Age-related changes in the autophagic proteolysis of rat isolated liver cells: Effects of antiaging dietary restrictions

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 56, Issue 9, 2001, Pages

  Donati, A ^a   Cavallini, G ^a   Paradiso, C ^a   Vittorini, S ^a   Pollera, M ^a   Gori, Z ^a   Bergamini, E ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GLUCAGON; INSULIN; VALINE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOPHAGY; CELL REGENERATION; CONTROLLED STUDY; DIET RESTRICTION; DIET THERAPY; HORMONAL REGULATION; ISOLATED LIVER; LIVER CELL; LONGEVITY; LYSOSOME; MALE; METABOLISM; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

EID: 0034875011     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/56.9.B375     Document Type: Article

References (47)

1. Non-selective autophagy
2. Studies on the mechanism of autophagy: Formation of the autophagic vacuole
3. Autophagy and other vacuolar protein degradation
4. Mechanisms of intralysosomal degradation with special reference to autophagocytosis and heterophagocytosis of cell organelles
5. Autophagic proteolysis: Control and specificity
6. Role of autophagy in hepatic macromolecular turnover
7. Autophagy
8. Mechanism and regulation of protein degradation in liver
9. Inhibition of macroautophagy and proteolysis in the isolated rat hepatocytes by a non-transportable derivative of the multiple antigen peptide Leu8-Lys4-Lys2-Lys-Ala
10. Signal transduction pathways in macroautophagy
11. Food restriction enhances the proteolytic capacity of the aging rat liver
12. Age-related changes in the regulation of autophagic proteolysis in rat isolated hepatocytes
13. Exploring the age-related changes in hormone-regulated protein breakdown by the use of a physiologic model of stimulation of liver autophagy
14. The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes
15. Mechanisms of membrane protein turnover
16. Age-dependent accumulation of dolichol in rat liver: Is tissue dolichol a biomarker of aging?
17. Intracellular and extracellular flow of dolichol
18. Food restriction in rodents: An evaluation of its role in the study of aging
19. Proposed modifiers of aging processes or aging phenotypes: Putative interventions
20. Dietary restriction and aging
21. Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence
22. The age related accumulation of protein carbonyl in rat liver correlates with the age related decline in liver proteolytic activities
23. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to dietary restriction in the mouse
24. Age-related decline of macroautophagy and liver protein breakdown in the Sprague-Dawley rat: Protective effect of caloric restriction
25. Towards an understanding of the antiaging mechanisms of dietary restriction: A signal transduction theory of aging
26. A proposed mechanism of the antiaging action of diet restriction
27. Different circadian variations of plasma glucose and insulin concentrations in rats submitted to 60% food restriction or intermittent feeding
28. Dietary restriction
29. Preparation of isolated liver cells
30. Multiphasic control of proteolysis by leucine and alanine in the isolated rat hepatocyte
31. 14C]sucrose, introduced into isolated rat hepatocytes by electropermeabilization
32. Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes
33. 3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
34. The phosphatidyl inositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
35. Dansylation of amino acids for high performance liquid chromatography analysis
36. Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy
37. Assessment of protein turnover in perfused rat liver. Evidence for amino acid compartmentation from differential labeling of free and tRNA bound valine
38. Lysosomal sequestration of intracellular protein as a regulatory step in hepatic proteolysis
39. Hepatocytic autophagy
40. Regulation of hepatic protein degradation
41. Impairment in both P70S6 kinase and extracellular signal-regulated kinase signalling pathways contribute to the decline in proliferative capacity of aged hepatocytes
42. Elevated protein tyrosine phosphatase activity and increased membrane viscosity are associated with impaired activation of the insulin receptor kinase in old rats
43. Distinct classes of phosphatidylinositol-3 kinase are involved in signalling pathways that control macroautophagy in HT29 cells
44. Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes
45. Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells
46. Dolichol alters GABA uptake and high affinity binding of agonist to rat brain synaptic plasma membranes