Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation

Cell Death and Differentiation

Volumn 17, Issue 9, 2010, Pages 1435-1447

  Ehrenschwender, M ^a   Siegmund, D ^a   Wicovsky, A ^a   Kracht, M ^b   Dittrich Breiholz, O ^c   Spindler, V ^d   Waschke, J ^d   Kalthoff, H ^e   Trauzold, A ^e   Wajant, H ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d UNIVERSITY OF WÜRZBURG   (Germany)

^e UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

amoeboid; caspase 8; CD95; PI3K; ROCK 1; TRAIL

Indexed keywords

CASPASE 8; FAS LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PROTEIN KINASE ROCK 1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL INVASION; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE; GENE MUTATION; HUMAN; HUMAN CELL; PIK3CA GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACID CHLOROMETHYL KETONES; ANTIGENS, CD95; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 8; CELL SHAPE; CYSTEINE PROTEINASE INHIBITORS; FAS LIGAND PROTEIN; HCT116 CELLS; HUMANS; I-KAPPA B KINASE; INTERLEUKIN-8; MUTATION, MISSENSE; NEOPLASM INVASIVENESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 77955713683     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2010.36     Document Type: Article

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