The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons

Aging Cell

Volumn 8, Issue 4, 2009, Pages 496-498

  Reeve, Amy K ^a   Krishnan, Kim J ^a   Taylor, Geoffrey ^a   Elson, Joanna L ^a   Bender, Andreas ^b   Taylor, Robert W ^a   Morris, Christopher M ^a   Turnbull, Doug M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Clonal expansion; mtDNA; Neurons; Point mutations

Indexed keywords

CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; SUCCINATE DEHYDROGENASE;

AGED; ARTICLE; CELL AGING; CELL TYPE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME DEFICIENCY; FEMALE; GENE DELETION; GENETIC POLYMORPHISM; HISTOCHEMISTRY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MITOSIS; MOLECULAR CLONING; MUTATIONAL ANALYSIS; NERVE CELL; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

AGED; AGED, 80 AND OVER; AGING; BASE SEQUENCE; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX IV; FEMALE; HUMANS; MALE; MITOSIS; NEURONS; POINT MUTATION; SUBSTANTIA NIGRA;

EID: 67651166799     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2009.00492.x     Document Type: Article

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