Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts

Aging Cell

Volumn 9, Issue 1, 2010, Pages 96-99

  Nooteboom, Marco ^a   Johnson, Riem ^a   Taylor, Robert W ^a   Wright, Nicholas A ^b   Lightowlers, Robert N ^a   Kirkwood, Thomas B L ^a   Mathers, John C ^a   Turnbull, Doug M ^a   Greaves, Laura C ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b London Research Institute   (United Kingdom)

Author keywords

Aging; Colon; Mitochondrial DNA; Respiratory chain; Stem cells

Indexed keywords

MITOCHONDRIAL DNA; CYTOCHROME C OXIDASE; KI 67 ANTIGEN;

AGED; APOPTOSIS; ARTICLE; CELL AGING; CELL DIVISION; CELL POPULATION; CELL PROLIFERATION; COLON CRYPT; CONTROLLED STUDY; CRYPT CELL; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE CRYPT; MOLECULAR CLONING; PRIORITY JOURNAL; PROGENY; RESPIRATORY CHAIN; STEM CELL; AGING; COLON; CYTOLOGY; FEMALE; GENETICS; MALE; METABOLISM; MUTATION;

AGING; APOPTOSIS; CELL PROLIFERATION; COLON; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX IV; FEMALE; HUMANS; KI-67 ANTIGEN; MALE; MUTATION; STEM CELLS;

EID: 76249101972     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2009.00531.x     Document Type: Article

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