Overexpression of the human aldehyde dehydrogenase class I results in increased resistance to 4-hydroperoxycyclophosphamide

Cancer Gene Therapy

Volumn 3, Issue 1, 1996, Pages 24-30

  Moreb, Jan ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

4 hydroperoxycyclophosphamide; Human aldehyde dehydrogenase class 1; Overexpression; Resistance

Indexed keywords

ALDEHYDE DEHYDROGENASE; ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; DRUG DERIVATIVE; MESSENGER RNA; PERFOSFAMIDE; PRIMER DNA;

ARTICLE; CELL CULTURE; CELL SURVIVAL; DRUG EFFECT; DRUG RESISTANCE; GENE EXPRESSION; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE;

ALDEHYDE DEHYDROGENASE; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CELL SURVIVAL; CYCLOPHOSPHAMIDE; DNA PRIMERS; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION; HUMANS; MOLECULAR SEQUENCE DATA; RNA, MESSENGER; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0029685930     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Dockham PA, Lee M-O, Sladek NE. Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde. Biochem Pharmacol. 1992;43:2453-2469.
2. Sladek NE, Landkamer GJ. Restoration of sensitivity to oxazaphosphorines by inhibitors of aldehyde dehydrogenase activity in cultured oxazaphosphorine-resistant P388 cell lines. Cancer Res. 1985;45:1549-1555.
3. Kohn FR, Sladek NE. Aldehyde dehydrogenase activity as the basis for the relative insensitivity of murine pluripotent hematopoietic stem cells to oxazaphosphorines. Biochem Pharmacol. 1985;34:3465-3471.
4. Russo JE, Hilton J. Characterization of cytosolic aldehyde dehydrogenase from cyclophosphamide-resistant L1210 cells. Cancer Res. 1988;48:1962-1968.