메뉴 건너뛰기




Volumn 332, Issue 2, 2013, Pages 141-150

Targeting c-FLIP in cancer

Author keywords

C FLIP; Cancer; Death receptors

Indexed keywords

ANISOMYCIN; CASPASE 3; CASPASE 7; CISPLATIN; CYCLOHEXAMIDE; DACTINOMYCIN; FLICE INHIBITORY PROTEIN; FLUOROURACIL; GIVINOSTAT; PROTEIN SYNTHESIS INHIBITOR; SMALL INTERFERING RNA; TRICHOSTATIN A; UNCLASSIFIED DRUG; VALPROIC ACID;

EID: 84876085177     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2010.10.009     Document Type: Review
Times cited : (121)

References (121)
  • 1
    • 68349154339 scopus 로고    scopus 로고
    • Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival
    • Hughes M.A., Harper N., Butterworth M., Cain K., Cohen G.M., MacFarlane M. Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival. Molecular Cell 2009, 35:265-279.
    • (2009) Molecular Cell , vol.35 , pp. 265-279
    • Hughes, M.A.1    Harper, N.2    Butterworth, M.3    Cain, K.4    Cohen, G.M.5    MacFarlane, M.6
  • 2
    • 0041853690 scopus 로고    scopus 로고
    • Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    • Micheau O., Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003, 114:181-190.
    • (2003) Cell , vol.114 , pp. 181-190
    • Micheau, O.1    Tschopp, J.2
  • 3
    • 0041828486 scopus 로고    scopus 로고
    • Cellular FLICE-inhibitory protein: an attractive therapeutic target?
    • Micheau O. Cellular FLICE-inhibitory protein: an attractive therapeutic target?. Exp. Opin. Ther. Targets 2003, 7:559-573.
    • (2003) Exp. Opin. Ther. Targets , vol.7 , pp. 559-573
    • Micheau, O.1
  • 5
    • 32044447161 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover
    • Chang L., Kamata H., Solinas G., Luo J.L., Maeda S., Venuprasad K., Liu Y.C., Karin M. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 2006, 124:601-613.
    • (2006) Cell , vol.124 , pp. 601-613
    • Chang, L.1    Kamata, H.2    Solinas, G.3    Luo, J.L.4    Maeda, S.5    Venuprasad, K.6    Liu, Y.C.7    Karin, M.8
  • 7
    • 0034637585 scopus 로고    scopus 로고
    • Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD)
    • Wajant H., Haas E., Schwenzer R., Muhlenbeck F., Kreuz S., Schubert G., Grell M., Smith C., Scheurich P. Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD). J. Biol. Chem. 2000, 275:24357-24366.
    • (2000) J. Biol. Chem. , vol.275 , pp. 24357-24366
    • Wajant, H.1    Haas, E.2    Schwenzer, R.3    Muhlenbeck, F.4    Kreuz, S.5    Schubert, G.6    Grell, M.7    Smith, C.8    Scheurich, P.9
  • 8
    • 0033556310 scopus 로고    scopus 로고
    • The role of c-FLIP in modulation of CD95-induced apoptosis
    • Scaffidi C., Schmitz I., Krammer P.H., Peter M.E. The role of c-FLIP in modulation of CD95-induced apoptosis. J. Biol. Chem. 1999, 274:1541-1548.
    • (1999) J. Biol. Chem. , vol.274 , pp. 1541-1548
    • Scaffidi, C.1    Schmitz, I.2    Krammer, P.H.3    Peter, M.E.4
  • 11
    • 0346399569 scopus 로고    scopus 로고
    • Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers
    • Nam S.Y., Jung G.A., Hur G.C., Chung H.Y., Kim W.H., Seol D.W., Lee B.L. Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers. Cancer Sci. 2003, 94:1066-1073.
    • (2003) Cancer Sci. , vol.94 , pp. 1066-1073
    • Nam, S.Y.1    Jung, G.A.2    Hur, G.C.3    Chung, H.Y.4    Kim, W.H.5    Seol, D.W.6    Lee, B.L.7
  • 13
    • 0032530612 scopus 로고    scopus 로고
    • Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells
    • Griffith T.S., Chin W.A., Jackson G.C., Lynch D.H., Kubin M.Z. Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells. J. Immunol. 1998, 161:2833-2840.
    • (1998) J. Immunol. , vol.161 , pp. 2833-2840
    • Griffith, T.S.1    Chin, W.A.2    Jackson, G.C.3    Lynch, D.H.4    Kubin, M.Z.5
  • 14
    • 0037320340 scopus 로고    scopus 로고
    • Resistance of human ovarian cancer cells to tumor necrosis factor alpha is a consequence of nuclear factor kappaB-mediated induction of Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitory protein
    • Xiao C.W., Yan X., Li Y., Reddy S.A., Tsang B.K. Resistance of human ovarian cancer cells to tumor necrosis factor alpha is a consequence of nuclear factor kappaB-mediated induction of Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitory protein. Endocrinology 2003, 144:623-630.
    • (2003) Endocrinology , vol.144 , pp. 623-630
    • Xiao, C.W.1    Yan, X.2    Li, Y.3    Reddy, S.A.4    Tsang, B.K.5
  • 15
    • 4944248109 scopus 로고    scopus 로고
    • Persistent c-FLIP(L) expression is necessary and sufficient to maintain resistance to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in prostate cancer
    • Zhang X., Jin T.G., Yang H., DeWolf W.C., Khosravi-Far R., Olumi A.F. Persistent c-FLIP(L) expression is necessary and sufficient to maintain resistance to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in prostate cancer. Cancer Res. 2004, 64:7086-7091.
    • (2004) Cancer Res. , vol.64 , pp. 7086-7091
    • Zhang, X.1    Jin, T.G.2    Yang, H.3    DeWolf, W.C.4    Khosravi-Far, R.5    Olumi, A.F.6
  • 16
    • 0035195486 scopus 로고    scopus 로고
    • Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D
    • Olsson A., Diaz T., Aguilar-Santelises M., Osterborg A., Celsing F., Jondal M., Osorio L.M. Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D. Leukemia 2001, 15:1868-1877.
    • (2001) Leukemia , vol.15 , pp. 1868-1877
    • Olsson, A.1    Diaz, T.2    Aguilar-Santelises, M.3    Osterborg, A.4    Celsing, F.5    Jondal, M.6    Osorio, L.M.7
  • 17
    • 0037015675 scopus 로고    scopus 로고
    • Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia
    • MacFarlane M., Harper N., Snowden R.T., Dyer M.J., Barnett G.A., Pringle J.H., Cohen G.M. Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia. Oncogene 2002, 21:6809-6818.
    • (2002) Oncogene , vol.21 , pp. 6809-6818
    • MacFarlane, M.1    Harper, N.2    Snowden, R.T.3    Dyer, M.J.4    Barnett, G.A.5    Pringle, J.H.6    Cohen, G.M.7
  • 18
    • 2942605086 scopus 로고    scopus 로고
    • C-FLIP expression in bladder urothelial carcinomas: its role in resistance to Fas-mediated apoptosis and clinicopathologic correlations
    • Korkolopoulou P., Goudopoulou A., Voutsinas G., Thomas-Tsagli E., Kapralos P., Patsouris E., Saetta A.A. c-FLIP expression in bladder urothelial carcinomas: its role in resistance to Fas-mediated apoptosis and clinicopathologic correlations. Urology 2004, 63:1198-1204.
    • (2004) Urology , vol.63 , pp. 1198-1204
    • Korkolopoulou, P.1    Goudopoulou, A.2    Voutsinas, G.3    Thomas-Tsagli, E.4    Kapralos, P.5    Patsouris, E.6    Saetta, A.A.7
  • 19
    • 30844469526 scopus 로고    scopus 로고
    • E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIP (short)
    • Salon C., Eymin B., Micheau O., Chaperot L., Plumas J., Brambilla C., Brambilla E., Gazzeri S. E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIP (short). Cell Death Differ. 2006, 13:260-272.
    • (2006) Cell Death Differ. , vol.13 , pp. 260-272
    • Salon, C.1    Eymin, B.2    Micheau, O.3    Chaperot, L.4    Plumas, J.5    Brambilla, C.6    Brambilla, E.7    Gazzeri, S.8
  • 20
    • 66149109196 scopus 로고    scopus 로고
    • Over-expression of c-FLIP confers the resistance to TRAIL-induced apoptosis on gallbladder carcinoma
    • Zong H., Yin B., Chen J., Ma B., Cai D., He X. Over-expression of c-FLIP confers the resistance to TRAIL-induced apoptosis on gallbladder carcinoma. Tohoku J. Exp. Med. 2009, 217:203-208.
    • (2009) Tohoku J. Exp. Med. , vol.217 , pp. 203-208
    • Zong, H.1    Yin, B.2    Chen, J.3    Ma, B.4    Cai, D.5    He, X.6
  • 22
    • 0038556793 scopus 로고    scopus 로고
    • Increased expression of FLIP, an inhibitor of Fas-mediated apoptosis, in stomach cancer
    • Lee S.H., Kim H.S., Kim S.Y., Lee Y.S., Park W.S., Kim S.H., Lee J.Y., Yoo N.J. Increased expression of FLIP, an inhibitor of Fas-mediated apoptosis, in stomach cancer. Apmis 2003, 111:309-314.
    • (2003) Apmis , vol.111 , pp. 309-314
    • Lee, S.H.1    Kim, H.S.2    Kim, S.Y.3    Lee, Y.S.4    Park, W.S.5    Kim, S.H.6    Lee, J.Y.7    Yoo, N.J.8
  • 23
    • 2142821427 scopus 로고    scopus 로고
    • Overexpression of cellular FLICE-inhibitory protein (FLIP) in gastric adenocarcinoma
    • Zhou X.D., Yu J.P., Liu J., Luo H.S., Chen H.X., Yu H.G. Overexpression of cellular FLICE-inhibitory protein (FLIP) in gastric adenocarcinoma. Clin. Sci. (London) 2004, 106:397-405.
    • (2004) Clin. Sci. (London) , vol.106 , pp. 397-405
    • Zhou, X.D.1    Yu, J.P.2    Liu, J.3    Luo, H.S.4    Chen, H.X.5    Yu, H.G.6
  • 25
    • 62849093368 scopus 로고    scopus 로고
    • Death receptor signal transducers: nodes of coordination in immune signaling networks
    • Wilson N.S., Dixit V., Ashkenazi A. Death receptor signal transducers: nodes of coordination in immune signaling networks. Nat. Immunol. 2009, 10:348-355.
    • (2009) Nat. Immunol. , vol.10 , pp. 348-355
    • Wilson, N.S.1    Dixit, V.2    Ashkenazi, A.3
  • 29
    • 0033523684 scopus 로고    scopus 로고
    • The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors
    • Djerbi M., Screpanti V., Catrina A.I., Bogen B., Biberfeld P., Grandien A. The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors. J. Exp. Med. 1999, 190:1025-1032.
    • (1999) J. Exp. Med. , vol.190 , pp. 1025-1032
    • Djerbi, M.1    Screpanti, V.2    Catrina, A.I.3    Bogen, B.4    Biberfeld, P.5    Grandien, A.6
  • 31
    • 34248349532 scopus 로고    scopus 로고
    • The relationship between c-FLIP expression and human papillomavirus E2 gene disruption in cervical carcinogenesis
    • Wang W., Wang S., Song X., Sima N., Xu X., Luo A., Chen G., Deng D., Xu Q., Meng L., Lu Y., Ma D. The relationship between c-FLIP expression and human papillomavirus E2 gene disruption in cervical carcinogenesis. Gynecol. Oncol. 2007, 105:571-577.
    • (2007) Gynecol. Oncol. , vol.105 , pp. 571-577
    • Wang, W.1    Wang, S.2    Song, X.3    Sima, N.4    Xu, X.5    Luo, A.6    Chen, G.7    Deng, D.8    Xu, Q.9    Meng, L.10    Lu, Y.11    Ma, D.12
  • 33
    • 33644885746 scopus 로고    scopus 로고
    • CFLIP expression correlates with tumour progression and patient outcome in non-Hodgkin lymphomas of low grade of malignancy
    • Valente G., Manfroi F., Peracchio C., Nicotra G., Castino R., Nicosia G., Kerim S., Isidoro C. cFLIP expression correlates with tumour progression and patient outcome in non-Hodgkin lymphomas of low grade of malignancy. Br. J. Haematol. 2006, 132:560-570.
    • (2006) Br. J. Haematol. , vol.132 , pp. 560-570
    • Valente, G.1    Manfroi, F.2    Peracchio, C.3    Nicotra, G.4    Castino, R.5    Nicosia, G.6    Kerim, S.7    Isidoro, C.8
  • 36
    • 0033583191 scopus 로고    scopus 로고
    • Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs
    • Micheau O., Solary E., Hammann A., Dimanche-Boitrel M.T. Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs. J. Biol. Chem. 1999, 274:7987-7992.
    • (1999) J. Biol. Chem. , vol.274 , pp. 7987-7992
    • Micheau, O.1    Solary, E.2    Hammann, A.3    Dimanche-Boitrel, M.T.4
  • 38
    • 0034744033 scopus 로고    scopus 로고
    • NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling
    • Kreuz S., Siegmund D., Scheurich P., Wajant H. NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Mol. Cell Biol. 2001, 21:3964-3973.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 3964-3973
    • Kreuz, S.1    Siegmund, D.2    Scheurich, P.3    Wajant, H.4
  • 39
    • 0035253051 scopus 로고    scopus 로고
    • P53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells
    • Bartke T., Siegmund D., Peters N., Reichwein M., Henkler F., Scheurich P., Wajant H. p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells. Oncogene 2001, 20:571-580.
    • (2001) Oncogene , vol.20 , pp. 571-580
    • Bartke, T.1    Siegmund, D.2    Peters, N.3    Reichwein, M.4    Henkler, F.5    Scheurich, P.6    Wajant, H.7
  • 41
    • 0347723879 scopus 로고    scopus 로고
    • The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP
    • Skurk C., Maatz H., Kim H.S., Yang J., Abid M.R., Aird W.C., Walsh K. The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J. Biol. Chem. 2004, 279:1513-1525.
    • (2004) J. Biol. Chem. , vol.279 , pp. 1513-1525
    • Skurk, C.1    Maatz, H.2    Kim, H.S.3    Yang, J.4    Abid, M.R.5    Aird, W.C.6    Walsh, K.7
  • 42
    • 76949102583 scopus 로고    scopus 로고
    • Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells
    • Mahalingam D., Natoni A., Keane M., Samali A., Szegezdi E. Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells. Br. J. Cancer 2010, 102:754-764.
    • (2010) Br. J. Cancer , vol.102 , pp. 754-764
    • Mahalingam, D.1    Natoni, A.2    Keane, M.3    Samali, A.4    Szegezdi, E.5
  • 44
    • 33745204446 scopus 로고    scopus 로고
    • Androgen receptor and prostate apoptosis response factor-4 target the c-FLIP gene to determine survival and apoptosis in the prostate gland
    • Gao S., Wang H., Lee P., Melamed J., Li C.X., Zhang F., Wu H., Zhou L., Wang Z. Androgen receptor and prostate apoptosis response factor-4 target the c-FLIP gene to determine survival and apoptosis in the prostate gland. J. Mol. Endocrinol. 2006, 36:463-483.
    • (2006) J. Mol. Endocrinol. , vol.36 , pp. 463-483
    • Gao, S.1    Wang, H.2    Lee, P.3    Melamed, J.4    Li, C.X.5    Zhang, F.6    Wu, H.7    Zhou, L.8    Wang, Z.9
  • 46
    • 59149091466 scopus 로고    scopus 로고
    • IRF-5 is a mediator of the death receptor-induced apoptotic signaling pathway
    • Hu G., Barnes B.J. IRF-5 is a mediator of the death receptor-induced apoptotic signaling pathway. J. Biol. Chem. 2009, 284:2767-2777.
    • (2009) J. Biol. Chem. , vol.284 , pp. 2767-2777
    • Hu, G.1    Barnes, B.J.2
  • 47
    • 33947206642 scopus 로고    scopus 로고
    • MG-132 sensitizes TRAIL-resistant prostate cancer cells by activating c-Fos/c-Jun heterodimers and repressing c-FLIP(L)
    • Li W., Zhang X., Olumi A.F. MG-132 sensitizes TRAIL-resistant prostate cancer cells by activating c-Fos/c-Jun heterodimers and repressing c-FLIP(L). Cancer Res. 2007, 67:2247-2255.
    • (2007) Cancer Res. , vol.67 , pp. 2247-2255
    • Li, W.1    Zhang, X.2    Olumi, A.F.3
  • 48
    • 49749139424 scopus 로고    scopus 로고
    • Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells
    • Ueffing N., Schuster M., Keil E., Schulze-Osthoff K., Schmitz I. Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells. Blood 2008, 112:690-698.
    • (2008) Blood , vol.112 , pp. 690-698
    • Ueffing, N.1    Schuster, M.2    Keil, E.3    Schulze-Osthoff, K.4    Schmitz, I.5
  • 49
    • 77955711835 scopus 로고    scopus 로고
    • The antiapoptotic protein, FLIP, is regulated by heterogeneous nuclear ribonucleoprotein K and correlates with poor overall survival of nasopharyngeal carcinoma patients
    • Chen L.C., Chung I.C., Hsueh C., Tsang N.M., Chi L.M., Liang Y., Chen C.C., Wang L.J., Chang Y.S. The antiapoptotic protein, FLIP, is regulated by heterogeneous nuclear ribonucleoprotein K and correlates with poor overall survival of nasopharyngeal carcinoma patients. Cell Death Differ. 2010.
    • (2010) Cell Death Differ.
    • Chen, L.C.1    Chung, I.C.2    Hsueh, C.3    Tsang, N.M.4    Chi, L.M.5    Liang, Y.6    Chen, C.C.7    Wang, L.J.8    Chang, Y.S.9
  • 51
    • 0034665308 scopus 로고    scopus 로고
    • Regulation of the Fas death pathway by FLICE-inhibitory protein in primary human B cells
    • Hennino A., Berard M., Casamayor-Palleja M., Krammer P.H., Defrance T. Regulation of the Fas death pathway by FLICE-inhibitory protein in primary human B cells. J. Immunol. 2000, 165:3023-3030.
    • (2000) J. Immunol. , vol.165 , pp. 3023-3030
    • Hennino, A.1    Berard, M.2    Casamayor-Palleja, M.3    Krammer, P.H.4    Defrance, T.5
  • 52
    • 49049086995 scopus 로고    scopus 로고
    • CD40 ligand protects from TRAIL-induced apoptosis in follicular lymphomas through NF-kappaB activation and up-regulation of c-FLIP and Bcl-xL
    • Travert M., Ame-Thomas P., Pangault C., Morizot A., Micheau O., Semana G., Lamy T., Fest T., Tarte K., Guillaudeux T. CD40 ligand protects from TRAIL-induced apoptosis in follicular lymphomas through NF-kappaB activation and up-regulation of c-FLIP and Bcl-xL. J. Immunol. 2008, 181:1001-1011.
    • (2008) J. Immunol. , vol.181 , pp. 1001-1011
    • Travert, M.1    Ame-Thomas, P.2    Pangault, C.3    Morizot, A.4    Micheau, O.5    Semana, G.6    Lamy, T.7    Fest, T.8    Tarte, K.9    Guillaudeux, T.10
  • 53
    • 54049086233 scopus 로고    scopus 로고
    • Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells
    • Wilson C., Wilson T., Johnston P.G., Longley D.B., Waugh D.J. Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells. Mol. Cancer Ther. 2008, 7:2649-2661.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 2649-2661
    • Wilson, C.1    Wilson, T.2    Johnston, P.G.3    Longley, D.B.4    Waugh, D.J.5
  • 54
    • 37249084581 scopus 로고    scopus 로고
    • Low-dose 12-O-tetradecanoylphorbol-13-acetate enhances tumor necrosis factor related apoptosis-inducing ligand induced apoptosis in prostate cancer cells
    • Zhang X., Li W., Olumi A.F. Low-dose 12-O-tetradecanoylphorbol-13-acetate enhances tumor necrosis factor related apoptosis-inducing ligand induced apoptosis in prostate cancer cells. Clin. Cancer Res. 2007, 13:7181-7190.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 7181-7190
    • Zhang, X.1    Li, W.2    Olumi, A.F.3
  • 56
  • 57
    • 40549115294 scopus 로고    scopus 로고
    • TNF signaling gets FLIPped off: TNF-induced regulation of FLIP
    • Rushworth S.A., Taylor A., Langa S., MacEwan D.J. TNF signaling gets FLIPped off: TNF-induced regulation of FLIP. Cell Cycle 2008, 7:194-199.
    • (2008) Cell Cycle , vol.7 , pp. 194-199
    • Rushworth, S.A.1    Taylor, A.2    Langa, S.3    MacEwan, D.J.4
  • 58
    • 0034660874 scopus 로고    scopus 로고
    • Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression
    • Fulda S., Meyer E., Debatin K.M. Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression. Cancer Res. 2000, 60:3947-3956.
    • (2000) Cancer Res. , vol.60 , pp. 3947-3956
    • Fulda, S.1    Meyer, E.2    Debatin, K.M.3
  • 62
    • 70350217430 scopus 로고    scopus 로고
    • A novel PTEN-dependent link to ubiquitination controls FLIPS stability and TRAIL sensitivity in glioblastoma multiforme
    • Panner A., Crane C.A., Weng C., Feletti A., Parsa A.T., Pieper R.O. A novel PTEN-dependent link to ubiquitination controls FLIPS stability and TRAIL sensitivity in glioblastoma multiforme. Cancer Res. 2009, 69:7911-7916.
    • (2009) Cancer Res. , vol.69 , pp. 7911-7916
    • Panner, A.1    Crane, C.A.2    Weng, C.3    Feletti, A.4    Parsa, A.T.5    Pieper, R.O.6
  • 63
    • 65549085701 scopus 로고    scopus 로고
    • Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
    • Jin Z., Li Y., Pitti R., Lawrence D., Pham V.C., Lill J.R., Ashkenazi A. Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 2009, 137:721-735.
    • (2009) Cell , vol.137 , pp. 721-735
    • Jin, Z.1    Li, Y.2    Pitti, R.3    Lawrence, D.4    Pham, V.C.5    Lill, J.R.6    Ashkenazi, A.7
  • 64
    • 77950861324 scopus 로고    scopus 로고
    • Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents
    • Sanchez-Perez T., Ortiz-Ferron G., Lopez-Rivas A. Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents. Cell Death Differ. 2010, 17:883-894.
    • (2010) Cell Death Differ. , vol.17 , pp. 883-894
    • Sanchez-Perez, T.1    Ortiz-Ferron, G.2    Lopez-Rivas, A.3
  • 65
    • 34548590339 scopus 로고    scopus 로고
    • Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin
    • Son Y.G., Kim E.H., Kim J.Y., Kim S.U., Kwon T.K., Yoon A.R., Yun C.O., Choi K.S. Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin. Cancer Res. 2007, 67:8274-8284.
    • (2007) Cancer Res. , vol.67 , pp. 8274-8284
    • Son, Y.G.1    Kim, E.H.2    Kim, J.Y.3    Kim, S.U.4    Kwon, T.K.5    Yoon, A.R.6    Yun, C.O.7    Choi, K.S.8
  • 66
    • 41649085883 scopus 로고    scopus 로고
    • C-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in human lung cancer cells
    • Zou W., Chen S., Liu X., Yue P., Sporn M.B., Khuri F.R., Sun S.Y. c-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in human lung cancer cells. Cancer Biol. Ther. 2007, 6:1614-1620.
    • (2007) Cancer Biol. Ther. , vol.6 , pp. 1614-1620
    • Zou, W.1    Chen, S.2    Liu, X.3    Yue, P.4    Sporn, M.B.5    Khuri, F.R.6    Sun, S.Y.7
  • 68
    • 67649803012 scopus 로고    scopus 로고
    • Activation-induced degradation of FLIP(L) is mediated via the phosphatidylinositol 3-kinase/Akt signaling pathway in macrophages
    • Shi B., Tran T., Sobkoviak R., Pope R.M. Activation-induced degradation of FLIP(L) is mediated via the phosphatidylinositol 3-kinase/Akt signaling pathway in macrophages. J. Biol. Chem. 2009, 284:14513-14523.
    • (2009) J. Biol. Chem. , vol.284 , pp. 14513-14523
    • Shi, B.1    Tran, T.2    Sobkoviak, R.3    Pope, R.M.4
  • 70
    • 49149130029 scopus 로고    scopus 로고
    • The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulation
    • Wang L., Azad N., Kongkaneramit L., Chen F., Lu Y., Jiang B.H., Rojanasakul Y. The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulation. J. Immunol. 2008, 180:3072-3080.
    • (2008) J. Immunol. , vol.180 , pp. 3072-3080
    • Wang, L.1    Azad, N.2    Kongkaneramit, L.3    Chen, F.4    Lu, Y.5    Jiang, B.H.6    Rojanasakul, Y.7
  • 72
    • 4344660599 scopus 로고    scopus 로고
    • Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis
    • Chawla-Sarkar M., Bae S.I., Reu F.J., Jacobs B.S., Lindner D.J., Borden E.C. Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis. Cell Death Differ. 2004, 11:915-923.
    • (2004) Cell Death Differ. , vol.11 , pp. 915-923
    • Chawla-Sarkar, M.1    Bae, S.I.2    Reu, F.J.3    Jacobs, B.S.4    Lindner, D.J.5    Borden, E.C.6
  • 73
    • 30344452318 scopus 로고    scopus 로고
    • Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP
    • Galligan L., Longley D.B., McEwan M., Wilson T.R., McLaughlin K., Johnston P.G. Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP. Mol. Cancer Ther. 2005, 4:2026-2036.
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 2026-2036
    • Galligan, L.1    Longley, D.B.2    McEwan, M.3    Wilson, T.R.4    McLaughlin, K.5    Johnston, P.G.6
  • 74
    • 0141678063 scopus 로고    scopus 로고
    • Cisplatin down-regulation of cellular Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitory proteins to restore tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human melanoma cells
    • Song J.H., Song D.K., Herlyn M., Petruk K.C., Hao C. Cisplatin down-regulation of cellular Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitory proteins to restore tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human melanoma cells. Clin. Cancer Res. 2003, 9:4255-4266.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 4255-4266
    • Song, J.H.1    Song, D.K.2    Herlyn, M.3    Petruk, K.C.4    Hao, C.5
  • 75
    • 49649110459 scopus 로고    scopus 로고
    • Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells
    • Abedini M.R., Muller E.J., Brun J., Bergeron R., Gray D.A., Tsang B.K. Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells. Cancer Res. 2008, 68:4511-4517.
    • (2008) Cancer Res. , vol.68 , pp. 4511-4517
    • Abedini, M.R.1    Muller, E.J.2    Brun, J.3    Bergeron, R.4    Gray, D.A.5    Tsang, B.K.6
  • 76
    • 73849152723 scopus 로고    scopus 로고
    • Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein
    • Abedini M.R., Muller E.J., Bergeron R., Gray D.A., Tsang B.K. Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein. Oncogene 2010, 29:11-25.
    • (2010) Oncogene , vol.29 , pp. 11-25
    • Abedini, M.R.1    Muller, E.J.2    Bergeron, R.3    Gray, D.A.4    Tsang, B.K.5
  • 77
    • 0037470166 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells
    • Yang B.F., Xiao C., Roa W.H., Krammer P.H., Hao C. Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells. J. Biol. Chem. 2003, 278:7043-7050.
    • (2003) J. Biol. Chem. , vol.278 , pp. 7043-7050
    • Yang, B.F.1    Xiao, C.2    Roa, W.H.3    Krammer, P.H.4    Hao, C.5
  • 78
    • 62549102884 scopus 로고    scopus 로고
    • Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway
    • Park S.J., Kim M.J., Kim H.B., Sohn H.Y., Bae J.H., Kang C.D., Kim S.H. Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway. Biochem. Pharmacol. 2009, 77:1328-1336.
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 1328-1336
    • Park, S.J.1    Kim, M.J.2    Kim, H.B.3    Sohn, H.Y.4    Bae, J.H.5    Kang, C.D.6    Kim, S.H.7
  • 80
    • 40749116017 scopus 로고    scopus 로고
    • Bone marrow stroma confers resistance to Apo2 ligand/TRAIL in multiple myeloma in part by regulating c-FLIP
    • Perez L.E., Parquet N., Shain K., Nimmanapalli R., Alsina M., Anasetti C., Dalton W. Bone marrow stroma confers resistance to Apo2 ligand/TRAIL in multiple myeloma in part by regulating c-FLIP. J. Immunol. 2008, 180:1545-1555.
    • (2008) J. Immunol. , vol.180 , pp. 1545-1555
    • Perez, L.E.1    Parquet, N.2    Shain, K.3    Nimmanapalli, R.4    Alsina, M.5    Anasetti, C.6    Dalton, W.7
  • 84
    • 0037468930 scopus 로고    scopus 로고
    • Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells
    • Lacour S., Micheau O., Hammann A., Drouineaud V., Tschopp J., Solary E., Dimanche-Boitrel M.T. Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells. Oncogene 2003, 22:1807-1816.
    • (2003) Oncogene , vol.22 , pp. 1807-1816
    • Lacour, S.1    Micheau, O.2    Hammann, A.3    Drouineaud, V.4    Tschopp, J.5    Solary, E.6    Dimanche-Boitrel, M.T.7
  • 85
    • 38949181537 scopus 로고    scopus 로고
    • Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential combination therapies
    • Zhao X., Qiu W., Kung J., Peng X., Yegappan M., Yen-Lieberman B., Hsi E.D. Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential combination therapies. Leukemia Res. 2008, 32:275-285.
    • (2008) Leukemia Res. , vol.32 , pp. 275-285
    • Zhao, X.1    Qiu, W.2    Kung, J.3    Peng, X.4    Yegappan, M.5    Yen-Lieberman, B.6    Hsi, E.D.7
  • 89
    • 76249085456 scopus 로고    scopus 로고
    • Bortezomib restores stroma-mediated APO2L/TRAIL apoptosis resistance in multiple myeloma
    • Perez L.E., Parquet N., Meads M., Anasetti C., Dalton W. Bortezomib restores stroma-mediated APO2L/TRAIL apoptosis resistance in multiple myeloma. Eur. J. Haematol. 2010, 84:212-222.
    • (2010) Eur. J. Haematol. , vol.84 , pp. 212-222
    • Perez, L.E.1    Parquet, N.2    Meads, M.3    Anasetti, C.4    Dalton, W.5
  • 91
    • 34250332128 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells
    • Liu X., Yue P., Chen S., Hu L., Lonial S., Khuri F.R., Sun S.Y. The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells. Cancer Res. 2007, 67:4981-4988.
    • (2007) Cancer Res. , vol.67 , pp. 4981-4988
    • Liu, X.1    Yue, P.2    Chen, S.3    Hu, L.4    Lonial, S.5    Khuri, F.R.6    Sun, S.Y.7
  • 93
    • 0034059667 scopus 로고    scopus 로고
    • C-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells
    • Gregory M.A., Hann S.R. c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells. Mol. Cell Biol. 2000, 20:2423-2435.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 2423-2435
    • Gregory, M.A.1    Hann, S.R.2
  • 95
    • 0038362751 scopus 로고    scopus 로고
    • Akt activation promotes degradation of tuberin and FOXO3a via the proteasome
    • Plas D.R., Thompson C.B. Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. J. Biol. Chem. 2003, 278:12361-12366.
    • (2003) J. Biol. Chem. , vol.278 , pp. 12361-12366
    • Plas, D.R.1    Thompson, C.B.2
  • 96
    • 0034672278 scopus 로고    scopus 로고
    • Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression
    • Kinoshita H., Yoshikawa H., Shiiki K., Hamada Y., Nakajima Y., Tasaka K. Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression. Int. J. Cancer 2000, 88:986-991.
    • (2000) Int. J. Cancer , vol.88 , pp. 986-991
    • Kinoshita, H.1    Yoshikawa, H.2    Shiiki, K.3    Hamada, Y.4    Nakajima, Y.5    Tasaka, K.6
  • 97
    • 68149157348 scopus 로고    scopus 로고
    • Oxidative stress sensitizes bladder cancer cells to TRAIL mediated apoptosis by down-regulating anti-apoptotic proteins
    • White-Gilbertson S.J., Kasman L., McKillop J., Tirodkar T., Lu P., Voelkel-Johnson C. Oxidative stress sensitizes bladder cancer cells to TRAIL mediated apoptosis by down-regulating anti-apoptotic proteins. J. Urol. 2009, 182:1178-1185.
    • (2009) J. Urol. , vol.182 , pp. 1178-1185
    • White-Gilbertson, S.J.1    Kasman, L.2    McKillop, J.3    Tirodkar, T.4    Lu, P.5    Voelkel-Johnson, C.6
  • 98
    • 13144297792 scopus 로고    scopus 로고
    • Doxorubicin increases the effectiveness of Apo2L/TRAIL for tumor growth inhibition of prostate cancer xenografts
    • El-Zawahry A., McKillop J., Voelkel-Johnson C. Doxorubicin increases the effectiveness of Apo2L/TRAIL for tumor growth inhibition of prostate cancer xenografts. BMC Cancer 2005, 5:2.
    • (2005) BMC Cancer , vol.5 , pp. 2
    • El-Zawahry, A.1    McKillop, J.2    Voelkel-Johnson, C.3
  • 101
    • 34548410333 scopus 로고    scopus 로고
    • Inhibition of RIP and c-FLIP enhances TRAIL-induced apoptosis in pancreatic cancer cells
    • Wang P., Zhang J., Bellail A., Jiang W., Hugh J., Kneteman N.M., Hao C. Inhibition of RIP and c-FLIP enhances TRAIL-induced apoptosis in pancreatic cancer cells. Cell Signal 2007, 19:2237-2246.
    • (2007) Cell Signal , vol.19 , pp. 2237-2246
    • Wang, P.1    Zhang, J.2    Bellail, A.3    Jiang, W.4    Hugh, J.5    Kneteman, N.M.6    Hao, C.7
  • 102
    • 16644392631 scopus 로고    scopus 로고
    • Reduction of 9-nitrocamptothecin-triggered apoptosis in DU-145 human prostate cancer cells by ectopic expression of 14-3-3zeta
    • Chatterjee D., Goldman M., Braastad C.D., Darnowski J., Wyche J.H., Pantazis P., Goodglick L. Reduction of 9-nitrocamptothecin-triggered apoptosis in DU-145 human prostate cancer cells by ectopic expression of 14-3-3zeta. Int. J. Oncol. 2004, 25:503-509.
    • (2004) Int. J. Oncol. , vol.25 , pp. 503-509
    • Chatterjee, D.1    Goldman, M.2    Braastad, C.D.3    Darnowski, J.4    Wyche, J.H.5    Pantazis, P.6    Goodglick, L.7
  • 103
    • 3242659227 scopus 로고    scopus 로고
    • Resistance to TRAIL-induced apoptosis in ovarian cancer cell lines is overcome by co-treatment with cytotoxic drugs
    • Tomek S., Horak P., Pribill I., Haller G., Rossler M., Zielinski C.C., Pils D., Krainer M. Resistance to TRAIL-induced apoptosis in ovarian cancer cell lines is overcome by co-treatment with cytotoxic drugs. Gynecol. Oncol. 2004, 94:107-114.
    • (2004) Gynecol. Oncol. , vol.94 , pp. 107-114
    • Tomek, S.1    Horak, P.2    Pribill, I.3    Haller, G.4    Rossler, M.5    Zielinski, C.C.6    Pils, D.7    Krainer, M.8
  • 104
    • 59149087882 scopus 로고    scopus 로고
    • Suppression of cFLIP by lupeol, a dietary triterpene, is sufficient to overcome resistance to TRAIL-mediated apoptosis in chemoresistant human pancreatic cancer cells
    • Murtaza I., Saleem M., Adhami V.M., Hafeez B.B., Mukhtar H. Suppression of cFLIP by lupeol, a dietary triterpene, is sufficient to overcome resistance to TRAIL-mediated apoptosis in chemoresistant human pancreatic cancer cells. Cancer Res. 2009, 69:1156-1165.
    • (2009) Cancer Res. , vol.69 , pp. 1156-1165
    • Murtaza, I.1    Saleem, M.2    Adhami, V.M.3    Hafeez, B.B.4    Mukhtar, H.5
  • 105
    • 77951215549 scopus 로고    scopus 로고
    • Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors
    • Sung B., Park B., Yadav V.R., Aggarwal B.B. Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors. J. Biol. Chem. 2010, 285:11498-11507.
    • (2010) J. Biol. Chem. , vol.285 , pp. 11498-11507
    • Sung, B.1    Park, B.2    Yadav, V.R.3    Aggarwal, B.B.4
  • 106
    • 27144512700 scopus 로고    scopus 로고
    • Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion
    • Takada Y., Murakami A., Aggarwal B.B. Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion. Oncogene 2005, 24:6957-6969.
    • (2005) Oncogene , vol.24 , pp. 6957-6969
    • Takada, Y.1    Murakami, A.2    Aggarwal, B.B.3
  • 107
    • 67349228750 scopus 로고    scopus 로고
    • Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP
    • Lee T.J., Um H.J., Min do S., Park J.W., Choi K.S., Kwon T.K. Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. Free Radic. Biol. Med. 2009, 46:1639-1649.
    • (2009) Free Radic. Biol. Med. , vol.46 , pp. 1639-1649
    • Lee, T.J.1    Um, H.J.2    Min do, S.3    Park, J.W.4    Choi, K.S.5    Kwon, T.K.6
  • 108
    • 84856319831 scopus 로고    scopus 로고
    • Inhibition of NF-{kappa}B signaling by quinacrine is cytotoxic to human colon carcinoma cell lines (cc) and is synergistic in combination with TRAIL or oxaliplatin
    • Jani T.S., Devecchio J., Mazumdar T., Agyeman A., Houghton J.A. Inhibition of NF-{kappa}B signaling by quinacrine is cytotoxic to human colon carcinoma cell lines (cc) and is synergistic in combination with TRAIL or oxaliplatin. J. Biol. Chem. 2010.
    • (2010) J. Biol. Chem.
    • Jani, T.S.1    Devecchio, J.2    Mazumdar, T.3    Agyeman, A.4    Houghton, J.A.5
  • 109
    • 77952428515 scopus 로고    scopus 로고
    • Chrysin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB
    • Li X., Huang Q., Ong C.N., Yang X.F., Shen H.M. Chrysin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB. Cancer Lett. 2010, 293:109-116.
    • (2010) Cancer Lett. , vol.293 , pp. 109-116
    • Li, X.1    Huang, Q.2    Ong, C.N.3    Yang, X.F.4    Shen, H.M.5
  • 110
    • 73349109760 scopus 로고    scopus 로고
    • Triterpenoids as new promising anticancer drugs
    • Petronelli A., Pannitteri G., Testa U. Triterpenoids as new promising anticancer drugs. Anticancer Drugs 2009, 20:880-892.
    • (2009) Anticancer Drugs , vol.20 , pp. 880-892
    • Petronelli, A.1    Pannitteri, G.2    Testa, U.3
  • 111
    • 69249229667 scopus 로고    scopus 로고
    • RNA interference in cancer: targeting the anti-apoptotic protein c-FLIP for drug discovery
    • Day T.W., Safa A.R. RNA interference in cancer: targeting the anti-apoptotic protein c-FLIP for drug discovery. Mini Rev. Med. Chem. 2009, 9:741-748.
    • (2009) Mini Rev. Med. Chem. , vol.9 , pp. 741-748
    • Day, T.W.1    Safa, A.R.2
  • 114
    • 77957013134 scopus 로고    scopus 로고
    • Insights on distinct pathways of thiazolidinediones (PPARgamma ligand)-promoted apoptosis in TRAIL-sensitive or -resistant malignant urothelial cells
    • Plissonnier M.L., Fauconnet S., Bittard H., Lascombe I. Insights on distinct pathways of thiazolidinediones (PPARgamma ligand)-promoted apoptosis in TRAIL-sensitive or -resistant malignant urothelial cells. Int. J. Cancer 2010.
    • (2010) Int. J. Cancer
    • Plissonnier, M.L.1    Fauconnet, S.2    Bittard, H.3    Lascombe, I.4
  • 116
    • 33747383912 scopus 로고    scopus 로고
    • Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and survivin
    • Schultze K., Bock B., Eckert A., Oevermann L., Ramacher D., Wiestler O., Roth W. Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and survivin. Apoptosis 2006, 11:1503-1512.
    • (2006) Apoptosis , vol.11 , pp. 1503-1512
    • Schultze, K.1    Bock, B.2    Eckert, A.3    Oevermann, L.4    Ramacher, D.5    Wiestler, O.6    Roth, W.7
  • 118
    • 75749135253 scopus 로고    scopus 로고
    • Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma
    • Katz S.I., Zhou L., Chao G., Smith C.D., Ferrara T., Wang W., Dicker D.T., El-Deiry W.S. Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma. Cancer Biol. Ther. 2009, 8:2406-2416.
    • (2009) Cancer Biol. Ther. , vol.8 , pp. 2406-2416
    • Katz, S.I.1    Zhou, L.2    Chao, G.3    Smith, C.D.4    Ferrara, T.5    Wang, W.6    Dicker, D.T.7    El-Deiry, W.S.8
  • 119
    • 33646086961 scopus 로고    scopus 로고
    • Cellular FLICE-like inhibitory protein (c-FLIP): a novel target for taxol-induced apoptosis
    • Day T.W., Najafi F., Wu C.H., Safa A.R. Cellular FLICE-like inhibitory protein (c-FLIP): a novel target for taxol-induced apoptosis. Biochem. Pharmacol. 2006, 71:1551-1561.
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 1551-1561
    • Day, T.W.1    Najafi, F.2    Wu, C.H.3    Safa, A.R.4
  • 120
    • 61449099307 scopus 로고    scopus 로고
    • Genistein enhances proteasomal degradation of the short isoform of FLIP in malignant glioma cells and thereby augments TRAIL-mediated apoptosis
    • Siegelin M.D., Siegelin Y., Habel A., Gaiser T. Genistein enhances proteasomal degradation of the short isoform of FLIP in malignant glioma cells and thereby augments TRAIL-mediated apoptosis. Neurosci. Lett. 2009, 453:92-97.
    • (2009) Neurosci. Lett. , vol.453 , pp. 92-97
    • Siegelin, M.D.1    Siegelin, Y.2    Habel, A.3    Gaiser, T.4
  • 121
    • 33845738765 scopus 로고    scopus 로고
    • Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells
    • Liu X., Yue P., Schonthal A.H., Khuri F.R., Sun S.Y. Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. Cancer Res. 2006, 66:11115-11119.
    • (2006) Cancer Res. , vol.66 , pp. 11115-11119
    • Liu, X.1    Yue, P.2    Schonthal, A.H.3    Khuri, F.R.4    Sun, S.Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.