Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 26, 2003, Pages 15853-15858

  Li, Yi ^a,b   Welm, Bryan ^c   Podsypanina, Katrina ^a   Huang, Shixia ^a   Chamorro, Mario ^a,d   Zhang, Xiaomei ^b   Rowlands, Tracey ^e   Egeblad, Mikala ^c   Cowin, Pam ^e   Werb, Zena ^c   Tan, Lee K ^a   Rosen, Jeffrey M ^b   Varmus, Harold E ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; BETA CATENIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GENE PRODUCT; KERATIN; KERATIN 6; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN H RAS; UNCLASSIFIED DRUG; VIRUS MIDDLE T ANTIGEN; WNT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER CELL; CELL POPULATION; CELL TYPE; DISEASE MARKER; EPITHELIUM CELL; FEMALE; GENE MUTATION; MOUSE; MYOEPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTO ONCOGENE; SIGNAL TRANSDUCTION; STEM CELL; TARGET CELL; TRANSGENE;

ANIMALS; BETA CATENIN; CYTOSKELETAL PROTEINS; FEMALE; GENES, MYC; MAMMARY NEOPLASMS, EXPERIMENTAL; MAMMARY TUMOR VIRUS, MOUSE; MICE; MICE, TRANSGENIC; MUTATION; PROTO-ONCOGENE PROTEINS; STEM CELLS; TRANS-ACTIVATORS; WNT PROTEINS; WNT1 PROTEIN; ZEBRAFISH PROTEINS;

ANIMALIA; MUS MUSCULUS;

EID: 9144269759     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.2136825100     Document Type: Article

References (49)

1. Morrison, B. W. & Leder, P. (1994) Oncogene 9, 3417-3426.
2. Rosner, A., Miyoshi, K., Landesman-Bollag, E., Xu, X., Seldin, D. C., Moser, A. R., MacLeod, C. L., Shyamala, G., Gillgrass, A. E. & Cardiff, R. D. (2002) Am. J. Pathol. 161, 1087-1097.
3. Cardiff, R. D., Anver, M. R., Gusterson, B. A., Hennighausen, L., Jensen, R. A., Merino, M. J., Rehm, S., Russo, J., Tavassoli, F. A., Wakefield, L. M., et al. (2000) Oncogene 19, 968-988.
4. Cardiff, R. D., Sinn, E., Muller, W. & Leder, P. (1991) Am. J. Pathol. 139, 495-501.
5. Hedenfalk, I., Duggan, D., Chen, Y., Radmacher, M., Bittner, M., Simon, R., Meltzer, P., Gusterson, B., Esteller, M., Kallioniemi, O. P., et al. (2001) N. Engl. J. Med. 344, 539-548.
6. Desai, K. V., Xiao, N., Wang, W., Gangi, L., Greene, J., Powell, J. I., Dickson, R., Furth, P., Hunter, K., Kucherlapati, R., et al. (2002) Proc. Natl. Acad. Sci. USA 99, 6967-6972.
7. Perou, C. M., Sorlie, T., Eisen, M. B., van de Rijn, M., Jeffrey, S. S., Rees, C. A., Pollack, J. R., Ross, D. T., Johnsen, H., Akslen, L. A., et al. (2000) Nature 406, 747-752.
8. Sorlie, T., Pcrou, C. M., Tibshirani, R., Aas, T., Geisler, S., Johnsen, H., Hastie, T., Eisen, M. B., van de Rijn, M., Jeffrey, S. S., et al. (2001) Proc. Natl. Acad. Sci. USA 98, 10869-10874.
9. Wagner, K. U., McAllister, K., Ward, T., Davis, B., Wiseman, R. & Hennighausen, L. (2001) Transgenic Res. 10, 545-553.
10. Gunther, E. J., Belka, G. K., Wertheim, G. B., Wang, J., Hartman, J. L., Boxer, R. B. & Chodosh, L. A. (2002) FASEB J. 16, 283-292.
11. Owens, D. M. & Watt, F. M. (2003) Nat. Rev. Cancer 3, 444-451.
12. Perez-Losada, J. & Balmain, A. (2003) Nat. Rev. Cancer 3, 434-443.
13. Grimm, S. L., Seagroves, T. N., Kabotyanski, E. B., Hovey, R. C., Vonderhaar, B. K., Lydon, P., Miyoshi, K., Hennighausen, L., Ormandy, C. J., Lee, A. V., et al. (2002) Mol. Endocrinol. 16, 2675-2691.
14. Sapino, A., Macri, L., Gugliotta, P., Pacchioni, D., Liu, Y. J., Medina, D. & Bussolati, G. (1993) Differentiation 55, 13-18.
15. Smith, G. H., Mehrel, T. & Roop, D. R. (1990) Cell Growth Differ. 1, 161-170.
16. Spangrude, G. J., Heimfeld, S. & Weissman, I. L. (1988) Science 241, 58-62.
17. Welm, B. E., Tepera, S. B., Venezia, T., Graubert, T. A., Rosen, J. M. & Goodell, M. A. (2002) Dev. Biol. 245, 42-56.
18. Dontu, G., Abdallah, W. M., Foley, J. M., Jackson, K. W., Clarke, M. F., Kawamura, M. J. & Wicha, M. S. (2003) Genes Dev. 17, 1253-1270.
19. Alonso, L. & Fuchs, E. (2003) Genes Dev. 17, 1189-1200.
20. Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R. & Weissman, I. L. (2003) Nature 423, 409-414.
21. van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A. P., et al. (2002) Cell III, 241-250.
22. Kielman, M. F., Rindapaa, M., Gaspar, C., van Poppel, N., Breukel, C., van Leeuwen, S., Taketo, M. M., Roberts, S., Smits, R. & Fodde, R. (2002) Nat. Genet. 32, 594-605.
23. Polesskaya, A., Seale, P. & Rudnicki, M. A. (2003) Cell 113, 841-852.
24. Yamashita, Y. M., Jones, D. L. & Fuller, M. T. (2003) Science 301, 1547-1550.
25. Andl, T., Reddy, S. T., Gaddapara, T. & Millar, S. E. (2002) Dev. Cell 2, 643-653.
26. van Genderen, C., Okamura, R. M., Farinas, I., Quo, R. G., Parslow, T. G., Bruhn, L. & Grosschedl, R. (1994) Genes Dev. 8, 2691-2703.
27. Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., III, & Nusse, R. (2003) Nature 423, 448-452.
28. Murdoch, B., Chadwick, K., Martin, M., Shojaei, F., Shah, K. V., Gallacher, L., Moon, R. T. & Bhatia, M. (2003) Proc. Natl. Acad. Sci. USA 100, 3422-3427.
29. Tsukamoto, A. S., Grosschedl, R., Guzman, R. C., Parslow, T. & Varmus, H. E. (1988) Cell 55, 619-625.
30. Imbert, A., Eelkema, R., Jordan, S., Feiner, H. & Cowin, P. (2001) J. Cell Biol. 153, 555-568.
31. Stewart, T. A., Pattengale, P. K. & Leder, P. (1984) Cell 38, 627-637.
32. Guy, C. T., Webster, M. A., Schaller, M., Parsons, T. J., Cardiff, R. D. & Muller, W. J. (1992) Proc. Natl. Acad. Sci. USA 89, 10578-10582.
33. Sinn, E., Muller, W., Pattengale, P., Tepler, I., Wallace, R. & Leder, P. (1987) Cell 49, 465-475.
34. Guy, C. T., Cardiff, R. D. & Muller, W. J. (1992) Mol. Cell. Biol. 12, 954-961.
35. Podsypanina, K., Ellenson, L. H., Nemes, A., Gu, J., Tamura, M., Yamada, K. M., Cordon-Cardo, C., Catoretti, G., Fisher, P. E. & Parsons, R. (1999) Proc. Natl. Acad. Sci. USA 96, 1563-1568.
36. Li, Y., Podsypanina, K., Liu, X., Crane, A., Tan, L. K., Parsons, R. & Varmus, H. E. (2001) BMC Mol. Biol. 2, 2.
37. Brulet, P., Babinet, C., Kemler, R. & Jacob, F. (1980) Proc. Natl. Acad. Sci. USA 77, 4113-4117.
38. Kemler, R., Brulet, P., Schnebelen, M. T., Gaillard, J. & Jacob, F. (1981) J. Embryol. Exp. Morphol. 64, 45-60.
39. Hennighausen, L., Wall, R. J., Tillmann, U., Li, M. & Furth, P. A. (1995) J. Cell. Biochem. 59, 463-472.
40. Hennighausen, L., McKnight, R., Burdon, T., Baik, M., Wall, R. J. & Smith, G. H. (1994) Cell Growth Differ. 5, 607-613.
41. Stocklin, E., Botteri, F. & Groner, B. (1993) J. Cell Biol. 122, 199-208.
42. Muller, W. J., Sinn, E., Pattengale, P. K., Wallace, R. & Leder, P. (1988) Cell 54, 105-115.
43. Moll, R., Franke, W. W., Schiller, D. L., Geiger, B. & Krepler, R. (1982) Cell 31, 11-24.
44. Guelstein, V. I., Tchypysheva, T. A., Ermilova, V. D., Litvinova, L. V., Troyanovsky, S. M. & Bannikov, G. A. (1988) Int. J. Cancer 42, 147-153.
45. Lazard, D., Sastre, X., Frid, M. G., Glukhova, M. A., Thiery, J. P. & Koteliansky, V. E. (1993) Proc. Natl. Acad. Sci. USA 90, 999-1003.
46. Wetzels, R. H., Holland, R., van Haelst, U. J., Lane, E. B., Leigh, I. M. & Ramaekers, F. C. (1989) Am. J. Pathol. 134, 571-579.
47. Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J. & Clarke, M. F. (2003) Proc. Natl. Acad. Sci. USA 100, 3983-3988.
48. Bienz, M. & Clevers, H. (2000) Cell 103, 311-320.
49. Cui, X. S. & Donehower, L. A. (2000) Oncogene 19, 5988-5996.