메뉴 건너뛰기




Volumn 10, Issue 3, 2014, Pages

Noise Genetics: Inferring Protein Function by Correlating Phenotype with Protein Levels and Localization in Individual Human Cells

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER CELL; CELL MOTILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENETIC VARIABILITY; GENETICS; HUMAN; HUMAN CELL; NOISE GENETICS; PHENOTYPE; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEOMICS; VALIDATION STUDY; CELL MOTION; SINGLE CELL ANALYSIS; TIME LAPSE IMAGING;

EID: 84897399093     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004176     Document Type: Article
Times cited : (16)

References (42)
  • 1
    • 77956520011 scopus 로고    scopus 로고
    • Functional roles for noise in genetic circuits
    • Eldar A, Elowitz MB, (2010) Functional roles for noise in genetic circuits. Nature 467: 167-173.
    • (2010) Nature , vol.467 , pp. 167-173
    • Eldar, A.1    Elowitz, M.B.2
  • 2
    • 77956528790 scopus 로고    scopus 로고
    • Fundamental limits on the suppression of molecular fluctuations
    • Lestas I, Vinnicombe G, Paulsson J, (2010) Fundamental limits on the suppression of molecular fluctuations. Nature 467: 174-178.
    • (2010) Nature , vol.467 , pp. 174-178
    • Lestas, I.1    Vinnicombe, G.2    Paulsson, J.3
  • 3
    • 25444468618 scopus 로고    scopus 로고
    • Noise in Gene Expression: Origins, Consequences, and Control
    • Raser JM, O'Shea EK, (2005) Noise in Gene Expression: Origins, Consequences, and Control. Science 309: 2010-2013.
    • (2005) Science , vol.309 , pp. 2010-2013
    • Raser, J.M.1    O'Shea, E.K.2
  • 4
    • 77952536835 scopus 로고    scopus 로고
    • Decision making at a subcellular level determines the outcome of bacteriophage infection
    • Zeng L, Skinner SO, Zong C, Sippy J, Feiss M, et al. (2010) Decision making at a subcellular level determines the outcome of bacteriophage infection. Cell 141: 682-691.
    • (2010) Cell , vol.141 , pp. 682-691
    • Zeng, L.1    Skinner, S.O.2    Zong, C.3    Sippy, J.4    Feiss, M.5
  • 5
    • 77249114260 scopus 로고    scopus 로고
    • Variability in gene expression underlies incomplete penetrance
    • Raj A, Rifkin SA, Andersen E, Oudenaarden A, (2010) Variability in gene expression underlies incomplete penetrance. Nature 463: 913-918.
    • (2010) Nature , vol.463 , pp. 913-918
    • Raj, A.1    Rifkin, S.A.2    Andersen, E.3    Oudenaarden, A.4
  • 7
    • 33845257870 scopus 로고    scopus 로고
    • Variability and memory of protein levels in human cells
    • Sigal A, Milo R, Cohen A, Geva-Zatorsky N, Klein Y, et al. (2006) Variability and memory of protein levels in human cells. Nature 444: 643-646.
    • (2006) Nature , vol.444 , pp. 643-646
    • Sigal, A.1    Milo, R.2    Cohen, A.3    Geva-Zatorsky, N.4    Klein, Y.5
  • 8
    • 84857437687 scopus 로고    scopus 로고
    • Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae
    • Stewart-Ornstein J, Weissman JS, El-Samad H, (2012) Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae. Mol Cell 45: 483-493.
    • (2012) Mol Cell , vol.45 , pp. 483-493
    • Stewart-Ornstein, J.1    Weissman, J.S.2    El-Samad, H.3
  • 9
    • 0017185026 scopus 로고
    • Non-genetic individuality: chance in the single cell
    • Spudich JL, Koshland DE Jr, (1976) Non-genetic individuality: chance in the single cell. Nature 262: 467-471.
    • (1976) Nature , vol.262 , pp. 467-471
    • Spudich, J.L.1    Koshland Jr., D.E.2
  • 11
    • 56749102636 scopus 로고    scopus 로고
    • Regulatory activity revealed by dynamic correlations in gene expression noise
    • Dunlop MJ, Cox RS 3rd, Levine JH, Murray RM, Elowitz MB, (2008) Regulatory activity revealed by dynamic correlations in gene expression noise. Nat Genet 40: 1493-1498.
    • (2008) Nat Genet , vol.40 , pp. 1493-1498
    • Dunlop, M.J.1    Cox 3rd, R.S.2    Levine, J.H.3    Murray, R.M.4    Elowitz, M.B.5
  • 12
    • 79959677602 scopus 로고    scopus 로고
    • Life at the leading edge
    • Ridley AJ, (2011) Life at the leading edge. Cell 145: 1012-1022.
    • (2011) Cell , vol.145 , pp. 1012-1022
    • Ridley, A.J.1
  • 14
    • 68549107934 scopus 로고    scopus 로고
    • Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown
    • Winograd-Katz SE, Itzkovitz S, Kam Z, Geiger B, (2009) Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown. J Cell Biol 186: 423-436.
    • (2009) J Cell Biol , vol.186 , pp. 423-436
    • Winograd-Katz, S.E.1    Itzkovitz, S.2    Kam, Z.3    Geiger, B.4
  • 15
    • 51049121572 scopus 로고    scopus 로고
    • Identification of genes that regulate epithelial cell migration using an siRNA screening approach
    • Simpson KJ, Selfors LM, Bui J, Reynolds A, Leake D, et al. (2008) Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nat Cell Biol 10: 1027-1038.
    • (2008) Nat Cell Biol , vol.10 , pp. 1027-1038
    • Simpson, K.J.1    Selfors, L.M.2    Bui, J.3    Reynolds, A.4    Leake, D.5
  • 16
    • 77950387346 scopus 로고    scopus 로고
    • Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes
    • Neumann B, Walter T, Hériché J-K, Bulkescher J, Erfle H, et al. (2010) Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature 464: 721-727.
    • (2010) Nature , vol.464 , pp. 721-727
    • Neumann, B.1    Walter, T.2    Hériché, J.-K.3    Bulkescher, J.4    Erfle, H.5
  • 17
    • 33745027397 scopus 로고    scopus 로고
    • Quantitative fluorescent speckle microscopy of cytoskeleton dynamics
    • Danuser G, Waterman-Storer CM, (2006) Quantitative fluorescent speckle microscopy of cytoskeleton dynamics. Annu Rev Biophys Biomol Struct 35: 361-387.
    • (2006) Annu Rev Biophys Biomol Struct , vol.35 , pp. 361-387
    • Danuser, G.1    Waterman-Storer, C.M.2
  • 19
    • 34250719724 scopus 로고    scopus 로고
    • Generation of a fluorescently labeled endogenous protein library in living human cells
    • Sigal A, Danon T, Cohen A, Milo R, Geva-Zatorsky N, et al. (2007) Generation of a fluorescently labeled endogenous protein library in living human cells. Nat Protoc 2: 1515-1527.
    • (2007) Nat Protoc , vol.2 , pp. 1515-1527
    • Sigal, A.1    Danon, T.2    Cohen, A.3    Milo, R.4    Geva-Zatorsky, N.5
  • 21
    • 34547650901 scopus 로고    scopus 로고
    • A multiresolution approach to automated classification of protein subcellular location images
    • Chebira A, Barbotin Y, Jackson C, Merryman T, Srinivasa G, et al. (2007) A multiresolution approach to automated classification of protein subcellular location images. BMC Bioinformatics 8: 210.
    • (2007) BMC Bioinformatics , vol.8 , pp. 210
    • Chebira, A.1    Barbotin, Y.2    Jackson, C.3    Merryman, T.4    Srinivasa, G.5
  • 22
    • 0036139314 scopus 로고    scopus 로고
    • A neural network classifier capable of recognizing the patterns of all major subcellular structures in fluorescence microscope images of HeLa cells
    • Boland MV, Murphy RF, (2001) A neural network classifier capable of recognizing the patterns of all major subcellular structures in fluorescence microscope images of HeLa cells. Bioinformatics 17: 1213-1223.
    • (2001) Bioinformatics , vol.17 , pp. 1213-1223
    • Boland, M.V.1    Murphy, R.F.2
  • 23
    • 84868688518 scopus 로고    scopus 로고
    • Dynamic Proteomics of Human Protein Level and Localization across the Cell Cycle
    • Farkash-Amar S, Eden E, Cohen A, Geva-Zatorsky N, Cohen L, et al. (2012) Dynamic Proteomics of Human Protein Level and Localization across the Cell Cycle. PLoS ONE 7: e48722.
    • (2012) PLoS ONE , vol.7
    • Farkash-Amar, S.1    Eden, E.2    Cohen, A.3    Geva-Zatorsky, N.4    Cohen, L.5
  • 24
    • 0030802671 scopus 로고    scopus 로고
    • The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly
    • Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ, (1997) The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. J Cell Biol 138: 375-384.
    • (1997) J Cell Biol , vol.138 , pp. 375-384
    • Welch, M.D.1    DePace, A.H.2    Verma, S.3    Iwamatsu, A.4    Mitchison, T.J.5
  • 25
    • 54949151864 scopus 로고    scopus 로고
    • Positive regulation of migration and invasion by vasodilator-stimulated phosphoprotein via Rac1 pathway in human breast cancer cells
    • Han G, Fan B, Zhang Y, Zhou X, Wang Y, et al. (2008) Positive regulation of migration and invasion by vasodilator-stimulated phosphoprotein via Rac1 pathway in human breast cancer cells. Oncol Rep 20: 929-939.
    • (2008) Oncol Rep , vol.20 , pp. 929-939
    • Han, G.1    Fan, B.2    Zhang, Y.3    Zhou, X.4    Wang, Y.5
  • 26
    • 0033600187 scopus 로고    scopus 로고
    • Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex
    • Suetsugu S, Miki H, Takenawa T, (1999) Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. Biochem Biophys Res Commun 260: 296-302.
    • (1999) Biochem Biophys Res Commun , vol.260 , pp. 296-302
    • Suetsugu, S.1    Miki, H.2    Takenawa, T.3
  • 27
    • 33745220278 scopus 로고    scopus 로고
    • Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise
    • Newman JRS, Ghaemmaghami S, Ihmels J, Breslow DK, Noble M, et al. (2006) Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise. Nature 441: 840-846.
    • (2006) Nature , vol.441 , pp. 840-846
    • Newman, J.R.S.1    Ghaemmaghami, S.2    Ihmels, J.3    Breslow, D.K.4    Noble, M.5
  • 28
    • 77955102352 scopus 로고    scopus 로고
    • Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells
    • Taniguchi Y, Choi PJ, Li G-W, Chen H, Babu M, et al. (2010) Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells. Science 329: 533-538.
    • (2010) Science , vol.329 , pp. 533-538
    • Taniguchi, Y.1    Choi, P.J.2    Li, G.-W.3    Chen, H.4    Babu, M.5
  • 29
    • 33746415885 scopus 로고    scopus 로고
    • A comprehensive library of fluorescent transcriptional reporters for Escherichia coli
    • Zaslaver A, Bren A, Ronen M, Itzkovitz S, Kikoin I, et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat Methods 3: 623-628.
    • (2006) Nat Methods , vol.3 , pp. 623-628
    • Zaslaver, A.1    Bren, A.2    Ronen, M.3    Itzkovitz, S.4    Kikoin, I.5
  • 30
    • 84865266808 scopus 로고    scopus 로고
    • A genome-scale resource for in vivo tag-based protein function exploration in C. elegans
    • Sarov M, Murray JI, Schanze K, Pozniakovski A, Niu W, et al. (2012) A genome-scale resource for in vivo tag-based protein function exploration in C. elegans. Cell 150: 855-866.
    • (2012) Cell , vol.150 , pp. 855-866
    • Sarov, M.1    Murray, J.I.2    Schanze, K.3    Pozniakovski, A.4    Niu, W.5
  • 31
    • 80455162302 scopus 로고    scopus 로고
    • A versatile gene trap to visualize and interrogate the function of the vertebrate proteome
    • Trinh LA, Hochgreb T, Graham M, Wu D, Ruf-Zamojski F, et al. (2011) A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Genes Dev 25: 2306-2320.
    • (2011) Genes Dev , vol.25 , pp. 2306-2320
    • Trinh, L.A.1    Hochgreb, T.2    Graham, M.3    Wu, D.4    Ruf-Zamojski, F.5
  • 32
    • 70449344685 scopus 로고    scopus 로고
    • Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells
    • Chan EM, Ratanasirintrawoot S, Park I-H, Manos PD, Loh Y-H, et al. (2009) Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. Nature Biotechnology 27: 1033-1037.
    • (2009) Nature Biotechnology , vol.27 , pp. 1033-1037
    • Chan, E.M.1    Ratanasirintrawoot, S.2    Park, I.-H.3    Manos, P.D.4    Loh, Y.-H.5
  • 33
    • 84861170964 scopus 로고    scopus 로고
    • Single-mRNA counting using fluorescent in situ hybridization in budding yeast
    • Trcek T, Chao JA, Larson DR, Park HY, Zenklusen D, et al. (2012) Single-mRNA counting using fluorescent in situ hybridization in budding yeast. Nat Protoc 7: 408-419.
    • (2012) Nat Protoc , vol.7 , pp. 408-419
    • Trcek, T.1    Chao, J.A.2    Larson, D.R.3    Park, H.Y.4    Zenklusen, D.5
  • 35
    • 84355162740 scopus 로고    scopus 로고
    • Single-molecule transcript counting of stem-cell markers in the mouse intestine
    • Itzkovitz S, Lyubimova A, Blat IC, Maynard M, van Es J, et al. (2012) Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nat Cell Biol 14: 106-114.
    • (2012) Nat Cell Biol , vol.14 , pp. 106-114
    • Itzkovitz, S.1    Lyubimova, A.2    Blat, I.C.3    Maynard, M.4    van Es, J.5
  • 36
    • 44349162752 scopus 로고    scopus 로고
    • Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
    • Chang HH, Hemberg M, Barahona M, Ingber DE, Huang S, (2008) Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature 453: 544-547.
    • (2008) Nature , vol.453 , pp. 544-547
    • Chang, H.H.1    Hemberg, M.2    Barahona, M.3    Ingber, D.E.4    Huang, S.5
  • 37
    • 67749117790 scopus 로고    scopus 로고
    • Partial penetrance facilitates developmental evolution in bacteria
    • Eldar A, Chary VK, Xenopoulos P, Fontes ME, Losón OC, et al. (2009) Partial penetrance facilitates developmental evolution in bacteria. Nature 460: 510-514.
    • (2009) Nature , vol.460 , pp. 510-514
    • Eldar, A.1    Chary, V.K.2    Xenopoulos, P.3    Fontes, M.E.4    Losón, O.C.5
  • 38
    • 35548960975 scopus 로고    scopus 로고
    • Dissecting timing variability in yeast meiosis
    • Nachman I, Regev A, Ramanathan S, (2007) Dissecting timing variability in yeast meiosis. Cell 131: 544-556.
    • (2007) Cell , vol.131 , pp. 544-556
    • Nachman, I.1    Regev, A.2    Ramanathan, S.3
  • 39
    • 79958015996 scopus 로고    scopus 로고
    • Modelling short time series in metabolomics: a functional data analysis approach
    • doi:10.1007/978-1419-7046-6_31
    • Montana G, Berk M, Ebbels T, (2011) Modelling short time series in metabolomics: a functional data analysis approach. Adv Exp Med Biol 696: 307-315 doi:10.1007/978-1419-7046-6_31.
    • (2011) Adv Exp Med Biol , vol.696 , pp. 307-315
    • Montana, G.1    Berk, M.2    Ebbels, T.3
  • 40
    • 84861782481 scopus 로고    scopus 로고
    • Using bleach-chase to measure protein half-lives in living cells
    • Geva-Zatorsky N, Issaeva I, Mayo A, Cohen A, Dekel E, et al. (2012) Using bleach-chase to measure protein half-lives in living cells. Nat Protoc 7: 801-811.
    • (2012) Nat Protoc , vol.7 , pp. 801-811
    • Geva-Zatorsky, N.1    Issaeva, I.2    Mayo, A.3    Cohen, A.4    Dekel, E.5
  • 41
    • 0018466704 scopus 로고
    • Statistical and structural approaches to texture
    • Haralick RM, (1979) Statistical and structural approaches to texture. Proceedings of the IEEE 67: 786-804.
    • (1979) Proceedings of the IEEE , vol.67 , pp. 786-804
    • Haralick, R.M.1
  • 42
    • 33847264343 scopus 로고    scopus 로고
    • Enrichment or depletion of a GO category within a class of genes: which test
    • Rivals I, Personnaz L, Taing L, Potier M-C, (2007) Enrichment or depletion of a GO category within a class of genes: which test? Bioinformatics 23: 401-407.
    • (2007) Bioinformatics , vol.23 , pp. 401-407
    • Rivals, I.1    Personnaz, L.2    Taing, L.3    Potier, M.-C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.