-
1
-
-
0030941458
-
P53, the cellular gatekeeper for growth and division
-
DOI 10.1016/S0092-8674(00)81871-1
-
Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88: 323-331 (Pubitemid 27131374)
-
(1997)
Cell
, vol.88
, Issue.3
, pp. 323-331
-
-
Levine, A.J.1
-
2
-
-
0030965946
-
Regulation of p53 stability by Mdm2
-
DOI 10.1038/387299a0
-
Kubbutat MH, Jones SN, Vousden KH (1997) Regulation of p53 stability by Mdm2. Nature 387: 299-303 (Pubitemid 27220767)
-
(1997)
Nature
, vol.387
, Issue.6630
, pp. 299-303
-
-
Kubbutat, M.H.G.1
Jones, S.N.2
Vousden, K.H.3
-
3
-
-
33847271089
-
Coping with stress: Multiple ways to activate p53
-
DOI 10.1038/sj.onc.1210263, PII 1210263
-
Horn HF, Vousden KH (2007) Coping with stress: multiple ways to activate p53. Oncogene 26: 1306-1316 (Pubitemid 46328472)
-
(2007)
Oncogene
, vol.26
, Issue.9
, pp. 1306-1316
-
-
Horn, H.F.1
Vousden, K.H.2
-
4
-
-
77955858336
-
Posttranslational modification of p53: Cooperative integrators of function
-
Meek DW, Anderson CW (2009) Posttranslational modification of p53: cooperative integrators of function. Cold Spring Harb Perspect Biol 1: a000950
-
(2009)
Cold Spring Harb Perspect Biol
, vol.1
-
-
Meek, D.W.1
Anderson, C.W.2
-
5
-
-
33845270990
-
Regulating the p53 pathway: In vitro hypotheses, in vivo veritas
-
DOI 10.1038/nrc2012, PII NRC2012
-
Toledo F, Wahl GM (2006) Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer 6: 909-923 (Pubitemid 44862676)
-
(2006)
Nature Reviews Cancer
, vol.6
, Issue.12
, pp. 909-923
-
-
Toledo, F.1
Wahl, G.M.2
-
6
-
-
65349103899
-
Blinded by the light: The growing complexity of p53
-
Vousden KH, Prives C (2009) Blinded by the light: the growing complexity of p53. Cell 137: 413-431
-
(2009)
Cell
, vol.137
, pp. 413-431
-
-
Vousden, K.H.1
Prives, C.2
-
7
-
-
0034656243
-
Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
-
Zhao R, Gish K, Murphy M, Yin Y, Notterman D, Hoffman WH, Tom E, Mack DH, Levine AJ (2000) Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev 14: 981-993 (Pubitemid 30253006)
-
(2000)
Genes and Development
, vol.14
, Issue.8
, pp. 981-993
-
-
Zhao, R.1
Gish, K.2
Murphy, M.3
Yin, Y.4
Notterman, D.5
Hoffman, W.H.6
Tom, E.7
Mack, D.H.8
Levine, A.J.9
-
8
-
-
12444252198
-
Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression
-
DOI 10.1038/sj.onc.1206477
-
Mirza A et al (2003) Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression. Oncogene 22: 3645-3654 (Pubitemid 36765324)
-
(2003)
Oncogene
, vol.22
, Issue.23
, pp. 3645-3654
-
-
Mirza, A.1
Wu, Q.2
Wang, L.3
McClanahan, T.4
Bishop, W.R.5
Gheyas, F.6
Ding, W.7
Hutchins, B.8
Hockenberry, T.9
Kirschmeier, P.10
Greene, J.R.11
Liu, S.12
-
9
-
-
0030930366
-
A model for p53-induced apoptosis
-
DOI 10.1038/38525
-
Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B (1997) A model for p53-induced apoptosis. Nature 389: 300-305 (Pubitemid 27406646)
-
(1997)
Nature
, vol.389
, Issue.6648
, pp. 300-305
-
-
Polyak, K.1
Xia, Y.2
Zweier, J.L.3
Kinzler, K.W.4
Vogelstein, B.5
-
10
-
-
84861973567
-
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
-
Li T, Kon N, Jiang L, Tan M, Ludwig T, Zhao Y, Baer R, Gu W (2012) Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell 149: 1269-1283
-
(2012)
Cell
, vol.149
, pp. 1269-1283
-
-
Li, T.1
Kon, N.2
Jiang, L.3
Tan, M.4
Ludwig, T.5
Zhao, Y.6
Baer, R.7
Gu, W.8
-
13
-
-
42449114966
-
Transcriptional control of human p53-regulated genes
-
DOI 10.1038/nrm2395, PII NRM2395
-
Riley T, Sontag E, Chen P, Levine A (2008) Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol 9: 402-412 (Pubitemid 351574202)
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, Issue.5
, pp. 402-412
-
-
Riley, T.1
Sontag, E.2
Chen, P.3
Levine, A.4
-
14
-
-
0026849821
-
Definition of a consensus binding site for p53
-
el-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW, Vogelstein B (1992) Definition of a consensus binding site for p53. Nat Genet 1: 45-49
-
(1992)
Nat Genet
, vol.1
, pp. 45-49
-
-
El-Deiry, W.S.1
Kern, S.E.2
Pietenpol, J.A.3
Kinzler, K.W.4
Vogelstein, B.5
-
15
-
-
78650018910
-
Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo
-
Jackson JG, Post SM, Lozano G (2011) Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo. J Pathol 223: 127-136
-
(2011)
J Pathol
, vol.223
, pp. 127-136
-
-
Jackson, J.G.1
Post, S.M.2
Lozano, G.3
-
16
-
-
0029802591
-
P53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
-
Chen X, Ko LJ, Jayaraman L, Prives C (1996) p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev 10: 2438-2451 (Pubitemid 26341879)
-
(1996)
Genes and Development
, vol.10
, Issue.19
, pp. 2438-2451
-
-
Chen, X.1
Ko, L.J.2
Jayaraman, L.3
Prives, C.4
-
17
-
-
0032528245
-
Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53
-
Resnick-Silverman L, St Clair S, Maurer M, Zhao K, Manfredi JJ (1998) Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53. Genes Dev 12: 2102-2107 (Pubitemid 28348033)
-
(1998)
Genes and Development
, vol.12
, Issue.14
, pp. 2102-2107
-
-
Resnick-Silverman, L.1
St. Clair, S.2
Maurer, M.3
Zhao, K.4
Manfredi, J.J.5
-
18
-
-
0036892060
-
Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence
-
DOI 10.1128/MCB.22.24.8612-8625.2002
-
Inga A, Storici F, Darden TA, Resnick MA (2002) Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence. Mol Cell Biol 22: 8612-8625 (Pubitemid 35397176)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.24
, pp. 8612-8625
-
-
Inga, A.1
Storici, F.2
Darden, T.A.3
Resnick, M.A.4
-
19
-
-
17144399973
-
Comparative binding of p53 to its promoter and DNA recognition elements
-
DOI 10.1016/j.jmb.2005.03.014
-
Weinberg RL, Veprintsev DB, Bycroft M, Fersht AR (2005) Comparative binding of p53 to its promoter and DNA recognition elements. J Mol Biol 348: 589-596 (Pubitemid 40515671)
-
(2005)
Journal of Molecular Biology
, vol.348
, Issue.3
, pp. 589-596
-
-
Weinberg, R.L.1
Veprintsev, D.B.2
Bycroft, M.3
Fersht, A.R.4
-
20
-
-
0242329884
-
P53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage
-
DOI 10.1016/S1097-2765(03)00359-9
-
Espinosa JM, Verdun RE, Emerson BM (2003) p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Mol Cell 12: 1015-1027 (Pubitemid 37352792)
-
(2003)
Molecular Cell
, vol.12
, Issue.4
, pp. 1015-1027
-
-
Espinosa, J.M.1
Verdun, R.E.2
Emerson, B.M.3
-
21
-
-
75149175733
-
Regulation of the p53 transcriptional response by structurally diverse core promoters
-
Morachis JM, Murawsky CM, Emerson BM (2010) Regulation of the p53 transcriptional response by structurally diverse core promoters. Genes Dev 24: 135-147
-
(2010)
Genes Dev
, vol.24
, pp. 135-147
-
-
Morachis, J.M.1
Murawsky, C.M.2
Emerson, B.M.3
-
22
-
-
0037108159
-
The RNA polymerase II core promoter: A key component in the regulation of gene expression
-
Butler JE, Kadonaga JT (2002) The RNA polymerase II core promoter: a key component in the regulation of gene expression. Genes Dev 16: 2583-2592
-
(2002)
Genes Dev
, vol.16
, pp. 2583-2592
-
-
Butler, J.E.1
Kadonaga, J.T.2
-
24
-
-
84862270480
-
P53 dynamics control cell fate
-
Purvis JE, Karhohs KW, Mock C, Batchelor E, Loewer A, Lahav G (2012) p53 dynamics control cell fate. Science 336: 1440-1444
-
(2012)
Science
, vol.336
, pp. 1440-1444
-
-
Purvis, J.E.1
Karhohs, K.W.2
Mock, C.3
Batchelor, E.4
Loewer, A.5
Lahav, G.6
-
25
-
-
0033485261
-
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
-
Bulavin DV, Saito S, Hollander MC, Sakaguchi K, Anderson CW, Appella E, Fornace AJ Jr (1999) Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J 18: 6845-6854
-
(1999)
EMBO J
, vol.18
, pp. 6845-6854
-
-
Bulavin, D.V.1
Saito, S.2
Hollander, M.C.3
Sakaguchi, K.4
Anderson, C.W.5
Appella, E.6
Fornace Jr., A.J.7
-
26
-
-
0034664733
-
P53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
-
Oda K et al (2000) p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 102: 849-862
-
(2000)
Cell
, vol.102
, pp. 849-862
-
-
Oda, K.1
-
27
-
-
18244379872
-
Homeodomain-interacting protein kinase-2 phosphorylates p53 at ser 46 and mediates apoptosis
-
D'Orazi G et al (2002) Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 4: 11-19
-
(2002)
Nat Cell Biol
, vol.4
, pp. 11-19
-
-
D'Orazi, G.1
-
28
-
-
0036141392
-
Regulation of p53 activity by its interaction with homeodomain- interacting protein kinase-2
-
DOI 10.1038/ncb715
-
Hofmann TG, Moller A, Sirma H, Zentgraf H, Taya Y, Droge W, Will H, Schmitz ML (2002) Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol 4: 1-10 (Pubitemid 34071974)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.1
, pp. 1-10
-
-
Hofmann, T.G.1
Moller, A.2
Sirma, H.3
Zentgraf, H.4
Taya, Y.5
Droge, W.6
Will, H.7
Lienhard Schmitz, M.8
-
29
-
-
33847365838
-
MDM2-Regulated Degradation of HIPK2 Prevents p53Ser46 Phosphorylation and DNA Damage-Induced Apoptosis
-
DOI 10.1016/j.molcel.2007.02.008, PII S1097276507000883
-
Rinaldo C, Prodosmo A, Mancini F, Iacovelli S, Sacchi A, Moretti F, Soddu S (2007) MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis. Mol Cell 25: 739-750 (Pubitemid 46341925)
-
(2007)
Molecular Cell
, vol.25
, Issue.5
, pp. 739-750
-
-
Rinaldo, C.1
Prodosmo, A.2
Mancini, F.3
Iacovelli, S.4
Sacchi, A.5
Moretti, F.6
Soddu, S.7
-
30
-
-
33847350861
-
DYRK2 Is Targeted to the Nucleus and Controls p53 via Ser46 Phosphorylation in the Apoptotic Response to DNA Damage
-
DOI 10.1016/j.molcel.2007.02.007, PII S1097276507000871
-
Taira N, Nihira K, Yamaguchi T, Miki Y, Yoshida K (2007) DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Mol Cell 25: 725-738 (Pubitemid 46341924)
-
(2007)
Molecular Cell
, vol.25
, Issue.5
, pp. 725-738
-
-
Taira, N.1
Nihira, K.2
Yamaguchi, T.3
Miki, Y.4
Yoshida, K.5
-
31
-
-
33845433364
-
Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence
-
Feng L, Hollstein M, Xu Y (2006) Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence. Cell Cycle 5: 2812-2819 (Pubitemid 44901744)
-
(2006)
Cell Cycle
, vol.5
, Issue.23
, pp. 2812-2819
-
-
Feng, L.1
Hollstein, M.2
Xu, Y.3
-
32
-
-
0026687883
-
Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53
-
Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E, Anderson CW (1992) Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol 12: 5041-5049
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5041-5049
-
-
Lees-Miller, S.P.1
Sakaguchi, K.2
Ullrich, S.J.3
Appella, E.4
Anderson, C.W.5
-
33
-
-
0031435944
-
DNA damage induces phosphorylation of the amino terminus of p53
-
Siliciano JD, Canman CE, Taya Y, Sakaguchi K, Appella E, Kastan MB (1997) DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev 11: 3471-3481 (Pubitemid 28023968)
-
(1997)
Genes and Development
, vol.11
, Issue.24
, pp. 3471-3481
-
-
Siliciano, J.D.1
Canman, C.E.2
Taya, Y.3
Sakaguchi, K.4
Appella, E.5
Kastan, M.B.6
-
34
-
-
0027155885
-
Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression
-
Fiscella M, Ullrich SJ, Zambrano N, Shields MT, Lin D, Lees-Miller SP, Anderson CW, Mercer WE, Appella E (1993) Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression. Oncogene 8: 1519-1528 (Pubitemid 23189048)
-
(1993)
Oncogene
, vol.8
, Issue.6
, pp. 1519-1528
-
-
Fiscella, M.1
Ullrich, S.J.2
Zambrano, N.3
Shields, M.T.4
Lin, D.5
Lees-Miller, S.P.6
Anderson, C.W.7
Mercer, W.E.8
Appella, E.9
-
35
-
-
0029941651
-
P53-Dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts
-
Huang LC, Clarkin KC, Wahl GM (1996) p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts. Cancer Res 56: 2940-2944 (Pubitemid 26199736)
-
(1996)
Cancer Research
, vol.56
, Issue.13
, pp. 2940-2944
-
-
Huang, L.-C.1
Clarkin, K.C.2
Wahl, G.M.3
-
36
-
-
0031025079
-
DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage
-
Rathmell WK, Kaufmann WK, Hurt JC, Byrd LL, Chu G (1997) DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage. Cancer Res 57: 68-74 (Pubitemid 27020332)
-
(1997)
Cancer Research
, vol.57
, Issue.1
, pp. 68-74
-
-
Rathmell, W.K.1
Kaufmann, W.K.2
Hurt, J.C.3
Byrd, L.L.4
Chu, G.5
-
37
-
-
0032508504
-
Enhanced phosphorylation of p53 by ATM in response to DNA damage
-
Banin S et al (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281: 1674-1677
-
(1998)
Science
, vol.281
, pp. 1674-1677
-
-
Banin, S.1
-
38
-
-
0032508608
-
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
-
DOI 10.1126/science.281.5383.1677
-
Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281: 1677-1679 (Pubitemid 28435584)
-
(1998)
Science
, vol.281
, Issue.5383
, pp. 1677-1679
-
-
Canman, C.E.1
Lim, D.-S.2
Cimprich, K.A.3
Taya, Y.4
Tamai, K.5
Sakaguchi, K.6
Appella, E.7
Kastan, M.B.8
Siliciano, J.D.9
-
39
-
-
0037066695
-
46, in response to ionizing radiation
-
DOI 10.1074/jbc.C200093200
-
Saito S, Goodarzi AA, Higashimoto Y, Noda Y, Lees-Miller SP, Appella E, Anderson CW (2002) ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. J Biol Chem 277: 12491-12494 (Pubitemid 34952604)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.15
, pp. 12491-12494
-
-
Saito, S.1
Goodarzi, A.A.2
Higashimoto, Y.3
Noda, Y.4
Lees-Miller, S.P.5
Appella, E.6
Anderson, C.W.7
-
40
-
-
0034142325
-
1 by stabilizing p53
-
Chehab NH, Malikzay A, Appel M, Halazonetis TD (2000) Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev 14: 278-288 (Pubitemid 30106483)
-
(2000)
Genes and Development
, vol.14
, Issue.3
, pp. 278-288
-
-
Chehab, N.H.1
Malikzay, A.2
Appel, M.3
Halazonetis, T.D.4
-
41
-
-
0034142034
-
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate, p53 at multiple DNA damage-inducible sites
-
Shieh SY, Ahn J, Tamai K, Taya Y, Prives C (2000) The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 14: 289-300 (Pubitemid 30106484)
-
(2000)
Genes and Development
, vol.14
, Issue.3
, pp. 289-300
-
-
Shieh, S.-Y.1
Ahn, J.2
Tamai, K.3
Taya, Y.4
Prives, C.5
-
42
-
-
33745752959
-
Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression
-
DOI 10.1038/sj.emboj.7601167, PII 7601167
-
Chao C, Herr D, Chun J, Xu Y (2006) Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J 25: 2615-2622 (Pubitemid 44012243)
-
(2006)
EMBO Journal
, vol.25
, Issue.11
, pp. 2615-2622
-
-
Chao, C.1
Herr, D.2
Chun, J.3
Xu, Y.4
-
43
-
-
79958068204
-
Phosphorylation of tip60 by gsk-3 determines the induction of puma and apoptosis by p53
-
Charvet C et al (2011) Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell 42: 584-596
-
(2011)
Mol Cell
, vol.42
, pp. 584-596
-
-
Charvet, C.1
-
44
-
-
33845668241
-
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
-
DOI 10.1016/j.molcel.2006.11.021, PII S109727650600815X
-
Tang Y, Luo J, Zhang W, Gu W (2006) Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell 24: 827-839 (Pubitemid 44960094)
-
(2006)
Molecular Cell
, vol.24
, Issue.6
, pp. 827-839
-
-
Tang, Y.1
Luo, J.2
Zhang, W.3
Gu, W.4
-
45
-
-
33845656738
-
Acetylation of the p53 DNA-binding domain regulates apoptosis induction
-
DOI 10.1016/j.molcel.2006.11.026, PII S1097276506008215
-
Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, McMahon SB (2006) Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell 24: 841-851 (Pubitemid 44960096)
-
(2006)
Molecular Cell
, vol.24
, Issue.6
, pp. 841-851
-
-
Sykes, S.M.1
Mellert, H.S.2
Holbert, M.A.3
Li, K.4
Marmorstein, R.5
Lane, W.S.6
McMahon, S.B.7
-
46
-
-
33750834640
-
E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation
-
DOI 10.1016/j.cell.2006.09.031, PII S0092867406012918
-
Le Cam L et al (2006) E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. Cell 127: 775-788 (Pubitemid 44716249)
-
(2006)
Cell
, vol.127
, Issue.4
, pp. 775-788
-
-
Le Cam, L.1
Linares, L.K.2
Paul, C.3
Julien, E.4
Lacroix, M.5
Hatchi, E.6
Triboulet, R.7
Bossis, G.8
Shmueli, A.9
Rodriguez, M.S.10
Coux, O.11
Sardet, C.12
-
47
-
-
0032906633
-
P53 Sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
-
Liu L, Scolnick DM, Trievel RC, Zhang HB, Marmorstein R, Halazonetis TD, Berger SL (1999) p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol 19: 1202-1209 (Pubitemid 29046862)
-
(1999)
Molecular and Cellular Biology
, vol.19
, Issue.2
, pp. 1202-1209
-
-
Liu, L.1
Scolnick, D.M.2
Trievel, R.C.3
Zhang, H.B.4
Marmorstein, R.5
Halazonetis, T.D.6
Berger, S.L.7
-
48
-
-
33646817028
-
Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate
-
DOI 10.1083/jcb.200512059
-
Knights CD et al (2006) Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate. J Cell Biol 173: 533-544 (Pubitemid 43765200)
-
(2006)
Journal of Cell Biology
, vol.173
, Issue.4
, pp. 533-544
-
-
Knights, C.D.1
Catania, J.2
Di Giovanni, S.3
Muratoglu, S.4
Perez, R.5
Swartzbeck, A.6
Quong, A.A.7
Zhang, X.8
Beerman, T.9
Pestell, R.G.10
Avantaggiati, M.L.11
-
49
-
-
33748667324
-
Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage
-
DOI 10.1128/MCB.00062-06
-
Chao C et al (2006) Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol Cell Biol 26: 6859-6869 (Pubitemid 44387635)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.18
, pp. 6859-6869
-
-
Chao, C.1
Wu, Z.2
Mazur, S.J.3
Borges, H.4
Rossi, M.5
Lin, T.6
Wang, J.Y.J.7
Anderson, C.W.8
Appella, E.9
Xu, Y.10
-
50
-
-
22544484456
-
The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation
-
DOI 10.1073/pnas.0503068102
-
Krummel KA, Lee CJ, Toledo F, Wahl GM (2005) The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc Natl Acad Sci USA 102: 10188-10193 (Pubitemid 41023347)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.29
, pp. 10188-10193
-
-
Krummel, K.A.1
Lee, C.J.2
Toledo, F.3
Wahl, G.M.4
-
51
-
-
33749118677
-
IASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53
-
DOI 10.1038/ng1879, PII NG1879
-
Bergamaschi D et al (2006) iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53. Nat Genet 38: 1133-1141 (Pubitemid 44470358)
-
(2006)
Nature Genetics
, vol.38
, Issue.10
, pp. 1133-1141
-
-
Bergamaschi, D.1
Samuels, Y.2
Sullivan, A.3
Zvelebil, M.4
Breyssens, H.5
Bisso, A.6
Del Sal, G.7
Syed, N.8
Smith, P.9
Gasco, M.10
Crook, T.11
Lu, X.12
-
52
-
-
17944379798
-
ASPP proteins specifically stimulate the apoptotic function of p53
-
DOI 10.1016/S1097-2765(01)00367-7
-
Samuels-Lev Y et al (2001) ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell 8: 781-794 (Pubitemid 33030212)
-
(2001)
Molecular Cell
, vol.8
, Issue.4
, pp. 781-794
-
-
Samuels-Lev, Y.1
O'Connor, D.J.2
Bergamaschi, D.3
Trigiante, G.4
Hsieh, J.-K.5
Zhong, S.6
Campargue, I.7
Naumovski, L.8
Crook, T.9
Lu, X.10
-
53
-
-
33646578801
-
ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth
-
DOI 10.1101/gad.374006
-
Vives V, Su J, Zhong S, Ratnayaka I, Slee E, Goldin R, Lu X (2006) ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. Genes Dev 20: 1262-1267 (Pubitemid 43727587)
-
(2006)
Genes and Development
, vol.20
, Issue.10
, pp. 1262-1267
-
-
Vives, V.1
Su, J.2
Zhong, S.3
Ratnayaka, I.4
Slee, E.5
Goldin, R.6
Lu, X.7
-
54
-
-
1642499353
-
ASPP1 and ASPP2: Common activators of p53 family members
-
DOI 10.1128/MCB.24.3.1341-1350.2004
-
Bergamaschi D, Samuels Y, Jin B, Duraisingham S, Crook T, Lu X (2004) ASPP1 and ASPP2: common activators of p53 family members. Mol Cell Biol 24: 1341-1350 (Pubitemid 38112194)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.3
, pp. 1341-1350
-
-
Bergamaschi, D.1
Samuels, Y.2
Jin, B.3
Duraisingham, S.4
Crook, T.5
Lu, X.6
-
55
-
-
34948830225
-
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP
-
DOI 10.1038/nsmb1306, PII NSMB1306
-
Mantovani F, Tocco F, Girardini J, Smith P, Gasco M, Lu X, Crook T, Del Sal G (2007) The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP. NatStruct Mol Biol 14: 912-920 (Pubitemid 47525182)
-
(2007)
Nature Structural and Molecular Biology
, vol.14
, Issue.10
, pp. 912-920
-
-
Mantovani, F.1
Tocco, F.2
Girardini, J.3
Smith, P.4
Gasco, M.5
Lu, X.6
Crook, T.7
Sal, G.D.8
-
56
-
-
18644384283
-
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults
-
DOI 10.1038/nature01120
-
Zacchi P et al (2002) The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature 419: 853-857 (Pubitemid 35238573)
-
(2002)
Nature
, vol.419
, Issue.6909
, pp. 853-857
-
-
Zacchi, P.1
Gostissa, M.2
Uchida, T.3
Salvagno, C.4
Avolio, F.5
Volinia, S.6
Ronai, Z.7
Blandino, G.8
Schneider, C.9
Del Sal, G.10
-
57
-
-
18644384688
-
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response
-
DOI 10.1038/nature01116
-
Zheng H et al (2002) The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature 419: 849-853 (Pubitemid 35238572)
-
(2002)
Nature
, vol.419
, Issue.6909
, pp. 849-853
-
-
Zheng, H.1
You, H.2
Zhou, X.Z.3
Murray, S.A.4
Uchida, T.5
Wulf, G.6
Gu, L.7
Tang, X.8
Lu, K.P.9
Xiao, Z.-X.J.10
-
58
-
-
82755186506
-
Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90
-
Dai C, Tang Y, Jung SY, Qin J, Aaronson SA, Gu W (2011) Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci USA 108: 18937-18942
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 18937-18942
-
-
Dai, C.1
Tang, Y.2
Jung, S.Y.3
Qin, J.4
Aaronson, S.A.5
Gu, W.6
-
59
-
-
34548049032
-
Hzf Determines Cell Survival upon Genotoxic Stress by Modulating p53 Transactivation
-
DOI 10.1016/j.cell.2007.06.013, PII S0092867407007799
-
Das S, Raj L, Zhao B, Kimura Y, Bernstein A, Aaronson SA, Lee SW (2007) Hzf determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell 130: 624-637 (Pubitemid 47277418)
-
(2007)
Cell
, vol.130
, Issue.4
, pp. 624-637
-
-
Das, S.1
Raj, L.2
Zhao, B.3
Kimura, Y.4
Bernstein, A.5
Aaronson, S.A.6
Lee, S.W.7
-
60
-
-
34547956843
-
HCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes
-
DOI 10.1016/j.cell.2007.08.001, PII S0092867407010203
-
Tanaka T, Ohkubo S, Tatsuno I, Prives C (2007) hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. Cell 130: 638-650 (Pubitemid 47268061)
-
(2007)
Cell
, vol.130
, Issue.4
, pp. 638-650
-
-
Tanaka, T.1
Ohkubo, S.2
Tatsuno, I.3
Prives, C.4
-
61
-
-
0037349289
-
P53 has a direct apoptogenic role at the mitochondria
-
DOI 10.1016/S1097-2765(03)00050-9
-
Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM (2003) p53 has a direct apoptogenic role at the mitochondria. Mol Cell 11: 577-590 (Pubitemid 36385115)
-
(2003)
Molecular Cell
, vol.11
, Issue.3
, pp. 577-590
-
-
Mihara, M.1
Erster, S.2
Zaika, A.3
Petrenko, O.4
Chittenden, T.5
Pancoska, P.6
Moll, U.M.7
-
62
-
-
0842278331
-
Direct activation of bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
-
DOI 10.1126/science.1092734
-
Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303: 1010-1014 (Pubitemid 38209704)
-
(2004)
Science
, vol.303
, Issue.5660
, pp. 1010-1014
-
-
Chipuk, J.E.1
Kuwana, T.2
Bouchier-Hayes, L.3
Droin, N.M.4
Newmeyer, D.D.5
Schuler, M.6
Green, D.R.7
-
63
-
-
24644436766
-
Cell biology: PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
-
DOI 10.1126/science.1114297
-
Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR (2005) PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 309: 1732-1735 (Pubitemid 41285944)
-
(2005)
Science
, vol.309
, Issue.5741
, pp. 1732-1735
-
-
Chipuk, J.E.1
Bouchier-Hayes, L.2
Kuwana, T.3
Newmeyer, D.D.4
Green, D.R.5
-
64
-
-
84872329426
-
The prolyl-isomerase Pin1 activates the mitochondrial death program of p53
-
Sorrentino G, Mioni M, Giorgi C, Ruggeri N, Pinton P, Moll U, Mantovani F, Del Sal G (2013) The prolyl-isomerase Pin1 activates the mitochondrial death program of p53. Cell Death Differ 20: 198-208
-
(2013)
Cell Death Differ
, vol.20
, pp. 198-208
-
-
Sorrentino, G.1
Mioni, M.2
Giorgi, C.3
Ruggeri, N.4
Pinton, P.5
Moll, U.6
Mantovani, F.7
Del Sal, G.8
-
65
-
-
84862675016
-
P53 opens the mitochondrial permeability transition pore to trigger necrosis
-
Vaseva AV, Marchenko ND, Ji K, Tsirka SE, Holzmann S, Moll UM (2012) p53 opens the mitochondrial permeability transition pore to trigger necrosis. Cell 149: 1536-1548
-
(2012)
Cell
, vol.149
, pp. 1536-1548
-
-
Vaseva, A.V.1
Marchenko, N.D.2
Ji, K.3
Tsirka, S.E.4
Holzmann, S.5
Moll, U.M.6
-
66
-
-
79955795151
-
Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression
-
Brady CA et al (2011) Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell 145: 571-583
-
(2011)
Cell
, vol.145
, pp. 571-583
-
-
Brady, C.A.1
-
67
-
-
65449154815
-
Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis
-
Grinkevich VV et al (2009) Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis. Cancer Cell 15: 441-453
-
(2009)
Cancer Cell
, vol.15
, pp. 441-453
-
-
Grinkevich, V.V.1
-
68
-
-
60649103811
-
MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53
-
Enge M, Bao W, Hedström E, Jackson SP, Moumen A, Selivanova G (2009) MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53. Cancer Cell 15: 171-183
-
(2009)
Cancer Cell
, vol.15
, pp. 171-183
-
-
Enge, M.1
Bao, W.2
Hedström, E.3
Jackson, S.P.4
Moumen, A.5
Selivanova, G.6
|