Time-course of mitochondrial gene expressions in mice brains: Implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging

Journal of Neurochemistry

Volumn 92, Issue 3, 2005, Pages 494-504

  Manczak, Maria ^a   Jung, Youngsin ^a   Park, Byung S ^a   Partovi, Dara ^a   Reddy, P Hemachandra ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

8 hydroxyguanosine; Aging; ATPase 6; C57BL6 mice; Cytochrome c; Mitochondrial dysfunction

Indexed keywords

8 HYDROXYGUANOSINE; ADENOSINE TRIPHOSPHATASE; CYTOCHROME C; CYTOCHROME C OXIDASE; GUANOSINE DERIVATIVE; MESSENGER RNA; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG;

ADOLESCENT; AGED; AGING; ALZHEIMER DISEASE; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE MUTATION; HIPPOCAMPUS; IMMUNOFLUORESCENCE; IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; NORTHERN BLOTTING; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; RESPIRATORY CHAIN; SENESCENCE;

AGING; ANIMALS; BLOTTING, NORTHERN; BRAIN; CYTOCHROMES C; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX III; ELECTRON TRANSPORT COMPLEX IV; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GUANOSINE; IN SITU HYBRIDIZATION; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; OXIDATIVE STRESS; PROTEIN SUBUNITS; RNA; RNA, MESSENGER; TIME;

ANIMALIA;

EID: 13244292394     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02884.x     Document Type: Article

References (37)

1. Aksenov M. Y., Tucker H. M., Nair P., Aksenova M. V., Butterfield D. A., Estus S. and Markesbery W. R. (1999) The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, NADH dehydrogenase in different brainregions in Alzheimer's disease. Neurochem. Res. 24, 767-774.
2. Beckman K. B. and Ames B. N. (1998) The free radical theory of aging matures. Physiol. Rev. 78, 547-581.
3. Beers M. and Jones T. V. (2004) Merck Manual of Health and Aging. Merck.
4. Biersalski H. K. (2002) Free radical theory of aging. Curr. Opin. Clin. Nutr. Metab. Care 5, 5-10.
5. Blass J. P. (2001) Brain metabolism and brain disease: is metabolic-deficiency the proximate cause of Alzheimer dementia? J. Neurosci Res. 66, 851-856.
6. Cadenas E. (2004) Mitochondrial free radical production and cell signaling. Mol. Aspects Med. 25, 17-26.
7. Cadenas E. and Davies K. J. (2000) Mitochondrial free radical generation, oxidative stress, and aging. Free Radic. Biol. Med. 29, 222-230.
8. de Carvalho C. V., Payao S. L. and Smith M. A. (2000) DNA methylation, ageing and ribosomal genes activity. Biogerontology 1, 357-361.
9. Chandrasekaran K., Giordano T., Brady D. R., Stoll J., Hatanpa;ä K., Martin L. S. and Rapoport S. I. (1994) Impairment in gene expression ox oxidative metabolism in vulnerable brain regions in Alzheimer's disease. Neurobiol. Aging 14, 343-532.
10. Chandrasekaran, K., Hatanpää K., Rapoport S. I. and Brady D. R. (1997) Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer disease. Mol. Brain Res. 44, 99-104.
11. Corral-Debrinski M., Horton T., Lott M. T., Shoffner J. M., Beal M. F. and Wallace D. C. (1992) Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nature Genet. 2, 324-329.
12. Cortopassi G. A. and Arnheim N. (1990) Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res. 18, 6927-6933.
13. Dunnette C. W. (1955) A multiple comparisons procedure for comparing several treatments with a control. J. Am. Stat. Assoc. 509, 1096-1121.
14. Fernandez-Silva S. P., Petruzzela V., Fracasso F., Gadaleta M. N. and Cantatore P. (1992) Reduced synthesis of mtRNA in isolkated mitochondria of senescent rat brains. Biochem. Biophys. Res. Commun. 176, 645-653.
15. Harman D. (1999) Aging: minimizing free radical damage. J. Anti-Aging Med. 2, 15-36.
16. Kayo T., Allison D. B., Weindruch R. and Prolla T. (2001) Influences of aging and calorie restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc. Natl Acad. Sci. USA 98, 5093-5098.
17. Khaidakov M., Heflich R. H., Manjanatha M. G., Myers M. B. and Aidoo A. (2003) Accumulation of point mutations in mitochondrial DNA of aging mice. Mutat. Res. 526, 1-7.
18. Lezza A. M., Boffoli D., Scacco S., Cantatore P. and Gadeleta M. N. (1994) Correlation between mitochondrial DNA 4977-bp deletion and respiratory chain enzyme activities in aging human skeletal muscles. Biophys. Biochem. Res. Commun. 205, 772-779.
19. Lu T., Pan Y., Kao S. Y., Li C., Kohane I., Chan J. and Yankner B. A. (2004) Gene regulation and DNA damage in the ageing human brain. Nature 429, 883-891.
20. Manczak M., Park B. S., Jung Y. and Reddy P. H. (2004) Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: implications for early mitochondrial dysfunction and oxidative damage. Neuromolecular Med. 5, 147-162.
21. Mattson M. P. (2000) Emerging neuroprotective strategies for Alzheimer's disease: dietary restriction, telomerase activation, and stem cell therapy. Exp. Gerontol. 35, 489-502.
22. Mattson M. P., Pederson W. A., Duan W., Culmsee C. and Camandola S. (1999) Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases. Ann. N. Y. Acad. Sci. 893, 154-175.
23. Munscher C., Rieger T., Muller-Hocker J. and Kadenbach B. (1993) The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages. FEBS Lett. 317, 27-30.
24. Navarro A., Del-Pino M. J. S., Gómez C., Peralta J. L. and Boveris A. (2002) Behavioral dysfunction, brain oxidative stress, and impaired mitochondrial electron transfer in aging mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282, R985-R992.
25. Navarro A., Gomez C., Lopez-Cepero J. M. and Boveris L. (2004) Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286, R505-R511.
26. Perry G., Nunomura A., Hirai K. et al. (2002) Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radic. Biol. Med. 1, 1475-1479.
27. Piko L., Bulpitt K. J. and Meyer R. (1984) Structural and replicative forms of mitochondrial DNA in tissues from adult and senescent BALB/c mice and Fischer 344 rats. Mech. Ageing Dev. 26, 113-131.
28. Piko L., Hougham A. J. and Bulpitt K. J. (1988) Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: evidence for an increased frequency of deletions/additions with aging. Mech. Ageing Dev. 43, 279-293.
29. Reddy P. H., McWeeney S., Manczak M., Park B. S., Gutala R. V., Jung Y., Yau V., Searles R., Mori M. and Quinn J. (2004) Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: upregulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease. Hum. Mol. Genet. 13, 1225-1240.
30. Schapira A. H. V. and Cock H. R. (1999) Mitochondrial myopathies and encepahlomyopathies. Eur. J. Clin. Invest. 29, 886-898.
31. Schwarze S. R., Lee C. M., Chung S. S., Roecker E. B., Weindruch R. and Aiken J. M. (1995) High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys. Mech. Ageing Dev. 83, 91-101.
32. Shigenaga M. K., Hagen T. M. and Ames B. N. (1994) Oxidative damage and mitochondrial decay in aging. Proc. Natl Acad. Sci. USA 91, 10 771-10 778.
33. Shoffner J. M. (1997) Oxidative phosphorylation defects and Alzheimer's disease. Neurogenetics. 1, 13-19.
34. Soong N. W., Hinton D. R., Cortopassi G. and Arnheim N. (1992) Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat. Genet. 2, 318-323.
35. Trifunovic A., Wredenberg A., Falkenberg M. et al. (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429, 417-423.
36. Vijg J. (2000) Somatic mutations and aging: a re-evaluation. Mutat. Res. 447, 117-135.
37. Wallace D. C. (1999) Mitochondrial diseases in man and mouse. Science 283, 1482-1488.