Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations

Journal of Pathology

Volumn 217, Issue 4, 2009, Pages 489-496

  Gutierrez Gonzalez, Lydia ^a,b   Deheragoda, Maesha ^a,c   Elia, George ^a   Leedham, Simon J ^a   Shankar, Arjun ^c   Imber, Charles ^c   Jankowski, Janusz A ^a,d   Turnbull, Douglass M ^e   Novelli, Marco ^c   Wright, Nicholas A ^a,f   McDonald, Stuart A C ^a,d  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

^f QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Mitochondrial DNA; Small intestine; Stem cell

Indexed keywords

CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; SUCCINATE DEHYDROGENASE; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; CELL DIFFERENTIATION; CELL DIVISION; CELL LINEAGE; CELL STRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; CRYPT CELL; DNA SEQUENCE; DUODENUM; ENZYME HISTOCHEMISTRY; FEMALE; FROZEN SECTION; GENE AMPLIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE VILLUS; LASER CAPTURE MICRODISSECTION; MALE; MITOCHONDRIAL GENOME; MOLECULAR CLONING; MUTATIONAL ANALYSIS; PANETH CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SMALL INTESTINE MUCOSA; STEM CELL; CELL CLONE; CYTOCHEMISTRY; CYTOLOGY; ENZYMOLOGY; EPITHELIUM CELL; GENETICS; INTESTINE MUCOSA; MIDDLE AGED; MUTATION; NUCLEOTIDE SEQUENCE;

AGED; BIOLOGICAL MARKERS; CELL LINEAGE; CLONE CELLS; DNA MUTATIONAL ANALYSIS; DNA, MITOCHONDRIAL; DUODENUM; ELECTRON TRANSPORT COMPLEX IV; EPITHELIAL CELLS; FEMALE; HISTOCYTOCHEMISTRY; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; MALE; MIDDLE AGED; MUTATION; PANETH CELLS; STEM CELLS;

EID: 62849099539     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2502     Document Type: Article

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