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Volumn 14, Issue 5, 2013, Pages 414-421

Another fork in the road - Life or death decisions by the tumour suppressor p53

Author keywords

apoptosis; cell cycle arrest; cellular stress; p53; transcription

Indexed keywords

PROTEIN P53; TUMOR SUPPRESSOR PROTEIN;

EID: 84877574804     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2013.25     Document Type: Review
Times cited : (128)

References (68)
  • 1
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • DOI 10.1016/S0092-8674(00)81871-1
    • Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88: 323-331 (Pubitemid 27131374)
    • (1997) Cell , vol.88 , Issue.3 , pp. 323-331
    • Levine, A.J.1
  • 2
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • DOI 10.1038/387299a0
    • Kubbutat MH, Jones SN, Vousden KH (1997) Regulation of p53 stability by Mdm2. Nature 387: 299-303 (Pubitemid 27220767)
    • (1997) Nature , vol.387 , Issue.6630 , pp. 299-303
    • Kubbutat, M.H.G.1    Jones, S.N.2    Vousden, K.H.3
  • 3
    • 33847271089 scopus 로고    scopus 로고
    • Coping with stress: Multiple ways to activate p53
    • DOI 10.1038/sj.onc.1210263, PII 1210263
    • Horn HF, Vousden KH (2007) Coping with stress: multiple ways to activate p53. Oncogene 26: 1306-1316 (Pubitemid 46328472)
    • (2007) Oncogene , vol.26 , Issue.9 , pp. 1306-1316
    • Horn, H.F.1    Vousden, K.H.2
  • 4
    • 77955858336 scopus 로고    scopus 로고
    • Posttranslational modification of p53: Cooperative integrators of function
    • Meek DW, Anderson CW (2009) Posttranslational modification of p53: cooperative integrators of function. Cold Spring Harb Perspect Biol 1: a000950
    • (2009) Cold Spring Harb Perspect Biol , vol.1
    • Meek, D.W.1    Anderson, C.W.2
  • 5
    • 33845270990 scopus 로고    scopus 로고
    • Regulating the p53 pathway: In vitro hypotheses, in vivo veritas
    • DOI 10.1038/nrc2012, PII NRC2012
    • Toledo F, Wahl GM (2006) Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer 6: 909-923 (Pubitemid 44862676)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.12 , pp. 909-923
    • Toledo, F.1    Wahl, G.M.2
  • 6
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the light: The growing complexity of p53
    • Vousden KH, Prives C (2009) Blinded by the light: the growing complexity of p53. Cell 137: 413-431
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 9
  • 10
    • 84861973567 scopus 로고    scopus 로고
    • Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
    • Li T, Kon N, Jiang L, Tan M, Ludwig T, Zhao Y, Baer R, Gu W (2012) Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell 149: 1269-1283
    • (2012) Cell , vol.149 , pp. 1269-1283
    • Li, T.1    Kon, N.2    Jiang, L.3    Tan, M.4    Ludwig, T.5    Zhao, Y.6    Baer, R.7    Gu, W.8
  • 15
    • 78650018910 scopus 로고    scopus 로고
    • Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo
    • Jackson JG, Post SM, Lozano G (2011) Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo. J Pathol 223: 127-136
    • (2011) J Pathol , vol.223 , pp. 127-136
    • Jackson, J.G.1    Post, S.M.2    Lozano, G.3
  • 16
    • 0029802591 scopus 로고    scopus 로고
    • P53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
    • Chen X, Ko LJ, Jayaraman L, Prives C (1996) p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev 10: 2438-2451 (Pubitemid 26341879)
    • (1996) Genes and Development , vol.10 , Issue.19 , pp. 2438-2451
    • Chen, X.1    Ko, L.J.2    Jayaraman, L.3    Prives, C.4
  • 17
    • 0032528245 scopus 로고    scopus 로고
    • Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53
    • Resnick-Silverman L, St Clair S, Maurer M, Zhao K, Manfredi JJ (1998) Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53. Genes Dev 12: 2102-2107 (Pubitemid 28348033)
    • (1998) Genes and Development , vol.12 , Issue.14 , pp. 2102-2107
    • Resnick-Silverman, L.1    St. Clair, S.2    Maurer, M.3    Zhao, K.4    Manfredi, J.J.5
  • 18
    • 0036892060 scopus 로고    scopus 로고
    • Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence
    • DOI 10.1128/MCB.22.24.8612-8625.2002
    • Inga A, Storici F, Darden TA, Resnick MA (2002) Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence. Mol Cell Biol 22: 8612-8625 (Pubitemid 35397176)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.24 , pp. 8612-8625
    • Inga, A.1    Storici, F.2    Darden, T.A.3    Resnick, M.A.4
  • 19
    • 17144399973 scopus 로고    scopus 로고
    • Comparative binding of p53 to its promoter and DNA recognition elements
    • DOI 10.1016/j.jmb.2005.03.014
    • Weinberg RL, Veprintsev DB, Bycroft M, Fersht AR (2005) Comparative binding of p53 to its promoter and DNA recognition elements. J Mol Biol 348: 589-596 (Pubitemid 40515671)
    • (2005) Journal of Molecular Biology , vol.348 , Issue.3 , pp. 589-596
    • Weinberg, R.L.1    Veprintsev, D.B.2    Bycroft, M.3    Fersht, A.R.4
  • 20
    • 0242329884 scopus 로고    scopus 로고
    • P53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage
    • DOI 10.1016/S1097-2765(03)00359-9
    • Espinosa JM, Verdun RE, Emerson BM (2003) p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Mol Cell 12: 1015-1027 (Pubitemid 37352792)
    • (2003) Molecular Cell , vol.12 , Issue.4 , pp. 1015-1027
    • Espinosa, J.M.1    Verdun, R.E.2    Emerson, B.M.3
  • 21
    • 75149175733 scopus 로고    scopus 로고
    • Regulation of the p53 transcriptional response by structurally diverse core promoters
    • Morachis JM, Murawsky CM, Emerson BM (2010) Regulation of the p53 transcriptional response by structurally diverse core promoters. Genes Dev 24: 135-147
    • (2010) Genes Dev , vol.24 , pp. 135-147
    • Morachis, J.M.1    Murawsky, C.M.2    Emerson, B.M.3
  • 22
    • 0037108159 scopus 로고    scopus 로고
    • The RNA polymerase II core promoter: A key component in the regulation of gene expression
    • Butler JE, Kadonaga JT (2002) The RNA polymerase II core promoter: a key component in the regulation of gene expression. Genes Dev 16: 2583-2592
    • (2002) Genes Dev , vol.16 , pp. 2583-2592
    • Butler, J.E.1    Kadonaga, J.T.2
  • 25
    • 0033485261 scopus 로고    scopus 로고
    • Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
    • Bulavin DV, Saito S, Hollander MC, Sakaguchi K, Anderson CW, Appella E, Fornace AJ Jr (1999) Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J 18: 6845-6854
    • (1999) EMBO J , vol.18 , pp. 6845-6854
    • Bulavin, D.V.1    Saito, S.2    Hollander, M.C.3    Sakaguchi, K.4    Anderson, C.W.5    Appella, E.6    Fornace Jr., A.J.7
  • 26
    • 0034664733 scopus 로고    scopus 로고
    • P53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
    • Oda K et al (2000) p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 102: 849-862
    • (2000) Cell , vol.102 , pp. 849-862
    • Oda, K.1
  • 27
    • 18244379872 scopus 로고    scopus 로고
    • Homeodomain-interacting protein kinase-2 phosphorylates p53 at ser 46 and mediates apoptosis
    • D'Orazi G et al (2002) Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 4: 11-19
    • (2002) Nat Cell Biol , vol.4 , pp. 11-19
    • D'Orazi, G.1
  • 29
    • 33847365838 scopus 로고    scopus 로고
    • MDM2-Regulated Degradation of HIPK2 Prevents p53Ser46 Phosphorylation and DNA Damage-Induced Apoptosis
    • DOI 10.1016/j.molcel.2007.02.008, PII S1097276507000883
    • Rinaldo C, Prodosmo A, Mancini F, Iacovelli S, Sacchi A, Moretti F, Soddu S (2007) MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis. Mol Cell 25: 739-750 (Pubitemid 46341925)
    • (2007) Molecular Cell , vol.25 , Issue.5 , pp. 739-750
    • Rinaldo, C.1    Prodosmo, A.2    Mancini, F.3    Iacovelli, S.4    Sacchi, A.5    Moretti, F.6    Soddu, S.7
  • 30
    • 33847350861 scopus 로고    scopus 로고
    • DYRK2 Is Targeted to the Nucleus and Controls p53 via Ser46 Phosphorylation in the Apoptotic Response to DNA Damage
    • DOI 10.1016/j.molcel.2007.02.007, PII S1097276507000871
    • Taira N, Nihira K, Yamaguchi T, Miki Y, Yoshida K (2007) DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Mol Cell 25: 725-738 (Pubitemid 46341924)
    • (2007) Molecular Cell , vol.25 , Issue.5 , pp. 725-738
    • Taira, N.1    Nihira, K.2    Yamaguchi, T.3    Miki, Y.4    Yoshida, K.5
  • 31
    • 33845433364 scopus 로고    scopus 로고
    • Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence
    • Feng L, Hollstein M, Xu Y (2006) Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence. Cell Cycle 5: 2812-2819 (Pubitemid 44901744)
    • (2006) Cell Cycle , vol.5 , Issue.23 , pp. 2812-2819
    • Feng, L.1    Hollstein, M.2    Xu, Y.3
  • 32
    • 0026687883 scopus 로고
    • Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53
    • Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E, Anderson CW (1992) Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol 12: 5041-5049
    • (1992) Mol Cell Biol , vol.12 , pp. 5041-5049
    • Lees-Miller, S.P.1    Sakaguchi, K.2    Ullrich, S.J.3    Appella, E.4    Anderson, C.W.5
  • 35
    • 0029941651 scopus 로고    scopus 로고
    • P53-Dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts
    • Huang LC, Clarkin KC, Wahl GM (1996) p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts. Cancer Res 56: 2940-2944 (Pubitemid 26199736)
    • (1996) Cancer Research , vol.56 , Issue.13 , pp. 2940-2944
    • Huang, L.-C.1    Clarkin, K.C.2    Wahl, G.M.3
  • 36
    • 0031025079 scopus 로고    scopus 로고
    • DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage
    • Rathmell WK, Kaufmann WK, Hurt JC, Byrd LL, Chu G (1997) DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage. Cancer Res 57: 68-74 (Pubitemid 27020332)
    • (1997) Cancer Research , vol.57 , Issue.1 , pp. 68-74
    • Rathmell, W.K.1    Kaufmann, W.K.2    Hurt, J.C.3    Byrd, L.L.4    Chu, G.5
  • 37
    • 0032508504 scopus 로고    scopus 로고
    • Enhanced phosphorylation of p53 by ATM in response to DNA damage
    • Banin S et al (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281: 1674-1677
    • (1998) Science , vol.281 , pp. 1674-1677
    • Banin, S.1
  • 41
    • 0034142034 scopus 로고    scopus 로고
    • The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate, p53 at multiple DNA damage-inducible sites
    • Shieh SY, Ahn J, Tamai K, Taya Y, Prives C (2000) The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 14: 289-300 (Pubitemid 30106484)
    • (2000) Genes and Development , vol.14 , Issue.3 , pp. 289-300
    • Shieh, S.-Y.1    Ahn, J.2    Tamai, K.3    Taya, Y.4    Prives, C.5
  • 42
    • 33745752959 scopus 로고    scopus 로고
    • Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression
    • DOI 10.1038/sj.emboj.7601167, PII 7601167
    • Chao C, Herr D, Chun J, Xu Y (2006) Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J 25: 2615-2622 (Pubitemid 44012243)
    • (2006) EMBO Journal , vol.25 , Issue.11 , pp. 2615-2622
    • Chao, C.1    Herr, D.2    Chun, J.3    Xu, Y.4
  • 43
    • 79958068204 scopus 로고    scopus 로고
    • Phosphorylation of tip60 by gsk-3 determines the induction of puma and apoptosis by p53
    • Charvet C et al (2011) Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell 42: 584-596
    • (2011) Mol Cell , vol.42 , pp. 584-596
    • Charvet, C.1
  • 44
    • 33845668241 scopus 로고    scopus 로고
    • Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
    • DOI 10.1016/j.molcel.2006.11.021, PII S109727650600815X
    • Tang Y, Luo J, Zhang W, Gu W (2006) Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell 24: 827-839 (Pubitemid 44960094)
    • (2006) Molecular Cell , vol.24 , Issue.6 , pp. 827-839
    • Tang, Y.1    Luo, J.2    Zhang, W.3    Gu, W.4
  • 45
    • 33845656738 scopus 로고    scopus 로고
    • Acetylation of the p53 DNA-binding domain regulates apoptosis induction
    • DOI 10.1016/j.molcel.2006.11.026, PII S1097276506008215
    • Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, McMahon SB (2006) Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell 24: 841-851 (Pubitemid 44960096)
    • (2006) Molecular Cell , vol.24 , Issue.6 , pp. 841-851
    • Sykes, S.M.1    Mellert, H.S.2    Holbert, M.A.3    Li, K.4    Marmorstein, R.5    Lane, W.S.6    McMahon, S.B.7
  • 53
    • 33646578801 scopus 로고    scopus 로고
    • ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth
    • DOI 10.1101/gad.374006
    • Vives V, Su J, Zhong S, Ratnayaka I, Slee E, Goldin R, Lu X (2006) ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. Genes Dev 20: 1262-1267 (Pubitemid 43727587)
    • (2006) Genes and Development , vol.20 , Issue.10 , pp. 1262-1267
    • Vives, V.1    Su, J.2    Zhong, S.3    Ratnayaka, I.4    Slee, E.5    Goldin, R.6    Lu, X.7
  • 58
    • 82755186506 scopus 로고    scopus 로고
    • Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90
    • Dai C, Tang Y, Jung SY, Qin J, Aaronson SA, Gu W (2011) Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci USA 108: 18937-18942
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 18937-18942
    • Dai, C.1    Tang, Y.2    Jung, S.Y.3    Qin, J.4    Aaronson, S.A.5    Gu, W.6
  • 59
    • 34548049032 scopus 로고    scopus 로고
    • Hzf Determines Cell Survival upon Genotoxic Stress by Modulating p53 Transactivation
    • DOI 10.1016/j.cell.2007.06.013, PII S0092867407007799
    • Das S, Raj L, Zhao B, Kimura Y, Bernstein A, Aaronson SA, Lee SW (2007) Hzf determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell 130: 624-637 (Pubitemid 47277418)
    • (2007) Cell , vol.130 , Issue.4 , pp. 624-637
    • Das, S.1    Raj, L.2    Zhao, B.3    Kimura, Y.4    Bernstein, A.5    Aaronson, S.A.6    Lee, S.W.7
  • 60
    • 34547956843 scopus 로고    scopus 로고
    • HCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes
    • DOI 10.1016/j.cell.2007.08.001, PII S0092867407010203
    • Tanaka T, Ohkubo S, Tatsuno I, Prives C (2007) hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. Cell 130: 638-650 (Pubitemid 47268061)
    • (2007) Cell , vol.130 , Issue.4 , pp. 638-650
    • Tanaka, T.1    Ohkubo, S.2    Tatsuno, I.3    Prives, C.4
  • 62
    • 0842278331 scopus 로고    scopus 로고
    • Direct activation of bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    • DOI 10.1126/science.1092734
    • Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303: 1010-1014 (Pubitemid 38209704)
    • (2004) Science , vol.303 , Issue.5660 , pp. 1010-1014
    • Chipuk, J.E.1    Kuwana, T.2    Bouchier-Hayes, L.3    Droin, N.M.4    Newmeyer, D.D.5    Schuler, M.6    Green, D.R.7
  • 63
    • 24644436766 scopus 로고    scopus 로고
    • Cell biology: PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
    • DOI 10.1126/science.1114297
    • Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR (2005) PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 309: 1732-1735 (Pubitemid 41285944)
    • (2005) Science , vol.309 , Issue.5741 , pp. 1732-1735
    • Chipuk, J.E.1    Bouchier-Hayes, L.2    Kuwana, T.3    Newmeyer, D.D.4    Green, D.R.5
  • 65
    • 84862675016 scopus 로고    scopus 로고
    • P53 opens the mitochondrial permeability transition pore to trigger necrosis
    • Vaseva AV, Marchenko ND, Ji K, Tsirka SE, Holzmann S, Moll UM (2012) p53 opens the mitochondrial permeability transition pore to trigger necrosis. Cell 149: 1536-1548
    • (2012) Cell , vol.149 , pp. 1536-1548
    • Vaseva, A.V.1    Marchenko, N.D.2    Ji, K.3    Tsirka, S.E.4    Holzmann, S.5    Moll, U.M.6
  • 66
    • 79955795151 scopus 로고    scopus 로고
    • Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression
    • Brady CA et al (2011) Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell 145: 571-583
    • (2011) Cell , vol.145 , pp. 571-583
    • Brady, C.A.1
  • 67
    • 65449154815 scopus 로고    scopus 로고
    • Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis
    • Grinkevich VV et al (2009) Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis. Cancer Cell 15: 441-453
    • (2009) Cancer Cell , vol.15 , pp. 441-453
    • Grinkevich, V.V.1
  • 68
    • 60649103811 scopus 로고    scopus 로고
    • MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53
    • Enge M, Bao W, Hedström E, Jackson SP, Moumen A, Selivanova G (2009) MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53. Cancer Cell 15: 171-183
    • (2009) Cancer Cell , vol.15 , pp. 171-183
    • Enge, M.1    Bao, W.2    Hedström, E.3    Jackson, S.P.4    Moumen, A.5    Selivanova, G.6


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