Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence

EMBO Journal

Volumn 21, Issue 9, 2002, Pages 2180-2188

  Macip, Salvador ^a   Igarashi, Makoto ^a   Fang, Li ^a   Chen, Angus ^b   Pan, Zhen Qiang ^c   Lee, Sam W ^d   Aaronson, Stuart A ^e  

^a DIVISION OF REPRODUCTIVE BIOLOGY   (United States)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c RESEARCH AND DEVELOPMENT   (Australia)

^d College of Chemistry and Molecular Engineering ^*  (China)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

CDK inhibitors; p21; PIG3; ROS; Senescence

Indexed keywords

ACETYLCYSTEINE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL AGING; CELL CYCLE; CELL GROWTH; CELL LEVEL; CONTROLLED STUDY; FIBROBLAST; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SENESCENCE;

ACETYLCYSTEINE; CELL AGING; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; FIBROBLASTS; FREE RADICAL SCAVENGERS; HUMANS; PROLIFERATING CELL NUCLEAR ANTIGEN; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED;

EID: 0036566326     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.9.2180     Document Type: Article

References (57)

1. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
2. 2/M arrest after DNA damage
3. Cell enlargement: One possible mechanism underlying cellular senescence
4. Radiation-induced cell cycle arrest compromised by p21 deficiency
5. 2-treated young MRC5 fibroblasts correlates with increased glutathione peroxidase levels and resistance to DNA breakage
6. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
7. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
8. Oxidative DNA damage and senescence of human diploid fibroblast cells
9. 1 arrest but not cell replication
10. 1 checkpoint control
11. Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control
12. A biomarker that identifies senescent human cells in culture and in aging skin in vivo
13. WAF1/Cip1: More than a break to the cell cycle?
14. Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast
15. WAF1, a potential mediator of p53 tumor suppression
16. waf1/cip1/sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53
17. p53-dependent expression of PIG3 during proliferation, genotoxic stress and reversible growth arrest
18. CIP1 on DNA synthesis catalyzed by the human and Saccharomyces cerevisiae polymerase delta holoenzymes
19. Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase
20. CDKN2 expression and its implications for cell immortalization and senescence
21. 1 cyclin-dependent kinases
22. The serial cultivation of human diploid strains
23. Participation of p53 protein in the cellular response to DNA damage
24. Effects of hypoxia and fasting on the cytochrome concentration in intestinal epithelial villous cell mitochondria. Role of changes in the life-span of the cells
25. p53 is required for radiation-induced apoptosis in mouse thymocytes
26. Cip1
27. Genetic analysis of ageing: Role of oxidative damage and environmental stresses
28. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
29. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
30. 1 in motorneurons
31. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator
32. Genetic determinants of p53-induced apoptosis and growth arrest
33. A model for p53-induced apoptosis
34. Induction of p21 mediated by reactive oxygen species formed during the metabolism of aziridinylbenzoquinones by HCT116 cells
35. Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16
36. 2 in cultured endothelial cells
37. Senescence as a mode of tumor suppression
38. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
39. INK4a
40. 1 cyclin-dependent kinases
41. The cellular response to p53: The decision between life and death
42. Replicative senescence: Implications for in vivo aging and tumor suppression
43. WAF1/CIP1 induction of p300 transactivation
44. Intracellular thiols regulate activation of nuclear factor κB and transcription of human immunodeficiency virus
45. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
46. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
47. INK4A
48. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence?
49. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
50. 1 arrest in human cancer cells
51. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
52. waf expression in H1299 cell line promotes cell senescence and protects against cytotoxic effect of radiation and doxorubicin
53. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA
54. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition
55. Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
56. Senescence of human fibroblasts induced by oncogenic Raf