메뉴 건너뛰기




Volumn 2, Issue 1, 2008, Pages 135-149

Systemic and targeted therapy for advanced colon cancer

Author keywords

Bevacizumab; Cetuximab; Chemotherapy; Fluorouracil; Innotecan; Metastatic colon cancer; Oxaliplatin; Panitumumab; Targeted therapy

Indexed keywords

ANTIHISTAMINIC AGENT; ANTIHYPERTENSIVE AGENT; ANTINEOPLASTIC AGENT; BEVACIZUMAB; BORTEZOMIB; CAPECITABINE; CETUXIMAB; CYTOTOXIC AGENT; DIPHENHYDRAMINE; ELOTAXIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FLUOROPYRIMIDINE DERIVATIVE; FLUOROURACIL; FOLINIC ACID; GEFITINIB; GEMCITABINE; IMATINIB; IRINOTECAN; ORZEL; OXALIPLATIN; PANITUMUMAB; PLACEBO; PROTEASOME INHIBITOR; PROTEIN P53; PROTEIN TYROSINE KINASE INHIBITOR; SUNITINIB; TEGAFUR; UFT; UNINDEXED DRUG; VATALANIB;

EID: 49149094340     PISSN: 17474124     EISSN: None     Source Type: Journal    
DOI: 10.1586/17474124.2.1.135     Document Type: Review
Times cited : (52)

References (117)
  • 2
    • 13744251436 scopus 로고    scopus 로고
    • Systemic therapy for colorectal cancer
    • Meyerhardt JA, Mayer RJ. Systemic therapy for colorectal cancer. N. Engl. J. Med. 352(5), 476-487 (2005).
    • (2005) N. Engl. J. Med , vol.352 , Issue.5 , pp. 476-487
    • Meyerhardt, J.A.1    Mayer, R.J.2
  • 4
    • 6944230093 scopus 로고    scopus 로고
    • Colon cancer survival rates with the New American Joint Committee On Cancer Sixth Edition Staging
    • O'Connell JB, Maggard MA, Ko CY. Colon cancer survival rates with the New American Joint Committee On Cancer Sixth Edition Staging. J. Natl Cancer Inst. 96(19), 1420-1425 (2004).
    • (2004) J. Natl Cancer Inst , vol.96 , Issue.19 , pp. 1420-1425
    • O'Connell, J.B.1    Maggard, M.A.2    Ko, C.Y.3
  • 5
    • 0027461840 scopus 로고
    • Randomised comparison of combination chemotherapy plus supportive care alone in patients with metastatic colorectal cancer
    • Scheitauer W RH, Kornek GV, Sebesta C, Depisch D. Randomised comparison of combination chemotherapy plus supportive care alone in patients with metastatic colorectal cancer. BMJ 306, 752-755 (1993).
    • (1993) BMJ , vol.306 , pp. 752-755
    • Scheitauer, W.R.1    Kornek, G.V.2    Sebesta, C.3    Depisch, D.4
  • 6
    • 0032585232 scopus 로고    scopus 로고
    • Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer
    • Cunningham D, Pyrhonen S, James RD et al. Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. Lancet 352(9138), 1413-1418 (1998).
    • (1998) Lancet , vol.352 , Issue.9138 , pp. 1413-1418
    • Cunningham, D.1    Pyrhonen, S.2    James, R.D.3
  • 7
    • 49149089947 scopus 로고    scopus 로고
    • Best PS, C Baughan, R Buchanan et al. Colorectal Meta-analysis Collaboration. Palliative chemotherapy for advanced or metastatic colorectal caricer. Cochrane Database Syst. Rev. 1, CD001545 (2000).
    • Best PS, C Baughan, R Buchanan et al. Colorectal Meta-analysis Collaboration. Palliative chemotherapy for advanced or metastatic colorectal caricer. Cochrane Database Syst. Rev. 1, CD001545 (2000).
  • 8
    • 0033783056 scopus 로고    scopus 로고
    • Mechanism of action of flouropyrimidines: Relevance to the new developments in colorectal cancer chemotherapy
    • Sobrero A GA, Grossi F, Puglisi F et al. Mechanism of action of flouropyrimidines: relevance to the new developments in colorectal cancer chemotherapy. Semin. Oncol. 27(Suppl. 10), 72-77 (2000).
    • (2000) Semin. Oncol , vol.27 , Issue.SUPPL. 10 , pp. 72-77
    • Sobrero, A.G.1    Grossi, F.2    Puglisi, F.3
  • 9
    • 0026540496 scopus 로고
    • Modulation of fluoropyrimidines: Role of dose and schedule of leucovorin administration
    • Zhang ZG HA, Rustum YM. Modulation of fluoropyrimidines: role of dose and schedule of leucovorin administration. Semin. Oncol. 19(Suppl. 3), 10-15 (1992).
    • (1992) Semin. Oncol , vol.19 , Issue.SUPPL. 3 , pp. 10-15
    • Zhang, Z.H.1    Rustum, Y.M.2
  • 10
    • 0034901306 scopus 로고    scopus 로고
    • Lethal outcome of a patient with a complete dihydropyrimidine dihydrogenase (DPD) deficiency after administration of 5-fluorouracil: Frequency of die common IVS14+1G>A mutation causing DPD deficiency
    • van Kuilenburg ABP, Muller EW, Haasjes J et al. Lethal outcome of a patient with a complete dihydropyrimidine dihydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of die common IVS14+1G>A mutation causing DPD deficiency. Clin. Cancer Res. 7(5), 1149-1153 (2001).
    • (2001) Clin. Cancer Res , vol.7 , Issue.5 , pp. 1149-1153
    • van Kuilenburg, A.B.P.1    Muller, E.W.2    Haasjes, J.3
  • 11
    • 4644252335 scopus 로고    scopus 로고
    • Modulation of fluorouraril by leucovorin in patients with advanced colorectal cancer an updated meta-analysis
    • The Meta-Analysis Group in C
    • The Meta-Analysis Group in C. Modulation of fluorouraril by leucovorin in patients with advanced colorectal cancer an updated meta-analysis. J. Clin. Oncol. 22(18), 3766-3775 (2004).
    • (2004) J. Clin. Oncol , vol.22 , Issue.18 , pp. 3766-3775
  • 12
    • 0034729931 scopus 로고    scopus 로고
    • Relation between tumour response to first-line chemotherapy and survival in advanced colorectal cancer: A meta-analysis
    • Buyse M, Thirion P, Carlson RW et al. Relation between tumour response to first-line chemotherapy and survival in advanced colorectal cancer: a meta-analysis. Lancet 356(9227), 373-378 (2000).
    • (2000) Lancet , vol.356 , Issue.9227 , pp. 373-378
    • Buyse, M.1    Thirion, P.2    Carlson, R.W.3
  • 13
    • 0016785582 scopus 로고
    • A double-blind comparison of intensive course 5-fluorouracil by oral vs intravenous route in the treatment of colorectal carcinoma
    • Hahn, RG, Moertel CG, Schutt AJ et al. A double-blind comparison of intensive course 5-fluorouracil by oral vs intravenous route in the treatment of colorectal carcinoma. Cancer 35(4), 1031-1035 (1975).
    • (1975) Cancer , vol.35 , Issue.4 , pp. 1031-1035
    • Hahn, R.G.1    Moertel, C.G.2    Schutt, A.J.3
  • 14
    • 0036875812 scopus 로고    scopus 로고
    • The rational development of capecitabine fiorn the laboratory to the clinic
    • Pentheroudakis G TC. The rational development of capecitabine fiorn the laboratory to the clinic. Anti Cancer Res. 22, 3589-3596 (2002).
    • (2002) Anti Cancer Res , vol.22 , pp. 3589-3596
    • Pentheroudakis, G.T.1
  • 15
    • 0032168166 scopus 로고    scopus 로고
    • Oral fluoropyrimidines in the treatment of colorectal cancer
    • Meropol NJ. Oral fluoropyrimidines in the treatment of colorectal cancer. Eur. J. Cancer 34(10), 1509-1513 (1998).
    • (1998) Eur. J. Cancer , vol.34 , Issue.10 , pp. 1509-1513
    • Meropol, N.J.1
  • 16
    • 0031727480 scopus 로고    scopus 로고
    • Uracilftorafur: An oral fluoropyrimidine active in colorectal cancer
    • Sulkes A, Benner SE, Catietta RM. Uracilftorafur: an oral fluoropyrimidine active in colorectal cancer. J. Clin. Oncol. 16(10), 3461-3475 (1998).
    • (1998) J. Clin. Oncol , vol.16 , Issue.10 , pp. 3461-3475
    • Sulkes, A.1    Benner, S.E.2    Catietta, R.M.3
  • 17
    • 0034016415 scopus 로고    scopus 로고
    • Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients
    • Schüller J, Cassidy J, Dumont E et al. Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients. Cancer Chemother. Pharmacol. 45(4), 291-297 (2000).
    • (2000) Cancer Chemother. Pharmacol , vol.45 , Issue.4 , pp. 291-297
    • Schüller, J.1    Cassidy, J.2    Dumont, E.3
  • 18
    • 0035503151 scopus 로고    scopus 로고
    • Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large Phase III study
    • Van Cutsem E, Twelves C, Cassidy J et al. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large Phase III study. J. Clin. Oncol. 19(21), 4097-4106 (2001).
    • (2001) J. Clin. Oncol , vol.19 , Issue.21 , pp. 4097-4106
    • Van Cutsem, E.1    Twelves, C.2    Cassidy, J.3
  • 19
    • 0035871538 scopus 로고    scopus 로고
    • Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized Phase III study
    • Hoff PM, Ansari R, Batist G et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized Phase III study. J. Clin. Oncol. 19(8), 2282-2292 (2001).
    • (2001) J. Clin. Oncol , vol.19 , Issue.8 , pp. 2282-2292
    • Hoff, P.M.1    Ansari, R.2    Batist, G.3
  • 20
    • 0035503436 scopus 로고    scopus 로고
    • Oral versus intravenous fluoropyrimidines for advanced colorectal cancer: By either route, it's all the same
    • Mayer RJ. Oral versus intravenous fluoropyrimidines for advanced colorectal cancer: by either route, it's all the same. J. Clin. Oncol. 19(21), 4093-4096 (2001).
    • (2001) J. Clin. Oncol , vol.19 , Issue.21 , pp. 4093-4096
    • Mayer, R.J.1
  • 21
    • 0036235128 scopus 로고    scopus 로고
    • First-line oral capecitabine therapy in metastatic colorectal cancer: A favorable safety profile compared with intravenous 5-fluorouracil/leucovorin
    • Cassidy J, Twelves C, Van Cutsern E et al. First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin. Ann. Oncol. 13(4), 566-575 (2002).
    • (2002) Ann. Oncol , vol.13 , Issue.4 , pp. 566-575
    • Cassidy, J.1    Twelves, C.2    Van Cutsern, E.3
  • 22
    • 0036727089 scopus 로고    scopus 로고
    • Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer
    • Carmichael J, Popiela T, Radstone D et al. Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J. Clin. Oncol. 20(17), 3617-3627 (2002).
    • (2002) J. Clin. Oncol , vol.20 , Issue.17 , pp. 3617-3627
    • Carmichael, J.1    Popiela, T.2    Radstone, D.3
  • 23
    • 0036731818 scopus 로고    scopus 로고
    • Multicenter Phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer
    • Douillard J-Y, Hoff PM, Skillings JR et al. Multicenter Phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J. Clin. Oncol. 20(17), 3605-3616 (2002).
    • (2002) J. Clin. Oncol , vol.20 , Issue.17 , pp. 3605-3616
    • Douillard, J.-Y.1    Hoff, P.M.2    Skillings, J.R.3
  • 24
    • 0031864830 scopus 로고    scopus 로고
    • Oxaliplatin: Mechanism of action and antineoplastic activity
    • Raymond E FS, Woynarowski JM, Chaney SG. Oxaliplatin: mechanism of action and antineoplastic activity. Semin. Oncol. 25, 4-12 (1998).
    • (1998) Semin. Oncol , vol.25 , pp. 4-12
    • Raymond, E.F.1    Woynarowski, J.M.2    Chaney, S.G.3
  • 25
    • 0000460127 scopus 로고
    • Oxaliplatin, tetraplatin, cisplatin, and carboplatin: Spectrum of activity in drug-resistant cell lines and in the cell lines of the national cancer institute's anticancer drug screen panel
    • 1996
    • Rixe O, Ortuzar W, Alvarez M et al. Oxaliplatin, tetraplatin, cisplatin, and carboplatin: Spectrum of activity in drug-resistant cell lines and in the cell lines of the national cancer institute's anticancer drug screen panel. Biochem. Pharmacol. 52(12), 1855-1865 (1996).
    • (1855) Biochem. Pharmacol , Issue.12 , pp. 52
    • Rixe, O.1    Ortuzar, W.2    Alvarez, M.3
  • 26
    • 0030722949 scopus 로고    scopus 로고
    • Antitiumor activity of oxaliplatin in combination with 5-fluorouracil-leucovorin and the thymidylate synthase inhibitor AG337 in human colon, breast, and ovarian cancers
    • Raymond E B-FC, Djelloul S et al. Antitiumor activity of oxaliplatin in combination with 5-fluorouracil-leucovorin and the thymidylate synthase inhibitor AG337 in human colon, breast, and ovarian cancers. Anticancer Drugs 8, 876-885 (1997).
    • (1997) Anticancer Drugs , vol.8 , pp. 876-885
    • Raymond, E.B.-F.C.1    Djelloul, S.2
  • 27
    • 0037531121 scopus 로고    scopus 로고
    • Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: Interim results of a Phase III trial
    • Rothenberg ML, Oza AM, Bigelow RH et al. Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: interim results of a Phase III trial. J. Clin. Oncol. 21(11), 2059-2069 (2003).
    • (2003) J. Clin. Oncol , vol.21 , Issue.11 , pp. 2059-2069
    • Rothenberg, M.L.1    Oza, A.M.2    Bigelow, R.H.3
  • 28
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • de Gramont A, Figer A, Seymour M et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J. Clin. Oncol. 18(16), 2938-2947 (2000).
    • (2000) J. Clin. Oncol , vol.18 , Issue.16 , pp. 2938-2947
    • de Gramont, A.1    Figer, A.2    Seymour, M.3
  • 29
  • 30
    • 0141890143 scopus 로고    scopus 로고
    • A. G. Oxaliplatin-safety profile: neurotoxicity. Semin. Oncol. 30, 5-13 (2003).
    • A. G. Oxaliplatin-safety profile: neurotoxicity. Semin. Oncol. 30, 5-13 (2003).
  • 31
    • 0033794047 scopus 로고    scopus 로고
    • Oxaliplatin in colorectal cancer: An overview
    • Armand JP BV, Raymond E et al. Oxaliplatin in colorectal cancer: an overview. Semin. Oncol. 5(Suppl. 10), 96-104 (2000).
    • (2000) Semin. Oncol , vol.5 , Issue.SUPPL. 10 , pp. 96-104
    • Armand1    JP, B.V.2    Raymond, E.3
  • 32
    • 0344783805 scopus 로고    scopus 로고
    • Phase II trial of oxatiplatin as first-line chemotherapy in metastatic colorectal cancer patients. Digestive Group of French Federation of Cancer Centers
    • Becouarn Y, Ychou M, Ducreux M et al. Phase II trial of oxatiplatin as first-line chemotherapy in metastatic colorectal cancer patients. Digestive Group of French Federation of Cancer Centers. J. Clin. Oncol. 16(8), 2739-2744 (1998).
    • (1998) J. Clin. Oncol , vol.16 , Issue.8 , pp. 2739-2744
    • Becouarn, Y.1    Ychou, M.2    Ducreux, M.3
  • 33
    • 0033989203 scopus 로고    scopus 로고
    • Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer
    • Giacchetti S, Perpoint B, Zidani R et al. Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J. Clin. Oncol. 18(1), 136- (2000).
    • (2000) J. Clin. Oncol , vol.18 , Issue.1 , pp. 136
    • Giacchetti, S.1    Perpoint, B.2    Zidani, R.3
  • 34
    • 0001120708 scopus 로고    scopus 로고
    • Phase III study of bolus 5-fluorouracil (5-FLD/folinic acid (FA) (Mayo) vs weekly high dose 24 h 5-FU infusion/FA + oxaliplatin (OXA) (FUFOX) in advanced colorectal cancer (ACRC)
    • Abstract 512
    • Grothey A, Deschler B, Kroening H et al. Phase III study of bolus 5-fluorouracil (5-FLD/folinic acid (FA) (Mayo) vs weekly high dose 24 h 5-FU infusion/FA + oxaliplatin (OXA) (FUFOX) in advanced colorectal cancer (ACRC). Proc. Am. Soc. Clin. Oncol. 21 (2002) (Abstract 512).
    • (2002) Proc. Am. Soc. Clin. Oncol , vol.21
    • Grothey, A.1    Deschler, B.2    Kroening, H.3
  • 35
    • 22244477362 scopus 로고    scopus 로고
    • Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal carcinoma
    • Comella P, Natale D, Farris A et al. Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal carcinoma. Cancer 104(2), 282-289 (2005).
    • (2005) Cancer , vol.104 , Issue.2 , pp. 282-289
    • Comella, P.1    Natale, D.2    Farris, A.3
  • 36
    • 49149096593 scopus 로고    scopus 로고
    • Porschen R, Arkenau H-T, Kubicka S et al. Capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin: a randomized comparison in metastatic colorectal cancer - a final report of the AIO Colorectal Study Group. J. Clin. Oncol. (2007) (Epub ahead of print).
    • Porschen R, Arkenau H-T, Kubicka S et al. Capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin: a randomized comparison in metastatic colorectal cancer - a final report of the AIO Colorectal Study Group. J. Clin. Oncol. (2007) (Epub ahead of print).
  • 37
    • 34948892881 scopus 로고    scopus 로고
    • Phase III study of capecitabine plus oxaliplatin versus continuous-infusion fluorouracil plus oxaliplatin as first-line therapy in metastatic colorectal cancer: Final report of the Spanish Cooperative Group for the Treatment of Digestive Tumors Trial
    • Diaz-Rubio E, Tabernero J, Gomez-Espana A et al. Phase III study of capecitabine plus oxaliplatin versus continuous-infusion fluorouracil plus oxaliplatin as first-line therapy in metastatic colorectal cancer: final report of the Spanish Cooperative Group for the Treatment of Digestive Tumors Trial. J. Clin. Oncol. 25, 4224-4230 (2007).
    • (2007) J. Clin. Oncol , vol.25 , pp. 4224-4230
    • Diaz-Rubio, E.1    Tabernero, J.2    Gomez-Espana, A.3
  • 38
    • 0031714683 scopus 로고    scopus 로고
    • Clinical pharmacology of camptothecins
    • Iyer L RM. Clinical pharmacology of camptothecins. Cancer Chemother. Pharmacol. 42(0), S31-S43 (1998).
    • (1998) Cancer Chemother. Pharmacol , vol.42 , Issue.0
    • Iyer, L.R.1
  • 39
    • 0034892379 scopus 로고    scopus 로고
    • Clinical Pharmacokinetics and Metabolism of Irinotecan (CPT-11)
    • Mathijssen RHJ, van Alphen RJ, Verweij J et al. Clinical Pharmacokinetics and Metabolism of Irinotecan (CPT-11). Clin. Cancer Res. 7(8), 2182-2194 (2001).
    • (2001) Clin. Cancer Res , vol.7 , Issue.8 , pp. 2182-2194
    • Mathijssen, R.H.J.1    van Alphen, R.J.2    Verweij, J.3
  • 40
    • 0036025450 scopus 로고    scopus 로고
    • UGTIA1*28 polymorphism as a determinant of irinotecan disposition and toxicity
    • Iyer L, Das S, Janisch L et al. UGTIA1*28 polymorphism as a determinant of irinotecan disposition and toxicity. Pharmacogenomics J. 2, 43-47 (2002).
    • (2002) Pharmacogenomics J , vol.2 , pp. 43-47
    • Iyer, L.1    Das, S.2    Janisch, L.3
  • 41
    • 0031661579 scopus 로고    scopus 로고
    • UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan
    • Ando Y, Saka H, Asai G et al. UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan. Ann. Oncol. 9(8), 845-847 (1998).
    • (1998) Ann. Oncol , vol.9 , Issue.8 , pp. 845-847
    • Ando, Y.1    Saka, H.2    Asai, G.3
  • 42
    • 2342459714 scopus 로고    scopus 로고
    • Genetic Variants in the UDP-glucuronosyltransferase 1a1 gene predict the risk of severe neutropenia of irinotecan
    • Innocenti F, Undevia SD, Iyer L et al. Genetic Variants in the UDP-glucuronosyltransferase 1a1 gene predict the risk of severe neutropenia of irinotecan. J. Clin. Oncol. 22(8),1382-1388 (2004).
    • (2004) J. Clin. Oncol , vol.22 , Issue.8 , pp. 1382-1388
    • Innocenti, F.1    Undevia, S.D.2    Iyer, L.3
  • 43
    • 0032585197 scopus 로고    scopus 로고
    • Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer
    • Rougier P, Van Cutsem E, Bajetta E et al. Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer. Lancet 352(9138), 1407-1412 (1998).
    • (1998) Lancet , vol.352 , Issue.9138 , pp. 1407-1412
    • Rougier, P.1    Van Cutsem, E.2    Bajetta, E.3
  • 44
    • 0036697173 scopus 로고    scopus 로고
    • The palliative benefit of irino,tecan in 5-fluorouracil-refractory colorectal cancer: Its prospective evaluation by a Multicenter Canadian Trial
    • Michael M HD, Oza A, et al. The palliative benefit of irino,tecan in 5-fluorouracil-refractory colorectal cancer: its prospective evaluation by a Multicenter Canadian Trial. Clin. Colorectal Cancer 2, 93-101 (2002).
    • (2002) Clin. Colorectal Cancer , vol.2 , pp. 93-101
    • Michael, M.H.1    Oza, A.2
  • 45
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as first-fine treatment for metastatic colorectal cancer: A multicentre randomised trial
    • Douillard JY, Cunningham D, Roth AD et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-fine treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 355(9209), 1041-1047 (2000).
    • (2000) Lancet , vol.355 , Issue.9209 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3
  • 46
    • 1342290189 scopus 로고    scopus 로고
    • FOLFIRI Followed by FOLFOX6 or tile reverse sequence in advanced colorectal cancer: A randomized GERCOR Study
    • Tournigand C, Andre T, Achille E et al. FOLFIRI Followed by FOLFOX6 or tile reverse sequence in advanced colorectal cancer: a randomized GERCOR Study. J. Clin. Oncol. 22(2), 229-237 (2004).
    • (2004) J. Clin. Oncol , vol.22 , Issue.2 , pp. 229-237
    • Tournigand, C.1    Andre, T.2    Achille, E.3
  • 47
    • 49149118455 scopus 로고    scopus 로고
    • C. Fuchs JM, E. Mitchell, R. Wierzbicki et al. A randomized trial of first-line irinotecan/fluoropymidine combinations with or without celecoxib in metastatic colorectal cancer (BICC-C). 2006 ASCO Annual Meeting Proceedings Part I. J. Clin. Oncol. 24(18 Suppl.) (2006) (Abstract 3506).
    • C. Fuchs JM, E. Mitchell, R. Wierzbicki et al. A randomized trial of first-line irinotecan/fluoropymidine combinations with or without celecoxib in metastatic colorectal cancer (BICC-C). 2006 ASCO Annual Meeting Proceedings Part I. J. Clin. Oncol. 24(18 Suppl.) (2006) (Abstract 3506).
  • 48
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
    • Saltz LB, Cox JV, Blanke C et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 343(13), 905-914 (2000).
    • (2000) N. Engl. J. Med , vol.343 , Issue.13 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3
  • 49
    • 7644244310 scopus 로고    scopus 로고
    • Mortality associated with daily bolus 5-fluorouracil/leucovorin administered in combination with either irinotecan or oxaliplatin
    • Delaunoit R GR, Sargent DJ et al. Mortality associated with daily bolus 5-fluorouracil/leucovorin administered in combination with either irinotecan or oxaliplatin. Cancer 101 (10), 2170-2176 (2004).
    • (2004) Cancer , vol.101 , Issue.10 , pp. 2170-2176
    • Delaunoit, R.G.1    Sargent, D.J.2
  • 50
    • 0035850303 scopus 로고    scopus 로고
    • Recommendation for caution with irinotecan, fluorouracil, and leucovorin for colorectal cancer
    • Sargent DJ ND, O'Connell MJ, Schilsky RL. Recommendation for caution with irinotecan, fluorouracil, and leucovorin for colorectal cancer. N. Engl. J. Med. 345 (2), 144-145 (2001).
    • (2001) N. Engl. J. Med , vol.345 , Issue.2 , pp. 144-145
    • Sargent, D.N.1    O'Connell, M.J.2    Schilsky, R.L.3
  • 51
    • 1842569206 scopus 로고    scopus 로고
    • A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    • Goldberg RM, Sargent DI, Morton RF et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J. Clin. Oncol. 22(1), 23-30 (2004).
    • (2004) J. Clin. Oncol , vol.22 , Issue.1 , pp. 23-30
    • Goldberg, R.M.1    Sargent, D.I.2    Morton, R.F.3
  • 52
    • 24644457747 scopus 로고    scopus 로고
    • Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: A multicenter study of the Gruppo Oncologico Dell'Italia Meridionale
    • Colucci G, Gebbia V, Paoletti G et al. Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: a multicenter study of the Gruppo Oncologico Dell'Italia Meridionale. J. Clin. Oncol. 23(22), 4866-4875 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.22 , pp. 4866-4875
    • Colucci, G.1    Gebbia, V.2    Paoletti, G.3
  • 53
    • 0042714530 scopus 로고    scopus 로고
    • Randomized phase II trial of capecitabine plus irinotecan (CapIri) vs capecitabine plus oxaliplatin (CapOx) as first-fine therapy of advanced colorectal cancer (ACRC)
    • Abstract 1022
    • Grothey A, Jordan K, Kellner O et al. Randomized phase II trial of capecitabine plus irinotecan (CapIri) vs capecitabine plus oxaliplatin (CapOx) as first-fine therapy of advanced colorectal cancer (ACRC). Proc. Am. Soc. Clin. Oncol. 22, 255 (2003) (Abstract 1022).
    • (2003) Proc. Am. Soc. Clin. Oncol , vol.22 , pp. 255
    • Grothey, A.1    Jordan, K.2    Kellner, O.3
  • 54
    • 33646457231 scopus 로고    scopus 로고
    • chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases
    • Vauthey J-N, Pawlik TM, Ribero D et al. chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J. Clin. Oncol. 24(13), 2065-2072 (2006).
    • (2006) J. Clin. Oncol , vol.24 , Issue.13 , pp. 2065-2072
    • Vauthey, J.-N.1    Pawlik, T.M.2    Ribero, D.3
  • 55
    • 2142703727 scopus 로고    scopus 로고
    • Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
    • Grothey A, Sargent D, Goldberg RM et al. Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J. Clin. Oncol. 22(7), 1209-1214 (2004).
    • (2004) J. Clin. Oncol , vol.22 , Issue.7 , pp. 1209-1214
    • Grothey, A.1    Sargent, D.2    Goldberg, R.M.3
  • 56
    • 33644825856 scopus 로고    scopus 로고
    • Overall survival of patients with advanced colorectal cancer correlates with availability of fluorouracil, irinotecan, and oxaliplatin regardless of whether doublet or single-agent therapy is used first line
    • Grothey A, Sargent D. Overall survival of patients with advanced colorectal cancer correlates with availability of fluorouracil, irinotecan, and oxaliplatin regardless of whether doublet or single-agent therapy is used first line. J. Clin. Oncol. 23(36), 9441-9442 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.36 , pp. 9441-9442
    • Grothey, A.1    Sargent, D.2
  • 58
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 100(1), 57-70. (2000).
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 59
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • Folkinan J. Angiogenesis: an organizing principle for drug discovery? Nat. Rev. Drug Discov. 6(4), 273-286 (2007).
    • (2007) Nat. Rev. Drug Discov , vol.6 , Issue.4 , pp. 273-286
    • Folkinan, J.1
  • 60
    • 0038745735 scopus 로고    scopus 로고
    • β-catenin regulates vascular endothelial growth factor expression in colon cancer
    • Easwaran V, Lee SH, Inge L et al. β-catenin regulates vascular endothelial growth factor expression in colon cancer. Cancer Res. 63(12), 3145-3153 (2003).
    • (2003) Cancer Res , vol.63 , Issue.12 , pp. 3145-3153
    • Easwaran, V.1    Lee, S.H.2    Inge, L.3
  • 61
    • 13444278498 scopus 로고    scopus 로고
    • Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoyic therapy in preclinical studies
    • Gerber H-P, Ferrara N. Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoyic therapy in preclinical studies. Cancer Res. 65(3), 671-680 (2005).
    • (2005) Cancer Res , vol.65 , Issue.3 , pp. 671-680
    • Gerber, H.-P.1    Ferrara, N.2
  • 62
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J. Clin. Oncol. 21(1), 60-65 (2003).
    • (2003) J. Clin. Oncol , vol.21 , Issue.1 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 63
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350(23), 2335-2342 (2004).
    • (2004) N. Engl. J. Med , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 64
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J. Clin. Oncol. 25(12), 1539-1544 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 65
    • 49149129709 scopus 로고    scopus 로고
    • Cassidy J, Clarke S, Diaz-Rub E et al. XELOX vs FOLFOX4: Efficacy results from XELOX-1/NO16966, a randomized Phase III trial in first-line metastatic colorectal cancer (MCRC). J. Clin. Oncol. 25(18 Suppl.) (2007) (Abstract 4030).
    • Cassidy J, Clarke S, Diaz-Rub E et al. XELOX vs FOLFOX4: Efficacy results from XELOX-1/NO16966, a randomized Phase III trial in first-line metastatic colorectal cancer (MCRC). J. Clin. Oncol. 25(18 Suppl.) (2007) (Abstract 4030).
  • 66
    • 49149087060 scopus 로고    scopus 로고
    • Saltz L, Clarke S, Diaz-Ru E et al. Bevacizumab (Bev) in combination with XELOX or FOLFOX4: updated efficacy results from XELOX-1/ NO16966, a randomized Phase III trial in first-line metastatic colorectal cancer. J. Clin. Oncol. 25(18 Suppl.) (2007) (Abstract 4028).
    • Saltz L, Clarke S, Diaz-Ru E et al. Bevacizumab (Bev) in combination with XELOX or FOLFOX4: updated efficacy results from XELOX-1/ NO16966, a randomized Phase III trial in first-line metastatic colorectal cancer. J. Clin. Oncol. 25(18 Suppl.) (2007) (Abstract 4028).
  • 67
    • 34548141828 scopus 로고    scopus 로고
    • Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab
    • Scappaticci FA, Skillings JR, Holden SN et al. Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J. Natl Cancer Inst. 99(16), 1232-1239 (2007).
    • (2007) J. Natl Cancer Inst , vol.99 , Issue.16 , pp. 1232-1239
    • Scappaticci, F.A.1    Skillings, J.R.2    Holden, S.N.3
  • 68
    • 34247849335 scopus 로고    scopus 로고
    • Target practice: Lessons from Phase III trials with bevacizumab and vatalanib in the treatment of advanced colorectal cancer
    • Los M, Roodhart JM, Voest EE. Target practice: lessons from Phase III trials with bevacizumab and vatalanib in the treatment of advanced colorectal cancer. Oncologist 12(4), 443-450 (2007).
    • (2007) Oncologist , vol.12 , Issue.4 , pp. 443-450
    • Los, M.1    Roodhart, J.M.2    Voest, E.E.3
  • 69
    • 33749587286 scopus 로고    scopus 로고
    • Reversible posterior leukoencephalopathy syndrome after bevacizumab/FOLFIRI regimen for metastatic colon cancer
    • Allen JA, Adlakha A, Bergethon PR. Reversible posterior leukoencephalopathy syndrome after bevacizumab/FOLFIRI regimen for metastatic colon cancer. Arch. Neurol. 63(10), 1475-1478 (2006).
    • (2006) Arch. Neurol , vol.63 , Issue.10 , pp. 1475-1478
    • Allen, J.A.1    Adlakha, A.2    Bergethon, P.R.3
  • 71
    • 0042783111 scopus 로고    scopus 로고
    • Clinical implications of the EGF receptor/ligand system for tumor progression and survival in gastrointestinal carcinomas: Evidence for new therapeutic options
    • Kopp R, Rothbauer E, Ruge M et al. Clinical implications of the EGF receptor/ligand system for tumor progression and survival in gastrointestinal carcinomas: evidence for new therapeutic options. Recent Results Cancer Res. 162, 115-132 (2003).
    • (2003) Recent Results Cancer Res , vol.162 , pp. 115-132
    • Kopp, R.1    Rothbauer, E.2    Ruge, M.3
  • 72
    • 33646585797 scopus 로고    scopus 로고
    • Prognostic significance of epidermal growth factor receptor expression in colon cancer patients undergoing curative surgery
    • Galizia G, Lieto E, Ferraraccio F et al. Prognostic significance of epidermal growth factor receptor expression in colon cancer patients undergoing curative surgery. Ann. Surg. Oncol. 13(6), 823-835 (2006).
    • (2006) Ann. Surg. Oncol , vol.13 , Issue.6 , pp. 823-835
    • Galizia, G.1    Lieto, E.2    Ferraraccio, F.3
  • 73
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz LB, Meropol NJ, Loehrer PJ Sr. et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J. Clin. Oncol. 22(7), 1201-1208 (2004).
    • (2004) J. Clin. Oncol , vol.22 , Issue.7 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr., P.J.3
  • 74
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med. 351(4), 337-345 (2004).
    • (2004) N. Engl. J. Med , vol.351 , Issue.4 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 75
    • 33750615769 scopus 로고    scopus 로고
    • Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines
    • Lenz HJ, Van Cutsem E, Khambata-Ford S et al. Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines. J. Clin. Oncol. 24(30), 4914-4921 (2006).
    • (2006) J. Clin. Oncol , vol.24 , Issue.30 , pp. 4914-4921
    • Lenz, H.J.1    Van Cutsem, E.2    Khambata-Ford, S.3
  • 76
    • 20144381957 scopus 로고    scopus 로고
    • Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
    • Chung KY, Shia J, Kemeny NE et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J. Clin. Oncol. 23(9), 1803-1810 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.9 , pp. 1803-1810
    • Chung, K.Y.1    Shia, J.2    Kemeny, N.E.3
  • 77
    • 49149124388 scopus 로고    scopus 로고
    • Van Cutsem E, Nowacki M, La I et al. Randomized Phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC): the CRYSTAL trial. J. Clin. Oncol. 25(18 Suppl.) (2007) (Abstract 4000).
    • Van Cutsem E, Nowacki M, La I et al. Randomized Phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC): the CRYSTAL trial. J. Clin. Oncol. 25(18 Suppl.) (2007) (Abstract 4000).
  • 78
    • 49149093263 scopus 로고    scopus 로고
    • Bokemeyer C, Bondarenko I, Makhs A et al. Cetuyimab plus 5-FU/FA/ oxaliplatin (FOLFOX-4) versus FOLFOX-4 in the first-line treatment of metastatic colorectal cancer (mCRC): OPUS, a randomized Phase II study. 2007 ASCO Annual Meeting Proceedings Part I. J. Clin. Oncol. 25(18 Suppl.) 4035, (2007).
    • Bokemeyer C, Bondarenko I, Makhs A et al. Cetuyimab plus 5-FU/FA/ oxaliplatin (FOLFOX-4) versus FOLFOX-4 in the first-line treatment of metastatic colorectal cancer (mCRC): OPUS, a randomized Phase II study. 2007 ASCO Annual Meeting Proceedings Part I. J. Clin. Oncol. 25(18 Suppl.) 4035, (2007).
  • 79
    • 33847717475 scopus 로고    scopus 로고
    • Incidence and management of cutaneous toxicities associated with cetuximab
    • Saif MW, Kim R. Incidence and management of cutaneous toxicities associated with cetuximab. Expert Opin. Drug Saf. 6(2), 175-182 (2007).
    • (2007) Expert Opin. Drug Saf , vol.6 , Issue.2 , pp. 175-182
    • Saif, M.W.1    Kim, R.2
  • 80
    • 49149121013 scopus 로고    scopus 로고
    • Tejpar S, Peeters M, Humb Y et al. Phase I/II study of cetuximab dose-escalation in patients with metastatic colorectal. cancer (mCRC) with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): pharmacokinetic (PK), pharmacodynamic (PD) and efficacy data. 2007 ASCO Annual Meeting Proceedings Part I. J. Clin. Oncol. 25(18 Suppl.) 4037, (2007).
    • Tejpar S, Peeters M, Humb Y et al. Phase I/II study of cetuximab dose-escalation in patients with metastatic colorectal. cancer (mCRC) with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): pharmacokinetic (PK), pharmacodynamic (PD) and efficacy data. 2007 ASCO Annual Meeting Proceedings Part I. J. Clin. Oncol. 25(18 Suppl.) 4037, (2007).
  • 81
    • 35648941728 scopus 로고    scopus 로고
    • Randomized Phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 study
    • Saltz LB, Lenz H-J, Kindler HL et al. Randomized Phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study. J. Clin. Oncol. 25(29), 4557-4561 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.29 , pp. 4557-4561
    • Saltz, L.B.1    Lenz, H.-J.2    Kindler, H.L.3
  • 82
    • 34147103678 scopus 로고    scopus 로고
    • Open-label Phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • Van Cutsem E, Peeters M, Siena S et al. Open-label Phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J. Clin. Oncol. 25(13), 1658-1664 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.13 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3
  • 83
    • 38049044037 scopus 로고    scopus 로고
    • An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy
    • Van Cutsem E, Siena S, Humblet Y et al. An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy. Ann. Oncol. 19(1), 92-98 (2007).
    • (2007) Ann. Oncol , vol.19 , Issue.1 , pp. 92-98
    • Van Cutsem, E.1    Siena, S.2    Humblet, Y.3
  • 84
    • 35648956232 scopus 로고    scopus 로고
    • Combined antiangiogenesis and antiepidermal growth factor receptor targeting in the treatment of cancer: Hold back, we are not there yet
    • Baselga J, Tabernero J. Combined antiangiogenesis and antiepidermal growth factor receptor targeting in the treatment of cancer: hold back, we are not there yet. J. Clin. Oncol. 25(29), 4516-4518 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.29 , pp. 4516-4518
    • Baselga, J.1    Tabernero, J.2
  • 85
    • 33846244217 scopus 로고    scopus 로고
    • Epidermal growth factor receptor activation: How exon 19 and 21 mutations changed our understanding of the pathway
    • Rosell R, Taron M, Reguart N, Isla D, Moran T. Epidermal growth factor receptor activation: how exon 19 and 21 mutations changed our understanding of the pathway. Clin. Cancer Res. 12(24), 7222-7231 (2006).
    • (2006) Clin. Cancer Res , vol.12 , Issue.24 , pp. 7222-7231
    • Rosell, R.1    Taron, M.2    Reguart, N.3    Isla, D.4    Moran, T.5
  • 86
    • 27644596760 scopus 로고    scopus 로고
    • The epidermal growth factor receptor tyrosine kinase inhibitor gefitinib sensitizes colon cancer cells to irinotecan
    • Braun AH, Stark K, Dirsch O et al. The epidermal growth factor receptor tyrosine kinase inhibitor gefitinib sensitizes colon cancer cells to irinotecan. Anticancer Drugs 16(10), 1099-1108 (2005).
    • (2005) Anticancer Drugs , vol.16 , Issue.10 , pp. 1099-1108
    • Braun, A.H.1    Stark, K.2    Dirsch, O.3
  • 87
    • 33846659399 scopus 로고    scopus 로고
    • Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis
    • Fichera A, Little N, Jagadeeswaran S et al. Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. Cancer Res. 67(2), 827-835 (2007).
    • (2007) Cancer Res , vol.67 , Issue.2 , pp. 827-835
    • Fichera, A.1    Little, N.2    Jagadeeswaran, S.3
  • 88
    • 24944484717 scopus 로고    scopus 로고
    • Phase II study of gefitinib, fluorouracil, leucovorin, and oxaliplatin therapy in previously treated patients with metastatic colorectal cancer
    • Kuo T, Cho CD, Halsey J et al. Phase II study of gefitinib, fluorouracil, leucovorin, and oxaliplatin therapy in previously treated patients with metastatic colorectal cancer. J. Clin. Oncol. 23(24), 5613-5619 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.24 , pp. 5613-5619
    • Kuo, T.1    Cho, C.D.2    Halsey, J.3
  • 89
    • 24944518101 scopus 로고    scopus 로고
    • Gefitinib in colorectal cancer: If wishes were horses
    • Blanke CD. Gefitinib in colorectal cancer: if wishes were horses. J. Clin. Oncol. 23(24), 5446-5449 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.24 , pp. 5446-5449
    • Blanke, C.D.1
  • 90
    • 34447544253 scopus 로고    scopus 로고
    • BCR-ABL tyrosine kinase inhibitors for chronic myelogenous leukemia
    • Schiffer CA. BCR-ABL tyrosine kinase inhibitors for chronic myelogenous leukemia. N. Engl. J. Med. 357(3), 258-265 (2007).
    • (2007) N. Engl. J. Med , vol.357 , Issue.3 , pp. 258-265
    • Schiffer, C.A.1
  • 91
    • 33947504730 scopus 로고    scopus 로고
    • Sunitinib: From rational design to clinical efficacy
    • Chow LQ, Eckhardt SG. Sunitinib: from rational design to clinical efficacy. J. Clin. Oncol. 25(7), 884-896 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.7 , pp. 884-896
    • Chow, L.Q.1    Eckhardt, S.G.2
  • 92
    • 36248960528 scopus 로고    scopus 로고
    • Imatinib inhibits colorectal cancer cell growth and suppresses stromal-induced growth stimulation, MT1-MMP expression and pro-MMP2 activation
    • Stahtea XN, Roussidis AE, Kanakis I et al. Imatinib inhibits colorectal cancer cell growth and suppresses stromal-induced growth stimulation, MT1-MMP expression and pro-MMP2 activation. Int. J. Cancer (2007).
    • (2007) Int. J. Cancer
    • Stahtea, X.N.1    Roussidis, A.E.2    Kanakis, I.3
  • 93
    • 34547643983 scopus 로고    scopus 로고
    • Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma
    • Kitadai Y, Sasaki T, Kuwai T et al. Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma. Am. J. Pathol. 169(6), 2054-2065 (2006).
    • (2006) Am. J. Pathol , vol.169 , Issue.6 , pp. 2054-2065
    • Kitadai, Y.1    Sasaki, T.2    Kuwai, T.3
  • 94
    • 23844524757 scopus 로고    scopus 로고
    • Early antiangiogenic activity of SU11248 evaluated in vivo by dynamic contrast-enhanced magnetic resonance imaging in an experimental model of colon carcinoma
    • Marzola P, Degrassi A, Calderan L et al. Early antiangiogenic activity of SU11248 evaluated in vivo by dynamic contrast-enhanced magnetic resonance imaging in an experimental model of colon carcinoma. Clin. Cancer Res. 11(16), 5827-5832 (2005).
    • (2005) Clin. Cancer Res , vol.11 , Issue.16 , pp. 5827-5832
    • Marzola, P.1    Degrassi, A.2    Calderan, L.3
  • 95
    • 1542426623 scopus 로고    scopus 로고
    • Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor
    • Morimoto AM, Tan N, West K et al. Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor. Oncogene 23(8), 1618-1626 (2004).
    • (2004) Oncogene , vol.23 , Issue.8 , pp. 1618-1626
    • Morimoto, A.M.1    Tan, N.2    West, K.3
  • 96
    • 36048992408 scopus 로고    scopus 로고
    • Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy
    • Saltz LB RL, Marshall JL et al. Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy. J. Clin. Oncol. 25 (30), 4793-4799 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.30 , pp. 4793-4799
    • Saltz1    LB, R.L.2    Marshall, J.L.3
  • 97
    • 49149130247 scopus 로고    scopus 로고
    • Kohne C, Bajetta E, Lin E et al. Final results of CONFIRM 2: a multinational, randomized, double-blind, Phase III study in 2nd line patients (pts) with metastatic colorectal cancer (mCRQ receiving FOLFOX4 and PTK787/ZK 222584 (PTK/ZK) or placebo. Proccedings of the 2007 ASCO Annual Meeting. J. Clin. Oncol. 25(18 Suppl.), 4033 (2007).
    • Kohne C, Bajetta E, Lin E et al. Final results of CONFIRM 2: a multinational, randomized, double-blind, Phase III study in 2nd line patients (pts) with metastatic colorectal cancer (mCRQ receiving FOLFOX4 and PTK787/ZK 222584 (PTK/ZK) or placebo. Proccedings of the 2007 ASCO Annual Meeting. J. Clin. Oncol. 25(18 Suppl.), 4033 (2007).
  • 98
    • 34247125164 scopus 로고    scopus 로고
    • The proteasome: A worthwhile target for the treatment of solid tumours?
    • Milano A, Iaffaioli RV, Caponigro F. The proteasome: a worthwhile target for the treatment of solid tumours? Eur. J. Cancer 43(7), 1125-1133 (2007).
    • (2007) Eur. J. Cancer , vol.43 , Issue.7 , pp. 1125-1133
    • Milano, A.1    Iaffaioli, R.V.2    Caponigro, F.3
  • 99
    • 26844452967 scopus 로고    scopus 로고
    • Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy
    • Boccadoro M, Morgan G, Cavenagh J. Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy. Cancer Cell Int. 5(1), 18 (2005).
    • (2005) Cancer Cell Int , vol.5 , Issue.1 , pp. 18
    • Boccadoro, M.1    Morgan, G.2    Cavenagh, J.3
  • 100
    • 25144521280 scopus 로고    scopus 로고
    • Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation
    • Zhu H, Guo W, Zhang L et al. Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation. Cancer Biol. Ther. 4(7), 791-786 (2005).
    • (2005) Cancer Biol. Ther , vol.4 , Issue.7 , pp. 791-786
    • Zhu, H.1    Guo, W.2    Zhang, L.3
  • 101
    • 33845288930 scopus 로고    scopus 로고
    • NPI-0052 enhances tumoricidal response to conventional cancer therapy in a colon cancer model
    • Cusack JC, Jr, Liu R, Xia L et al. NPI-0052 enhances tumoricidal response to conventional cancer therapy in a colon cancer model. Clin. Cancer Res. 12(22), 6758-6764 (2006).
    • (2006) Clin. Cancer Res , vol.12 , Issue.22 , pp. 6758-6764
    • Cusack Jr, J.C.1    Liu, R.2    Xia, L.3
  • 102
    • 0035912144 scopus 로고    scopus 로고
    • Molecular predictors of survival after adjuvant chemotherapy for colon cancer
    • Watanabe T, Wu T-T, Catalano PJ et al. Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N. Engl. J. Med. 344(16), 1196-1206 (2001).
    • (2001) N. Engl. J. Med , vol.344 , Issue.16 , pp. 1196-1206
    • Watanabe, T.1    Wu, T.-T.2    Catalano, P.J.3
  • 103
    • 0031922771 scopus 로고    scopus 로고
    • Characterization of MLH1 and MSH2 alternative splicing and its relevance to molecular testing of colorectal. cancer susceptibility
    • Genuardi M, Viel A, Bonora D et al. Characterization of MLH1 and MSH2 alternative splicing and its relevance to molecular testing of colorectal. cancer susceptibility. Hum. Genet. 102(1), 15-20 (1998).
    • (1998) Hum. Genet , vol.102 , Issue.1 , pp. 15-20
    • Genuardi, M.1    Viel, A.2    Bonora, D.3
  • 104
    • 0038002289 scopus 로고    scopus 로고
    • Microsatellite instability
    • de la Chapelle A. Microsatellite instability. N. Engl. J. Med. 349(3), 209-210 (2003).
    • (2003) N. Engl. J. Med , vol.349 , Issue.3 , pp. 209-210
    • de la Chapelle, A.1
  • 105
    • 0038002279 scopus 로고    scopus 로고
    • Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer
    • Ribic CM, Sargent DJ, Moore MJ et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N. Engl. J. Med. 349(3), 247-257 (2003).
    • (2003) N. Engl. J. Med , vol.349 , Issue.3 , pp. 247-257
    • Ribic, C.M.1    Sargent, D.J.2    Moore, M.J.3
  • 106
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal-tumor development
    • Vogelstein B FE, Hamilton SR et al. Genetic alterations during colorectal-tumor development. N. Engl. J. Med. 319 (9), 525-532 (1988).
    • (1988) N. Engl. J. Med , vol.319 , Issue.9 , pp. 525-532
    • Vogelstein, B.F.1    Hamilton, S.R.2
  • 107
    • 0027474820 scopus 로고
    • Concordant p53 and DCC alterations and allelic losses on chromosomes 13q and 14q associated with liver metastases of colorectal carcinoma
    • Ookawa K SM, Hiroshi S et al. Concordant p53 and DCC alterations and allelic losses on chromosomes 13q and 14q associated with liver metastases of colorectal carcinoma. Int. J. Cancer 53 (3), 385-387 (1993).
    • (1993) Int. J. Cancer , vol.53 , Issue.3 , pp. 385-387
    • Ookawa, K.S.1    Hiroshi, S.2
  • 108
    • 0028959978 scopus 로고
    • DCC: Linking tumor suppressor genes and altered cell surface interactions in cancer? Curr. Opin. Genet. Dev
    • Cho KR FE. DCC: linking tumor suppressor genes and altered cell surface interactions in cancer? Curr. Opin. Genet. Dev. 5(1), 72-78 (1995).
    • (1995) , vol.5 , Issue.1 , pp. 72-78
    • Cho, K.F.1
  • 109
    • 0028321495 scopus 로고
    • Allelic loss of chromosome 18q and prognosis in colorectal cancer
    • Jen J, Kim H, Piantadosi S et al. Allelic loss of chromosome 18q and prognosis in colorectal cancer. N. Engl. J. Med. 331(4), 213-221 (1994).
    • (1994) N. Engl. J. Med , vol.331 , Issue.4 , pp. 213-221
    • Jen, J.1    Kim, H.2    Piantadosi, S.3
  • 110
    • 0003119527 scopus 로고    scopus 로고
    • Confirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator
    • Ogunbiyi OA, Goodfellow PJ, Herfarth K et al. Confirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator. J. Clin. Oncol. 16(2), 427-433 (1998).
    • (1998) J. Clin. Oncol , vol.16 , Issue.2 , pp. 427-433
    • Ogunbiyi, O.A.1    Goodfellow, P.J.2    Herfarth, K.3
  • 111
    • 33748659432 scopus 로고    scopus 로고
    • Lymph node status and TS gene expression are prognostic markers in Stage II/III rectal cancer after neoadjuvant fluorouracil-based chemoradiotherapy
    • Liersch T, Langer C, Ghadimi BM et al. Lymph node status and TS gene expression are prognostic markers in Stage II/III rectal cancer after neoadjuvant fluorouracil-based chemoradiotherapy. J. Clin. Oncol. 24(25), 4062-4068 (2006).
    • (2006) J. Clin. Oncol , vol.24 , Issue.25 , pp. 4062-4068
    • Liersch, T.1    Langer, C.2    Ghadimi, B.M.3
  • 112
    • 0030934802 scopus 로고    scopus 로고
    • Mutated p53 gene is an independent adverse predictor of survival in colon carcinoma
    • Prcolo VE F S, Hansen K et al. Mutated p53 gene is an independent adverse predictor of survival in colon carcinoma. Arch. Surg. 132 (4), 371-375 (1997).
    • (1997) Arch. Surg , vol.132 , Issue.4 , pp. 371-375
    • Prcolo, V.F.S.1    Hansen, K.2
  • 113
    • 0032521205 scopus 로고    scopus 로고
    • Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: A Southwest Oncology Group study
    • Ahnen DJ, Feigl P, Quan G et al. Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study. Cancer Res. 58(6), 1149-1158 (1998).
    • (1998) Cancer Res , vol.58 , Issue.6 , pp. 1149-1158
    • Ahnen, D.J.1    Feigl, P.2    Quan, G.3
  • 114
    • 34247392921 scopus 로고    scopus 로고
    • Prognosis of Stage II colon cancer by non-neoplastic mucosa gene expression profiling
    • Barrier A, Roser F, Boelle PY et al. Prognosis of Stage II colon cancer by non-neoplastic mucosa gene expression profiling. Oncogene 26 (18), 2642-2648 (2006).
    • (2006) Oncogene , vol.26 , Issue.18 , pp. 2642-2648
    • Barrier, A.1    Roser, F.2    Boelle, P.Y.3
  • 115
    • 34447545773 scopus 로고    scopus 로고
    • Plasma lysophosphatidylcholine levels: Potential biomarkers for colorectal cancer
    • Zhao Z XY, Elson P et al. Plasma lysophosphatidylcholine levels: potential biomarkers for colorectal cancer. J. Clin. Oncol. 25(19), 2696-2701 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.19 , pp. 2696-2701
    • Zhao, Z.X.1    Elson, P.2
  • 116
    • 34548238762 scopus 로고    scopus 로고
    • Expression of epiregulin and amphiregulin and K-ras Mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
    • Khambata-Ford S, Garrett CR, Meropol NJ et al. Expression of epiregulin and amphiregulin and K-ras Mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J. Clin. Oncol. 25(22), 3230-3237 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.22 , pp. 3230-3237
    • Khambata-Ford, S.1    Garrett, C.R.2    Meropol, N.J.3
  • 117
    • 36749081020 scopus 로고    scopus 로고
    • New approaches to assessing and treating early-stage colon and rectal cancers: Cooperative Group strategies for assessing optimal approaches in early-stage disease
    • Benson AB, III. New approaches to assessing and treating early-stage colon and rectal cancers: Cooperative Group strategies for assessing optimal approaches in early-stage disease. Clin. Cancer Res. 13(22), 6913-6920 (2007).
    • (2007) Clin. Cancer Res , vol.13 , Issue.22 , pp. 6913-6920
    • Benson III, A.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.