Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 31, 2006, Pages 11707-11712

  Chute, John P ^a   Muramoto, Garrett G ^a   Whitesides, John ^a   Colvin, Michael ^a   Safi, Rachid ^a   Chao, Nelson J ^a   McDonnell, Donald P ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Diethylaminobenzaldehyde; Long term repopulating cells; Retinoic acid; Self renewal

Indexed keywords

ALDEHYDE DEHYDROGENASE; BENZALDEHYDE DERIVATIVE; CALCITRIOL; CD34 ANTIGEN; CD38 ANTIGEN; DIETHYLAMINOBENZALDEHYDE; FLT3 LIGAND; HOX PROTEIN; NOTCH RECEPTOR; PROTEIN HOXB4; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID; RETINOID X RECEPTOR; RETINOL; RNA; STEM CELL FACTOR; THROMBOPOIETIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL RENEWAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SCID MOUSE;

ALDEHYDE DEHYDROGENASE; ANIMALS; ANTIGENS, CD; CELL DIFFERENTIATION; CELLS, CULTURED; HEMATOPOIETIC STEM CELLS; HOMEODOMAIN PROTEINS; HUMANS; ISOENZYMES; MICE; MICE, SCID; P-AMINOAZOBENZENE; RETINOIDS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 33746846201     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0603806103     Document Type: Article

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