메뉴 건너뛰기




Volumn 144, Issue 6, 2011, Pages 926-939

Measuring and modeling apoptosis in single cells

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE;

EID: 79952635820     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2011.03.002     Document Type: Review
Times cited : (271)

References (93)
  • 2
    • 41549132691 scopus 로고    scopus 로고
    • Quantitative Analysis of Pathways Controlling Extrinsic Apoptosis in Single Cells
    • DOI 10.1016/j.molcel.2008.02.012, PII S1097276508001317
    • Albeck, J.G., Burke, J.M., Aldridge, B.B., Zhang, M., Lauffenburger, D.A., and Sorger, P.K. (2008a). Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol. Cell 30, 11-25. (Pubitemid 351470145)
    • (2008) Molecular Cell , vol.30 , Issue.1 , pp. 11-25
    • Albeck, J.G.1    Burke, J.M.2    Aldridge, B.B.3    Zhang, M.4    Lauffenburger, D.A.5    Sorger, P.K.6
  • 3
    • 84883829346 scopus 로고    scopus 로고
    • Modeling a snap-action, variable-delay switch controlling extrinsic cell death
    • Albeck, J.G., Burke, J.M., Spencer, S.L., Lauffenburger, D.A., and Sorger, P.K. (2008b). Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol. 6, 2831-2852.
    • (2008) PLoS Biol. , vol.6 , pp. 2831-2852
    • Albeck, J.G.1    Burke, J.M.2    Spencer, S.L.3    Lauffenburger, D.A.4    Sorger, P.K.5
  • 5
    • 33646124974 scopus 로고    scopus 로고
    • Bistability in apoptosis: Roles of bax, bcl-2, and mitochondrial permeability transition pores
    • Bagci, E.Z., Vodovotz, Y., Billiar, T.R., Ermentrout, G.B., and Bahar, I. (2006). Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores. Biophys. J. 90, 1546-1559.
    • (2006) Biophys. J. , vol.90 , pp. 1546-1559
    • Bagci, E.Z.1    Vodovotz, Y.2    Billiar, T.R.3    Ermentrout, G.B.4    Bahar, I.5
  • 7
    • 28544437234 scopus 로고    scopus 로고
    • Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity
    • DOI 10.1038/sj.leu.2403966, PII 2403966
    • Betti, C.J., Villalobos, M.J., Jiang, Q., Cline, E., Diaz, M.O., Loredo, G., and Vaughan, A.T. (2005). Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity. Leukemia 19, 2289-2295. (Pubitemid 41741626)
    • (2005) Leukemia , vol.19 , Issue.12 , pp. 2289-2295
    • Betti, C.J.1    Villalobos, M.J.2    Jiang, Q.3    Cline, E.4    Diaz, M.O.5    Loredo, G.6    Vaughan, A.T.M.7
  • 8
    • 70849090419 scopus 로고    scopus 로고
    • Determinism and divergence of apoptosis susceptibility in mammalian cells
    • Bhola, P.D., and Simon, S.M. (2009). Determinism and divergence of apoptosis susceptibility in mammalian cells. J. Cell Sci. 122, 4296-4302.
    • (2009) J. Cell Sci. , vol.122 , pp. 4296-4302
    • Bhola, P.D.1    Simon, S.M.2
  • 12
    • 34250350056 scopus 로고    scopus 로고
    • Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision
    • DOI 10.1529/biophysj.106.099606
    • Chen, C., Cui, J., Lu, H., Wang, R., Zhang, S., and Shen, P. (2007). Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision. Biophys. J. 92, 4304-4315. (Pubitemid 46910545)
    • (2007) Biophysical Journal , vol.92 , Issue.12 , pp. 4304-4315
    • Chen, C.1    Cui, J.2    Lu, H.3    Wang, R.4    Zhang, S.5    Shen, P.6
  • 13
    • 77956289955 scopus 로고    scopus 로고
    • Classic and contemporary approaches to modeling biochemical reactions
    • Chen, W.W., Niepel, M., and Sorger, P.K. (2010). Classic and contemporary approaches to modeling biochemical reactions. Genes Dev. 24, 1861-1875.
    • (2010) Genes Dev. , vol.24 , pp. 1861-1875
    • Chen, W.W.1    Niepel, M.2    Sorger, P.K.3
  • 14
    • 33745950626 scopus 로고    scopus 로고
    • Mitochondrial outer membrane permeabilization during apoptosis: The innocent bystander scenario
    • DOI 10.1038/sj.cdd.4401963, PII 4401963
    • Chipuk, J.E., Bouchier-Hayes, L., and Green, D.R. (2006). Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death Differ. 13, 1396-1402. (Pubitemid 44057475)
    • (2006) Cell Death and Differentiation , vol.13 , Issue.8 , pp. 1396-1402
    • Chipuk, J.E.1    Bouchier-Hayes, L.2    Green, D.R.3
  • 15
    • 41149152733 scopus 로고    scopus 로고
    • How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
    • Chipuk, J.E., and Green, D.R. (2008). How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol. 18, 157-164.
    • (2008) Trends Cell Biol. , vol.18 , pp. 157-164
    • Chipuk, J.E.1    Green, D.R.2
  • 18
    • 34547603628 scopus 로고    scopus 로고
    • BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents
    • Deng, J., Carlson, N., Takeyama, K., Dal Cin, P., Shipp, M., and Letai, A. (2007). BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Cancer Cell 12, 171-185.
    • (2007) Cancer Cell , vol.12 , pp. 171-185
    • Deng, J.1    Carlson, N.2    Takeyama, K.3    Dal Cin, P.4    Shipp, M.5    Letai, A.6
  • 19
    • 74249096386 scopus 로고    scopus 로고
    • Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation
    • Dussmann, H., Rehm, M., Concannon, C.G., Anguissola, S., Wurstle, M., Kacmar, S., Voller, P., Huber, H.J., and Prehn, J.H. (2010). Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation. Cell Death Differ. 17, 278-290.
    • (2010) Cell Death Differ. , vol.17 , pp. 278-290
    • Dussmann, H.1    Rehm, M.2    Concannon, C.G.3    Anguissola, S.4    Wurstle, M.5    Kacmar, S.6    Voller, P.7    Huber, H.J.8    Prehn, J.H.9
  • 22
    • 31144431501 scopus 로고    scopus 로고
    • Robustness properties of apoptosis models with respect to parameter variations and intrinsic noise
    • Stevenage
    • Eissing, T., Allgower, F., and Bullinger, E. (2005). Robustness properties of apoptosis models with respect to parameter variations and intrinsic noise. Syst. Biol. (Stevenage) 152, 221-228.
    • (2005) Syst. Biol. , vol.152 , pp. 221-228
    • Eissing, T.1    Allgower, F.2    Bullinger, E.3
  • 24
    • 65649154507 scopus 로고    scopus 로고
    • Rule-based modeling of biochemical systems with BioNetGen
    • Faeder, J.R., Blinov, M.L., and Hlavacek, W.S. (2009). Rule-based modeling of biochemical systems with BioNetGen. Methods Mol. Biol. 500, 113-167.
    • (2009) Methods Mol. Biol. , vol.500 , pp. 113-167
    • Faeder, J.R.1    Blinov, M.L.2    Hlavacek, W.S.3
  • 26
    • 0032496358 scopus 로고    scopus 로고
    • The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes
    • Ferrell, J.E., Jr., and Machleder, E.M. (1998). The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. Science 280, 895-898.
    • (1998) Science , vol.280 , pp. 895-898
    • Ferrell Jr., J.E.1    Machleder, E.M.2
  • 27
    • 77955465116 scopus 로고    scopus 로고
    • Model-based dissection of CD95 signaling dynamics reveals both a pro- And antiapoptotic role of c-FLIPL
    • Fricker, N., Beaudouin, J., Richter, P., Eils, R., Krammer, P.H., and Lavrik, I.N. (2010). Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL. J. Cell Biol. 190, 377-389.
    • (2010) J. Cell Biol. , vol.190 , pp. 377-389
    • Fricker, N.1    Beaudouin, J.2    Richter, P.3    Eils, R.4    Krammer, P.H.5    Lavrik, I.N.6
  • 28
    • 33750247101 scopus 로고    scopus 로고
    • Linking stochastic dynamics to population distribution: An analytical framework of gene expression
    • Friedman, N., Cai, L., and Xie, X.S. (2006). Linking stochastic dynamics to population distribution: an analytical framework of gene expression. Phys. Rev. Lett. 97, 168302.
    • (2006) Phys. Rev. Lett. , vol.97 , pp. 168302
    • Friedman, N.1    Cai, L.2    Xie, X.S.3
  • 29
    • 10644282148 scopus 로고    scopus 로고
    • The protein structures that shape caspase activity, specificity, activation and inhibition
    • DOI 10.1042/BJ20041142
    • Fuentes-Prior, P., and Salvesen, G.S. (2004). The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem. J. 384, 201-232. (Pubitemid 39656233)
    • (2004) Biochemical Journal , vol.384 , Issue.2 , pp. 201-232
    • Fuentes-Prior, P.1    Salvesen, G.S.2
  • 30
    • 0033925842 scopus 로고    scopus 로고
    • A mathematical model of caspase function in apoptosis
    • Fussenegger, M., Bailey, J.E., and Varner, J. (2000). A mathematical model of caspase function in apoptosis. Nat. Biotechnol. 18, 768-774.
    • (2000) Nat. Biotechnol. , vol.18 , pp. 768-774
    • Fussenegger, M.1    Bailey, J.E.2    Varner, J.3
  • 31
    • 48449098623 scopus 로고    scopus 로고
    • Cancer cells display profound intraand interline variation following prolonged exposure to antimitotic drugs
    • Gascoigne, K.E., and Taylor, S.S. (2008). Cancer cells display profound intraand interline variation following prolonged exposure to antimitotic drugs. Cancer Cell 14, 111-122.
    • (2008) Cancer Cell , vol.14 , pp. 111-122
    • Gascoigne, K.E.1    Taylor, S.S.2
  • 33
    • 33645429016 scopus 로고
    • Exact stochastic simulation of coupled chemical reactions
    • Gillespie, D.T. (1977). Exact stochastic simulation of coupled chemical reactions. J. Phys. Chem. 81, 2340-2361.
    • (1977) J. Phys. Chem. , vol.81 , pp. 2340-2361
    • Gillespie, D.T.1
  • 34
    • 0034517367 scopus 로고    scopus 로고
    • A single cell analysis of apoptosis. Ordering the apoptotic phenotype
    • Goldstein, J.C., Kluck, R.M., and Green, D.R. (2000a). A single cell analysis of apoptosis. Ordering the apoptotic phenotype. Ann. N Y Acad. Sci. 926, 132-141.
    • (2000) Ann. N Y Acad. Sci. , vol.926 , pp. 132-141
    • Goldstein, J.C.1    Kluck, R.M.2    Green, D.R.3
  • 35
    • 0033781027 scopus 로고    scopus 로고
    • The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
    • Goldstein, J.C., Waterhouse, N.J., Juin, P., Evan, G.I., and Green, D.R. (2000b). The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant. Nat. Cell Biol. 2, 156-162.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 156-162
    • Goldstein, J.C.1    Waterhouse, N.J.2    Juin, P.3    Evan, G.I.4    Green, D.R.5
  • 37
    • 77956170550 scopus 로고    scopus 로고
    • New insights into apoptosis signaling by Apo2L/TRAIL
    • Gonzalvez, F., and Ashkenazi, A. (2010). New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene 29, 4752-4765.
    • (2010) Oncogene , vol.29 , pp. 4752-4765
    • Gonzalvez, F.1    Ashkenazi, A.2
  • 39
    • 52049091499 scopus 로고    scopus 로고
    • Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation
    • Hellwig, C.T., Kohler, B.F., Lehtivarjo, A.K., Dussmann, H., Courtney, M.J., Prehn, J.H., and Rehm, M. (2008). Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation. J. Biol. Chem. 283, 21676-21685.
    • (2008) J. Biol. Chem. , vol.283 , pp. 21676-21685
    • Hellwig, C.T.1    Kohler, B.F.2    Lehtivarjo, A.K.3    Dussmann, H.4    Courtney, M.J.5    Prehn, J.H.6    Rehm, M.7
  • 41
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner, M.O. (2000). The biochemistry of apoptosis. Nature 407, 770-776.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 43
    • 78349284384 scopus 로고    scopus 로고
    • Bistability in apoptosis by receptor clustering
    • Ho, K.L., and Harrington, H.A. (2010). Bistability in apoptosis by receptor clustering. PLoS Comput. Biol. 6, e1000956.
    • (2010) PLoS Comput. Biol. , vol.6
    • Ho, K.L.1    Harrington, H.A.2
  • 44
    • 0037044575 scopus 로고    scopus 로고
    • The IkappaB-NF-kappaB signaling module: Temporal control and selective gene activation
    • DOI 10.1126/science.1071914
    • Hoffmann, A., Levchenko, A., Scott, M.L., and Baltimore, D. (2002). The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science 298, 1241-1245. (Pubitemid 35285493)
    • (2002) Science , vol.298 , Issue.5596 , pp. 1241-1245
    • Hoffmann, A.1    Levchenko, A.2    Scott, M.L.3    Baltimore, D.4
  • 45
    • 23244462491 scopus 로고    scopus 로고
    • Effects of Bcl-2 levels on fas signaling-induced caspase-3 activation: Molecular genetic tests of computational model predictions
    • Hua, F., Cornejo, M.G., Cardone, M.H, Stokes, C.L., and Lauffenburger, D.A. (2005). Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation: molecular genetic tests of computational model predictions. J. Immunol. 175, 985-995. (Pubitemid 41094983)
    • (2005) Journal of Immunology , vol.175 , Issue.2 , pp. 985-995
    • Hua, F.1    Cornejo, M.G.2    Cardone, M.H.3    Stokes, C.L.4    Lauffenburger, D.A.5
  • 46
    • 78650992174 scopus 로고    scopus 로고
    • Stochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrest
    • Huang, H.C., Mitchison, T.J., and Shi, J. (2010). Stochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrest. PLoS One 5, e15724.
    • (2010) PLoS One , vol.5
    • Huang, H.C.1    Mitchison, T.J.2    Shi, J.3
  • 47
    • 33750374139 scopus 로고    scopus 로고
    • Linking data to models: Data regression
    • Jaqaman, K., and Danuser, G. (2006). Linking data to models: data regression. Nat. Rev. Mol. Cell Biol. 7, 813-819.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 813-819
    • Jaqaman, K.1    Danuser, G.2
  • 49
    • 0034630167 scopus 로고    scopus 로고
    • Induction of apoptosis by cancer chemotherapy
    • Kaufmann, S.H., and Earnshaw, W.C. (2000). Induction of apoptosis by cancer chemotherapy. Exp. Cell Res. 256, 42-49.
    • (2000) Exp. Cell Res. , vol.256 , pp. 42-49
    • Kaufmann, S.H.1    Earnshaw, W.C.2
  • 52
    • 16344387146 scopus 로고    scopus 로고
    • Stochastic simulations of the origins and implications of long-tailed distributions in gene expression
    • Krishna, S., Banerjee, B., Ramakrishnan, T.V., and Shivashankar, G.V. (2005). Stochastic simulations of the origins and implications of long-tailed distributions in gene expression. Proc. Natl. Acad. Sci. USA 102, 4771-4776.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 4771-4776
    • Krishna, S.1    Banerjee, B.2    Ramakrishnan, T.V.3    Shivashankar, G.V.4
  • 53
    • 34250346095 scopus 로고    scopus 로고
    • Analysis of CD95 threshold signaling: Triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling
    • Lavrik, I.N., Golks, A., Riess, D., Bentele, M., Eils, R., and Krammer, P.H. (2007). Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling. J. Biol. Chem. 282, 13664-13671.
    • (2007) J. Biol. Chem. , vol.282 , pp. 13664-13671
    • Lavrik, I.N.1    Golks, A.2    Riess, D.3    Bentele, M.4    Eils, R.5    Krammer, P.H.6
  • 55
    • 33749370199 scopus 로고    scopus 로고
    • Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability
    • Legewie, S., Bluthgen, N., and Herzel, H. (2006). Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability. PLoS Comput. Biol. 2, e120.
    • (2006) PLoS Comput. Biol. , vol.2
    • Legewie, S.1    Bluthgen, N.2    Herzel, H.3
  • 56
    • 38549145044 scopus 로고    scopus 로고
    • Diagnosing and exploiting cancer's addiction to blocks in apoptosis
    • Letai, A.G. (2008). Diagnosing and exploiting cancer's addiction to blocks in apoptosis. Nat. Rev. Cancer 8, 121-132.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 121-132
    • Letai, A.G.1
  • 57
    • 57149135309 scopus 로고    scopus 로고
    • Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax
    • Lovell, J.F., Billen, L.P., Bindner, S., Shamas-Din, A., Fradin, C., Leber, B., and Andrews, D.W. (2008). Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. Cell 135, 1074-1084.
    • (2008) Cell , vol.135 , pp. 1074-1084
    • Lovell, J.F.1    Billen, L.P.2    Bindner, S.3    Shamas-Din, A.4    Fradin, C.5    Leber, B.6    Andrews, D.W.7
  • 58
    • 77956630795 scopus 로고    scopus 로고
    • TRAIL treatment provokes mutations in surviving cells
    • Lovric, M.M., and Hawkins, C.J. (2010). TRAIL treatment provokes mutations in surviving cells. Oncogene 29, 5048-5060.
    • (2010) Oncogene , vol.29 , pp. 5048-5060
    • Lovric, M.M.1    Hawkins, C.J.2
  • 59
    • 34547577428 scopus 로고    scopus 로고
    • Computationally derived points of fragility of a human cascade are consistent with current therapeutic strategies
    • Luan, D., Zai, M., and Varner, J.D. (2007). Computationally derived points of fragility of a human cascade are consistent with current therapeutic strategies. PLoS Comput. Biol. 3, e142.
    • (2007) PLoS Comput. Biol. , vol.3
    • Luan, D.1    Zai, M.2    Varner, J.D.3
  • 60
    • 0037414451 scopus 로고    scopus 로고
    • Measuring dynamics of caspase-8 activation in a single living HeLa cell during TNFalpha-induced apoptosis
    • Luo, K.Q., Yu, V.C., Pu, Y., and Chang, D.C. (2003). Measuring dynamics of caspase-8 activation in a single living HeLa cell during TNFalpha-induced apoptosis. Biochem. Biophys. Res. Commun. 304, 217-222.
    • (2003) Biochem. Biophys. Res. Commun. , vol.304 , pp. 217-222
    • Luo, K.Q.1    Yu, V.C.2    Pu, Y.3    Chang, D.C.4
  • 61
    • 77956702972 scopus 로고    scopus 로고
    • Smac/DIABLO release from mitochondria and XIAP inhibition are essential to limit clonogenicity of type I tumor cells after TRAIL receptor stimulation
    • Maas, C., Verbrugge, I., de Vries, E., Savich, G., van de Kooij, L.W., Tait, S.W., and Borst, J. (2010). Smac/DIABLO release from mitochondria and XIAP inhibition are essential to limit clonogenicity of type I tumor cells after TRAIL receptor stimulation. Cell Death Differ. 17, 1613-1623.
    • (2010) Cell Death Differ. , vol.17 , pp. 1613-1623
    • Maas, C.1    Verbrugge, I.2    De Vries, E.3    Savich, G.4    Van De Kooij, L.W.5    Tait, S.W.6    Borst, J.7
  • 62
    • 0037085380 scopus 로고    scopus 로고
    • Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization
    • Madesh, M., Antonsson, B., Srinivasula, S.M., Alnemri, E.S., and Hajnoczky, G. (2002). Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization. J. Biol. Chem. 277, 5651-5659.
    • (2002) J. Biol. Chem. , vol.277 , pp. 5651-5659
    • Madesh, M.1    Antonsson, B.2    Srinivasula, S.M.3    Alnemri, E.S.4    Hajnoczky, G.5
  • 65
    • 70549093092 scopus 로고    scopus 로고
    • Non-genetic cell-to-cell variability and the consequences for pharmacology
    • Niepel, M., Spencer, S.L., and Sorger, P.K. (2009). Non-genetic cell-to-cell variability and the consequences for pharmacology. Curr. Opin. Chem. Biol. 13, 556-561.
    • (2009) Curr. Opin. Chem. Biol. , vol.13 , pp. 556-561
    • Niepel, M.1    Spencer, S.L.2    Sorger, P.K.3
  • 66
    • 56249107716 scopus 로고    scopus 로고
    • Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
    • Orth, J.D., Tang, Y., Shi, J., Loy, C.T., Amendt, C., Wilm, C., Zenke, F.T., and Mitchison, T.J. (2008). Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate. Mol. Cancer Ther. 7, 3480-3489.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 3480-3489
    • Orth, J.D.1    Tang, Y.2    Shi, J.3    Loy, C.T.4    Amendt, C.5    Wilm, C.6    Zenke, F.T.7    Mitchison, T.J.8
  • 67
    • 1442354192 scopus 로고    scopus 로고
    • Multistability in the lactose utilization network of Escherichia coli
    • DOI 10.1038/nature02298
    • Ozbudak, E.M., Thattai, M., Lim, H.N., Shraiman, B.I., and Van Oudenaarden, A. (2004). Multistability in the lactose utilization network of Escherichia coli. Nature 427, 737-740. (Pubitemid 38294592)
    • (2004) Nature , vol.427 , Issue.6976 , pp. 737-740
    • Ozbudak, E.M.1    Thattal, M.2    Lim, H.H.3    Shraiman, B.I.4    Van Oudenaarden, A.5
  • 68
    • 53549123008 scopus 로고    scopus 로고
    • Nature, nurture, or chance: Stochastic gene expression and its consequences
    • Raj, A., and van Oudenaarden, A. (2008). Nature, nurture, or chance: stochastic gene expression and its consequences. Cell 135, 216-226.
    • (2008) Cell , vol.135 , pp. 216-226
    • Raj, A.1    Van Oudenaarden, A.2
  • 69
    • 0037025346 scopus 로고    scopus 로고
    • Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3
    • Rehm, M., Dussmann, H., Janicke, R.U., Tavare, J.M., Kogel, D., and Prehn, J.H. (2002). Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3. J. Biol. Chem. 277, 24506-24514.
    • (2002) J. Biol. Chem. , vol.277 , pp. 24506-24514
    • Rehm, M.1    Dussmann, H.2    Janicke, R.U.3    Tavare, J.M.4    Kogel, D.5    Prehn, J.H.6
  • 70
    • 0141768255 scopus 로고    scopus 로고
    • Real-time single cell analysis of Smac/DIABLO release during apoptosis
    • DOI 10.1083/jcb.200303123
    • Rehm, M., Dussmann, H., and Prehn, J.H. (2003). Real-time single cell analysis of Smac/DIABLO release during apoptosis. J. Cell Biol. 162, 1031-1043. (Pubitemid 37174186)
    • (2003) Journal of Cell Biology , vol.162 , Issue.6 , pp. 1031-1043
    • Rehm, M.1    Dussgmann, H.2    Prehn, J.H.M.3
  • 71
    • 33748941571 scopus 로고    scopus 로고
    • Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein
    • DOI 10.1038/sj.emboj.7601295, PII 7601295
    • Rehm, M., Huber, H.J., Dussmann, H., and Prehn, J.H. (2006). Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein. EMBO J. 25, 4338-4349. (Pubitemid 44435231)
    • (2006) EMBO Journal , vol.25 , Issue.18 , pp. 4338-4349
    • Rehm, M.1    Huber, H.J.2    Dussmann, H.3    Prehn, J.H.M.4
  • 73
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • DOI 10.1038/35102167
    • Reya, T., Morrison, S.J., Clarke, M.F., and Weissman, I.L. (2001). Stem cells, cancer, and cancer stem cells. Nature 414, 105-111. (Pubitemid 33041634)
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 75
    • 50049110244 scopus 로고    scopus 로고
    • Regulation of apoptosis by XIAP ubiquitin-ligase activity
    • Schile, A.J., Garcia-Fernandez, M., and Steller, H. (2008). Regulation of apoptosis by XIAP ubiquitin-ligase activity. Genes Dev. 22, 2256-2266.
    • (2008) Genes Dev. , vol.22 , pp. 2256-2266
    • Schile, A.J.1    Garcia-Fernandez, M.2    Steller, H.3
  • 76
    • 47749089820 scopus 로고    scopus 로고
    • Regulation of TNFR1 and CD95 signalling by receptor compartmentalization
    • Schutze, S., Tchikov, V., and Schneider-Brachert, W. (2008). Regulation of TNFR1 and CD95 signalling by receptor compartmentalization. Nat. Rev. Mol. Cell Biol. 9, 655-662.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 655-662
    • Schutze, S.1    Tchikov, V.2    Schneider-Brachert, W.3
  • 79
    • 0005578015 scopus 로고    scopus 로고
    • Sixth Edition Philadelphia: Lippincott Williams & Wilkins
    • Skeel, R.T. (2003). Handbook of Cancer Chemotherapy, Sixth Edition (Philadelphia: Lippincott Williams & Wilkins).
    • (2003) Handbook of Cancer Chemotherapy
    • Skeel, R.T.1
  • 80
    • 66249136447 scopus 로고    scopus 로고
    • Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
    • Spencer, S.L., Gaudet, S., Albeck, J.G., Burke, J.M., and Sorger, P.K. (2009). Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 459, 428-432.
    • (2009) Nature , vol.459 , pp. 428-432
    • Spencer, S.L.1    Gaudet, S.2    Albeck, J.G.3    Burke, J.M.4    Sorger, P.K.5
  • 81
    • 0034283578 scopus 로고    scopus 로고
    • Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8
    • Stennicke, H.R., Renatus, M., Meldal, M., and Salvesen, G.S. (2000). Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8. Biochem. J. 350, 563-568.
    • (2000) Biochem. J. , vol.350 , pp. 563-568
    • Stennicke, H.R.1    Renatus, M.2    Meldal, M.3    Salvesen, G.S.4
  • 82
    • 76749131517 scopus 로고    scopus 로고
    • Evaluating bistability of Bax activation switch
    • Sun, T., Lin, X., Wei, Y., Xu, Y., and Shen, P. (2010). Evaluating bistability of Bax activation switch. FEBS Lett. 584, 954-960.
    • (2010) FEBS Lett. , vol.584 , pp. 954-960
    • Sun, T.1    Lin, X.2    Wei, Y.3    Xu, Y.4    Shen, P.5
  • 84
  • 85
    • 0034280126 scopus 로고    scopus 로고
    • Rapid caspase-3 activation during apoptosis revealed using fluorescence-resonance energy transfer
    • Tyas, L., Brophy, V.A., Pope, A., Rivett, A.J., and Tavare, J.M. (2000). Rapid caspase-3 activation during apoptosis revealed using fluorescence- resonance energy transfer. EMBO Rep. 1, 266-270.
    • (2000) EMBO Rep. , vol.1 , pp. 266-270
    • Tyas, L.1    Brophy, V.A.2    Pope, A.3    Rivett, A.J.4    Tavare, J.M.5
  • 86
    • 0036211060 scopus 로고    scopus 로고
    • Surviving apoptosis
    • DOI 10.1023/A:1014374717773
    • Vaughan, A.T., Betti, C.J., and Villalobos, M.J. (2002). Surviving apoptosis. Apoptosis 7, 173-177. (Pubitemid 34273133)
    • (2002) Apoptosis , vol.7 , Issue.2 , pp. 173-177
    • Vaughan, A.T.M.1    Betti, C.J.2    Villalobos, M.J.3
  • 88
    • 33744760150 scopus 로고    scopus 로고
    • Detection of DNA double-strand breaks and chromosome translocations using ligation-mediated PCR and inverse PCR
    • Villalobos, M.J., Betti, C.J., and Vaughan, A.T. (2006). Detection of DNA double-strand breaks and chromosome translocations using ligation-mediated PCR and inverse PCR. Methods Mol. Biol. 314, 109-121.
    • (2006) Methods Mol. Biol. , vol.314 , pp. 109-121
    • Villalobos, M.J.1    Betti, C.J.2    Vaughan, A.T.3
  • 89
    • 0034605121 scopus 로고    scopus 로고
    • Preservation of mitochondrial structure and function after Bid- Or Bax-mediated cytochrome c release
    • von Ahsen, O., Renken, C., Perkins, G., Kluck, R.M., Bossy-Wetzel, E., and Newmeyer, D.D. (2000). Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release. J. Cell Biol. 150, 1027-1036.
    • (2000) J. Cell Biol. , vol.150 , pp. 1027-1036
    • Von Ahsen, O.1    Renken, C.2    Perkins, G.3    Kluck, R.M.4    Bossy-Wetzel, E.5    Newmeyer, D.D.6
  • 91
    • 77958493422 scopus 로고    scopus 로고
    • The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling
    • Wurstle, M.L., Laussmann, M.A., and Rehm, M. (2010). The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling. J. Biol. Chem. 285, 33209-33218.
    • (2010) J. Biol. Chem. , vol.285 , pp. 33209-33218
    • Wurstle, M.L.1    Laussmann, M.A.2    Rehm, M.3
  • 92
    • 14644437742 scopus 로고    scopus 로고
    • Mechanisms of resistance to TRAIL-induced apoptosis in cancer
    • DOI 10.1038/sj.cgt.7700792
    • Zhang, L., and Fang, B. (2005). Mechanisms of resistance to TRAIL-induced apoptosis in cancer. Cancer Gene Ther. 12, 228-237. (Pubitemid 40315182)
    • (2005) Cancer Gene Therapy , vol.12 , Issue.3 , pp. 228-237
    • Zhang, L.1    Fang, B.2
  • 93
    • 0001508049 scopus 로고
    • Comparison of deterministic and stochastic kinetics for nonlinear systems
    • Zheng, Q., and Ross, J. (1991). Comparison of deterministic and stochastic kinetics for nonlinear systems. J. Chem. Phys. 94, 3644-3648.
    • (1991) J. Chem. Phys. , vol.94 , pp. 3644-3648
    • Zheng, Q.1    Ross, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.