
, vol.175
, Issue.1
, pp. 311-318
-
-
Dohrman, A.1
Russell, J.Q.2
Cuenin, S.3
Fortner, K.4
Tschopp, J.5
Budd, R.C.6
-
27
-
-
0033662341
-
Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development
-
Yeh, W. C., Itie, A., Elia, A. J., Ng, M., Shu, H. B., Wakeham, A., Mirtsos, C., Suzuki, N., Bonnard, M., Goeddel, D. V., and Mak, T. W. (2000) Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development. Immunity 12, 633-642
-
(2000)
Immunity
, vol.12
, pp. 633-642
-
-
Yeh, W.C.1
Itie, A.2
Elia, A.J.3
Ng, M.4
Shu, H.B.5
Wakeham, A.6
Mirtsos, C.7
Suzuki, N.8
Bonnard, M.9
Goeddel, D.V.10
Mak, T.W.11
-
28
-
-
7144263731
-
FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis
-
DOI 10.1126/science.279.5358.1954
-
Yeh, W. C., Pompa, J. L., McCurrach, M. E., Shu, H. B., Elia, A. J., Shahinian, A., Ng, M., Wakeham, A., Khoo, W., Mitchell, K., El-Deiry, W. S., Lowe, S. W., Goeddel, D. V., and Mak, T. W. (1998) FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 279, 1954-1958 (Pubitemid 28168653)
-
(1998)
Science
, vol.279
, Issue.5358
, pp. 1954-1958
-
-
Yeh, W.-C.1
De La Pompa, J.L.2
McCurrach, M.E.3
Shu, H.-B.4
Elia, A.J.5
Shahinian, A.6
Ng, M.7
Wakeham, A.8
Khoo, W.9
Mitchell, K.10
El-Deiry, W.S.11
Lowe, S.W.12
Goeddel, D.V.13
Mak, T.W.14
-
29
-
-
0037276437
-
The CD95(APO-1/ Fas) DISC and beyond
-
Peter, M. E., and Krammer, P. H. (2003) The CD95(APO-1/ Fas) DISC and beyond. Cell Death Differ. 10, 26-35
-
(2003)
Cell Death Differ.
, vol.10
, pp. 26-35
-
-
Peter, M.E.1
Krammer, P.H.2
-
30
-
-
0032555697
-
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
-
Li, H., Zhu, H., Xu, C. J., and Yuan, J. (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94, 491-501 (Pubitemid 28391865)
-
(1998)
Cell
, vol.94
, Issue.4
, pp. 491-501
-
-
Li, H.1
Zhu, H.2
Xu, C.-J.3
Yuan, J.4
-
31
-
-
0032555716
-
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
-
Luo, X., Budihardjo, I., Zou, H., Slaughter, C., and Wang, X. (1998) Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94, 481-490 (Pubitemid 28391864)
-
(1998)
Cell
, vol.94
, Issue.4
, pp. 481-490
-
-
Luo, X.1
Budihardjo, I.2
Zou, H.3
Slaughter, C.4
Wang, X.5
-
32
-
-
21244502158
-
Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis
-
Milhas, D., Cuvillier, O., Therville, N., Clave, P., Thomsen, M., Levade, T., Benoist, H., and Segui, B. (2005) Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis. J. Biol. Chem. 280, 19836-19842
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19836-19842
-
-
Milhas, D.1
Cuvillier, O.2
Therville, N.3
Clave, P.4
Thomsen, M.5
Levade, T.6
Benoist, H.7
Segui, B.8
-
33
-
-
0034523818
-
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
-
DOI 10.1038/sj.cdd.4400783
-
Korsmeyer, S. J., Wei, M. C., Saito, M., Weiler, S., Oh, K. J., and Schlesinger, P. H. (2000) Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ. 7, 1166-1173 (Pubitemid 32042223)
-
(2000)
Cell Death and Differentiation
, vol.7
, Issue.12
, pp. 1166-1173
-
-
Korsmeyer, S.J.1
Wei, M.C.2
Saito, M.3
Weiler, S.4
Oh, K.J.5
Schlesinger, P.H.6
-
34
-
-
14744299357
-
The RIP kinases: Crucial integrators of cellular stress
-
Meylan, E., and Tschopp, J. (2005) The RIP kinases: crucial integrators of cellular stress. Trends Biochem. Sci. 30, 151-159
-
(2005)
Trends Biochem. Sci.
, vol.30
, pp. 151-159
-
-
Meylan, E.1
Tschopp, J.2
-
35
-
-
33646034316
-
Activation of IKK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
-
Ea, C. K., Deng, L., Xia, Z. P., Pineda, G., and Chen, Z. J. (2006) Activation of IKK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol. Cell. 22, 245-257
-
(2006)
Mol. Cell.
, vol.22
, pp. 245-257
-
-
Ea, C.K.1
Deng, L.2
Xia, Z.P.3
Pineda, G.4
Chen, Z.J.5
-
36
-
-
0042090891
-
The role of the death-domain kinase RIP in tumour-necrosis-factor-induced activation of mitogen-activated protein kinases
-
DOI 10.1038/sj.embor.embor854
-
Devin, A., Lin, Y., and Liu, Z. G. (2003) The role of the death-domain kinase RIP in tumour-necrosis-factor-induced activation of mitogen-activated protein kinases. EMBO Rep. 4, 623-627 (Pubitemid 36939955)
-
(2003)
EMBO Reports
, vol.4
, Issue.6
, pp. 623-627
-
-
Devin, A.1
Lin, Y.2
Liu, Z.-G.3
-
37
-
-
4043136609
-
The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IκB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2
-
Lee, T. H., Shank, J., Cusson, N., and Kelliher, M. A. (2004) The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IκB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2. J. Biol. Chem. 279, 33185-33191
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 33185-33191
-
-
Lee, T.H.1
Shank, J.2
Cusson, N.3
Kelliher, M.A.4
-
38
-
-
33847251527
-
Ubiquitination of RIP1 regulates an NF-κB-independent cell-death switch in TNF signaling
-
O'Donnell, M. A., Legarda-Addison, D., Skountzos, P., Yeh, W. C., and Ting, A. T. (2007) Ubiquitination of RIP1 regulates an NF-κB-independent cell-death switch in TNF signaling. Curr. Biol. 17, 418-424
-
(2007)
Curr. Biol.
, vol.17
, pp. 418-424
-
-
O'Donnell, M.A.1
Legarda-Addison, D.2
Skountzos, P.3
Yeh, W.C.4
Ting, A.T.5
-
39
-
-
0033214236
-
Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis
-
DOI 10.1101/gad.13.19.2514
-
Lin, Y., Devin, A., Rodriguez, Y., and Liu, Z. G. (1999) Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev. 13, 2514-2526 (Pubitemid 29489643)
-
(1999)
Genes and Development
, vol.13
, Issue.19
, pp. 2514-2526
-
-
Lin, Y.1
Devin, A.2
Rodriguez, Y.3
Liu, Z.-G.4
-
40
-
-
33847051539
-
RIP1, a kinase on the crossroads of a cell's decision to live or die
-
DOI 10.1038/sj.cdd.4402085, PII 4402085
-
Festjens, N., Vanden Berghe, T., Cornelis, S., and Vandenabeele, P. (2007) RIP1, a kinase on the crossroads of a cell's decision to live or die. Cell Death Differ. 14, 400-410 (Pubitemid 46259948)
-
(2007)
Cell Death and Differentiation
, vol.14
, Issue.3
, pp. 400-410
-
-
Festjens, N.1
Vanden Berghe, T.2
Cornelis, S.3
Vandenabeele, P.4
-
41
-
-
5944233768
-
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
-
Holler, N., Zaru, R., Micheau, O., Thome, M., Attinger, A., Valitutti, S., Bodmer, J. L., Schneider, P., Seed, B., and Tschopp, J. (2000) Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat. Immunol. 1, 489-495
-
(2000)
Nat. Immunol.
, vol.1
, pp. 489-495
-
-
Holler, N.1
Zaru, R.2
Micheau, O.3
Thome, M.4
Attinger, A.5
Valitutti, S.6
Bodmer, J.L.7
Schneider, P.8
Seed, B.9
Tschopp, J.10
-
42
-
-
0028963667
-
Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing
-
Cascino, I., Fiucci, G., Papoff, G., and Ruberti, G. (1995) Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing. J. Immunol. 154, 2706-2713
-
(1995)
J. Immunol.
, vol.154
, pp. 2706-2713
-
-
Cascino, I.1
Fiucci, G.2
Papoff, G.3
Ruberti, G.4
-
43
-
-
0028274042
-
Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule
-
Cheng, J., Zhou, T., Liu, C., Shapiro, J. P., Brauer, M. J., Kiefer, M. C., Barr, P. J., and Mountz, J. D. (1994) Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science 263, 1759-1762 (Pubitemid 24131584)
-
(1994)
Science
, vol.263
, Issue.5154
, pp. 1759-1762
-
-
Cheng, J.1
Zhou, T.2
Liu, C.3
Shapiro, J.P.4
Brauer, M.J.5
Kiefer, M.C.6
Barr, P.J.7
Mountz, J.D.8
-
44
-
-
33846192430
-
Palmitoylation is required for efficient Fas cell death signaling
-
DOI 10.1038/sj.emboj.7601456, PII 7601456
-
Chakrabandhu, K., Herincs, Z., Huault, S., Dost, B., Peng, L., Conchonaud, F., Marguet, D., He, H. T., and Hueber, A. O. (2007) Palmitoylation is required for efficient Fas cell death signaling. EMBO J. 26, 209-220 (Pubitemid 46094712)
-
(2007)
EMBO Journal
, vol.26
, Issue.1
, pp. 209-220
-
-
Chakrabandhu, K.1
Herincs, Z.2
Huault, S.3
Dost, B.4
Peng, L.5
Conchonaud, F.6
Marguet, D.7
He, H.-T.8
Hueber, A.-O.9
-
45
-
-
33846247103
-
Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling
-
DOI 10.1038/sj.emboj.7601460, PII 7601460
-
Feig, C., Tchikov, V., Schutze, S., and Peter, M. E. (2007) Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling. EMBO J. 26, 221-231 (Pubitemid 46094713)
-
(2007)
EMBO Journal
, vol.26
, Issue.1
, pp. 221-231
-
-
Feig, C.1
Tchikov, V.2
Schutze, S.3
Peter, M.E.4
-
46
-
-
16844381848
-
The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability
-
DOI 10.1083/jcb.200501048
-
Henkler, F., Behrle, E., Dennehy, K. M., Wicovsky, A., Peters, N., Warnke, C., Pfizenmaier, K., and Wajant, H. (2005) The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability. J. Cell Biol. 168, 1087-1098 (Pubitemid 40491178)
-
(2005)
Journal of Cell Biology
, vol.168
, Issue.7
, pp. 1087-1098
-
-
Henkler, F.1
Behrle, E.2
Dennehy, K.M.3
Wicovsky, A.4
Peters, N.5
Warnke, C.6
Pfizenmaier, K.7
Wajant, H.8
-
47
-
-
9444268061
-
SPOTS: Signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane
-
DOI 10.1083/jcb.200406101
-
Siegel, R. M., Muppidi, J. R., Sarker, M., Lobito, A., Jen, M., Martin, D., Straus, S. E., and Lenardo, M. J. (2004) SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane. J. Cell Biol. 167, 735-744 (Pubitemid 39565153)
-
(2004)
Journal of Cell Biology
, vol.167
, Issue.4
, pp. 735-744
-
-
Siegel, R.M.1
Muppidi, J.R.2
Sarker, M.3
Lobito, A.4
Jen, M.5
Martin, D.6
Straus, S.E.7
Lenardo, M.J.8
-
48
-
-
30744459357
-
Cutting edge: Modulation of Fas-mediated apoptosis by lipid rafts in T lymphocytes
-
Legembre, P., Daburon, S., Moreau, P., Moreau, J. F., and Taupin, J. L. (2006) Modulation of Fas-mediated apoptosis by lipid rafts in T lymphocytes. J. Immunol. 176, 716-720 (Pubitemid 43099665)
-
(2006)
Journal of Immunology
, vol.176
, Issue.2
, pp. 716-720
-
-
Legembre, P.1
Daburon, S.2
Moreau, P.3
Moreau, J.-F.4
Taupin, J.-L.5
-
49
-
-
0036133127
-
Molecular ordering of the initial signaling events of CD95
-
Algeciras-Schimnich, A., Shen, L., Barnhart, B. C., Murmann, A. E., Burkhardt, J. K., and Peter, M. E. (2002) Molecular ordering of the initial signaling events of CD95. Mol. Cell. Biol. 22, 207-220
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 207-220
-
-
Algeciras-Schimnich, A.1
Shen, L.2
Barnhart, B.C.3
Murmann, A.E.4
Burkhardt, J.K.5
Peter, M.E.6
-
50
-
-
3442895056
-
CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells
-
Eramo, A., Sargiacomo, M., Ricci-Vitiani, L., Todaro, M., Stassi, G., Messina, C. G., Parolini, I., Lotti, F., Sette, G., Peschle, C., and De Maria, R. (2004) CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells. Eur. J. Immunol. 34, 1930-1940
-
(2004)
Eur. J. Immunol.
, vol.34
, pp. 1930-1940
-
-
Eramo, A.1
Sargiacomo, M.2
Ricci-Vitiani, L.3
Todaro, M.4
Stassi, G.5
Messina, C.G.6
Parolini, I.7
Lotti, F.8
Sette, G.9
Peschle, C.10
De Maria, R.11
-
51
-
-
33644858084
-
The role of receptor internalization in CD95 signaling
-
DOI 10.1038/sj.emboj.7601016, PII 7601016
-
Lee, K. H., Feig, C., Tchikov, V., Schickel, R., Hallas, C., Schutze, S., Peter, M. E., and Chan, A. C. (2006) The role of receptor internalization in CD95 signaling. EMBO J. 25, 1009-1023 (Pubitemid 43372115)
-
(2006)
EMBO Journal
, vol.25
, Issue.5
, pp. 1009-1023
-
-
Lee, K.-H.1
Feig, C.2
Tchikov, V.3
Schickel, R.4
Hallas, C.5
Schutze, S.6
Peter, M.E.7
Chan, A.C.8
-
52
-
-
55549107524
-
CD95 stimulation results in the formation of a novel death effector domain protein-containing complex
-
Lavrik, I. N., Mock, T., Golks, A., Hoffmann, J. C., Baumann, S., and Krammer, P. H. (2008) CD95 stimulation results in the formation of a novel death effector domain protein-containing complex. J. Biol. Chem. 283, 26401-26408
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 26401-26408
-
-
Lavrik, I.N.1
Mock, T.2
Golks, A.3
Hoffmann, J.C.4
Baumann, S.5
Krammer, P.H.6
-
53
-
-
0032536771
-
Two CD95 (APO-1/Fas) signaling pathways
-
DOI 10.1093/emboj/17.6.1675
-
Scaffidi, C., Fulda, S., Srinivasan, A., Friesen, C., Li, F., Tomaselli, K. J., Debatin, K. M., Krammer, P. H., and Peter, M. E. (1998) Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 17, 1675-1687 (Pubitemid 28119121)
-
(1998)
EMBO Journal
, vol.17
, Issue.6
, pp. 1675-1687
-
-
Scaffidi, C.1
Fulda, S.2
Srinivasan, A.3
Friesen, C.4
Li, F.5
Tomaselli, K.J.6
Debatin, K.-M.7
Krammer, P.H.8
Peter, M.E.9
-
54
-
-
0042303323
-
The CD95 type I/type II model
-
Barnhart, B. C., Alappat, E. C., and Peter, M. E. (2003) The CD95 type I/type II model. Semin. Immunol. 15, 185-193
-
(2003)
Semin. Immunol.
, vol.15
, pp. 185-193
-
-
Barnhart, B.C.1
Alappat, E.C.2
Peter, M.E.3
-
55
-
-
0038198615
-
Actin dependent CD95 internalization is specific for Type I cells
-
DOI 10.1016/S0014-5793(03)00558-1
-
Algeciras-Schimnich, A., and Peter, M. E. (2003) Actin dependent CD95 internalization is specific for Type I cells. FEBS Lett. 546, 185-188 (Pubitemid 36782408)
-
(2003)
FEBS Letters
, vol.546
, Issue.2-3
, pp. 185-188
-
-
Algeciras-Schimnich, A.1
Peter, M.E.2
-
56
-
-
0036195136
-
An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes
-
DOI 10.1093/embo-reports/kvf022
-
Hueber, A. O., Bernard, A. M., Herincs, Z., Couzinet, A., and He, H. T. (2002) An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes. EMBO Rep. 3, 190-196 (Pubitemid 34213499)
-
(2002)
EMBO Reports
, vol.3
, Issue.2
, pp. 190-196
-
-
Hueber, A.-O.1
Bernard, A.-M.2
Herincs, Z.3
Couzinet, A.4
He, H.-T.5
-
57
-
-
0033529534
-
Differential modulation of apoptosis sensitivity in CD95 type I and type II cells
-
Scaffidi, C., Schmitz, I., Zha, J., Korsmeyer, S. J., Krammer, P. H., and Peter, M. E. (1999) Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J. Biol. Chem. 274, 22532-22538
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 22532-22538
-
-
Scaffidi, C.1
Schmitz, I.2
Zha, J.3
Korsmeyer, S.J.4
Krammer, P.H.5
Peter, M.E.6
-
58
-
-
4143108125
-
CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells
-
DOI 10.1038/sj.emboj.7600325
-
Barnhart, B. C., Legembre, P., Pietras, E., Bubici, C., Franzoso, G., and Peter, M. E. (2004) CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells. EMBO J. 23, 3175-3185 (Pubitemid 39093611)
-
(2004)
EMBO Journal
, vol.23
, Issue.15
, pp. 3175-3185
-
-
Barnhart, B.C.1
Legembre, P.2
Pietras, E.3
Bubici, C.4
Franzoso, G.5
Peter, M.E.6
-
59
-
-
0037299282
-
Nonapoptotic Fas signaling
-
Wajant, H., Pfizenmaier, K., and Scheurich, P. (2003) Nonapoptotic Fas signaling. Cytokine Growth Factor Rev. 14, 53-66
-
(2003)
Cytokine Growth Factor Rev.
, vol.14
, pp. 53-66
-
-
Wajant, H.1
Pfizenmaier, K.2
Scheurich, P.3
-
60
-
-
0037321075
-
Fas engagement induces neurite growth through ERK activation and p35 upregulation
-
Desbarats, J., Birge, R. B., Mimouni-Rongy, M., Weinstein, D. E., Palerme, J. S., and Newell, M. K. (2003) Fas engagement induces neurite growth through ERK activation and p35 upregulation. Nat. Cell Biol. 5, 118-125
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 118-125
-
-
Desbarats, J.1
Birge, R.B.2
Mimouni-Rongy, M.3
Weinstein, D.E.4
Palerme, J.S.5
Newell, M.K.6
-
61
-
-
42949177536
-
CD95 Ligand Is a Proliferative and Antiapoptotic Signal in Quiescent Hepatic Stellate Cells
-
DOI 10.1053/j.gastro.2008.02.021, PII S0016508508002540
-
Reinehr, R., Sommerfeld, A., and Haussinger, D. (2008) CD95 ligand is a proliferative and antiapoptotic signal in quiescent hepatic stellate cells. Gastroenterology 134, 1494-1506 (Pubitemid 351615364)
-
(2008)
Gastroenterology
, vol.134
, Issue.5
-
-
Reinehr, R.1
Sommerfeld, A.2
Haussinger, D.3
-
62
-
-
0033835065
-
Fas engagement accelerates liver regeneration after partial hepatectomy
-
Desbarats, J., and Newell, M. K. (2000) Fas engagement accelerates liver regeneration after partial hepatectomy. Nat. Med. 6, 920-923
-
(2000)
Nat. Med.
, vol.6
, pp. 920-923
-
-
Desbarats, J.1
Newell, M.K.2
-
63
-
-
0034731449
-
Rapid activation of protein kinase B/Akt has a key role in antiapoptotic signaling during liver regeneration
-
Hong, F., Nguyen, V. A., Shen, X., Kunos, G., and Gao, B. (2000) Rapid activation of protein kinase B/Akt has a key role in antiapoptotic signaling during liver regeneration. Biochem. Biophys. Res. Commun. 279, 974-979
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.279
, pp. 974-979
-
-
Hong, F.1
Nguyen, V.A.2
Shen, X.3
Kunos, G.4
Gao, B.5
-
64
-
-
48249122445
-
PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy
-
Jackson, L. N., Larson, S. D., Silva, S. R., Rychahou, P. G., Chen, L. A., Qiu, S., Rajaraman, S., and Evers, B. M. (2008) PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy. Am. J. Physiol. Gastrointest Liver Physiol. 294, G1401-G1410
-
(2008)
Am. J. Physiol. Gastrointest Liver Physiol.
, vol.294
-
-
Jackson, L.N.1
Larson, S.D.2
Silva, S.R.3
Rychahou, P.G.4
Chen, L.A.5
Qiu, S.6
Rajaraman, S.7
Evers, B.M.8
-
65
-
-
0030098001
-
Liver regeneration 4: Transcriptional control of liver regeneration
-
Taub, R. (1996) Liver regeneration 4: transcriptional control of liver regeneration. FASEB J. 10, 413-427
-
(1996)
FASEB J.
, vol.10
, pp. 413-427
-
-
Taub, R.1
-
66
-
-
0030996170
-
Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene
-
Tzung, S. P., Fausto, N., and Hockenbery, D. M. (1997) Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene. Am. J. Pathol. 150, 1985-1995
-
(1997)
Am. J. Pathol.
, vol.150
, pp. 1985-1995
-
-
Tzung, S.P.1
Fausto, N.2
Hockenbery, D.M.3
-
67
-
-
0033386808
-
Caspase activation is required for T cell proliferation
-
Kennedy, N. J., Kataoka, T., Tschopp, J., and Budd, R. C. (1999) Caspase activation is required for T cell proliferation. J. Exp. Med. 190, 1891-1896
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1891-1896
-
-
Kennedy, N.J.1
Kataoka, T.2
Tschopp, J.3
Budd, R.C.4
-
68
-
-
0032472916
-
A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
-
DOI 10.1093/emboj/17.3.706
-
Newton, K., Harris, A. W., Bath, M. L., Smith, K. G., and Strasser, A. (1998) A dominant interfering mutant of FADD/ MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J. 17, 706-718 (Pubitemid 28062050)
-
(1998)
EMBO Journal
, vol.17
, Issue.3
, pp. 706-718
-
-
Newton, K.1
Harris, A.W.2
Bath, M.L.3
Smith, K.G.C.4
Strasser, A.5
-
69
-
-
0033850799
-
Defining CD95 as a tumor suppressor gene
-
Muschen, M., Warskulat, U., and Beckmann, M. W. (2000) Defining CD95 as a tumor suppressor gene. J. Mol. Med. 78, 312-325
-
(2000)
J. Mol. Med.
, vol.78
, pp. 312-325
-
-
Muschen, M.1
Warskulat, U.2
Beckmann, M.W.3
-
70
-
-
0035412359
-
The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis
-
Straus, S. E., Jaffe, E. S., Puck, J. M., Dale, J. K., Elkon, K. B., Rosen-Wolff, A., Peters, A. M., Sneller, M. C., Hallahan, C. W., Wang, J., Fischer, R. E., Jackson, C. M., Lin, A. Y., Baumler, C., Siegert, E., Marx, A., Vaishnaw, A. K., Grodzicky, T., Fleisher, T. A., and Lenardo, M. J. (2001) The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis. Blood 98, 194-200
-
(2001)
Blood
, vol.98
, pp. 194-200
-
-
Straus, S.E.1
Jaffe, E.S.2
Puck, J.M.3
Dale, J.K.4
Elkon, K.B.5
Rosen-Wolff, A.6
Peters, A.M.7
Sneller, M.C.8
Hallahan, C.W.9
Wang, J.10
Fischer, R.E.11
Jackson, C.M.12
Lin, A.Y.13
Baumler, C.14
Siegert, E.15
Marx, A.16
Vaishnaw, A.K.17
Grodzicky, T.18
Fleisher, T.A.19
Lenardo, M.J.20
more..
-
71
-
-
13944263937
-
The relevance of NF-κB for CD95 signaling in tumor cells
-
Legembre, P., Barnhart, B. C., and Peter, M. E. (2004) The relevance of NF-κB for CD95 signaling in tumor cells. Cell Cycle 3, 1235-1239 (Pubitemid 40268600)
-
(2004)
Cell Cycle
, vol.3
, Issue.10
, pp. 1235-1239
-
-
Legembre, P.1
Barnhart, B.C.2
Peter, M.E.3
-
72
-
-
40149099894
-
Yes and PI3K Bind CD95 to Signal Invasion of Glioblastoma
-
DOI 10.1016/j.ccr.2008.02.003, PII S1535610808000433
-
Kleber, S., Sancho-Martinez, I., Wiestler, B., Beisel, A., Gieffers, C., Hill, O., Thiemann, M., Mueller, W., Sykora, J., Kuhn, A., Schreglmann, N., Letellier, E., Zuliani, C., Klussmann, S., Teodorczyk, M., Grone, H. J., Ganten, T. M., Sultmann, H., Tuttenberg, J., von Deimling, A., Regnier-Vigouroux, A., Herold-Mende, C., and Martin-Villalba, A. (2008) Yes and PI3K bind CD95 to signal invasion of glioblastoma. Cancer Cell 13, 235-248 (Pubitemid 351324880)
-
(2008)
Cancer Cell
, vol.13
, Issue.3
, pp. 235-248
-
-
Kleber, S.1
Sancho-Martinez, I.2
Wiestler, B.3
Beisel, A.4
Gieffers, C.5
Hill, O.6
Thiemann, M.7
Mueller, W.8
Sykora, J.9
Kuhn, A.10
Schreglmann, N.11
Letellier, E.12
Zuliani, C.13
Klussmann, S.14
Teodorczyk, M.15
Grone, H.-J.16
Ganten, T.M.17
Sultmann, H.18
Tuttenberg, J.19
Von Deimling, A.20
Regnier-Vigouroux, A.21
Herold-Mende, C.22
Martin-Villalba, A.23
more..
-
73
-
-
19344372267
-
Does CD95 have tumor promoting activities? Biochim
-
Peter, M. E., Legembre, P., and Barnhart, B. C. (2005) Does CD95 have tumor promoting activities? Biochim. Biophys. Acta 1755, 25-36
-
(2005)
Biophys. Acta
, vol.1755
, pp. 25-36
-
-
Peter, M.E.1
Legembre, P.2
Barnhart, B.C.3
-
74
-
-
10044232636
-
Induction of apoptosis and activation of NF-κB by CD95 require different signalling thresholds
-
DOI 10.1038/sj.embor.7400280
-
Legembre, P., Barnhart, B. C., Zheng, L., Vijayan, S., Straus, S. E., Puck, J., Dale, J. K., Lenardo, M., and Peter, M. E. (2004) Induction of apoptosis and activation of NF-κB by CD95 require different signalling thresholds. EMBO Rep. 5, 1084-1089 (Pubitemid 39600208)
-
(2004)
EMBO Reports
, vol.5
, Issue.11
, pp. 1084-1089
-
-
Legembre, P.1
Barnhart, B.C.2
Zheng, L.3
Vijayan, S.4
Straus, S.E.5
Puck, J.6
Dale, J.K.7
Lenardo, M.8
Peter, M.E.9
-
75
-
-
56349087320
-
The extracellular glycosphingolipid-binding motif of Fas defines its internalization route, mode and outcome of signals upon activation by ligand
-
Chakrabandhu, K., Huault, S., Garmy, N., Fantini, J., Stebe, E., Mailfert, S., Marguet, D., and Hueber, A. O. (2008) The extracellular glycosphingolipid-binding motif of Fas defines its internalization route, mode and outcome of signals upon activation by ligand. Cell Death Differ. 15, 1824-1837
-
(2008)
Cell Death Differ.
, vol.15
, pp. 1824-1837
-
-
Chakrabandhu, K.1
Huault, S.2
Garmy, N.3
Fantini, J.4
Stebe, E.5
Mailfert, S.6
Marguet, D.7
Hueber, A.O.8
-
76
-
-
0030762815
-
An antagonist decoy receptor and a death domain-containing receptor for TRAIL
-
DOI 10.1126/science.277.5327.815
-
Pan, G., Ni, J., Wei, Y. F., Yu, G., Gentz, R., and Dixit, V. M. (1997) An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277, 815-818 (Pubitemid 27366732)
-
(1997)
Science
, vol.277
, Issue.5327
, pp. 815-818
-
-
Pan, G.1
Ni, J.2
Wei, Y.-F.3
Yu, G.-I.4
Gentz, R.5
Dixit, V.M.6
-
77
-
-
0030996297
-
The receptor for the cytotoxic ligand TRAIL
-
Pan, G., O'Rourke, K., Chinnaiyan, A. M., Gentz, R., Ebner, R., Ni, J., and Dixit, V. M. (1997) The receptor for the cytotoxic ligand TRAIL. Science 276, 111-113
-
(1997)
Science
, vol.276
, pp. 111-113
-
-
Pan, G.1
O'Rourke, K.2
Chinnaiyan, A.M.3
Gentz, R.4
Ebner, R.5
Ni, J.6
Dixit, V.M.7
-
78
-
-
0031472042
-
Cell death: TRAIL and its receptors
-
Golstein, P. (1997) Cell death: TRAIL and its receptors. Curr. Biol. 7, R750-R753
-
(1997)
Curr. Biol.
, vol.7
-
-
Golstein, P.1
-
79
-
-
38149122326
-
TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development
-
Grosse-Wilde, A., Voloshanenko, O., Bailey, S. L., Longton, G. M., Schaefer, U., Csernok, A. I., Schutz, G., Greiner, E. F., Kemp, C. J., and Walczak, H. (2008) TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development. J. Clin. Invest. 118, 100-110
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 100-110
-
-
Grosse-Wilde, A.1
Voloshanenko, O.2
Bailey, S.L.3
Longton, G.M.4
Schaefer, U.5
Csernok, A.I.6
Schutz, G.7
Greiner, E.F.8
Kemp, C.J.9
Walczak, H.10
-
80
-
-
51049122396
-
Metastasis suppressor function of tumor necrosis factor-related apoptosis-inducing ligand-R in mice: Implications for TRAIL-based therapy in humans?
-
Grosse-Wilde, A., and Kemp, C. J. (2008) Metastasis suppressor function of tumor necrosis factor-related apoptosis-inducing ligand-R in mice: implications for TRAIL-based therapy in humans? Cancer Res. 68, 6035-6037
-
(2008)
Cancer Res.
, vol.68
, pp. 6035-6037
-
-
Grosse-Wilde, A.1
Kemp, C.J.2
-
81
-
-
38149139518
-
TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis
-
Finnberg, N., Klein-Szanto, A. J., and El-Deiry, W. S. (2008) TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis. J. Clin. Invest. 118, 111-123
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 111-123
-
-
Finnberg, N.1
Klein-Szanto, A.J.2
El-Deiry, W.S.3
-
82
-
-
34347253556
-
TRAIL: A multifunctional cytokine
-
Schaefer, U., Voloshanenko, O., Willen, D., and Walczak, H. (2007) TRAIL: a multifunctional cytokine. Front. Biosci. 12, 3813-3824
-
(2007)
Front. Biosci.
, vol.12
, pp. 3813-3824
-
-
Schaefer, U.1
Voloshanenko, O.2
Willen, D.3
Walczak, H.4
-
83
-
-
0030869432
-
Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family
-
Degli-Esposti, M. A., Smolak, P. J., Walczak, H., Waugh, J., Huang, C. P., DuBose, R. F., Goodwin, R. G., and Smith, C. A. (1997) Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. J. Exp. Med. 186, 1165-1170
-
(1997)
J. Exp. Med.
, vol.186
, pp. 1165-1170
-
-
Degli-Esposti, M.A.1
Smolak, P.J.2
Walczak, H.3
Waugh, J.4
Huang, C.P.5
DuBose, R.F.6
Goodwin, R.G.7
Smith, C.A.8
-
84
-
-
0031414749
-
The novel receptor TRAIL-R4 induces NF-κB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain
-
Degli-Esposti, M. A., Dougall, W. C., Smolak, P. J., Waugh, J. Y., Smith, C. A., and Goodwin, R. G. (1997) The novel receptor TRAIL-R4 induces NF-κB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity 7, 813-820
-
(1997)
Immunity
, vol.7
, pp. 813-820
-
-
Degli-Esposti, M.A.1
Dougall, W.C.2
Smolak, P.J.3
Waugh, J.Y.4
Smith, C.A.5
Goodwin, R.G.6
-
85
-
-
20344396647
-
TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL
-
Riccioni, R., Pasquini, L., Mariani, G., Saulle, E., Rossini, A., Diverio, D., Pelosi, E., Vitale, A., Chierichini, A., Cedrone, M., Foa, R., Lo Coco, F., Peschle, C., and Testa, U. (2005) TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL. Haematologica 90, 612-624 (Pubitemid 40780880)
-
(2005)
Haematologica
, vol.90
, Issue.5
, pp. 612-624
-
-
Riccioni, R.1
Pasquini, L.2
Mariani, G.3
Saulle, E.4
Rossini, A.5
Diverio, D.6
Pelosi, E.7
Vitale, A.8
Chierichini, A.9
Cedrone, M.10
Foa, R.11
Lo Coco, F.12
Peschle, C.13
Testa, U.14
-
86
-
-
33749164762
-
Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2
-
Merino, D., Lalaoui, N., Morizot, A., Schneider, P., Solary, E., and Micheau, O. (2006) Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol. Cell. Biol. 26, 7046-7055
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 7046-7055
-
-
Merino, D.1
Lalaoui, N.2
Morizot, A.3
Schneider, P.4
Solary, E.5
Micheau, O.6
-
87
-
-
0034725664
-
Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor
-
Truneh, A., Sharma, S., Silverman, C., Khandekar, S., Reddy, M. P., Deen, K. C., McLaughlin, M. M., Srinivasula, S. M., Livi, G. P., Marshall, L. A., Alnemri, E. S., Williams, W. V., and Doyle, M. L. (2000) Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor. J. Biol. Chem. 275, 23319-23325
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 23319-23325
-
-
Truneh, A.1
Sharma, S.2
Silverman, C.3
Khandekar, S.4
Reddy, M.P.5
Deen, K.C.6
McLaughlin, M.M.7
Srinivasula, S.M.8
Livi, G.P.9
Marshall, L.A.10
Alnemri, E.S.11
Williams, W.V.12
Doyle, M.L.13
-
88
-
-
0031905817
-
Differential regulation of TRAIL and CD95 ligand in transformed cells of the T and B lymphocyte lineage
-
Mariani, S. M., and Krammer, P. H. (1998) Differential regulation of TRAIL and CD95 ligand in transformed cells of the T and B lymphocyte lineage. Eur. J. Immunol. 28, 973-982
-
(1998)
Eur. J. Immunol.
, vol.28
, pp. 973-982
-
-
Mariani, S.M.1
Krammer, P.H.2
-
89
-
-
0034617304
-
Cysteine 230 is essential for the structure and activity of the cytotoxic ligand TRAIL
-
Bodmer, J. L., Meier, P., Tschopp, J., and Schneider, P. (2000) Cysteine 230 is essential for the structure and activity of the cytotoxic ligand TRAIL. J. Biol. Chem. 275, 20632-20637
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 20632-20637
-
-
Bodmer, J.L.1
Meier, P.2
Tschopp, J.3
Schneider, P.4
-
90
-
-
0034283184
-
Functional analysis of tumour necrosis factor-α-related apoptosis-inducing ligand (TRAIL): Cysteine-230 plays a critical role in the homotrimerization and biological activity of this novel tumoricidal cytokine
-
DOI 10.1042/0264-6021:3500505
-
Trabzuni, D., Famulski, K. S., and Ahmad, M. (2000) Functional analysis of tumour necrosis factor-alpha-related apoptosis- inducing ligand (TRAIL): cysteine-230 plays a critical role in the homotrimerization and biological activity of this novel tumoricidal cytokine. Biochem. J. 350, 505-510 (Pubitemid 30708418)
-
(2000)
Biochemical Journal
, vol.350
, Issue.2
, pp. 505-510
-
-
Trabzuni, D.1
Famulski, K.S.2
Ahmad, M.3
-
91
-
-
0347364696
-
NK Cell TRAIL Eliminates Immature Dendritic Cells in Vivo and Limits Dendritic Cell Vaccination Efficacy
-
Hayakawa, Y., Screpanti, V., Yagita, H., Grandien, A., Ljunggren, H. G., Smyth, M. J., and Chambers, B. J. (2004) NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy. J. Immunol. 172, 123-129 (Pubitemid 38020463)
-
(2004)
Journal of Immunology
, vol.172
, Issue.1
, pp. 123-129
-
-
Hayakawa, Y.1
Screpanti, V.2
Yagita, H.3
Grandien, A.4
Ljunggren, H.-G.5
Smyth, M.J.6
Chambers, B.J.7
-
92
-
-
14544288632
-
CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death
-
Janssen, E. M., Droin, N. M., Lemmens, E. E., Pinkoski, M. J., Bensinger, S. J., Ehst, B. D., Griffith, T. S., Green, D. R., and Schoenberger, S. P. (2005) CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature 434, 88-93
-
(2005)
Nature
, vol.434
, pp. 88-93
-
-
Janssen, E.M.1
Droin, N.M.2
Lemmens, E.E.3
Pinkoski, M.J.4
Bensinger, S.J.5
Ehst, B.D.6
Griffith, T.S.7
Green, D.R.8
Schoenberger, S.P.9
-
93
-
-
0037240850
-
Nature's TRAIL - On a path to cancer immunotherapy
-
DOI 10.1016/S1074-7613(02)00502-2
-
Smyth, M. J., Takeda, K., Hayakawa, Y., Peschon, J. J., van den Brink, M. R., and Yagita, H. (2003) Nature's TRAIL - on a path to cancer immunotherapy. Immunity 18, 1-6 (Pubitemid 36120682)
-
(2003)
Immunity
, vol.18
, Issue.1
, pp. 1-6
-
-
Smyth, M.J.1
Takeda, K.2
Hayakawa, Y.3
Peschon, J.J.4
Van Den Brink, M.R.M.5
Yagita, H.6
-
94
-
-
13344285339
-
Identification and characterization of a new member of the TNF family that induces apoptosis
-
DOI 10.1016/1074-7613(95)90057-8
-
Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C. P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., and Goodwin, R. G. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3, 673-682 (Pubitemid 26091143)
-
(1995)
Immunity
, vol.3
, Issue.6
, pp. 673-682
-
-
Wiley, S.R.1
Schooley, K.2
Smolak, P.J.3
Din, W.S.4
Huang, C.-P.5
Nicholl, J.K.6
Sutherland, G.R.7
Smith, T.D.8
Rauch, C.9
Smith, C.A.10
Goodwin, R.G.11
-
95
-
-
17544367410
-
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
-
Pitti, R. M., Marsters, S. A., Ruppert, S., Donahue, C. J., Moore, A., and Ashkenazi, A. (1996) Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271, 12687-12690
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 12687-12690
-
-
Pitti, R.M.1
Marsters, S.A.2
Ruppert, S.3
Donahue, C.J.4
Moore, A.5
Ashkenazi, A.6
-
96
-
-
0032713075
-
Safety and antitumor activity of recombinant soluble Apo2 ligand
-
Ashkenazi, A., Pai, R. C., Fong, S., Leung, S., Lawrence, D. A., Marsters, S. A., Blackie, C., Chang, L., McMurtrey, A. E., Hebert, A., DeForge, L., Koumenis, I. L., Lewis, D., Harris, L., Bussiere, J., Koeppen, H., Shahrokh, Z., and Schwall, R. H. (1999) Safety and antitumor activity of recombinant soluble Apo2 ligand. J. Clin. Invest. 104, 155-162
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 155-162
-
-
Ashkenazi, A.1
Pai, R.C.2
Fong, S.3
Leung, S.4
Lawrence, D.A.5
Marsters, S.A.6
Blackie, C.7
Chang, L.8
McMurtrey, A.E.9
Hebert, A.10
DeForge, L.11
Koumenis, I.L.12
Lewis, D.13
Harris, L.14
Bussiere, J.15
Koeppen, H.16
Shahrokh, Z.17
Schwall, R.H.18
-
97
-
-
0035050960
-
Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions
-
Lawrence, D., Shahrokh, Z., Marsters, S., Achilles, K., Shih, D., Mounho, B., Hillan, K., Totpal, K., DeForge, L., Schow, P., Hooley, J., Sherwood, S., Pai, R., Leung, S., Khan, L., Gliniak, B., Bussiere, J., Smith, C. A., Strom, S. S., Kelley, S., Fox, J. A., Thomas, D., and Ashkenazi, A. (2001) Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions. Nat. Med. 7, 383-385
-
(2001)
Nat. Med.
, vol.7
, pp. 383-385
-
-
Lawrence, D.1
Shahrokh, Z.2
Marsters, S.3
Achilles, K.4
Shih, D.5
Mounho, B.6
Hillan, K.7
Totpal, K.8
DeForge, L.9
Schow, P.10
Hooley, J.11
Sherwood, S.12
Pai, R.13
Leung, S.14
Khan, L.15
Gliniak, B.16
Bussiere, J.17
Smith, C.A.18
Strom, S.S.19
Kelley, S.20
Fox, J.A.21
Thomas, D.22
Ashkenazi, A.23
more..
-
98
-
-
0032929520
-
Tumoricidal activity of tumor necrosis factor-related apoptosis- Inducing ligand in vivo
-
Walczak, H., Miller, R. E., Ariail, K., Gliniak, B., Griffith, T. S., Kubin, M., Chin, W., Jones, J., Woodward, A., Le, T., Smith, C., Smolak, P., Goodwin, R. G., Rauch, C. T., Schuh, J. C., and Lynch, D. H. (1999) Tumoricidal activity of tumor necrosis factor-related apoptosis- inducing ligand in vivo. Nat. Med. 5, 157-163
-
(1999)
Nat. Med.
, vol.5
, pp. 157-163
-
-
Walczak, H.1
Miller, R.E.2
Ariail, K.3
Gliniak, B.4
Griffith, T.S.5
Kubin, M.6
Chin, W.7
Jones, J.8
Woodward, A.9
Le, T.10
Smith, C.11
Smolak, P.12
Goodwin, R.G.13
Rauch, C.T.14
Schuh, J.C.15
Lynch, D.H.16
-
100
-
-
33646393778
-
Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs
-
Ganten, T. M., Koschny, R., Sykora, J., Schulze-Bergkamen, H., Buchler, P., Haas, T. L., Schader, M. B., Untergasser, A., Stremmel, W., and Walczak, H. (2006) Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs. Clin. Cancer Res. 12, 2640-2646
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 2640-2646
-
-
Ganten, T.M.1
Koschny, R.2
Sykora, J.3
Schulze-Bergkamen, H.4
Buchler, P.5
Haas, T.L.6
Schader, M.B.7
Untergasser, A.8
Stremmel, W.9
Walczak, H.10
-
101
-
-
45749098451
-
To kill a tumor cell: The potential of proapoptotic receptor agonists
-
Ashkenazi, A., and Herbst, R. S. (2008) To kill a tumor cell: the potential of proapoptotic receptor agonists. J. Clin. Invest. 118, 1979-1990
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 1979-1990
-
-
Ashkenazi, A.1
Herbst, R.S.2
-
102
-
-
12544255082
-
Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signaling
-
Kelley, R. F., Totpal, K., Lindstrom, S. H., Mathieu, M., Billeci, K., Deforge, L., Pai, R., Hymowitz, S. G., and Ashkenazi, A. (2005) Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signaling. J. Biol. Chem. 280, 2205-2212
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 2205-2212
-
-
Kelley, R.F.1
Totpal, K.2
Lindstrom, S.H.3
Mathieu, M.4
Billeci, K.5
Deforge, L.6
Pai, R.7
Hymowitz, S.G.8
Ashkenazi, A.9
-
103
-
-
0034682802
-
FADD is required for DR4- And DR5-mediated apoptosis: Lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts
-
Kuang, A. A., Diehl, G. E., Zhang, J., and Winoto, A. (2000) FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts. J. Biol. Chem. 275, 25065-25068
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 25065-25068
-
-
Kuang, A.A.1
Diehl, G.E.2
Zhang, J.3
Winoto, A.4
-
104
-
-
34250331231
-
Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis
-
Kohlhaas, S. L., Craxton, A., Sun, X. M., Pinkoski, M. J., and Cohen, G. M. (2007) Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. J. Biol. Chem. 282, 12831-12841
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 12831-12841
-
-
Kohlhaas, S.L.1
Craxton, A.2
Sun, X.M.3
Pinkoski, M.J.4
Cohen, G.M.5
-
105
-
-
34948894931
-
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
-
Wagner, K. W., Punnoose, E. A., Januario, T., Lawrence, D. A., Pitti, R. M., Lancaster, K., Lee, D., von Goetz, M., Yee, S. F., Totpal, K., Huw, L., Katta, V., Cavet, G., Hymowitz, S. G., Amler, L., and Ashkenazi, A. (2007) Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat. Med. 13, 1070-1077
-
(2007)
Nat. Med.
, vol.13
, pp. 1070-1077
-
-
Wagner, K.W.1
Punnoose, E.A.2
Januario, T.3
Lawrence, D.A.4
Pitti, R.M.5
Lancaster, K.6
Lee, D.7
Von Goetz, M.8
Yee, S.F.9
Totpal, K.10
Huw, L.11
Katta, V.12
Cavet, G.13
Hymowitz, S.G.14
Amler, L.15
Ashkenazi, A.16
-
106
-
-
34447094000
-
TRAIL signalling: Decisions between life and death
-
Falschlehner, C., Emmerich, C. H., Gerlach, B., and Walczak, H. (2007) TRAIL signalling: decisions between life and death. Int. J. Biochem. Cell Biol. 39, 1462-1475
-
(2007)
Int. J. Biochem. Cell Biol.
, vol.39
, pp. 1462-1475
-
-
Falschlehner, C.1
Emmerich, C.H.2
Gerlach, B.3
Walczak, H.4
-
107
-
-
0032697485
-
Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-κB and JNK activation and apoptosis through distinct pathways
-
Hu, W. H., Johnson, H., and Shu, H. B. (1999) Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-κB and JNK activation and apoptosis through distinct pathways. J. Biol. Chem. 274, 30603-30610
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 30603-30610
-
-
Hu, W.H.1
Johnson, H.2
Shu, H.B.3
-
108
-
-
0036895749
-
TRAIL-mediated apoptosis requires NF-κB inhibition and the mitochondrial permeability transition in human hepatoma cells
-
DOI 10.1053/jhep.2002.36942
-
Kim, Y. S., Schwabe, R. F., Qian, T., Lemasters, J. J., and Brenner, D. A. (2002) TRAIL-mediated apoptosis requires NF-κB inhibition and the mitochondrial permeability transition in human hepatoma cells. Hepatology 36, 1498-1508 (Pubitemid 35403540)
-
(2002)
Hepatology
, vol.36
, Issue.6
, pp. 1498-1508
-
-
Kim, Y.-S.1
Schwabe, R.F.2
Qian, T.3
Lemasters, J.J.4
Brenner, D.A.5
-
109
-
-
28844441555
-
Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand
-
Varfolomeev, E., Maecker, H., Sharp, D., Lawrence, D., Renz, M., Vucic, D., and Ashkenazi, A. (2005) Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. J. Biol. Chem. 280, 40599-40608
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 40599-40608
-
-
Varfolomeev, E.1
Maecker, H.2
Sharp, D.3
Lawrence, D.4
Renz, M.5
Vucic, D.6
Ashkenazi, A.7
-
110
-
-
35948994157
-
Autocrine TNFα Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis
-
DOI 10.1016/j.ccr.2007.08.029, PII S1535610807002619
-
Petersen, S. L., Wang, L., Yalcin-Chin, A., Li, L., Peyton, M., Minna, J., Harran, P., and Wang, X. (2007) Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic- induced apoptosis. Cancer Cell 12, 445-456 (Pubitemid 350064365)
-
(2007)
Cancer Cell
, vol.12
, Issue.5
, pp. 445-456
-
-
Petersen, S.L.1
Wang, L.2
Yalcin-Chin, A.3
Li, L.4
Peyton, M.5
Minna, J.6
Harran, P.7
Wang, X.8
-
111
-
-
0037105386
-
Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8
-
Soderstrom, T. S., Poukkula, M., Holmstrom, T. H., Heiskanen, K. M., and Eriksson, J. E. (2002) Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8. J. Immunol. 169, 2851-2860 (Pubitemid 35013125)
-
(2002)
Journal of Immunology
, vol.169
, Issue.6
, pp. 2851-2860
-
-
Soderstrom, T.S.1
Poukkula, M.2
Holmstrom, T.H.3
Heiskanen, K.M.4
Eriksson, J.E.5
-
112
-
-
0035844129
-
MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors
-
Tran, S. E., Holmstrom, T. H., Ahonen, M., Kahari, V. M., and Eriksson, J. E. (2001) MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors. J. Biol. Chem. 276, 16484-16490
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 16484-16490
-
-
Tran, S.E.1
Holmstrom, T.H.2
Ahonen, M.3
Kahari, V.M.4
Eriksson, J.E.5
-
113
-
-
33750813868
-
Acquired TRAIL resistance in human breast cancer cells are caused by the sustained cFLIP(L) and XIAP protein levels and ERK activation
-
Lee, T. J., Lee, J. T., Park, J. W., and Kwon, T. K. (2006) Acquired TRAIL resistance in human breast cancer cells are caused by the sustained cFLIP(L) and XIAP protein levels and ERK activation. Biochem. Biophys. Res. Commun. 351, 1024-1030
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.351
, pp. 1024-1030
-
-
Lee, T.J.1
Lee, J.T.2
Park, J.W.3
Kwon, T.K.4
-
114
-
-
34347392130
-
cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis
-
Guicciardi, M. E., Bronk, S. F., Werneburg, N. W., and Gores, G. J. (2007) cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis. Am. J. Physiol. Gastrointest. Liver Physiol. 292, G1337-G1346
-
(2007)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.292
-
-
Guicciardi, M.E.1
Bronk, S.F.2
Werneburg, N.W.3
Gores, G.J.4
-
115
-
-
33644801980
-
Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells
-
Ishimura, N., Isomoto, H., Bronk, S. F., and Gores, G. J. (2006) Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells. Am. J. Physiol. Gastrointest. Liver Physiol. 290, G129-G136
-
(2006)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.290
-
-
Ishimura, N.1
Isomoto, H.2
Bronk, S.F.3
Gores, G.J.4
-
116
-
-
33845221022
-
TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma
-
DOI 10.1038/sj.onc.1209719, PII 1209719
-
Trauzold, A., Siegmund, D., Schniewind, B., Sipos, B., Egberts, J., Zorenkov, D., Emme, D., Roder, C., Kalthoff, H., and Wajant, H. (2006) TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma. Oncogene 25, 7434-7439 (Pubitemid 44853434)
-
(2006)
Oncogene
, vol.25
, Issue.56
, pp. 7434-7439
-
-
Trauzold, A.1
Siegmund, D.2
Schniewind, B.3
Sipos, B.4
Egberts, J.5
Zorenkov, D.6
Emme, D.7
Roder, C.8
Kalthoff, H.9
Wajant, H.10
-
117
-
-
0042844783
-
TRAIL-induced apoptosis and gene induction in HaCaT keratinocytes: Differential contribution of TRAIL receptors 1 and 2
-
Leverkus, M., Sprick, M. R., Wachter, T., Denk, A., Brocker, E. B., Walczak, H., and Neumann, M. (2003) TRAIL-induced apoptosis and gene induction in HaCaT keratinocytes: differential contribution of TRAIL receptors 1 and 2. J. Invest. Dermatol. 121, 149-155
-
(2003)
J. Invest. Dermatol.
, vol.121
, pp. 149-155
-
-
Leverkus, M.1
Sprick, M.R.2
Wachter, T.3
Denk, A.4
Brocker, E.B.5
Walczak, H.6
Neumann, M.7
-
118
-
-
0036719734
-
Functional expression of tumor necrosis factor-related apoptosis-inducing ligand in human colonic adenocarcinoma cells
-
Inoue, H., Shiraki, K., Yamanaka, T., Ohmori, S., Sakai, T., Deguchi, M., Okano, H., Murata, K., Sugimoto, K., and Nakano, T. (2002) Functional expression of tumor necrosis factor-related apoptosis-inducing ligand in human colonic adenocarcinoma cells. Lab. Invest. 82, 1111-1119
-
(2002)
Lab. Invest.
, vol.82
, pp. 1111-1119
-
-
Inoue, H.1
Shiraki, K.2
Yamanaka, T.3
Ohmori, S.4
Sakai, T.5
Deguchi, M.6
Okano, H.7
Murata, K.8
Sugimoto, K.9
Nakano, T.10
-
119
-
-
3142733468
-
Evidence for a proangiogenic activity of TNF-related apoptosis-inducing ligand
-
DOI 10.1593/neo.03421
-
Secchiero, P., Gonelli, A., Carnevale, E., Corallini, F., Rizzardi, C., Zacchigna, S., Melato, M., and Zauli, G. (2004) Evidence for a proangiogenic activity of TNF-related apoptosis-inducing ligand. Neoplasia 6, 364-373 (Pubitemid 38924851)
-
(2004)
Neoplasia
, vol.6
, Issue.4
, pp. 364-373
-
-
Secchiero, P.1
Gonelli, A.2
Carnevale, E.3
Corallini, F.4
Rizzardi, C.5
Zacchigna, S.6
Melato, M.7
Zauli, G.8
-
120
-
-
0036162557
-
Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: A possible mechanism of immune evasion of the tumor
-
Koyama, S., Koike, N., and Adachi, S. (2002) Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor. J. Cancer Res. Clin. Oncol. 128, 73-79
-
(2002)
J. Cancer Res. Clin. Oncol.
, vol.128
, pp. 73-79
-
-
Koyama, S.1
Koike, N.2
Adachi, S.3
-
121
-
-
0032846783
-
Functional expression of TRAIL by lymphoid and myeloid tumour cells
-
Zhao, S., Asgary, Z., Wang, Y., Goodwin, R., Andreeff, M., and Younes, A. (1999) Functional expression of TRAIL by lymphoid and myeloid tumour cells. Br. J. Haematol. 106, 827-832
-
(1999)
Br. J. Haematol.
, vol.106
, pp. 827-832
-
-
Zhao, S.1
Asgary, Z.2
Wang, Y.3
Goodwin, R.4
Andreeff, M.5
Younes, A.6
-
122
-
-
0033001788
-
Human astrocytic brain tumors express APO2L/TRAIL
-
DOI 10.1007/s004010050948
-
Rieger, J., Ohgaki, H., Kleihues, P., and Weller, M. (1999) Human astrocytic brain tumors express AP02L/TRAIL. Acta Neuropathol. 97, 1-4 (Pubitemid 29132639)
-
(1999)
Acta Neuropathologica
, vol.97
, Issue.1
, pp. 1-4
-
-
Rieger, J.1
Ohgaki, H.2
Kleihues, P.3
Weller, M.4
-
123
-
-
0344171990
-
Expression of TRAIL and its receptors in human brain tumors
-
Frank, S., Kohler, U., Schackert, G., and Schackert, H. K. (1999) Expression of TRAIL and its receptors in human brain tumors. Biochem. Biophys. Res. Commun. 257, 454-459
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.257
, pp. 454-459
-
-
Frank, S.1
Kohler, U.2
Schackert, G.3
Schackert, H.K.4
-
124
-
-
0037312472
-
High expression of tumor necrosis factor-related apoptosis- Inducing ligand is associated with favorable ovarian cancer survival
-
Lancaster, J. M., Sayer, R., Blanchette, C., Calingaert, B., Whitaker, R., Schildkraut, J., Marks, J., and Berchuck, A. (2003) High expression of tumor necrosis factor-related apoptosis- inducing ligand is associated with favorable ovarian cancer survival. Clin. Cancer Res. 9, 762-766
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 762-766
-
-
Lancaster, J.M.1
Sayer, R.2
Blanchette, C.3
Calingaert, B.4
Whitaker, R.5
Schildkraut, J.6
Marks, J.7
Berchuck, A.8
-
125
-
-
0032969285
-
Tumor necrosis factor receptor and Fas signaling mechanisms
-
Wallach, D., Varfolomeev, E. E., Malinin, N. L., Goltsev, Y. V., Kovalenko, A. V., and Boldin, M. P. (1999) Tumor necrosis factor receptor and Fas signaling mechanisms. Annu. Rev. Immunol. 17, 331-367
-
(1999)
Annu. Rev. Immunol.
, vol.17
, pp. 331-367
-
-
Wallach, D.1
Varfolomeev, E.E.2
Malinin, N.L.3
Goltsev, Y.V.4
Kovalenko, A.V.5
Boldin, M.P.6
-
126
-
-
0027297663
-
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
-
DOI 10.1016/0092-8674(93)90134-C
-
Pfeffer, K., Matsuyama, T., Kundig, T. M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P. S., Kronke, M., and Mak, T. W. (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73, 457-467 (Pubitemid 23143346)
-
(1993)
Cell
, vol.73
, Issue.3
, pp. 457-467
-
-
Pfeffer, K.1
Matsuyama, T.2
Kundig, T.M.3
Wakeham, A.4
Kishihara, K.5
Shahinian, A.6
Wlegmann, K.7
Ohashi, P.S.8
Kronke, M.9
Mak, T.W.10
-
127
-
-
0033982986
-
Tumor necrosis factor receptor p55- Deficient mice respond to acute Yersinia enterocolitica infection with less apoptosis and more effective host resistance
-
Zhao, Y. X., Lajoie, G., Zhang, H., Chiu, B., Payne, U., and Inman, R. D. (2000) Tumor necrosis factor receptor p55- deficient mice respond to acute Yersinia enterocolitica infection with less apoptosis and more effective host resistance. Infect. Immun. 68, 1243-1251
-
(2000)
Infect. Immun.
, vol.68
, pp. 1243-1251
-
-
Zhao, Y.X.1
Lajoie, G.2
Zhang, H.3
Chiu, B.4
Payne, U.5
Inman, R.D.6
-
128
-
-
0037276438
-
Tumor necrosis factor signaling
-
Wajant, H., Pfizenmaier, K., and Scheurich, P. (2003) Tumor necrosis factor signaling. Cell Death Differ. 10, 45-65
-
(2003)
Cell Death Differ.
, vol.10
, pp. 45-65
-
-
Wajant, H.1
Pfizenmaier, K.2
Scheurich, P.3
-
129
-
-
0041853690
-
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
-
DOI 10.1016/S0092-8674(03)00521-X
-
Micheau, O., and Tschopp, J. (2003) Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114, 181-190 (Pubitemid 36936912)
-
(2003)
Cell
, vol.114
, Issue.2
, pp. 181-190
-
-
Micheau, O.1
Tschopp, J.2
-
130
-
-
0037815277
-
Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis
-
Harper, N., Hughes, M., MacFarlane, M., and Cohen, G. M. (2003) Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis. J. Biol. Chem. 278, 25534-25541
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25534-25541
-
-
Harper, N.1
Hughes, M.2
MacFarlane, M.3
Cohen, G.M.4
-
131
-
-
4444341939
-
Compartmentalization of TNF receptor 1 signaling: Internalized TNF receptosomes as death signaling vesicles
-
DOI 10.1016/j.immuni.2004.08.017, PII S1074761304002341
-
Schneider-Brachert, W., Tchikov, V., Neumeyer, J., Jakob, M., Winoto-Morbach, S., Held-Feindt, J., Heinrich, M., Merkel, O., Ehrenschwender, M., Adam, D., Mentlein, R., Kabelitz, D., and Schutze, S. (2004) Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity 21, 415-428 (Pubitemid 39208342)
-
(2004)
Immunity
, vol.21
, Issue.3
, pp. 415-428
-
-
Schneider-Brachert, W.1
Tchikov, V.2
Neumeyer, J.3
Jakob, M.4
Winoto-Morbach, S.5
Held-Feindt, J.6
Heinrich, M.7
Merkel, O.8
Ehrenschwender, M.9
Adam, D.10
Mentlein, R.11
Kabelitz, D.12
Schutze, S.13
-
132
-
-
0038742813
-
Recruitment of TNF receptor 1 to lipid rafts is essential for TNFα-mediated NF-κB activation
-
DOI 10.1016/S1074-7613(03)00092-X
-
Legler, D. F., Micheau, O., Doucey, M. A., Tschopp, J., and Bron, C. (2003) Recruitment of TNF receptor 1 to lipid rafts is essential for TNFα-mediated NF-κB activation. Immunity 18, 655-664 (Pubitemid 36588582)
-
(2003)
Immunity
, vol.18
, Issue.5
, pp. 655-664
-
-
Legler, D.F.1
Micheau, O.2
Doucey, M.-A.3
Tschopp, J.4
Bron, C.5
-
133
-
-
33744951304
-
Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-κB activation
-
Li, H., Kobayashi, M., Blonska, M., You, Y., and Lin, X. (2006) Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-κB activation. J. Biol. Chem. 281, 13636-13643
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 13636-13643
-
-
Li, H.1
Kobayashi, M.2
Blonska, M.3
You, Y.4
Lin, X.5
-
134
-
-
0035122689
-
Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling
-
Wajant, H., and Scheurich, P. (2001) Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling. Int. J. Biochem. Cell Biol. 33, 19-32
-
(2001)
Int. J. Biochem. Cell Biol.
, vol.33
, pp. 19-32
-
-
Wajant, H.1
Scheurich, P.2
-
135
-
-
0032508414
-
NF-κB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c- IAP2 to suppress caspase-8 activation
-
DOI 10.1126/science.281.5383.1680
-
Wang, C. Y., Mayo, M. W., Korneluk, R. G., Goeddel, D. V., and Baldwin, A. S. (1998) NF-κB antiapoptosis: induction of TRAF 1 and TRAF 2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281, 1680-1683 (Pubitemid 28435585)
-
(1998)
Science
, vol.281
, Issue.5383
, pp. 1680-1683
-
-
Wang, C.-Y.1
Mayo, M.W.2
Korneluk, R.G.3
Goeddel, D.V.4
Baldwin Jr., A.S.5
-
136
-
-
0035891320
-
Inhibition of JNK activation through NF-κB target genes
-
DOI 10.1038/35104568
-
Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., and Lin, A. (2001) Inhibition of JNK activation through NF-κB target genes. Nature 414, 313-317 (Pubitemid 33097808)
-
(2001)
Nature
, vol.414
, Issue.6861
, pp. 313-317
-
-
Tang, G.1
Minemoto, Y.2
Dibling, B.3
Purcell, N.H.4
Li, Z.5
Karin, M.6
Lin, A.7
-
137
-
-
32044447161
-
L turnover
-
DOI 10.1016/j.cell.2006.01.021, PII S0092867406001139
-
Chang, L., Kamata, H., Solinas, G., Luo, J. L., Maeda, S., Venuprasad, K., Liu, Y. C., and Karin, M. (2006) The E3 ubiquitin ligase itch couples JNK activation to TNFα-induced cell death by inducing c-FLIP(L) turnover. Cell 124, 601-613 (Pubitemid 43199444)
-
(2006)
Cell
, vol.124
, Issue.3
, pp. 601-613
-
-
Chang, L.1
Kamata, H.2
Solinas, G.3
Luo, J.-L.4
Maeda, S.5
Venuprasad, K.6
Liu, Y.-C.7
Karin, M.8
-
138
-
-
33750593637
-
Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism
-
Schneider-Brachert, W., Tchikov, V., Merkel, O., Jakob, M., Hallas, C., Kruse, M. L., Groitl, P., Lehn, A., Hildt, E., Held- Feindt, J., Dobner, T., Kabelitz, D., Kronke, M., and Schutze, S. (2006) Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism. J. Clin. Invest. 116, 2901-2913
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 2901-2913
-
-
Schneider-Brachert, W.1
Tchikov, V.2
Merkel, O.3
Jakob, M.4
Hallas, C.5
Kruse, M.L.6
Groitl, P.7
Lehn, A.8
Hildt, E.9
Held- Feindt, J.10
Dobner, T.11
Kabelitz, D.12
Kronke, M.13
Schutze, S.14
-
139
-
-
0029992609
-
Suppression of TNF-alpha-induced apoptosis by NF-κB
-
Van Antwerp, D. J., Martin, S. J., Kafri, T., Green, D. R., and Verma, I. M. (1996) Suppression of TNF-alpha-induced apoptosis by NF-κB. Science 274, 787-789
-
(1996)
Science
, vol.274
, pp. 787-789
-
-
Van Antwerp, D.J.1
Martin, S.J.2
Kafri, T.3
Green, D.R.4
Verma, I.M.5
-
140
-
-
33746690768
-
TNF-receptor I defective in internalization allows for cell death through activation of neutral sphingomyelinase
-
Neumeyer, J., Hallas, C., Merkel, O., Winoto-Morbach, S., Jakob, M., Thon, L., Adam, D., Schneider-Brachert, W., and Schutze, S. (2006) TNF-receptor I defective in internalization allows for cell death through activation of neutral sphingomyelinase. Exp. Cell. Res. 312, 2142-2153
-
(2006)
Exp. Cell. Res.
, vol.312
, pp. 2142-2153
-
-
Neumeyer, J.1
Hallas, C.2
Merkel, O.3
Winoto-Morbach, S.4
Jakob, M.5
Thon, L.6
Adam, D.7
Schneider-Brachert, W.8
Schutze, S.9
-
141
-
-
15144359445
-
Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation
-
Yoshimura, S., Banno, Y., Nakashima, S., Takenaka, K., Sakai, H., Nishimura, Y., Sakai, N., Shimizu, S., Eguchi, Y., Tsujimoto, Y., and Nozawa, Y. (1998) Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation. J. Biol. Chem. 273, 6921-6927
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 6921-6927
-
-
Yoshimura, S.1
Banno, Y.2
Nakashima, S.3
Takenaka, K.4
Sakai, H.5
Nishimura, Y.6
Sakai, N.7
Shimizu, S.8
Eguchi, Y.9
Tsujimoto, Y.10
Nozawa, Y.11
-
142
-
-
36048999753
-
IAP antagonists induce autoubiquitination of c-IAPs, NF-κB activation, and TNFα-dependent apoptosis
-
Varfolomeev, E., Blankenship, J. W., Wayson, S. M., Fedorova, A. V., Kayagaki, N., Garg, P., Zobel, K., Dynek, J. N., Elliott, L. O., Wallweber, H. J., Flygare, J. A., Fairbrother, W. J., Deshayes, K., Dixit, V. M., and Vucic, D. (2007) IAP antagonists induce autoubiquitination of c-IAPs, NF-κB activation, and TNFα-dependent apoptosis. Cell 131, 669-681
-
(2007)
Cell
, vol.131
, pp. 669-681
-
-
Varfolomeev, E.1
Blankenship, J.W.2
Wayson, S.M.3
Fedorova, A.V.4
Kayagaki, N.5
Garg, P.6
Zobel, K.7
Dynek, J.N.8
Elliott, L.O.9
Wallweber, H.J.10
Flygare, J.A.11
Fairbrother, W.J.12
Deshayes, K.13
Dixit, V.M.14
Vucic, D.15
-
143
-
-
43049152912
-
TNF-α Induces Two Distinct Caspase-8 Activation Pathways
-
DOI 10.1016/j.cell.2008.03.036, PII S0092867408005011
-
Wang, L., Du, F., and Wang, X. (2008) TNF-α induces two distinct caspase-8 activation pathways. Cell 133, 693-703 (Pubitemid 351636305)
-
(2008)
Cell
, vol.133
, Issue.4
, pp. 693-703
-
-
Wang, L.1
Du, F.2
Wang, X.3
-
144
-
-
44949240664
-
CIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
-
Bertrand, M. J., Milutinovic, S., Dickson, K. M., Ho, W. C., Boudreault, A., Durkin, J., Gillard, J. W., Jaquith, J. B., Morris, S. J., and Barker, P. A. (2008) cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol. Cell. 30, 689-700
-
(2008)
Mol. Cell.
, vol.30
, pp. 689-700
-
-
Bertrand, M.J.1
Milutinovic, S.2
Dickson, K.M.3
Ho, W.C.4
Boudreault, A.5
Durkin, J.6
Gillard, J.W.7
Jaquith, J.B.8
Morris, S.J.9
Barker, P.A.10
|