Reconstitution of the Death-Inducing Signaling Complex Reveals a Substrate Switch that Determines CD95-Mediated Death or Survival

Molecular Cell

Volumn 35, Issue 3, 2009, Pages 265-279

  Hughes, Michelle A ^a   Harper, Nicholas ^a   Butterworth, Michael ^a   Cain, Kelvin ^a   Cohen, Gerald M ^a   MacFarlane, Marion ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

CELLCYCLE; PROTEINS

Indexed keywords

CASPASE 3; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; DEATH RECEPTOR; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; FLICE INHIBITORY PROTEIN; PROCASPASE 8; PROTEIN BID;

APOPTOSIS; ARTICLE; CATALYSIS; CELL SURVIVAL; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MUTAGENESIS; OLIGOMERIZATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANTIGENS, CD95; APOPTOSIS; CASPASE 8; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; DIMERIZATION; ENZYME ACTIVATION; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HUMANS; JURKAT CELLS;

EID: 68349154339     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2009.06.012     Document Type: Article

References (31)

1. Bidere N., Su H.C., and Lenardo M.J. Genetic disorders of programmed cell death in the immune system. Annu. Rev. Immunol. 24 (2006) 321-352
2. Blanchard H., Kodandapani L., Mittl P.R., Marco S.D., Krebs J.F., Wu J.C., Tomaselli K.J., and Grutter M.G. The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis. Structure 7 (1999) 1125-1133
3. Boatright K.M., Renatus M., Scott F.L., Sperandio S., Shin H., Pedersen I.M., Ricci J.E., Edris W.A., Sutherlin D.P., Green D.R., and Salvesen G.S. A unified model for apical caspase activation. Mol. Cell 11 (2003) 529-541
4. Boldin M.P., Goncharov T.M., Goltsev Y.V., and Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85 (1996) 803-815
5. Chang D.W., Xing Z., Pan Y., Algeciras-Schimnich A., Barnhart B.C., Yaish-Ohad S., Peter M.E., and Yang X. c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. EMBO J. 21 (2002) 3704-3714
6. Chang D.W., Xing Z., Capacio V.L., Peter M.E., and Yang X. Interdimer processing mechanism of procaspase-8 activation. EMBO J. 22 (2003) 4132-4142
7. Chun H.J., Zheng L., Ahmad M., Wang J., Speirs C.K., Siegel R.M., Dale J.K., Puck J., Davis J., Hall C.G., et al. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature 419 (2002) 395-399
8. Donepudi M., Mac Sweeney A., Briand C., and Grutter M.G. Insights into the regulatory mechanism for caspase-8 activation. Mol. Cell 11 (2003) 543-549
9. Eberstadt M., Huang B., Olejniczak E.T., and Fesik S.W. The lymphoproliferation mutation in Fas locally unfolds the Fas death domain. Nat. Struct. Biol. 4 (1997) 983-985
10. Festjens N., Vanden Berghe T., Cornelis S., and Vandenabeele P. RIP1, a kinase on the crossroads of a cell's decision to live or die. Cell Death Differ. 14 (2007) 400-410
11. Fuentes-Prior P., and Salvesen G.S. The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem. J. 384 (2004) 201-232
12. Harper N., Hughes M., MacFarlane M., and Cohen G.M. FADD and caspase-8 are not recruited to the TNF-R1 signaling complex during TNF-induced apoptosis. J. Biol. Chem. 278 (2003) 25534-25541
13. Hill J.M., Morisawa G., Kim T., Huang T., Wei Y., Wei Y., and Werner M.H. Identification of an expanded binding surface on the FADD death domain responsible for interaction with CD95/Fas. J. Biol. Chem. 279 (2004) 1474-1481
14. Kang T.B., Oh G.S., Scandella E., Bolinger B., Ludewig B., Kovalenko A., and Wallach D. Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice. J. Immunol. 181 (2008) 2522-2532
15. Kataoka T., and Tschopp J. N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway. Mol. Cell. Biol. 24 (2004) 2627-2636
16. Kischkel F.C., Hellbardt S., Behrmann I., Germer M., Pawlita M., Krammer P.H., and Peter M.E. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 14 (1995) 5579-5588
17. Lin Y., Devin A., Rodriguez Y., and Liu Z.G. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev. 13 (1999) 2514-2526
18. Martin D.A., Siegel R.M., Zheng L., and Lenardo M.J. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal. J. Biol. Chem. 273 (1998) 4345-4349
19. Medema J.P., Scaffidi C., Kischkel F.C., Shevchenko A., Mann M., Krammer P.H., and Peter M.E. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J. 16 (1997) 2794-2804
20. Micheau O., Thome M., Schneider P., Holler N., Tschopp J., Nicholson D.W., Briand C., and Grutter M.G. The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J. Biol. Chem. 277 (2002) 45162-45171
21. Muppidi J.R., Lobito A.A., Ramaswamy M., Yang J.K., Wang L., Wu H., and Siegel R.M. Homotypic FADD interactions through a conserved RXDLL motif are required for death receptor-induced apoptosis. Cell Death Differ. 13 (2006) 1641-1650
22. Muzio M., Chinnaiyan A.M., Kischkel F.C., O'Rourke K., Shevchenko A., Ni J., Scaffidi C., Bretz J.D., Zhang M., Gentz R., et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85 (1996) 817-827
23. Muzio M., Stockwell B.R., Stennicke H.R., Salvesen G.S., and Dixit V.M. An induced proximity model for caspase-8 activation. J. Biol. Chem. 273 (1998) 2926-2930
24. Peter M.E., Budd R.C., Desbarats J., Hedrick S.M., Hueber A.O., Newell M.K., Owen L.B., Pope R.M., Tschopp J., Wajant H., et al. The CD95 receptor: apoptosis revisited. Cell 129 (2007) 447-450
25. Piana S., Taylor Z., and Rothlisberger U. Folding pathways for initiator and effector procaspases from computer simulations. Proteins 59 (2005) 765-772
26. Srinivasula S.M., Ahmad M., Fernandes-Alnemri T., Litwack G., and Alnemri E.S. Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE- like cysteine proteases. Proc. Natl. Acad. Sci. USA 93 (1996) 14486-14491
27. Su H., Bidere N., Zheng L., Cubre A., Sakai K., Dale J., Salmena L., Hakem R., Straus S., and Lenardo M. Requirement for caspase-8 in NF-kappaB activation by antigen receptor. Science 307 (2005) 1465-1468
28. Thomas L.R., Stillman D.J., and Thorburn A. Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid screen. J. Biol. Chem. 277 (2002) 34343-34348
29. Wallach D., Varfolomeev E.E., Malinin N.L., Goltsev Y.V., Kovalenko A.V., and Boldin M.P. Tumor necrosis factor receptor and Fas signaling mechanisms. Annu. Rev. Immunol. 17 (1999) 331-367
30. Watt W., Koeplinger K.A., Mildner A.M., Heinrikson R.L., Tomasselli A.G., and Watenpaugh K.D. The atomic-resolution structure of human caspase-8, a key activator of apoptosis. Structure 7 (1999) 1135-1143
31. Yu J.W., and Shi Y. FLIP and the death effector domain family. Oncogene 27 (2008) 6216-6227