TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer

Molecular Cell

Volumn 48, Issue 6, 2012, Pages 888-899

  Gonzalvez, Francois ^a   Lawrence, David ^a   Yang, Becky ^a   Yee, Sharon ^a   Pitti, Robert ^a   Marsters, Scot ^a   Pham, Victoria C ^a   Stephan, Jean Philippe ^a   Lill, Jennie ^a   Ashkenazi, Avi ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; CULLIN; CULLIN 3; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; PROTEASOME; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UBIQUITIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CATALYSIS; CELL CYCLE; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; POLYUBIQUITINATION; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; UBIQUITINATION;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CASPASE 8; CATALYTIC DOMAIN; CELL SURVIVAL; CULLIN PROTEINS; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; ENZYME ACTIVATION; HCT116 CELLS; HUMANS; LEUPEPTINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PEPTIDE MAPPING; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; TNF RECEPTOR-ASSOCIATED FACTOR 2; UBIQUITINATION;

EID: 84871679702     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.09.031     Document Type: Article

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