메뉴 건너뛰기




Volumn 1293, Issue , 2015, Pages 1-49

Breast cancer stem cells: Current advances and clinical implications

Author keywords

Breast cancer; Cancer stem cells (CSCs); Circulating tumor cells (CTCs); Patient derived xenograft (PDX); Phenotypic plasticity

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; MICRORNA; NOTCH RECEPTOR; SONIC HEDGEHOG PROTEIN; WNT PROTEIN; BIOLOGICAL MARKER;

EID: 84930664656     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-2519-3_1     Document Type: Article
Times cited : (88)

References (282)
  • 1
    • 33747040785 scopus 로고    scopus 로고
    • Hormonal and local control of mammary branching morphogenesis
    • Sternlicht MD et al (2006) Hormonal and local control of mammary branching morphogenesis. Differentiation 74(7):365–381
    • (2006) Differentiation , vol.74 , Issue.7 , pp. 365-381
    • Sternlicht, M.D.1
  • 2
    • 29244451536 scopus 로고    scopus 로고
    • Key stages in mammary gland development: The mammary end bud as a motile organ
    • Hinck L, Silberstein GB (2005) Key stages in mammary gland development: the mammary end bud as a motile organ. Breast Cancer Res 7(6):245–251
    • (2005) Breast Cancer Res , vol.7 , Issue.6 , pp. 245-251
    • Hinck, L.1    Silberstein, G.B.2
  • 3
    • 27744522671 scopus 로고    scopus 로고
    • Information networks in the mammary gland
    • Hennighausen L, Robinson GW (2005) Information networks in the mammary gland. Nat Rev Mol Cell Biol 6(9):715–725
    • (2005) Nat Rev Mol Cell Biol , vol.6 , Issue.9 , pp. 715-725
    • Hennighausen, L.1    Robinson, G.W.2
  • 4
    • 0242667837 scopus 로고    scopus 로고
    • Stem cells and breast cancer: A field in transit
    • Smalley M, Ashworth A (2003) Stem cells and breast cancer: a field in transit. Nat Rev Cancer 3(11):832–844
    • (2003) Nat Rev Cancer , vol.3 , Issue.11 , pp. 832-844
    • Smalley, M.1    Ashworth, A.2
  • 5
    • 0031748344 scopus 로고    scopus 로고
    • An entire functional mammary gland may comprise the progeny from a single cell
    • Kordon EC, Smith GH (1998) An entire functional mammary gland may comprise the progeny from a single cell. Development 125(10):1921–1930
    • (1998) Development , vol.125 , Issue.10 , pp. 1921-1930
    • Kordon, E.C.1    Smith, G.H.2
  • 6
    • 0029868224 scopus 로고    scopus 로고
    • Experimental mammary epithelial morphogenesis in an in vivo model: Evidence for distinct cellular progenitors of the ductal and lobular phenotype
    • Smith GH (1996) Experimental mammary epithelial morphogenesis in an in vivo model: evidence for distinct cellular progenitors of the ductal and lobular phenotype. Breast Cancer Res Treat 39(1):21–31
    • (1996) Breast Cancer Res Treat , vol.39 , Issue.1 , pp. 21-31
    • Smith, G.H.1
  • 7
    • 33847126689 scopus 로고    scopus 로고
    • Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
    • Asselin-Labat ML et al (2007) Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation. Nat Cell Biol 9(2):201–209
    • (2007) Nat Cell Biol , vol.9 , Issue.2 , pp. 201-209
    • Asselin-Labat, M.L.1
  • 8
    • 30144432901 scopus 로고    scopus 로고
    • Purification and unique properties of mammary epithelial stem cells
    • Stingl J et al (2006) Purification and unique properties of mammary epithelial stem cells. Nature 439(7079):993–997
    • (2006) Nature , vol.439 , Issue.7079 , pp. 993-997
    • Stingl, J.1
  • 9
    • 30144433093 scopus 로고    scopus 로고
    • Generation of a functional mammary gland from a single stem cell
    • Shackleton M et al (2006) Generation of a functional mammary gland from a single stem cell. Nature 439(7072):84–88
    • (2006) Nature , vol.439 , Issue.7072 , pp. 84-88
    • Shackleton, M.1
  • 10
    • 33750470097 scopus 로고    scopus 로고
    • CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells
    • Sleeman KE et al (2006) CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells. Breast Cancer Res 8(1):R7
    • (2006) Breast Cancer Res , vol.8 , Issue.1
    • Sleeman, K.E.1
  • 11
    • 33847419142 scopus 로고    scopus 로고
    • Molecular definition of breast tumor heterogeneity
    • Shipitsin M et al (2007) Molecular definition of breast tumor heterogeneity. Cancer Cell 11(3):259–273
    • (2007) Cancer Cell , vol.11 , Issue.3 , pp. 259-273
    • Shipitsin, M.1
  • 12
    • 34247117277 scopus 로고    scopus 로고
    • Evidence for a stem cell hierarchy in the adult human breast
    • Villadsen R et al (2007) Evidence for a stem cell hierarchy in the adult human breast. J Cell Biol 177(1):87–101
    • (2007) J Cell Biol , vol.177 , Issue.1 , pp. 87-101
    • Villadsen, R.1
  • 13
    • 68349130357 scopus 로고    scopus 로고
    • Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
    • Lim E et al (2009) Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med 15(8):907–913
    • (2009) Nat Med , vol.15 , Issue.8 , pp. 907-913
    • Lim, E.1
  • 14
    • 57349148680 scopus 로고    scopus 로고
    • A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability
    • Eirew P et al (2008) A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat Med 14(12):1384–1389
    • (2008) Nat Med , vol.14 , Issue.12 , pp. 1384-1389
    • Eirew, P.1
  • 15
    • 84863116790 scopus 로고    scopus 로고
    • Defining the cellular precursors to human breast cancer
    • Keller PJ et al (2011) Defining the cellular precursors to human breast cancer. Proc Natl Acad Sci U S A 109:2772–2777
    • (2011) Proc Natl Acad Sci U S A , vol.109 , pp. 2772-2777
    • Keller, P.J.1
  • 16
    • 72749103664 scopus 로고    scopus 로고
    • Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis
    • Visvader JE (2009) Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev 23(22):2563–2577
    • (2009) Genes Dev , vol.23 , Issue.22 , pp. 2563-2577
    • Visvader, J.E.1
  • 17
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3(7):730–737
    • (1997) Nat Med , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 18
    • 33644560281 scopus 로고    scopus 로고
    • Cancer stem cells: An old idea—a paradigm shift
    • discussion 1895-6
    • Wicha MS, Liu S, Dontu G (2006) Cancer stem cells: an old idea—a paradigm shift. Cancer Res 66(4):1883–1890, discussion 1895-6
    • (2006) Cancer Res , vol.66 , Issue.4 , pp. 1883-1890
    • Wicha, M.S.1    Liu, S.2    Dontu, G.3
  • 19
    • 77957591579 scopus 로고    scopus 로고
    • Targeting breast cancer stem cells
    • Liu S, Wicha MS (2010) Targeting breast cancer stem cells. J Clin Oncol 28(25):4006–4012
    • (2010) J Clin Oncol , vol.28 , Issue.25 , pp. 4006-4012
    • Liu, S.1    Wicha, M.S.2
  • 20
    • 44949169522 scopus 로고    scopus 로고
    • Cancer stem cells in breast: Current opinion and future challenges
    • Charafe-Jauffret E et al (2008) Cancer stem cells in breast: current opinion and future challenges. Pathobiology 75(2):75–84
    • (2008) Pathobiology , vol.75 , Issue.2 , pp. 75-84
    • Charafe-Jauffret, E.1
  • 21
    • 0037388204 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic breast cancer cells
    • Al-Hajj M et al (2003) Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 100(7):3983–3988
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.7 , pp. 3983-3988
    • Al-Hajj, M.1
  • 22
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier C et al (2007) ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1(5):555–567
    • (2007) Cell Stem Cell , vol.1 , Issue.5 , pp. 555-567
    • Ginestier, C.1
  • 23
    • 84892619683 scopus 로고    scopus 로고
    • Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts
    • Liu S et al (2014) Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts. Stem Cell Reports 2(1):78–91
    • (2014) Stem Cell Reports , vol.2 , Issue.1 , pp. 78-91
    • Liu, S.1
  • 24
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh SK et al (2004) Identification of human brain tumour initiating cells. Nature 432(7015):396–401
    • (2004) Nature , vol.432 , Issue.7015 , pp. 396-401
    • Singh, S.K.1
  • 25
    • 28244472369 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic prostate cancer stem cells
    • Collins AT et al (2005) Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 65(23):10946–10951
    • (2005) Cancer Res , vol.65 , Issue.23 , pp. 10946-10951
    • Collins, A.T.1
  • 26
    • 33645026803 scopus 로고    scopus 로고
    • Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells
    • Patrawala L et al (2006) Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene 25(12):1696–1708
    • (2006) Oncogene , vol.25 , Issue.12 , pp. 1696-1708
    • Patrawala, L.1
  • 27
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O’Brien CA et al (2007) A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445(7123):106–110
    • (2007) Nature , vol.445 , Issue.7123 , pp. 106-110
    • O’Brien, C.A.1
  • 28
    • 33846095137 scopus 로고    scopus 로고
    • Identification and expansion of human colon-cancer-initiating cells
    • Ricci-Vitiani L et al (2007) Identification and expansion of human colon-cancer-initiating cells. Nature 445(7123):111–115
    • (2007) Nature , vol.445 , Issue.7123 , pp. 111-115
    • Ricci-Vitiani, L.1
  • 29
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • Li C et al (2007) Identification of pancreatic cancer stem cells. Cancer Res 67(3):1030–1037
    • (2007) Cancer Res , vol.67 , Issue.3 , pp. 1030-1037
    • Li, C.1
  • 30
    • 34249980343 scopus 로고    scopus 로고
    • Identification and characterization of tumorigenic liver cancer stem/progenitor cells
    • Ma S et al (2007) Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 132(7):2542–2556
    • (2007) Gastroenterology , vol.132 , Issue.7 , pp. 2542-2556
    • Ma, S.1
  • 31
    • 78649681554 scopus 로고    scopus 로고
    • MiR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1
    • Ma S et al (2010) MiR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell 7(6):694–707
    • (2010) Cell Stem Cell , vol.7 , Issue.6 , pp. 694-707
    • Ma, S.1
  • 32
    • 20444397431 scopus 로고    scopus 로고
    • Identification of bronchioalveolar stem cells in normal lung and lung cancer
    • Kim CF et al (2005) Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121(6):823–835
    • (2005) Cell , vol.121 , Issue.6 , pp. 823-835
    • Kim, C.F.1
  • 33
    • 33846512398 scopus 로고    scopus 로고
    • Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
    • Prince ME et al (2007) Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A 104(3):973–978
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.3 , pp. 973-978
    • Prince, M.E.1
  • 35
    • 21744462604 scopus 로고    scopus 로고
    • Cancer biology: Summing up cancer stem cells
    • Huntly BJ, Gilliland DG (2005) Cancer biology: summing up cancer stem cells. Nature 435(7046):1169–1170
    • (2005) Nature , vol.435 , Issue.7046 , pp. 1169-1170
    • Huntly, B.J.1    Gilliland, D.G.2
  • 36
    • 2942691389 scopus 로고    scopus 로고
    • Stem cell origin of cancer and differentiation therapy
    • Sell S (2004) Stem cell origin of cancer and differentiation therapy. Crit Rev Oncol Hematol 51(1):1–28
    • (2004) Crit Rev Oncol Hematol , vol.51 , Issue.1 , pp. 1-28
    • Sell, S.1
  • 37
    • 67650588404 scopus 로고    scopus 로고
    • Isolation of tumour stem-like cells from benign tumours
    • Xu Q et al (2009) Isolation of tumour stem-like cells from benign tumours. Br J Cancer 101(2):303–311
    • (2009) Br J Cancer , vol.101 , Issue.2 , pp. 303-311
    • Xu, Q.1
  • 38
    • 77954901231 scopus 로고    scopus 로고
    • Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase
    • Clay MR et al (2010) Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head Neck 32(9):1195–1201
    • (2010) Head Neck , vol.32 , Issue.9 , pp. 1195-1201
    • Clay, M.R.1
  • 39
    • 79957917044 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival
    • Silva IA et al (2011) Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival. Cancer Res 71(11):3991–4001
    • (2011) Cancer Res , vol.71 , Issue.11 , pp. 3991-4001
    • Silva, I.A.1
  • 40
    • 78649939527 scopus 로고    scopus 로고
    • Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells
    • Krishnamurthy S et al (2010) Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells. Cancer Res 70(23):9969–9978
    • (2010) Cancer Res , vol.70 , Issue.23 , pp. 9969-9978
    • Krishnamurthy, S.1
  • 41
    • 27144557960 scopus 로고    scopus 로고
    • A tumorigenic subpopulation with stem cell properties in melanomas
    • Fang D et al (2005) A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res 65(20):9328–9337
    • (2005) Cancer Res , vol.65 , Issue.20 , pp. 9328-9337
    • Fang, D.1
  • 42
    • 57349143739 scopus 로고    scopus 로고
    • Efficient tumour formation by single human melanoma cells
    • Quintana E et al (2008) Efficient tumour formation by single human melanoma cells. Nature 456(7222):593–598
    • (2008) Nature , vol.456 , Issue.7222 , pp. 593-598
    • Quintana, E.1
  • 43
    • 77952502408 scopus 로고    scopus 로고
    • A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
    • Roesch A et al (2010) A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell 141(4):583–594
    • (2010) Cell , vol.141 , Issue.4 , pp. 583-594
    • Roesch, A.1
  • 44
    • 77954238710 scopus 로고    scopus 로고
    • Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271
    • Boiko AD et al (2010) Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature 466(7302):133–137
    • (2010) Nature , vol.466 , Issue.7302 , pp. 133-137
    • Boiko, A.D.1
  • 45
    • 84866671365 scopus 로고    scopus 로고
    • ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets
    • Luo Y et al (2012) ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets. Stem Cells 30(10):2100–2113
    • (2012) Stem Cells , vol.30 , Issue.10 , pp. 2100-2113
    • Luo, Y.1
  • 46
    • 34547113747 scopus 로고    scopus 로고
    • Tumor growth need not be driven by rare cancer stem cells
    • Kelly PN et al (2007) Tumor growth need not be driven by rare cancer stem cells. Science 317(5836):337
    • (2007) Science , vol.317 , Issue.5836
    • Kelly, P.N.1
  • 47
    • 60549111070 scopus 로고    scopus 로고
    • Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature
    • Charafe-Jauffret E et al (2009) Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res 69(4):1302–1313
    • (2009) Cancer Res , vol.69 , Issue.4 , pp. 1302-1313
    • Charafe-Jauffret, E.1
  • 48
    • 84891278007 scopus 로고    scopus 로고
    • ALDH1-positive cancer stem cells predict engraftment of primary breast tumors and are governed by a common stem cell program
    • Charafe-Jauffret E et al (2013) ALDH1-positive cancer stem cells predict engraftment of primary breast tumors and are governed by a common stem cell program. Cancer Res 73(24):7290–7300
    • (2013) Cancer Res , vol.73 , Issue.24 , pp. 7290-7300
    • Charafe-Jauffret, E.1
  • 49
    • 73149110562 scopus 로고    scopus 로고
    • Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content
    • Pece S et al (2010) Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell 140(1):62–73
    • (2010) Cell , vol.140 , Issue.1 , pp. 62-73
    • Pece, S.1
  • 50
    • 0036163796 scopus 로고    scopus 로고
    • ABC transporters as phenotypic markers and functional regulators of stem cells
    • Bunting KD (2002) ABC transporters as phenotypic markers and functional regulators of stem cells. Stem Cells 20(1):11–20
    • (2002) Stem Cells , vol.20 , Issue.1 , pp. 11-20
    • Bunting, K.D.1
  • 51
    • 33750302541 scopus 로고    scopus 로고
    • SP analysis may be used to identify cancer stem cell populations
    • Hadnagy A et al (2006) SP analysis may be used to identify cancer stem cell populations. Exp Cell Res 312(19):3701–3710
    • (2006) Exp Cell Res , vol.312 , Issue.19 , pp. 3701-3710
    • Hadnagy, A.1
  • 52
    • 4644306516 scopus 로고    scopus 로고
    • A distinct “side population” of cells with high drug efflux capacity in human tumor cells
    • Hirschmann-Jax C et al (2004) A distinct “side population” of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A 101(39):14228–14233
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.39 , pp. 14228-14233
    • Hirschmann-Jax, C.1
  • 53
    • 1642474273 scopus 로고    scopus 로고
    • Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line
    • Kondo T, Setoguchi T, Taga T (2004) Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci U S A 101(3):781–786
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.3 , pp. 781-786
    • Kondo, T.1    Setoguchi, T.2    Taga, T.3
  • 54
    • 11144340909 scopus 로고    scopus 로고
    • A putative human breast stem cell population is enriched for steroid receptor-positive cells
    • Clarke RB et al (2005) A putative human breast stem cell population is enriched for steroid receptor-positive cells. Dev Biol 277(2):443–456
    • (2005) Dev Biol , vol.277 , Issue.2 , pp. 443-456
    • Clarke, R.B.1
  • 55
    • 1642486729 scopus 로고    scopus 로고
    • Functional and molecular characterisation of mammary side population cells
    • Alvi AJ et al (2003) Functional and molecular characterisation of mammary side population cells. Breast Cancer Res 5(1):R1–R8
    • (2003) Breast Cancer Res , vol.5 , Issue.1 , pp. R1-R8
    • Alvi, A.J.1
  • 56
    • 2942748109 scopus 로고    scopus 로고
    • Growth and differentiation of progenitor/stem cells derived from the human mammary gland
    • Clayton H, Titley I, Vivanco M (2004) Growth and differentiation of progenitor/stem cells derived from the human mammary gland. Exp Cell Res 297(2):444–460
    • (2004) Exp Cell Res , vol.297 , Issue.2 , pp. 444-460
    • Clayton, H.1    Titley, I.2    Vivanco, M.3
  • 57
    • 0036570144 scopus 로고    scopus 로고
    • Sca-1(Pos) cells in the mouse mammary gland represent an enriched progenitor cell population
    • Welm BE et al (2002) Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population. Dev Biol 245(1):42–56
    • (2002) Dev Biol , vol.245 , Issue.1 , pp. 42-56
    • Welm, B.E.1
  • 58
    • 22244433866 scopus 로고    scopus 로고
    • Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic
    • Patrawala L et al (2005) Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic. Cancer Res 65(14):6207–6219
    • (2005) Cancer Res , vol.65 , Issue.14 , pp. 6207-6219
    • Patrawala, L.1
  • 59
    • 84861815719 scopus 로고    scopus 로고
    • Breast cancer, side population cells and ABCG2 expression
    • Britton KM et al (2012) Breast cancer, side population cells and ABCG2 expression. Cancer Lett 323(1):97–105
    • (2012) Cancer Lett , vol.323 , Issue.1 , pp. 97-105
    • Britton, K.M.1
  • 60
    • 77649270350 scopus 로고    scopus 로고
    • Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signalling
    • Nakanishi T et al (2010) Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signalling. Br J Cancer 102(5):815–826
    • (2010) Br J Cancer , vol.102 , Issue.5 , pp. 815-826
    • Nakanishi, T.1
  • 61
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA et al (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133(4):704–715
    • (2008) Cell , vol.133 , Issue.4 , pp. 704-715
    • Mani, S.A.1
  • 62
    • 79959956046 scopus 로고    scopus 로고
    • The JAK2/STAT3 signaling pathway is required for growth of CD44CD24 stem cell-like breast cancer cells in human tumors
    • Marotta LL et al (2011) The JAK2/STAT3 signaling pathway is required for growth of CD44CD24 stem cell-like breast cancer cells in human tumors. J Clin Invest 121(7):2723–2735
    • (2011) J Clin Invest , vol.121 , Issue.7 , pp. 2723-2735
    • Marotta, L.L.1
  • 63
    • 55749104730 scopus 로고    scopus 로고
    • The CD44+/CD24- phenotype is enriched in basal-like breast tumors
    • Honeth G et al (2008) The CD44+/CD24- phenotype is enriched in basal-like breast tumors. Breast Cancer Res 10(3):R53
    • (2008) Breast Cancer Res , vol.10 , Issue.3
    • Honeth, G.1
  • 64
    • 77953163539 scopus 로고    scopus 로고
    • CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer
    • Meyer MJ et al (2010) CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer. Cancer Res 70(11):4624–4633
    • (2010) Cancer Res , vol.70 , Issue.11 , pp. 4624-4633
    • Meyer, M.J.1
  • 65
    • 0028813315 scopus 로고
    • High expression level of alpha 6 integrin in human breast carcinoma is correlated with reduced survival
    • Friedrichs K et al (1995) High expression level of alpha 6 integrin in human breast carcinoma is correlated with reduced survival. Cancer Res 55(4):901–906
    • (1995) Cancer Res , vol.55 , Issue.4 , pp. 901-906
    • Friedrichs, K.1
  • 66
    • 28244470818 scopus 로고    scopus 로고
    • The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo
    • Lipscomb EA et al (2005) The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo. Cancer Res 65(23):10970–10976
    • (2005) Cancer Res , vol.65 , Issue.23 , pp. 10970-10976
    • Lipscomb, E.A.1
  • 67
    • 33746846201 scopus 로고    scopus 로고
    • Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells
    • Chute JP et al (2006) Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. Proc Natl Acad Sci U S A 103(31):11707–11712
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.31 , pp. 11707-11712
    • Chute, J.P.1
  • 68
    • 0033529756 scopus 로고    scopus 로고
    • Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity
    • Storms RW et al (1999) Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity. Proc Natl Acad Sci U S A 96(16):9118–9123
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.16 , pp. 9118-9123
    • Storms, R.W.1
  • 69
    • 0032849465 scopus 로고    scopus 로고
    • The chemistry of the metabolites of cyclophosphamide
    • Ludeman SM (1999) The chemistry of the metabolites of cyclophosphamide. Curr Pharm Des 5(8):627–643
    • (1999) Curr Pharm Des , vol.5 , Issue.8 , pp. 627-643
    • Ludeman, S.M.1
  • 70
    • 34250732230 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential
    • Cheung AM et al (2007) Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential. Leukemia 21(7):1423–1430
    • (2007) Leukemia , vol.21 , Issue.7 , pp. 1423-1430
    • Cheung, A.M.1
  • 71
    • 78649960144 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling
    • Sullivan JP et al (2010) Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res 70(23):9937–9948
    • (2010) Cancer Res , vol.70 , Issue.23 , pp. 9937-9948
    • Sullivan, J.P.1
  • 72
    • 65949112714 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
    • Huang EH et al (2009) Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res 69(8):3382–3389
    • (2009) Cancer Res , vol.69 , Issue.8 , pp. 3382-3389
    • Huang, E.H.1
  • 73
    • 70350247558 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer
    • Carpentino JE et al (2009) Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer. Cancer Res 69(20):8208–8215
    • (2009) Cancer Res , vol.69 , Issue.20 , pp. 8208-8215
    • Carpentino, J.E.1
  • 74
    • 77953789724 scopus 로고    scopus 로고
    • High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer
    • van den Hoogen C et al (2010) High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer. Cancer Res 70(12):5163–5173
    • (2010) Cancer Res , vol.70 , Issue.12 , pp. 5163-5173
    • Van Den Hoogen, C.1
  • 75
    • 0037948854 scopus 로고    scopus 로고
    • In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    • Dontu G et al (2003) In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 17(10):1253–1270
    • (2003) Genes Dev , vol.17 , Issue.10 , pp. 1253-1270
    • Dontu, G.1
  • 77
    • 73649107330 scopus 로고    scopus 로고
    • Cancer stem cells and aneuploid populations within developing tumors are the major determinants of tumor dormancy
    • Kusumbe AP, Bapat SA (2009) Cancer stem cells and aneuploid populations within developing tumors are the major determinants of tumor dormancy. Cancer Res 69(24):9245–9253
    • (2009) Cancer Res , vol.69 , Issue.24 , pp. 9245-9253
    • Kusumbe, A.P.1    Bapat, S.A.2
  • 78
    • 0029868646 scopus 로고    scopus 로고
    • Homing of fluorescently labeled murine hematopoietic stem cells
    • Hendrikx PJ et al (1996) Homing of fluorescently labeled murine hematopoietic stem cells. Exp Hematol 24(2):129–140
    • (1996) Exp Hematol , vol.24 , Issue.2 , pp. 129-140
    • Hendrikx, P.J.1
  • 79
    • 0033058762 scopus 로고    scopus 로고
    • Homing of long-term and short-term engrafting cells in vivo
    • discussion 54-6
    • Lanzkron SM, Collector MI, Sharkis SJ (1999) Homing of long-term and short-term engrafting cells in vivo. Ann N Y Acad Sci 872:48–54, discussion 54-6
    • (1999) Ann N Y Acad Sci , vol.872 , pp. 48-54
    • Lanzkron, S.M.1    Collector, M.I.2    Sharkis, S.J.3
  • 80
    • 0036457106 scopus 로고    scopus 로고
    • Optical imaging of PKH-labeled hematopoietic cells in recipient bone marrow in vivo
    • Askenasy N, Farkas DL (2002) Optical imaging of PKH-labeled hematopoietic cells in recipient bone marrow in vivo. Stem Cells 20(6):501–513
    • (2002) Stem Cells , vol.20 , Issue.6 , pp. 501-513
    • Askenasy, N.1    Farkas, D.L.2
  • 81
    • 70349123829 scopus 로고    scopus 로고
    • The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells
    • Cicalese A et al (2009) The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell 138(6):1083–1095
    • (2009) Cell , vol.138 , Issue.6 , pp. 1083-1095
    • Cicalese, A.1
  • 82
    • 77955891615 scopus 로고    scopus 로고
    • Microenvironmental contaminations induced by fluorescent lipophilic dyes used for noninvasive in vitro and in vivo cell tracking
    • Lassailly F, Griessinger E, Bonnet D (2010) “Microenvironmental contaminations” induced by fluorescent lipophilic dyes used for noninvasive in vitro and in vivo cell tracking. Blood 115(26):5347–5354
    • (2010) Blood , vol.115 , Issue.26 , pp. 5347-5354
    • Lassailly, F.1    Griessinger, E.2    Bonnet, D.3
  • 83
    • 84862777563 scopus 로고    scopus 로고
    • Role of microRNAs in the regulation of breast cancer stem cells
    • Liu S, Clouthier SG, Wicha MS (2012) Role of microRNAs in the regulation of breast cancer stem cells. J Mammary Gland Biol Neoplasia 17(1):15–21
    • (2012) J Mammary Gland Biol Neoplasia , vol.17 , Issue.1 , pp. 15-21
    • Liu, S.1    Clouthier, S.G.2    Wicha, M.S.3
  • 84
    • 84864026356 scopus 로고    scopus 로고
    • MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells
    • Liu S et al (2012) MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells. PLoS Genet 8(6):e1002751
    • (2012) Plos Genet 8(6) , vol.8 , Issue.6
    • Liu, S.1
  • 85
    • 0344845003 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and pathologies
    • Thiery JP (2003) Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15(6):740–746
    • (2003) Curr Opin Cell Biol , vol.15 , Issue.6 , pp. 740-746
    • Thiery, J.P.1
  • 86
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J et al (2004) Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117(7):927–939
    • (2004) Cell , vol.117 , Issue.7 , pp. 927-939
    • Yang, J.1
  • 87
    • 65349092794 scopus 로고    scopus 로고
    • Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion
    • Wu Y et al (2009) Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell 15(5):416–428
    • (2009) Cancer Cell , vol.15 , Issue.5 , pp. 416-428
    • Wu, Y.1
  • 88
    • 40249113328 scopus 로고    scopus 로고
    • Direct regulation of TWIST by HIF-1alpha promotes metastasis
    • Yang MH et al (2008) Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 10(3):295–305
    • (2008) Nat Cell Biol , vol.10 , Issue.3 , pp. 295-305
    • Yang, M.H.1
  • 89
    • 77956320116 scopus 로고    scopus 로고
    • Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming
    • Samavarchi-Tehrani P et al (2010) Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell 7(1):64–77
    • (2010) Cell Stem Cell , vol.7 , Issue.1 , pp. 64-77
    • Samavarchi-Tehrani, P.1
  • 90
    • 84861527239 scopus 로고    scopus 로고
    • To differentiate or not: Routes towards metastasis
    • Brabletz T (2012) To differentiate or not: routes towards metastasis. Nat Rev Cancer 12(6):425–436
    • (2012) Nat Rev Cancer , vol.12 , Issue.6 , pp. 425-436
    • Brabletz, T.1
  • 91
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • Tsai JH et al (2012) Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 22(6):725–736
    • (2012) Cancer Cell , vol.22 , Issue.6 , pp. 725-736
    • Tsai, J.H.1
  • 92
    • 84870816403 scopus 로고    scopus 로고
    • Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1
    • Ocana OH et al (2012) Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell 22(6):709–724
    • (2012) Cancer Cell , vol.22 , Issue.6 , pp. 709-724
    • Ocana, O.H.1
  • 93
    • 84855425160 scopus 로고    scopus 로고
    • Interactions between cancer stem cells and their niche govern metastatic colonization
    • Malanchi I et al (2012) Interactions between cancer stem cells and their niche govern metastatic colonization. Nature 481(7379):85–89
    • (2012) Nature , vol.481 , Issue.7379 , pp. 85-89
    • Malanchi, I.1
  • 94
    • 80052470207 scopus 로고    scopus 로고
    • Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization
    • Korpal M et al (2011) Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med 17(9):1101–1108
    • (2011) Nat Med , vol.17 , Issue.9 , pp. 1101-1108
    • Korpal, M.1
  • 95
    • 84890192124 scopus 로고    scopus 로고
    • TGF-beta-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition
    • Stankic M et al (2013) TGF-beta-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition. Cell Rep 5(5):1228–1242
    • (2013) Cell Rep , vol.5 , Issue.5 , pp. 1228-1242
    • Stankic, M.1
  • 96
    • 34548863946 scopus 로고    scopus 로고
    • Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    • Herschkowitz JI et al (2007) Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol 8(5):R76
    • (2007) Genome Biol , vol.8 , Issue.5
    • Herschkowitz, J.I.1
  • 97
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM et al (2000) Molecular portraits of human breast tumours. Nature 406(6797):747–752
    • (2000) Nature , vol.406 , Issue.6797 , pp. 747-752
    • Perou, C.M.1
  • 98
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie T et al (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 98(19):10869–10874
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.19 , pp. 10869-10874
    • Sorlie, T.1
  • 99
    • 0042838307 scopus 로고    scopus 로고
    • Breast cancer classification and prognosis based on gene expression profiles from a population-based study
    • Sotiriou C et al (2003) Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci U S A 100(18):10393–10398
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.18 , pp. 10393-10398
    • Sotiriou, C.1
  • 100
    • 20044390359 scopus 로고    scopus 로고
    • Patterns of resistance and incomplete response to docetaxel by gene expression profiling in breast cancer patients
    • Chang JC et al (2005) Patterns of resistance and incomplete response to docetaxel by gene expression profiling in breast cancer patients. J Clin Oncol 23(6):1169–1177
    • (2005) J Clin Oncol , vol.23 , Issue.6 , pp. 1169-1177
    • Chang, J.C.1
  • 101
    • 69549131213 scopus 로고    scopus 로고
    • Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
    • Creighton CJ et al (2009) Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci U S A 106(33):13820–13825
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.33 , pp. 13820-13825
    • Creighton, C.J.1
  • 102
    • 77956218241 scopus 로고    scopus 로고
    • BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells
    • Molyneux G et al (2010) BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 7(3):403–417
    • (2010) Cell Stem Cell , vol.7 , Issue.3 , pp. 403-417
    • Molyneux, G.1
  • 103
    • 79551614327 scopus 로고    scopus 로고
    • Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate
    • Proia TA et al (2011) Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Cell Stem Cell 8(2):149–163
    • (2011) Cell Stem Cell , vol.8 , Issue.2 , pp. 149-163
    • Proia, T.A.1
  • 104
    • 84863116790 scopus 로고    scopus 로고
    • Defining the cellular precursors to human breast cancer
    • Keller PJ et al (2012) Defining the cellular precursors to human breast cancer. Proc Natl Acad Sci U S A 109(8):2772–2777
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.8 , pp. 2772-2777
    • Keller, P.J.1
  • 105
    • 80855130470 scopus 로고    scopus 로고
    • Distinct stem cells contribute to mammary gland development and maintenance
    • Van Keymeulen A et al (2011) Distinct stem cells contribute to mammary gland development and maintenance. Nature 479(7372):189–193
    • (2011) Nature , vol.479 , Issue.7372 , pp. 189-193
    • Van Keymeulen, A.1
  • 106
    • 73649115686 scopus 로고    scopus 로고
    • Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis
    • Jeselsohn R et al (2010) Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis. Cancer Cell 17(1):65–76
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 65-76
    • Jeselsohn, R.1
  • 107
    • 40349100163 scopus 로고    scopus 로고
    • BRCA1 regulates human mammary stem/progenitor cell fate
    • Liu S et al (2008) BRCA1 regulates human mammary stem/progenitor cell fate. Proc Natl Acad Sci U S A 105(5):1680–1685
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.5 , pp. 1680-1685
    • Liu, S.1
  • 108
    • 77956034139 scopus 로고    scopus 로고
    • Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment
    • Lagadec C et al (2010) Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment. Breast Cancer Res 12(1):R13
    • (2010) Breast Cancer Res , vol.12 , Issue.1
    • Lagadec, C.1
  • 109
    • 33845904383 scopus 로고    scopus 로고
    • The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation
    • Phillips TM, McBride WH, Pajonk F (2006) The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst 98(24):1777–1785
    • (2006) J Natl Cancer Inst , vol.98 , Issue.24 , pp. 1777-1785
    • Phillips, T.M.1    McBride, W.H.2    Pajonk, F.3
  • 110
    • 77956886271 scopus 로고    scopus 로고
    • Senescence evasion by MCF-7 human breast tumor-initiating cells
    • Karimi-Busheri F et al (2010) Senescence evasion by MCF-7 human breast tumor-initiating cells. Breast Cancer Res 12(3):R31
    • (2010) Breast Cancer Res , vol.12 , Issue.3
    • Karimi-Busheri, F.1
  • 111
    • 48949119473 scopus 로고    scopus 로고
    • Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
    • Fillmore CM, Kuperwasser C (2008) Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res 10(2):R25
    • (2008) Breast Cancer Res , vol.10 , Issue.2
    • Fillmore, C.M.1    Kuperwasser, C.2
  • 112
    • 44849143103 scopus 로고    scopus 로고
    • Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors
    • Shafee N et al (2008) Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors. Cancer Res 68(9):3243–3250
    • (2008) Cancer Res , vol.68 , Issue.9 , pp. 3243-3250
    • Shafee, N.1
  • 113
    • 33846287519 scopus 로고    scopus 로고
    • WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells
    • Woodward WA et al (2007) WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc Natl Acad Sci U S A 104(2):618–623
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.2 , pp. 618-623
    • Woodward, W.A.1
  • 114
    • 64749093574 scopus 로고    scopus 로고
    • Association of reactive oxygen species levels and radioresistance in cancer stem cells
    • Diehn M et al (2009) Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 458(7239):780–783
    • (2009) Nature , vol.458 , Issue.7239 , pp. 780-783
    • Diehn, M.1
  • 115
    • 36849078711 scopus 로고    scopus 로고
    • Let-7 regulates self renewal and tumorigenicity of breast cancer cells
    • Yu F et al (2007) let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131(6):1109–23
    • (2007) Cell , vol.131 , Issue.6 , pp. 1109-1123
    • Yu, F.1
  • 116
    • 79960317000 scopus 로고    scopus 로고
    • Ablation of breast cancer stem cells with radiation
    • Zielske SP et al (2011) Ablation of breast cancer stem cells with radiation. Transl Oncol 4(4):227–233
    • (2011) Transl Oncol , vol.4 , Issue.4 , pp. 227-233
    • Zielske, S.P.1
  • 117
    • 44049100934 scopus 로고    scopus 로고
    • Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy
    • Li X et al (2008) Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst 100(9):672–679
    • (2008) J Natl Cancer Inst , vol.100 , Issue.9 , pp. 672-679
    • Li, X.1
  • 118
    • 54049096261 scopus 로고    scopus 로고
    • HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion
    • Korkaya H et al (2008) HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion. Oncogene 27(47):6120–6130
    • (2008) Oncogene , vol.27 , Issue.47 , pp. 6120-6130
    • Korkaya, H.1
  • 119
    • 67449113764 scopus 로고    scopus 로고
    • Association of breast cancer stem cells identified by aldehyde dehydrogenase 1 expression with resistance to sequential Paclitaxel and epirubicin-based chemotherapy for breast cancers
    • Tanei T et al (2009) Association of breast cancer stem cells identified by aldehyde dehydrogenase 1 expression with resistance to sequential Paclitaxel and epirubicin-based chemotherapy for breast cancers. Clin Cancer Res 15(12):4234–4241
    • (2009) Clin Cancer Res , vol.15 , Issue.12 , pp. 4234-4241
    • Tanei, T.1
  • 120
    • 33745488426 scopus 로고    scopus 로고
    • Transcriptional profiling of mammary gland side population cells
    • Behbod F et al (2006) Transcriptional profiling of mammary gland side population cells. Stem Cells 24(4):1065–1074
    • (2006) Stem Cells , vol.24 , Issue.4 , pp. 1065-1074
    • Behbod, F.1
  • 121
    • 84874857331 scopus 로고    scopus 로고
    • HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: Implications for efficacy of adjuvant trastuzumab
    • Ithimakin S et al (2013) HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab. Cancer Res 73(5):1635–1646
    • (2013) Cancer Res , vol.73 , Issue.5 , pp. 1635-1646
    • Ithimakin, S.1
  • 122
    • 0037259979 scopus 로고    scopus 로고
    • Human aldehyde dehydrogenases: Potential pathological, pharmacological, and toxicological impact
    • Sladek NE (2003) Human aldehyde dehydrogenases: potential pathological, pharmacological, and toxicological impact. J Biochem Mol Toxicol 17(1):7–23
    • (2003) J Biochem Mol Toxicol , vol.17 , Issue.1 , pp. 7-23
    • Sladek, N.E.1
  • 123
    • 76149125786 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer
    • Su Y et al (2010) Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer. Cancer Epidemiol Biomarkers Prev 19(2):327–337
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , Issue.2 , pp. 327-337
    • Su, Y.1
  • 124
    • 79958716191 scopus 로고    scopus 로고
    • ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma
    • Kim MP et al (2011) ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma. PLoS One 6(6):e20636
    • (2011) Plos One , vol.6 , Issue.6
    • Kim, M.P.1
  • 125
    • 78650455641 scopus 로고    scopus 로고
    • Targeting aldehyde dehydrogenase cancer stem cells in ovarian cancer
    • Landen CN Jr et al (2010) Targeting aldehyde dehydrogenase cancer stem cells in ovarian cancer. Mol Cancer Ther 9(12):3186–3199
    • (2010) Mol Cancer Ther , vol.9 , Issue.12 , pp. 3186-3199
    • Landen, C.N.1
  • 126
    • 0030024868 scopus 로고    scopus 로고
    • Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer
    • Magni M et al (1996) Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer. Blood 87(3):1097–1103
    • (1996) Blood , vol.87 , Issue.3 , pp. 1097-1103
    • Magni, M.1
  • 127
    • 0029685930 scopus 로고    scopus 로고
    • Overexpression of the human aldehyde dehydrogenase class I results in increased resistance to 4-hydroperoxycyclophosphamide
    • Moreb J et al (1996) Overexpression of the human aldehyde dehydrogenase class I results in increased resistance to 4-hydroperoxycyclophosphamide. Cancer Gene Ther 3(1):24–30
    • (1996) Cancer Gene Ther , vol.3 , Issue.1 , pp. 24-30
    • Moreb, J.1
  • 128
    • 0034099052 scopus 로고    scopus 로고
    • Expression of antisense RNA to aldehyde dehydrogenase class-1 sensitizes tumor cells to 4-hydroperoxycyclophosphamide in vitro
    • Moreb JS et al (2000) Expression of antisense RNA to aldehyde dehydrogenase class-1 sensitizes tumor cells to 4-hydroperoxycyclophosphamide in vitro. J Pharmacol Exp Ther 293(2):390–396
    • (2000) J Pharmacol Exp Ther , vol.293 , Issue.2 , pp. 390-396
    • Moreb, J.S.1
  • 129
    • 79954432202 scopus 로고    scopus 로고
    • Comparative proteomic analysis of paclitaxel sensitive A549 lung adenocarcinoma cell line and its resistant counterpart A549-Taxol
    • Sun QL et al (2011) Comparative proteomic analysis of paclitaxel sensitive A549 lung adenocarcinoma cell line and its resistant counterpart A549-Taxol. J Cancer Res Clin Oncol 137(3):521–532
    • (2011) J Cancer Res Clin Oncol , vol.137 , Issue.3 , pp. 521-532
    • Sun, Q.L.1
  • 130
    • 0036202207 scopus 로고    scopus 로고
    • Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: A retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens
    • Sladek NE et al (2002) Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: a retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens. Cancer Chemother Pharmacol 49(4):309–321
    • (2002) Cancer Chemother Pharmacol , vol.49 , Issue.4 , pp. 309-321
    • Sladek, N.E.1
  • 131
    • 84860347162 scopus 로고    scopus 로고
    • Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44(+) human breast cancer cells
    • Croker AK, Allan AL (2012) Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44(+) human breast cancer cells. Breast Cancer Res Treat 133(1):75–87
    • (2012) Breast Cancer Res Treat , vol.133 , Issue.1 , pp. 75-87
    • Croker, A.K.1    Allan, A.L.2
  • 132
    • 0022312389 scopus 로고
    • Biochemistry of DNA lesions
    • Ward JF (1985) Biochemistry of DNA lesions. Radiat Res Suppl 8:S103–S111
    • (1985) Radiat Res Suppl , vol.8 , pp. S103-S111
    • Ward, J.F.1
  • 133
    • 0025029088 scopus 로고
    • DNA damage and repair following treatment with ionizing radiation
    • Powell S, McMillan TJ (1990) DNA damage and repair following treatment with ionizing radiation. Radiother Oncol 19(2):95–108
    • (1990) Radiother Oncol , vol.19 , Issue.2 , pp. 95-108
    • Powell, S.1    McMillan, T.J.2
  • 134
    • 79956191022 scopus 로고    scopus 로고
    • Role of oxidative stress and DNA damage in human carcinogenesis
    • Kryston TB et al (2011) Role of oxidative stress and DNA damage in human carcinogenesis. Mutat Res 711(1–2):193–201
    • (2011) Mutat Res , vol.711 , Issue.12 , pp. 193-201
    • Kryston, T.B.1
  • 135
    • 7244250309 scopus 로고    scopus 로고
    • Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
    • Ito K et al (2004) Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431(7011):997–1002
    • (2004) Nature , vol.431 , Issue.7011 , pp. 997-1002
    • Ito, K.1
  • 136
    • 33645730667 scopus 로고    scopus 로고
    • Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
    • Ito K et al (2006) Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med 12(4):446–451
    • (2006) Nat Med , vol.12 , Issue.4 , pp. 446-451
    • Ito, K.1
  • 137
    • 33846419112 scopus 로고    scopus 로고
    • FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    • Tothova Z et al (2007) FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128(2):325–339
    • (2007) Cell , vol.128 , Issue.2 , pp. 325-339
    • Tothova, Z.1
  • 138
    • 34249882777 scopus 로고    scopus 로고
    • Foxo3a is essential for maintenance of the hematopoietic stem cell pool
    • Miyamoto K et al (2007) Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 1(1):101–112
    • (2007) Cell Stem Cell , vol.1 , Issue.1 , pp. 101-112
    • Miyamoto, K.1
  • 139
    • 16844363378 scopus 로고    scopus 로고
    • The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
    • Guzman ML et al (2005) The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood 105(11):4163–4169
    • (2005) Blood , vol.105 , Issue.11 , pp. 4163-4169
    • Guzman, M.L.1
  • 140
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S et al (2006) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444(7120):756–760
    • (2006) Nature , vol.444 , Issue.7120 , pp. 756-760
    • Bao, S.1
  • 141
    • 80052841288 scopus 로고    scopus 로고
    • The phenotypic radiation resistance of CD44+/CD24(-or low) breast cancer cells is mediated through the enhanced activation of ATM signaling
    • Yin H, Glass J (2011) The phenotypic radiation resistance of CD44+/CD24(-or low) breast cancer cells is mediated through the enhanced activation of ATM signaling. PLoS One 6(9):e24080
    • (2011) Plos One , vol.6 , Issue.9
    • Yin, H.1    Glass, J.2
  • 142
    • 77649257221 scopus 로고    scopus 로고
    • Selective targeting of radiation-resistant tumor-initiating cells
    • Zhang M, Atkinson RL, Rosen JM (2010) Selective targeting of radiation-resistant tumor-initiating cells. Proc Natl Acad Sci U S A 107(8):3522–3527
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.8 , pp. 3522-3527
    • Zhang, M.1    Atkinson, R.L.2    Rosen, J.M.3
  • 143
    • 0037227965 scopus 로고    scopus 로고
    • CD44: From adhesion molecules to signalling regulators
    • Ponta H, Sherman L, Herrlich PA (2003) CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol 4(1):33–45
    • (2003) Nat Rev Mol Cell Biol , vol.4 , Issue.1 , pp. 33-45
    • Ponta, H.1    Sherman, L.2    Herrlich, P.A.3
  • 144
    • 33745606029 scopus 로고    scopus 로고
    • A positive feedback loop couples Ras activation and CD44 alternative splicing
    • Cheng C, Yaffe MB, Sharp PA (2006) A positive feedback loop couples Ras activation and CD44 alternative splicing. Genes Dev 20(13):1715–1720
    • (2006) Genes Dev , vol.20 , Issue.13 , pp. 1715-1720
    • Cheng, C.1    Yaffe, M.B.2    Sharp, P.A.3
  • 145
    • 0036896923 scopus 로고    scopus 로고
    • CD44 is required for two consecutive steps in HGF/c-Met signaling
    • Orian-Rousseau V et al (2002) CD44 is required for two consecutive steps in HGF/c-Met signaling. Genes Dev 16(23):3074–3086
    • (2002) Genes Dev , vol.16 , Issue.23 , pp. 3074-3086
    • Orian-Rousseau, V.1
  • 146
    • 0034605041 scopus 로고    scopus 로고
    • CD44 enhances neuregulin signaling by Schwann cells
    • Sherman LS et al (2000) CD44 enhances neuregulin signaling by Schwann cells. J Cell Biol 150(5):1071–1084
    • (2000) J Cell Biol , vol.150 , Issue.5 , pp. 1071-1084
    • Sherman, L.S.1
  • 147
    • 0030783518 scopus 로고    scopus 로고
    • Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation
    • Bourguignon LY et al (1997) Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation. J Biol Chem 272(44):27913–27918
    • (1997) J Biol Chem , vol.272 , Issue.44 , pp. 27913-27918
    • Bourguignon, L.Y.1
  • 148
    • 4143149778 scopus 로고    scopus 로고
    • CD44 potentiates the adherence of metastatic prostate and breast cancer cells to bone marrow endothelial cells
    • Draffin JE et al (2004) CD44 potentiates the adherence of metastatic prostate and breast cancer cells to bone marrow endothelial cells. Cancer Res 64(16):5702–5711
    • (2004) Cancer Res , vol.64 , Issue.16 , pp. 5702-5711
    • Draffin, J.E.1
  • 149
    • 84880059674 scopus 로고    scopus 로고
    • Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production
    • Hiraga T, Ito S, Nakamura H (2013) Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production. Cancer Res 73(13):4112–4122
    • (2013) Cancer Res , vol.73 , Issue.13 , pp. 4112-4122
    • Hiraga, T.1    Ito, S.2    Nakamura, H.3
  • 150
    • 79952227361 scopus 로고    scopus 로고
    • CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression
    • Brown RL et al (2011) CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. J Clin Invest 121(3):1064–1074
    • (2011) J Clin Invest , vol.121 , Issue.3 , pp. 1064-1074
    • Brown, R.L.1
  • 151
    • 38549131901 scopus 로고    scopus 로고
    • GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model
    • Kouros-Mehr H et al (2008) GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell 13(2):141–152
    • (2008) Cancer Cell , vol.13 , Issue.2 , pp. 141-152
    • Kouros-Mehr, H.1
  • 152
    • 32244439441 scopus 로고    scopus 로고
    • CD24 affects CXCR4 function in pre-B lymphocytes and breast carcinoma cells
    • Schabath H et al (2006) CD24 affects CXCR4 function in pre-B lymphocytes and breast carcinoma cells. J Cell Sci 119(Pt 2):314–325
    • (2006) J Cell Sci , vol.119 , pp. 314-325
    • Schabath, H.1
  • 153
    • 84885237107 scopus 로고    scopus 로고
    • Emerging targets in cancer management: Role of the CXCL12/CXCR4 axis
    • Cojoc M et al (2013) Emerging targets in cancer management: role of the CXCL12/CXCR4 axis. Onco Targets Ther 6:1347–1361
    • (2013) Onco Targets Ther , vol.6 , pp. 1347-1361
    • Cojoc, M.1
  • 154
    • 33751346643 scopus 로고    scopus 로고
    • CD44+/CD24− breast cancer cells exhibit enhanced invasive properties: An early step necessary for metastasis
    • Sheridan C et al (2006) CD44+/CD24− breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis. Breast Cancer Res 8(5):R59
    • (2006) Breast Cancer Res , vol.8 , Issue.5
    • Sheridan, C.1
  • 155
    • 33846425793 scopus 로고    scopus 로고
    • The prognostic role of a gene signature from tumorigenic breast-cancer cells
    • Liu R et al (2007) The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med 356(3):217–226
    • (2007) N Engl J Med , vol.356 , Issue.3 , pp. 217-226
    • Liu, R.1
  • 156
    • 33750306612 scopus 로고    scopus 로고
    • Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype
    • Balic M et al (2006) Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype. Clin Cancer Res 12(19):5615–5621
    • (2006) Clin Cancer Res , vol.12 , Issue.19 , pp. 5615-5621
    • Balic, M.1
  • 157
    • 78149262994 scopus 로고    scopus 로고
    • Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models
    • Liu H et al (2010) Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci U S A 107(42):18115–18120
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.42 , pp. 18115-18120
    • Liu, H.1
  • 158
    • 73649125337 scopus 로고    scopus 로고
    • Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer
    • Theodoropoulos PA et al (2010) Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer. Cancer Lett 288(1):99–106
    • (2010) Cancer Lett , vol.288 , Issue.1 , pp. 99-106
    • Theodoropoulos, P.A.1
  • 159
    • 74949129868 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer
    • Charafe-Jauffret E et al (2010) Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer. Clin Cancer Res 16(1):45–55
    • (2010) Clin Cancer Res , vol.16 , Issue.1 , pp. 45-55
    • Charafe-Jauffret, E.1
  • 160
    • 78751522709 scopus 로고    scopus 로고
    • Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks
    • Liu S et al (2011) Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks. Cancer Res 71(2):614–624
    • (2011) Cancer Res , vol.71 , Issue.2 , pp. 614-624
    • Liu, S.1
  • 161
    • 80052190496 scopus 로고    scopus 로고
    • Circulating tumor cells in breast cancer: Detection systems, molecular characterization, and future challenges
    • Lianidou ES, Markou A (2011) Circulating tumor cells in breast cancer: detection systems, molecular characterization, and future challenges. Clin Chem 57(9):1242–1255
    • (2011) Clin Chem , vol.57 , Issue.9 , pp. 1242-1255
    • Lianidou, E.S.1    Markou, A.2
  • 162
    • 84866520971 scopus 로고    scopus 로고
    • Redefining micrometastasis in prostate cancer: A comparison of circulating prostate cells, bone marrow disseminated tumor cells and micrometastasis—implications in determining local or systemic treatment for biochemical failure after radical prostatectomy
    • Murray NP et al (2012) Redefining micrometastasis in prostate cancer: a comparison of circulating prostate cells, bone marrow disseminated tumor cells and micrometastasis—implications in determining local or systemic treatment for biochemical failure after radical prostatectomy. Int J Mol Med 30(4):896–904
    • (2012) Int J Mol Med , vol.30 , Issue.4 , pp. 896-904
    • Murray, N.P.1
  • 163
    • 20144385756 scopus 로고    scopus 로고
    • Circulating tumor cells: A novel prognostic factor for newly diagnosed metastatic breast cancer
    • Cristofanilli M et al (2005) Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. J Clin Oncol 23(7):1420–1430
    • (2005) J Clin Oncol , vol.23 , Issue.7 , pp. 1420-1430
    • Cristofanilli, M.1
  • 164
    • 84871990259 scopus 로고    scopus 로고
    • Biologic challenges in the detection of circulating tumor cells
    • Joosse SA, Pantel K (2013) Biologic challenges in the detection of circulating tumor cells. Cancer Res 73(1):8–11
    • (2013) Cancer Res , vol.73 , Issue.1 , pp. 8-11
    • Joosse, S.A.1    Pantel, K.2
  • 165
    • 47949114668 scopus 로고    scopus 로고
    • Detection of mutations in EGFR in circulating lung-cancer cells
    • Maheswaran S et al (2008) Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med 359(4):366–377
    • (2008) N Engl J Med , vol.359 , Issue.4 , pp. 366-377
    • Maheswaran, S.1
  • 166
    • 37549002543 scopus 로고    scopus 로고
    • Isolation of rare circulating tumour cells in cancer patients by microchip technology
    • Nagrath S et al (2007) Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450(7173):1235–1239
    • (2007) Nature , vol.450 , Issue.7173 , pp. 1235-1239
    • Nagrath, S.1
  • 167
    • 84880270290 scopus 로고    scopus 로고
    • Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
    • Baccelli I et al (2013) Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat Biotechnol 31(6):539–544
    • (2013) Nat Biotechnol , vol.31 , Issue.6 , pp. 539-544
    • Baccelli, I.1
  • 168
    • 84877726784 scopus 로고    scopus 로고
    • The identification and characterization of breast cancer CTCs competent for brain metastasis
    • Zhang L et al (2013) The identification and characterization of breast cancer CTCs competent for brain metastasis. Sci Transl Med 5(180): 180ra48
    • (2013) Sci Transl Med , vol.5 , Issue.180
    • Zhang, L.1
  • 169
    • 84873811988 scopus 로고    scopus 로고
    • Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition
    • Yu M et al (2013) Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science 339(6119):580–584
    • (2013) Science , vol.339 , Issue.6119 , pp. 580-584
    • Yu, M.1
  • 170
    • 84863984494 scopus 로고    scopus 로고
    • Final results of a multicenter phase II clinical trial evaluating the activity of single-agent lapatinib in patients with HER2-negative metastatic breast cancer and HER2-positive circulating tumor cells. A proof-of-concept study
    • Pestrin M et al (2012) Final results of a multicenter phase II clinical trial evaluating the activity of single-agent lapatinib in patients with HER2-negative metastatic breast cancer and HER2-positive circulating tumor cells. A proof-of-concept study. Breast Cancer Res Treat 134(1):283–289
    • (2012) Breast Cancer Res Treat , vol.134 , Issue.1 , pp. 283-289
    • Pestrin, M.1
  • 171
    • 80052632043 scopus 로고    scopus 로고
    • Artificial neural network analysis of circulating tumor cells in metastatic breast cancer patients
    • Giordano A et al (2011) Artificial neural network analysis of circulating tumor cells in metastatic breast cancer patients. Breast Cancer Res Treat 129(2):451–458
    • (2011) Breast Cancer Res Treat , vol.129 , Issue.2 , pp. 451-458
    • Giordano, A.1
  • 172
    • 67650354361 scopus 로고    scopus 로고
    • Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer
    • Cohen SJ et al (2009) Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer. Ann Oncol 20(7):1223–1229
    • (2009) Ann Oncol , vol.20 , Issue.7 , pp. 1223-1229
    • Cohen, S.J.1
  • 173
    • 58949088650 scopus 로고    scopus 로고
    • Circulating tumour cell (CTC) counts as intermediate end points in castration-resistant prostate cancer (CRPC): A single-centre experience
    • Olmos D et al (2009) Circulating tumour cell (CTC) counts as intermediate end points in castration-resistant prostate cancer (CRPC): a single-centre experience. Ann Oncol 20(1):27–33
    • (2009) Ann Oncol , vol.20 , Issue.1 , pp. 27-33
    • Olmos, D.1
  • 174
    • 6044259206 scopus 로고    scopus 로고
    • Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases
    • Allard WJ et al (2004) Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases. Clin Cancer Res 10(20):6897–6904
    • (2004) Clin Cancer Res , vol.10 , Issue.20 , pp. 6897-6904
    • Allard, W.J.1
  • 175
    • 33747117373 scopus 로고    scopus 로고
    • The origins and the future of microfluidics
    • Whitesides GM (2006) The origins and the future of microfluidics. Nature 442(7101):368–373
    • (2006) Nature , vol.442 , Issue.7101 , pp. 368-373
    • Whitesides, G.M.1
  • 176
    • 0034235973 scopus 로고    scopus 로고
    • Integrated system for rapid PCR-based DNA analysis in microfluidic devices
    • Khandurina J et al (2000) Integrated system for rapid PCR-based DNA analysis in microfluidic devices. Anal Chem 72(13):2995–3000
    • (2000) Anal Chem , vol.72 , Issue.13 , pp. 2995-3000
    • Khandurina, J.1
  • 177
    • 10644274582 scopus 로고    scopus 로고
    • Electrokinetically controlled DNA hybridization microfluidic chip enabling rapid target analysis
    • Erickson D et al (2004) Electrokinetically controlled DNA hybridization microfluidic chip enabling rapid target analysis. Anal Chem 76(24):7269–7277
    • (2004) Anal Chem , vol.76 , Issue.24 , pp. 7269-7277
    • Erickson, D.1
  • 178
    • 34548077793 scopus 로고    scopus 로고
    • Microfluidic platforms for lab-on-a-chip applications
    • Haeberle S, Zengerle R (2007) Microfluidic platforms for lab-on-a-chip applications. Lab Chip 7(9):1094–1110
    • (2007) Lab Chip , vol.7 , Issue.9 , pp. 1094-1110
    • Haeberle, S.1    Zengerle, R.2
  • 179
    • 77951922478 scopus 로고    scopus 로고
    • Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody
    • Gleghorn JP et al (2010) Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody. Lab Chip 10(1):27–29
    • (2010) Lab Chip , vol.10 , Issue.1 , pp. 27-29
    • Gleghorn, J.P.1
  • 180
    • 46949084705 scopus 로고    scopus 로고
    • Highly efficient circulating tumor cell isolation from whole blood and label-free enumeration using polymer-based microfluidics with an integrated conductivity sensor
    • Adams AA et al (2008) Highly efficient circulating tumor cell isolation from whole blood and label-free enumeration using polymer-based microfluidics with an integrated conductivity sensor. J Am Chem Soc 130(27):8633–8641
    • (2008) J am Chem Soc , vol.130 , Issue.27 , pp. 8633-8641
    • Adams, A.A.1
  • 181
    • 78649872067 scopus 로고    scopus 로고
    • Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
    • Stott SL et al (2010) Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc Natl Acad Sci U S A 107(43):18392–18397
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.43 , pp. 18392-18397
    • Stott, S.L.1
  • 182
    • 84885482664 scopus 로고    scopus 로고
    • Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets
    • Yoon HJ et al (2013) Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets. Nat Nanotechnol 8(10):735–741
    • (2013) Nat Nanotechnol , vol.8 , Issue.10 , pp. 735-741
    • Yoon, H.J.1
  • 183
    • 77958037272 scopus 로고    scopus 로고
    • Portable filter-based microdevice for detection and characterization of circulating tumor cells
    • Lin HK et al (2010) Portable filter-based microdevice for detection and characterization of circulating tumor cells. Clin Cancer Res 16(20):5011–5018
    • (2010) Clin Cancer Res , vol.16 , Issue.20 , pp. 5011-5018
    • Lin, H.K.1
  • 184
    • 12144287967 scopus 로고    scopus 로고
    • Impact of cytomorphological detection of circulating tumor cells in patients with liver cancer
    • Vona G et al (2004) Impact of cytomorphological detection of circulating tumor cells in patients with liver cancer. Hepatology 39(3):792–797
    • (2004) Hepatology , vol.39 , Issue.3 , pp. 792-797
    • Vona, G.1
  • 185
    • 34547529462 scopus 로고    scopus 로고
    • Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells
    • Zheng S et al (2007) Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells. J Chromatogr A 1162(2):154–161
    • (2007) J Chromatogr A , vol.1162 , Issue.2 , pp. 154-161
    • Zheng, S.1
  • 186
    • 79751533744 scopus 로고    scopus 로고
    • 3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood
    • Zheng S et al (2011) 3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood. Biomed Microdevices 13(1):203–213
    • (2011) Biomed Microdevices , vol.13 , Issue.1 , pp. 203-213
    • Zheng, S.1
  • 187
    • 77949796890 scopus 로고    scopus 로고
    • Deformability considerations in filtration of biological cells
    • Kuo JS et al (2010) Deformability considerations in filtration of biological cells. Lab Chip 10(7):837–842
    • (2010) Lab Chip , vol.10 , Issue.7 , pp. 837-842
    • Kuo, J.S.1
  • 188
    • 84875859663 scopus 로고    scopus 로고
    • Fundamentals of inertial focusing in microchannels
    • Zhou J, Papautsky I (2013) Fundamentals of inertial focusing in microchannels. Lab Chip 13(6):1121–1132
    • (2013) Lab Chip , vol.13 , Issue.6 , pp. 1121-1132
    • Zhou, J.1    Papautsky, I.2
  • 189
    • 54349103530 scopus 로고    scopus 로고
    • Continuous particle separation in spiral microchannels using Dean flows and differential migration
    • Bhagat AA, Kuntaegowdanahalli SS, Papautsky I (2008) Continuous particle separation in spiral microchannels using Dean flows and differential migration. Lab Chip 8(11):1906–1914
    • (2008) Lab Chip , vol.8 , Issue.11 , pp. 1906-1914
    • Bhagat, A.A.1    Kuntaegowdanahalli, S.S.2    Papautsky, I.3
  • 190
    • 84874309411 scopus 로고    scopus 로고
    • Isolation and retrieval of circulating tumor cells using centrifugal forces
    • Hou HW et al (2013) Isolation and retrieval of circulating tumor cells using centrifugal forces. Sci Rep 3:1259
    • (2013) Sci Rep , vol.3
    • Hou, H.W.1
  • 191
    • 84875970076 scopus 로고    scopus 로고
    • Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells
    • Ozkumur E et al (2013) Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells. Sci Transl Med 5(179):179ra47
    • (2013) Sci Transl Med , vol.5 , Issue.179
    • Ozkumur, E.1
  • 192
    • 84869237943 scopus 로고    scopus 로고
    • Microfluidics separation reveals the stem-cell-like deformability of tumor-initiating cells
    • Zhang W et al (2012) Microfluidics separation reveals the stem-cell-like deformability of tumor-initiating cells. Proc Natl Acad Sci U S A 109(46):18707–18712
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.46 , pp. 18707-18712
    • Zhang, W.1
  • 193
    • 1842687362 scopus 로고    scopus 로고
    • Reconstruction of functionally normal and malignant human breast tissues in mice
    • Kuperwasser C et al (2004) Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci U S A 101(14):4966–4971
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.14 , pp. 4966-4971
    • Kuperwasser, C.1
  • 194
    • 81255135837 scopus 로고    scopus 로고
    • Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes
    • DeRose YS et al (2011) Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes. Nat Med 17(11):1514–1520
    • (2011) Nat Med , vol.17 , Issue.11 , pp. 1514-1520
    • Derose, Y.S.1
  • 195
    • 84881415504 scopus 로고    scopus 로고
    • A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models
    • Zhang X et al (2013) A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models. Cancer Res 73(15):4885–4897
    • (2013) Cancer Res , vol.73 , Issue.15 , pp. 4885-4897
    • Zhang, X.1
  • 196
    • 34447123764 scopus 로고    scopus 로고
    • A new model of patient tumor-derived breast cancer xenografts for preclinical assays
    • Marangoni E et al (2007) A new model of patient tumor-derived breast cancer xenografts for preclinical assays. Clin Cancer Res 13(13):3989–3998
    • (2007) Clin Cancer Res , vol.13 , Issue.13 , pp. 3989-3998
    • Marangoni, E.1
  • 197
    • 0037648621 scopus 로고    scopus 로고
    • Efficient engraftment of human primary breast cancer transplants in nonconditioned NOD/Scid mice
    • Beckhove P et al (2003) Efficient engraftment of human primary breast cancer transplants in nonconditioned NOD/Scid mice. Int J Cancer 105(4):444–453
    • (2003) Int J Cancer , vol.105 , Issue.4 , pp. 444-453
    • Beckhove, P.1
  • 198
    • 70350571374 scopus 로고    scopus 로고
    • Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft models
    • Bergamaschi A et al (2009) Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft models. Mol Oncol 3(5–6):469–482
    • (2009) Mol Oncol , vol.3 , Issue.56 , pp. 469-482
    • Bergamaschi, A.1
  • 199
    • 84894305985 scopus 로고    scopus 로고
    • Breast tumor PDXs are genetically plastic and correspond to a subset of aggressive cancers prone to relapse
    • du Manoir S et al (2013) Breast tumor PDXs are genetically plastic and correspond to a subset of aggressive cancers prone to relapse. Mol Oncol 8:431–43
    • (2013) Mol Oncol , vol.8 , pp. 431-443
    • Du Manoir, S.1
  • 200
    • 0035101145 scopus 로고    scopus 로고
    • Cellular and molecular pharmacology of antiestrogen action and resistance
    • Clarke R et al (2001) Cellular and molecular pharmacology of antiestrogen action and resistance. Pharmacol Rev 53(1):25–71
    • (2001) Pharmacol Rev , vol.53 , Issue.1 , pp. 25-71
    • Clarke, R.1
  • 201
    • 84863722104 scopus 로고    scopus 로고
    • Modeling of response to endocrine therapy in a panel of human luminal breast cancer xenografts
    • Cottu P et al (2012) Modeling of response to endocrine therapy in a panel of human luminal breast cancer xenografts. Breast Cancer Res Treat 133(2):595–606
    • (2012) Breast Cancer Res Treat , vol.133 , Issue.2 , pp. 595-606
    • Cottu, P.1
  • 202
    • 84866557855 scopus 로고    scopus 로고
    • Patient-derived luminal breast cancer xenografts retain hormone receptor heterogeneity and help define unique estrogen-dependent gene signatures
    • Kabos P et al (2012) Patient-derived luminal breast cancer xenografts retain hormone receptor heterogeneity and help define unique estrogen-dependent gene signatures. Breast Cancer Res Treat 135(2):415–432
    • (2012) Breast Cancer Res Treat , vol.135 , Issue.2 , pp. 415-432
    • Kabos, P.1
  • 203
    • 76649113726 scopus 로고    scopus 로고
    • CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
    • Ginestier C et al (2010) CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J Clin Invest 120(2):485–497
    • (2010) J Clin Invest , vol.120 , Issue.2 , pp. 485-497
    • Ginestier, C.1
  • 204
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: Novel molecular targets for cancer drug discovery
    • Turkson J, Jove R (2000) STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 19(56):6613–6626
    • (2000) Oncogene , vol.19 , Issue.56 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 205
    • 22944434871 scopus 로고    scopus 로고
    • Targeting transcription factors for cancer therapy
    • Redell MS, Tweardy DJ (2005) Targeting transcription factors for cancer therapy. Curr Pharm Des 11(22):2873–2887
    • (2005) Curr Pharm Des , vol.11 , Issue.22 , pp. 2873-2887
    • Redell, M.S.1    Tweardy, D.J.2
  • 206
    • 39549102220 scopus 로고    scopus 로고
    • STAT3: A critical transcription activator in angiogenesis
    • Chen Z, Han ZC (2008) STAT3: a critical transcription activator in angiogenesis. Med Res Rev 28(2):185–200
    • (2008) Med Res Rev , vol.28 , Issue.2 , pp. 185-200
    • Chen, Z.1    Han, Z.C.2
  • 207
    • 84864673390 scopus 로고    scopus 로고
    • Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model
    • Dave B et al (2012) Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model. PLoS One 7(8):e30207
    • (2012) Plos One , vol.7 , Issue.8
    • Dave, B.1
  • 208
    • 33845877157 scopus 로고    scopus 로고
    • Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
    • Noguera-Troise I et al (2006) Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 444(7122):1032–1037
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1032-1037
    • Noguera-Troise, I.1
  • 209
    • 33845907380 scopus 로고    scopus 로고
    • Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
    • Ridgway J et al (2006) Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444(7122):1083–1087
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1083-1087
    • Ridgway, J.1
  • 210
    • 34247479498 scopus 로고    scopus 로고
    • Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion
    • Scehnet JS et al (2007) Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood 109(11):4753–4760
    • (2007) Blood , vol.109 , Issue.11 , pp. 4753-4760
    • Scehnet, J.S.1
  • 211
    • 67849124654 scopus 로고    scopus 로고
    • DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency
    • Hoey T et al (2009) DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency. Cell Stem Cell 5(2):168–177
    • (2009) Cell Stem Cell , vol.5 , Issue.2 , pp. 168-177
    • Hoey, T.1
  • 212
    • 84875168492 scopus 로고    scopus 로고
    • Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors
    • Schott AF et al (2013) Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors. Clin Cancer Res 19(6):1512–1524
    • (2013) Clin Cancer Res , vol.19 , Issue.6 , pp. 1512-1524
    • Schott, A.F.1
  • 213
    • 84887148630 scopus 로고    scopus 로고
    • Erythropoietin activates cell survival pathways in breast cancer stem-like cells to protect them from chemotherapy
    • Todaro M et al (2013) Erythropoietin activates cell survival pathways in breast cancer stem-like cells to protect them from chemotherapy. Cancer Res 73(21):6393–6400
    • (2013) Cancer Res , vol.73 , Issue.21 , pp. 6393-6400
    • Todaro, M.1
  • 214
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • Ingham PW, McMahon AP (2001) Hedgehog signaling in animal development: paradigms and principles. Genes Dev 15(23):3059–3087
    • (2001) Genes Dev , vol.15 , Issue.23 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 215
    • 33745728170 scopus 로고    scopus 로고
    • Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    • Liu S et al (2006) Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 66(12):6063–6071
    • (2006) Cancer Res , vol.66 , Issue.12 , pp. 6063-6071
    • Liu, S.1
  • 216
    • 4344586961 scopus 로고    scopus 로고
    • Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer
    • Kubo M et al (2004) Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res 64(17):6071–6074
    • (2004) Cancer Res , vol.64 , Issue.17 , pp. 6071-6074
    • Kubo, M.1
  • 217
    • 56249121238 scopus 로고    scopus 로고
    • Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists
    • Tremblay MR et al (2008) Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists. J Med Chem 51(21):6646–6649
    • (2008) J Med Chem , vol.51 , Issue.21 , pp. 6646-6649
    • Tremblay, M.R.1
  • 218
    • 69949084378 scopus 로고    scopus 로고
    • GDC-0449-a potent inhibitor of the hedgehog pathway
    • Robarge KD et al (2009) GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg Med Chem Lett 19(19):5576–5581
    • (2009) Bioorg Med Chem Lett , vol.19 , Issue.19 , pp. 5576-5581
    • Robarge, K.D.1
  • 219
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP et al (2009) Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324(5933):1457–1461
    • (2009) Science , vol.324 , Issue.5933 , pp. 1457-1461
    • Olive, K.P.1
  • 220
    • 33750566665 scopus 로고    scopus 로고
    • Notch signaling in stem cell systems
    • Chiba S (2006) Notch signaling in stem cell systems. Stem Cells 24(11):2437–2447
    • (2006) Stem Cells , vol.24 , Issue.11 , pp. 2437-2447
    • Chiba, S.1
  • 221
    • 33846236394 scopus 로고    scopus 로고
    • The multifaceted role of Notch in cancer
    • Roy M, Pear WS, Aster JC (2007) The multifaceted role of Notch in cancer. Curr Opin Genet Dev 17(1):52–59
    • (2007) Curr Opin Genet Dev , vol.17 , Issue.1 , pp. 52-59
    • Roy, M.1    Pear, W.S.2    Aster, J.C.3
  • 222
    • 0142259346 scopus 로고    scopus 로고
    • The role of Notch in tumorigenesis: Oncogene or tumour suppressor?
    • Radtke F, Raj K (2003) The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer 3(10):756–767
    • (2003) Nat Rev Cancer , vol.3 , Issue.10 , pp. 756-767
    • Radtke, F.1    Raj, K.2
  • 223
    • 0026517312 scopus 로고
    • Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands
    • Jhappan C et al (1992) Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev 6(3):345–355
    • (1992) Genes Dev , vol.6 , Issue.3 , pp. 345-355
    • Jhappan, C.1
  • 224
    • 52949134150 scopus 로고    scopus 로고
    • Notch signaling regulates mammary stem cell function and luminal cell-fate commitment
    • Bouras T et al (2008) Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell 3(4):429–441
    • (2008) Cell Stem Cell , vol.3 , Issue.4 , pp. 429-441
    • Bouras, T.1
  • 225
    • 24944506696 scopus 로고    scopus 로고
    • High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
    • Reedijk M et al (2005) High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res 65(18):8530–8537
    • (2005) Cancer Res , vol.65 , Issue.18 , pp. 8530-8537
    • Reedijk, M.1
  • 226
    • 76549084826 scopus 로고    scopus 로고
    • Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor
    • Harrison H et al (2010) Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res 70(2):709–718
    • (2010) Cancer Res , vol.70 , Issue.2 , pp. 709-718
    • Harrison, H.1
  • 227
    • 77949457142 scopus 로고    scopus 로고
    • RNAi-mediated knockdown of Notch-1 leads to cell growth inhibition and enhanced chemosensitivity in human breast cancer
    • Zang S et al (2010) RNAi-mediated knockdown of Notch-1 leads to cell growth inhibition and enhanced chemosensitivity in human breast cancer. Oncol Rep 23(4):893–899
    • (2010) Oncol Rep , vol.23 , Issue.4 , pp. 893-899
    • Zang, S.1
  • 229
    • 75149125614 scopus 로고    scopus 로고
    • ErbB2 induces Notch1 activity and function in breast cancer cells
    • Lindsay J et al (2008) ErbB2 induces Notch1 activity and function in breast cancer cells. Clin Transl Sci 1(2):107–115
    • (2008) Clin Transl Sci , vol.1 , Issue.2 , pp. 107-115
    • Lindsay, J.1
  • 230
    • 84874012962 scopus 로고    scopus 로고
    • Combined inhibition of ErbB1/2 and Notch receptors effectively targets breast ductal carcinoma in situ (DCIS) stem/progenitor cell activity regardless of ErbB2 status
    • Farnie G et al (2013) Combined inhibition of ErbB1/2 and Notch receptors effectively targets breast ductal carcinoma in situ (DCIS) stem/progenitor cell activity regardless of ErbB2 status. PLoS One 8(2):e56840
    • (2013) Plos One , vol.8 , Issue.2
    • Farnie, G.1
  • 231
    • 50649125794 scopus 로고    scopus 로고
    • ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor
    • Osipo C et al (2008) ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor. Oncogene 27(37):5019–5032
    • (2008) Oncogene , vol.27 , Issue.37 , pp. 5019-5032
    • Osipo, C.1
  • 232
    • 84870346423 scopus 로고    scopus 로고
    • Loss of Mel-18 enhances breast cancer stem cell activity and tumorigenicity through activating Notch signaling mediated by the Wnt/TCF pathway
    • Won HY et al (2012) Loss of Mel-18 enhances breast cancer stem cell activity and tumorigenicity through activating Notch signaling mediated by the Wnt/TCF pathway. FASEB J 26(12):5002–5013
    • (2012) FASEB J , vol.26 , Issue.12 , pp. 5002-5013
    • Won, H.Y.1
  • 233
    • 84880065874 scopus 로고    scopus 로고
    • Optimal targeting of HER2-PI3K signaling in breast cancer: Mechanistic insights and clinical implications
    • Rexer BN, Arteaga CL (2013) Optimal targeting of HER2-PI3K signaling in breast cancer: mechanistic insights and clinical implications. Cancer Res 73(13):3817–3820
    • (2013) Cancer Res , vol.73 , Issue.13 , pp. 3817-3820
    • Rexer, B.N.1    Arteaga, C.L.2
  • 234
    • 5144226211 scopus 로고    scopus 로고
    • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
    • Nagata Y et al (2004) PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 6(2):117–127
    • (2004) Cancer Cell , vol.6 , Issue.2 , pp. 117-127
    • Nagata, Y.1
  • 235
    • 67649969473 scopus 로고    scopus 로고
    • Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling
    • Korkaya H et al (2009) Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS Biol 7(6):e1000121
    • (2009) Plos Biol , vol.7 , Issue.6
    • Korkaya, H.1
  • 236
    • 65349101151 scopus 로고    scopus 로고
    • Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
    • Junttila TT et al (2009) Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941. Cancer Cell 15(5):429–440
    • (2009) Cancer Cell , vol.15 , Issue.5 , pp. 429-440
    • Junttila, T.T.1
  • 237
    • 51849111524 scopus 로고    scopus 로고
    • NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
    • Serra V et al (2008) NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res 68(19):8022–8030
    • (2008) Cancer Res , vol.68 , Issue.19 , pp. 8022-8030
    • Serra, V.1
  • 238
    • 78650984926 scopus 로고    scopus 로고
    • Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab
    • Andre F et al (2010) Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab. J Clin Oncol 28(34):5110–5115
    • (2010) J Clin Oncol , vol.28 , Issue.34 , pp. 5110-5115
    • Andre, F.1
  • 239
    • 84873445750 scopus 로고    scopus 로고
    • Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors
    • Chakrabarty A et al (2013) Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors. Cancer Res 73(3):1190–1200
    • (2013) Cancer Res , vol.73 , Issue.3 , pp. 1190-1200
    • Chakrabarty, A.1
  • 240
    • 42549164807 scopus 로고    scopus 로고
    • Wnt signalling and its impact on development and cancer
    • Klaus A, Birchmeier W (2008) Wnt signalling and its impact on development and cancer. Nat Rev Cancer 8(5):387–398
    • (2008) Nat Rev Cancer , vol.8 , Issue.5 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 241
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan CY, Nusse R (2004) The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20:781–810
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 242
    • 68949154567 scopus 로고    scopus 로고
    • The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage
    • Badders NM et al (2009) The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. PLoS One 4(8):e6594
    • (2009) Plos One , vol.4 , Issue.8
    • Badders, N.M.1
  • 243
    • 7944230668 scopus 로고    scopus 로고
    • An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells
    • Bafico A et al (2004) An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell 6(5):497–506
    • (2004) Cancer Cell , vol.6 , Issue.5 , pp. 497-506
    • Bafico, A.1
  • 244
    • 13644251086 scopus 로고    scopus 로고
    • Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors
    • Klopocki E et al (2004) Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors. Int J Oncol 25(3):641–649
    • (2004) Int J Oncol , vol.25 , Issue.3 , pp. 641-649
    • Klopocki, E.1
  • 245
    • 0038301969 scopus 로고    scopus 로고
    • Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers
    • Nagahata T et al (2003) Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers. Cancer Sci 94(6):515–518
    • (2003) Cancer Sci , vol.94 , Issue.6 , pp. 515-518
    • Nagahata, T.1
  • 246
    • 33645313198 scopus 로고    scopus 로고
    • Study of phospho-beta-catenin subcellular distribution in invasive breast carcinomas in relation to their phenotype and the clinical outcome
    • Nakopoulou L et al (2006) Study of phospho-beta-catenin subcellular distribution in invasive breast carcinomas in relation to their phenotype and the clinical outcome. Mod Pathol 19(4):556–563
    • (2006) Mod Pathol , vol.19 , Issue.4 , pp. 556-563
    • Nakopoulou, L.1
  • 247
    • 84891904837 scopus 로고    scopus 로고
    • Sox2 promotes tamoxifen resistance in breast cancer cells
    • Piva et al (2014) Sox2 promotes tamoxifen resistance in breast cancer cells. EMBO Mol Med 6:66–79
    • (2014) EMBO Mol Med , vol.6 , pp. 66-79
    • Piva1
  • 248
    • 9144269759 scopus 로고    scopus 로고
    • Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
    • Li Y et al (2003) Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci U S A 100(26):15853–15858
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.26 , pp. 15853-15858
    • Li, Y.1
  • 249
    • 1642570244 scopus 로고    scopus 로고
    • The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells
    • Liu BY et al (2004) The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. Proc Natl Acad Sci U S A 101(12):4158–4163
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.12 , pp. 4158-4163
    • Liu, B.Y.1
  • 250
    • 84857407549 scopus 로고    scopus 로고
    • Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
    • Conley SJ et al (2012) Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc Natl Acad Sci U S A 109(8):2784–2789
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.8 , pp. 2784-2789
    • Conley, S.J.1
  • 251
    • 68549133226 scopus 로고    scopus 로고
    • Methylation-associated silencing of SFRP1 with an 8p11-12 amplification inhibits canonical and non-canonical WNT pathways in breast cancers
    • Yang ZQ et al (2009) Methylation-associated silencing of SFRP1 with an 8p11-12 amplification inhibits canonical and non-canonical WNT pathways in breast cancers. Int J Cancer 125(7):1613–1621
    • (2009) Int J Cancer , vol.125 , Issue.7 , pp. 1613-1621
    • Yang, Z.Q.1
  • 252
    • 1642341682 scopus 로고    scopus 로고
    • A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells
    • He B et al (2004) A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia 6(1):7–14
    • (2004) Neoplasia , vol.6 , Issue.1 , pp. 7-14
    • He, B.1
  • 253
    • 34347254641 scopus 로고    scopus 로고
    • The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo
    • DeAlmeida VI et al (2007) The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo. Cancer Res 67(11):5371–5379
    • (2007) Cancer Res , vol.67 , Issue.11 , pp. 5371-5379
    • Dealmeida, V.I.1
  • 254
    • 33846531356 scopus 로고    scopus 로고
    • The tumour microenvironment as a target for chemoprevention
    • Albini A, Sporn MB (2007) The tumour microenvironment as a target for chemoprevention. Nat Rev Cancer 7(2):139–147
    • (2007) Nat Rev Cancer , vol.7 , Issue.2 , pp. 139-147
    • Albini, A.1    Sporn, M.B.2
  • 255
    • 34948896045 scopus 로고    scopus 로고
    • Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    • Karnoub AE et al (2007) Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449(7162):557–563
    • (2007) Nature , vol.449 , Issue.7162 , pp. 557-563
    • Karnoub, A.E.1
  • 256
    • 77953384898 scopus 로고    scopus 로고
    • Control of mammary stem cell function by steroid hormone signalling
    • Asselin-Labat ML et al (2010) Control of mammary stem cell function by steroid hormone signalling. Nature 465(7299):798–802
    • (2010) Nature , vol.465 , Issue.7299 , pp. 798-802
    • Asselin-Labat, M.L.1
  • 257
    • 78650732630 scopus 로고    scopus 로고
    • Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling
    • Fillmore CM et al (2010) Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci U S A 107(50):21737–21742
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.50 , pp. 21737-21742
    • Fillmore, C.M.1
  • 258
    • 70249127607 scopus 로고    scopus 로고
    • Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients
    • Pierce BL et al (2009) Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients. J Clin Oncol 27(21):3437–3444
    • (2009) J Clin Oncol , vol.27 , Issue.21 , pp. 3437-3444
    • Pierce, B.L.1
  • 259
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420(6917):860–867
    • (2002) Nature , vol.420 , Issue.6917 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 260
    • 36849039660 scopus 로고    scopus 로고
    • IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
    • Sansone P et al (2007) IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J Clin Invest 117(12):3988–4002
    • (2007) J Clin Invest , vol.117 , Issue.12 , pp. 3988-4002
    • Sansone, P.1
  • 261
    • 0035893768 scopus 로고    scopus 로고
    • Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells
    • Conze D et al (2001) Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells. Cancer Res 61(24):8851–8858
    • (2001) Cancer Res , vol.61 , Issue.24 , pp. 8851-8858
    • Conze, D.1
  • 262
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
    • Iliopoulos D, Hirsch HA, Struhl K (2009) An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 139(4):693–706
    • (2009) Cell , vol.139 , Issue.4 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 263
    • 84865401715 scopus 로고    scopus 로고
    • Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population
    • Korkaya H et al (2012) Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population. Mol Cell 47(4):570–584
    • (2012) Mol Cell , vol.47 , Issue.4 , pp. 570-584
    • Korkaya, H.1
  • 264
    • 35348893870 scopus 로고    scopus 로고
    • Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy
    • Germain D, Frank DA (2007) Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy. Clin Cancer Res 13(19):5665–5669
    • (2007) Clin Cancer Res , vol.13 , Issue.19 , pp. 5665-5669
    • Germain, D.1    Frank, D.A.2
  • 265
    • 84893511414 scopus 로고    scopus 로고
    • Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24− subpopulations of breast cancer cells
    • Lin L et al (2013) Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24− subpopulations of breast cancer cells. PLoS One 8(12):e82821
    • (2013) Plos One , vol.8 , Issue.12
    • Lin, L.1
  • 266
    • 77954954098 scopus 로고    scopus 로고
    • Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells
    • Yu F et al (2010) Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells. Oncogene 29(29):4194–4204
    • (2010) Oncogene , vol.29 , Issue.29 , pp. 4194-4204
    • Yu, F.1
  • 267
    • 68049114782 scopus 로고    scopus 로고
    • Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells
    • Shimono Y et al (2009) Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell 138(3):592–603
    • (2009) Cell , vol.138 , Issue.3 , pp. 592-603
    • Shimono, Y.1
  • 268
    • 79955374410 scopus 로고    scopus 로고
    • World Health Organization (2012) Cancer Fact Sheet N297. http://publications.cancerresearchuk.org/downloads/product/CS_REPORT_WORLD.pdf
    • (2012) Cancer Fact Sheet N297
  • 271
    • 0041435762 scopus 로고    scopus 로고
    • Accessed 31 Mar
    • American Cancer Society. Cancer facts and figures 2012. Accessed 31 Mar 12. http://www.cancer.org/research/cancerfactsstatistics/cancerfactsfigures2012/
    • (2012) Cancer Facts and Figures 2012
  • 272
    • 78049431141 scopus 로고    scopus 로고
    • HER2 and chromosome 17 effect on patient outcome in the N9831 adjuvant trastuzumab trial
    • Perez EA et al (2010) HER2 and chromosome 17 effect on patient outcome in the N9831 adjuvant trastuzumab trial. J Clin Oncol 28(28):4307–4315
    • (2010) J Clin Oncol , vol.28 , Issue.28 , pp. 4307-4315
    • Perez, E.A.1
  • 273
    • 0029878679 scopus 로고    scopus 로고
    • The sequencing of chemotherapy and radiation therapy after conservative surgery for early-stage breast cancer
    • Recht A et al (1996) The sequencing of chemotherapy and radiation therapy after conservative surgery for early-stage breast cancer. N Engl J Med 334(21):1356–1361
    • (1996) N Engl J Med , vol.334 , Issue.21 , pp. 1356-1361
    • Recht, A.1
  • 274
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ et al (2001) Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344(11):783–792
    • (2001) N Engl J Med , vol.344 , Issue.11 , pp. 783-792
    • Slamon, D.J.1
  • 275
    • 49149094340 scopus 로고    scopus 로고
    • Systemic and targeted therapy for advanced colon cancer
    • Hedge SR, Sun W, Lynch JP (2008) Systemic and targeted therapy for advanced colon cancer. Expert Rev Gastroenterol Hepatol 2(1):135–149
    • (2008) Expert Rev Gastroenterol Hepatol , vol.2 , Issue.1 , pp. 135-149
    • Hedge, S.R.1    Sun, W.2    Lynch, J.P.3
  • 276
    • 30344446398 scopus 로고    scopus 로고
    • Targeted therapy for the treatment of advanced non-small cell lung cancer: A review of the epidermal growth factor receptor antagonists
    • Silvestri GA, Rivera MP (2005) Targeted therapy for the treatment of advanced non-small cell lung cancer: a review of the epidermal growth factor receptor antagonists. Chest 128(6):3975–3984
    • (2005) Chest , vol.128 , Issue.6 , pp. 3975-3984
    • Silvestri, G.A.1    Rivera, M.P.2
  • 277
    • 34547673400 scopus 로고    scopus 로고
    • Applying the discovery of the Philadelphia chromosome
    • Sherbenou DW, Druker BJ (2007) Applying the discovery of the Philadelphia chromosome. J Clin Invest 117(8):2067–2074
    • (2007) J Clin Invest , vol.117 , Issue.8 , pp. 2067-2074
    • Sherbenou, D.W.1    Druker, B.J.2
  • 278
    • 36048981199 scopus 로고    scopus 로고
    • Cancer stem cells as mediators of treatment resistance in brain tumors: Status and controversies
    • Sakariassen PO, Immervoll H, Chekenya M (2007) Cancer stem cells as mediators of treatment resistance in brain tumors: status and controversies. Neoplasia 9(11):882–892
    • (2007) Neoplasia , vol.9 , Issue.11 , pp. 882-892
    • Sakariassen, P.O.1    Immervoll, H.2    Chekenya, M.3
  • 279
    • 33847668823 scopus 로고    scopus 로고
    • Tumour characteristics, survival and prognostic factors of hereditary breast cancer from BRCA2-, BRCA1- and non-BRCA1/2 families as compared to sporadic breast cancer cases
    • Brekelmans CT et al (2007) Tumour characteristics, survival and prognostic factors of hereditary breast cancer from BRCA2-, BRCA1- and non-BRCA1/2 families as compared to sporadic breast cancer cases. Eur J Cancer 43(5):867–876
    • (2007) Eur J Cancer , vol.43 , Issue.5 , pp. 867-876
    • Brekelmans, C.T.1
  • 280
    • 34948837444 scopus 로고    scopus 로고
    • Selective targeting of cancer stem cells: A new concept in cancer therapeutics
    • Korkaya H, Wicha MS (2007) Selective targeting of cancer stem cells: a new concept in cancer therapeutics. BioDrugs 21(5):299–310
    • (2007) Biodrugs , vol.21 , Issue.5 , pp. 299-310
    • Korkaya, H.1    Wicha, M.S.2
  • 281
    • 84930683886 scopus 로고    scopus 로고
    • ChemistryWorld.org
    • Houston S (2011) Stemming the tide. ChemistryWorld.org. http://www.rsc.org/chemistryworld/restricted/2011/September/StemmingTheTide.asp
    • (2011) Stemming the Tide
    • Houston, S.1
  • 282
    • 77952284422 scopus 로고    scopus 로고
    • Firms seek to prove cancer stem cell hypothesis
    • Markey K (2009) Firms seek to prove cancer stem cell hypothesis. Bio Market Trends. 29(18). http://www.genengnews.com/gen-articles/firms-seek-to-prove-cancer-stem-cell-hypothesis/3066/
    • (2009) Bio Market Trends , vol.29 , Issue.18
    • Markey, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.