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Volumn 11, Issue 22, 2005, Pages 2873-2887

Targeting transcription factors for cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTISENSE OLIGODEOXYNUCLEOTIDE; ANTISENSE OLIGONUCLEOTIDE; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PEPTIDE DERIVATIVE; PLASMID DNA; REGULATOR PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; STEROID; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 22944434871     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612054546699     Document Type: Review
Times cited : (86)

References (165)
  • 1
    • 0035971496 scopus 로고    scopus 로고
    • Distinct roles of Jun:Fos and Jun:ATF dimers in oncogenesis
    • van Dam H, Castellazzi M. Distinct roles of Jun:Fos and Jun:ATF dimers in oncogenesis. Oncogene 2001; 20: 243-64.
    • (2001) Oncogene , vol.20 , pp. 243-264
    • van Dam, H.1    Castellazzi, M.2
  • 2
    • 0036098552 scopus 로고    scopus 로고
    • AP-1 as a regulator of cell life and death
    • Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 2002; 4: E131-E6.
    • (2002) Nat. Cell Biol. , vol.4
    • Shaulian, E.1    Karin, M.2
  • 3
    • 0033551391 scopus 로고    scopus 로고
    • Reassessing the role of C-MYB in tumorigenesis
    • Weston K. Reassessing the role of C-MYB in tumorigenesis. Oncogene 1999; 18: 3034-8.
    • (1999) Oncogene , vol.18 , pp. 3034-3038
    • Weston, K.1
  • 5
    • 0037251326 scopus 로고    scopus 로고
    • Promising molecular targets for cancer prevention: AP-I, NF-kappa B and Pdcd4
    • Young MR, Yang HS, Colburn NH. Promising molecular targets for cancer prevention: AP-I, NF-kappa B and Pdcd4. Trends Mol Med 2003; 9: 36-41.
    • (2003) Trends Mol. Med. , vol.9 , pp. 36-41
    • Young, M.R.1    Yang, H.S.2    Colburn, N.H.3
  • 6
    • 0037541152 scopus 로고    scopus 로고
    • The MYC oncogene as a cancer drug target
    • Hermeking H. The MYC oncogene as a cancer drug target. Curr Cancer Drug Targets 2003; 3: 163-75.
    • (2003) Curr. Cancer Drug Targets , vol.3 , pp. 163-175
    • Hermeking, H.1
  • 7
    • 0038105419 scopus 로고    scopus 로고
    • The MYCN oncoprotein as a drug development target
    • Lu X, Pearson A, Lunec J. The MYCN oncoprotein as a drug development target. Cancer Lett 2003; 197: 125-30.
    • (2003) Cancer Lett. , vol.197 , pp. 125-130
    • Lu, X.1    Pearson, A.2    Lunec, J.3
  • 8
    • 0033551376 scopus 로고    scopus 로고
    • Myb targeted therapeutics for the treatment of human malignancies
    • Gewirtz AM. Myb targeted therapeutics for the treatment of human malignancies. Oncogene 1999; 18: 3056-62.
    • (1999) Oncogene , vol.18 , pp. 3056-3062
    • Gewirtz, A.M.1
  • 10
    • 0035749803 scopus 로고    scopus 로고
    • The promise of retinoids to fight against cancer
    • Altucci L, Gronemeyer H. The promise of retinoids to fight against cancer. Nat Rev Cancer 2001; 1: 181-93.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 181-193
    • Altucci, L.1    Gronemeyer, H.2
  • 11
    • 0036142502 scopus 로고    scopus 로고
    • Retinoids and their receptors in cancer development and chemoprevention
    • Sun SY, Lotan R. Retinoids and their receptors in cancer development and chemoprevention. Crit Rev Oncol Hematol 2002; 41: 41-55.
    • (2002) Crit. Rev. Oncol. Hematol. , vol.41 , pp. 41-55
    • Sun, S.Y.1    Lotan, R.2
  • 12
    • 0036279780 scopus 로고    scopus 로고
    • Receptor selective synthetic retinoids as potential cancer chemotherapy agents
    • Crowe DL. Receptor selective synthetic retinoids as potential cancer chemotherapy agents. Curr Cancer Drug Targets 2002; 2: 77-86.
    • (2002) Curr. Cancer Drug Targets , vol.2 , pp. 77-86
    • Crowe, D.L.1
  • 15
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z, Zhong Z, Darnell JE, Jr. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995; 82: 241-50.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell Jr., J.E.3
  • 16
    • 0028942656 scopus 로고
    • Requirement of serine phosphorylation for formation of STAT-promoter complexes
    • Zhang X, Blenis J, Li HC, Schindler C, Chen-Kiang S. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science 1995; 267: 1990-4.
    • (1995) Science , vol.267 , pp. 1990-1994
    • Zhang, X.1    Blenis, J.2    Li, H.C.3    Schindler, C.4    Chen-Kiang, S.5
  • 17
    • 0032934156 scopus 로고    scopus 로고
    • Functional roles of STAT family proteins: Lessons from knockout mice
    • Akira S. Functional roles of STAT family proteins: lessons from knockout mice. Stem Cells 1999; 17: 138-46.
    • (1999) Stem Cells , vol.17 , pp. 138-146
    • Akira, S.1
  • 18
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
    • Durbin JE, Hackenmiller R, Simon MC, Levy DE. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 1996; 84: 443-50.
    • (1996) Cell , vol.84 , pp. 443-450
    • Durbin, J.E.1    Hackenmiller, R.2    Simon, M.C.3    Levy, D.E.4
  • 19
    • 13344282731 scopus 로고    scopus 로고
    • Targeted disruption of Stat1 gene in mice reveals unexpected physiologic specificity in the JAK STAT signaling pathway
    • Meraz MA, White JM, Sheehan KCF, Bach EA, Rodig SJ, Dighe AS, et al. Targeted disruption of Stat1 gene in mice reveals unexpected physiologic specificity in the JAK STAT signaling pathway. Cell 1996; 84: 431-42.
    • (1996) Cell , vol.84 , pp. 431-442
    • Meraz, M.A.1    White, J.M.2    Sheehan, K.C.F.3    Bach, E.A.4    Rodig, S.J.5    Dighe, A.S.6
  • 20
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan MH, Sun Y-L, Hoey T, Grusby MJ. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 1996; 382: 174-7.
    • (1996) Nature , vol.382 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.-L.2    Hoey, T.3    Grusby, M.J.4
  • 22
    • 0033548259 scopus 로고    scopus 로고
    • Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
    • Livnah O, Stura EA, Middleton SA, Johnson DL, Jolliffe LK, Wilson IA. Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science 1999; 283: 987-90.
    • (1999) Science , vol.283 , pp. 987-990
    • Livnah, O.1    Stura, E.A.2    Middleton, S.A.3    Johnson, D.L.4    Jolliffe, L.K.5    Wilson, I.A.6
  • 23
    • 0033548048 scopus 로고    scopus 로고
    • Erythropoietin receptor activation by a ligand-induced conformational change
    • Remy I, Wilson IA, Michnick SW. Erythropoietin receptor activation by a ligand-induced conformational change. Science 1999; 283: 990-3.
    • (1999) Science , vol.283 , pp. 990-993
    • Remy, I.1    Wilson, I.A.2    Michnick, S.W.3
  • 24
    • 0029075875 scopus 로고
    • Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3
    • Schaefer TS, Sanders LK, Nathans D. Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3. Proc Natl Acad Sci USA 1995; 92: 9097-101.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9097-9101
    • Schaefer, T.S.1    Sanders, L.K.2    Nathans, D.3
  • 25
    • 0029796380 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor activation of Stat3α and Stat3β in immature normal and leukemic human myeloid cells
    • Chakraborty A, White SM, Schaefer TS, Ball ED, Dyer KF, Tweardy DJ. Granulocyte colony-stimulating factor activation of Stat3α and Stat3β in immature normal and leukemic human myeloid cells. Blood 1996; 88: 2442-9.
    • (1996) Blood , vol.88 , pp. 2442-2449
    • Chakraborty, A.1    White, S.M.2    Schaefer, T.S.3    Ball, E.D.4    Dyer, K.F.5    Tweardy, D.J.6
  • 27
    • 0035895101 scopus 로고    scopus 로고
    • Identification and characterization of cis elements in the STAT3 gene regulating STAT3α and STAT3β messenger RNA splicing
    • Shao H, Quintero AJ, Tweardy DJ. Identification and characterization of cis elements in the STAT3 gene regulating STAT3α and STAT3β messenger RNA splicing. Blood 2001; 98: 3853-6.
    • (2001) Blood , vol.98 , pp. 3853-3856
    • Shao, H.1    Quintero, A.J.2    Tweardy, D.J.3
  • 28
    • 0032895874 scopus 로고    scopus 로고
    • Expression of granulocyte colony-stimulating factor- and granulocyte-macrophage colony-stimulating factor-associated signal transduction proteins of the JAK/STAT pathway in normal granulopoiesis and in blast cells of acute myelogenous leukemia
    • Biethan S, Alves F, Wilde S, Hiddemann W, Spiekermann K. Expression of granulocyte colony-stimulating factor- and granulocyte-macrophage colony-stimulating factor-associated signal transduction proteins of the JAK/STAT pathway in normal granulopoiesis and in blast cells of acute myelogenous leukemia. Exp Hematol 1999; 27: 885-94.
    • (1999) Exp. Hematol. , vol.27 , pp. 885-894
    • Biethan, S.1    Alves, F.2    Wilde, S.3    Hiddemann, W.4    Spiekermann, K.5
  • 29
    • 0031728894 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils
    • Chakraborty A, Tweardy DJ. Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils. J Leukoc Biol 1998; 64: 675-80.
    • (1998) J. Leukoc. Biol. , vol.64 , pp. 675-680
    • Chakraborty, A.1    Tweardy, D.J.2
  • 31
    • 0030292721 scopus 로고    scopus 로고
    • Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: Involvement of STAT3 in anti-apoptosis
    • Fukada T, Hibi M, Yamanaka Y, Takahashi-Tezuka M, Fujitani Y, Yamaguchi T, et al. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity 1996; 5: 449-60.
    • (1996) Immunity , vol.5 , pp. 449-460
    • Fukada, T.1    Hibi, M.2    Yamanaka, Y.3    Takahashi-Tezuka, M.4    Fujitani, Y.5    Yamaguchi, T.6
  • 33
    • 0034193958 scopus 로고    scopus 로고
    • Stat3-dependent induction of p19INK4D by IL-10 contributes to inhibition of macrophage proliferation
    • O'Farrell AM, Parry DA, Zindy F, Roussel ME, Lees E, Moore KW, et al. Stat3-dependent induction of p19INK4D by IL-10 contributes to inhibition of macrophage proliferation. J Immunol 2000; 164: 4607-15.
    • (2000) J. Immunol. , vol.164 , pp. 4607-4615
    • O'Farrell, A.M.1    Parry, D.A.2    Zindy, F.3    Roussel, M.E.4    Lees, E.5    Moore, K.W.6
  • 35
    • 0032984589 scopus 로고    scopus 로고
    • Constitutive activation of STAT3 signaling confers resistance to apoptosis in human U266 myeloma cells
    • Catlett-Falcone R, Landowski TH, Oshiro MM, Turkson J, Levitzki A, Savino R, et al. Constitutive activation of STAT3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999; 10: 105-15.
    • (1999) Immunity , vol.10 , pp. 105-115
    • Catlett-Falcone, R.1    Landowski, T.H.2    Oshiro, M.M.3    Turkson, J.4    Levitzki, A.5    Savino, R.6
  • 36
    • 0035136846 scopus 로고    scopus 로고
    • Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
    • Epling-Burnette PK, Liu JH, Catlett-Falcone R, Turkson J, Oshiro M, Kothapalli R, et al. Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest 2001; 107: 351-62.
    • (2001) J. Clin. Invest. , vol.107 , pp. 351-362
    • Epling-Burnette, P.K.1    Liu, J.H.2    Catlett-Falcone, R.3    Turkson, J.4    Oshiro, M.5    Kothapalli, R.6
  • 37
    • 0033451992 scopus 로고    scopus 로고
    • Synergistic roles for Pim-I and c-Myc in STAT3-mediated cell cycle progression and anti-apoptosis
    • Shirogane T, Fukada T, Muller JM, Shima DT, Hibi M, Hirano T. Synergistic roles for Pim-I and c-Myc in STAT3-mediated cell cycle progression and anti-apoptosis. Immunity 1999; 11: 709-19.
    • (1999) Immunity , vol.11 , pp. 709-719
    • Shirogane, T.1    Fukada, T.2    Muller, J.M.3    Shima, D.T.4    Hibi, M.5    Hirano, T.6
  • 38
    • 0035865517 scopus 로고    scopus 로고
    • STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma
    • Brender C, Nielsen M, Mikkelsen G, Zhang Q, Wasik M, Billestrup N, et al. STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma. Blood 2001; 97: 1056-62.
    • (2001) Blood , vol.97 , pp. 1056-1062
    • Brender, C.1    Nielsen, M.2    Mikkelsen, G.3    Zhang, Q.4    Wasik, M.5    Billestrup, N.6
  • 39
    • 85047695527 scopus 로고    scopus 로고
    • Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
    • Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 2002; 21: 2000-8.
    • (2002) Oncogene , vol.21 , pp. 2000-2008
    • Niu, G.1    Wright, K.L.2    Huang, M.3    Song, L.4    Haura, E.5    Turkson, J.6
  • 40
    • 0029069540 scopus 로고
    • Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
    • Yu C-L, Meyer DJ, Campbell GS, Larner AC, Carter-Su C, Schwartz J, et al. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 1995; 269: 81-3.
    • (1995) Science , vol.269 , pp. 81-83
    • Yu, C.-L.1    Meyer, D.J.2    Campbell, G.S.3    Larner, A.C.4    Carter-Su, C.5    Schwartz, J.6
  • 41
    • 0031443156 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells
    • Garcia R, Yu C-L, Hudnall A, Catlett R, Nelson KL, Smithgall T, et al. Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ 1997; 8: 1267-76.
    • (1997) Cell Growth Differ. , vol.8 , pp. 1267-1276
    • Garcia, R.1    Yu, C.-L.2    Hudnall, A.3    Catlett, R.4    Nelson, K.L.5    Smithgall, T.6
  • 43
    • 0031953831 scopus 로고    scopus 로고
    • Stat3 activation by Src induces specific gene regulation and is required for cell transformation
    • Turkson J, Bowman T, Garcia R, Caldenhoven E, de Groot RP, Jove R. Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol Cell Biol 1998; 18: 2545-52.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 2545-2552
    • Turkson, J.1    Bowman, T.2    Garcia, R.3    Caldenhoven, E.4    de Groot, R.P.5    Jove, R.6
  • 45
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner R, Mora LB, Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 2002; 8: 945-54.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 46
    • 0034658153 scopus 로고    scopus 로고
    • STAT signaling in the pathogenesis and treatment of leukemias
    • Lin TS, Mahajan S, Frank DA. STAT signaling in the pathogenesis and treatment of leukemias. Oncogene 2000; 19: 2496-504.
    • (2000) Oncogene , vol.19 , pp. 2496-2504
    • Lin, T.S.1    Mahajan, S.2    Frank, D.A.3
  • 47
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: Novel molecular targets for cancer drug discovery
    • Turkson J, Jove R. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 2000; 19: 6613-26.
    • (2000) Oncogene , vol.19 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 48
    • 0034660463 scopus 로고    scopus 로고
    • Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6
    • Schuringa J-j, Wierenga ATJ, Kruijer W, Vellenga E. Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6. Blood 2000; 95: 3765-70.
    • (2000) Blood , vol.95 , pp. 3765-3770
    • Schuringa, J.-J.1    Wierenga, A.T.J.2    Kruijer, W.3    Vellenga, E.4
  • 49
    • 0027183870 scopus 로고
    • Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer
    • Grandis JR, Tweardy DJ. Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res 1993; 53: 3579-84.
    • (1993) Cancer Res. , vol.53 , pp. 3579-3584
    • Grandis, J.R.1    Tweardy, D.J.2
  • 50
    • 0029831041 scopus 로고    scopus 로고
    • Quantitative immunohistochemical analysis of transforming growth factor-alpha and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck
    • Grandis JR, Melhem MF, Barnes EL, Tweardy DJ. Quantitative immunohistochemical analysis of transforming growth factor-alpha and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck. Cancer 1996; 78: 1284-92.
    • (1996) Cancer , vol.78 , pp. 1284-1292
    • Grandis, J.R.1    Melhem, M.F.2    Barnes, E.L.3    Tweardy, D.J.4
  • 51
    • 0030757686 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells
    • Grandis JR, Chakraborty A, Melhem MF, Zeng Q, Tweardy DJ. Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. Oncogene 1997; 15: 409-16.
    • (1997) Oncogene , vol.15 , pp. 409-416
    • Grandis, J.R.1    Chakraborty, A.2    Melhem, M.F.3    Zeng, Q.4    Tweardy, D.J.5
  • 52
    • 0032053944 scopus 로고    scopus 로고
    • Downmodulation of TGF-alpha protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells
    • Grandis JR, Chakraborty A, Zeng Q, Melhem ME, Tweardy DJ. Downmodulation of TGF-alpha protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. J Cell Biochem 1998; 69: 55-62.
    • (1998) J. Cell Biochem. , vol.69 , pp. 55-62
    • Grandis, J.R.1    Chakraborty, A.2    Zeng, Q.3    Melhem, M.E.4    Tweardy, D.J.5
  • 53
    • 0034021563 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-mediated Stat3 signaling blocks apoptosis in head and neck cancer
    • Grandis JR, Zeng Q, Drenning SD. Epidermal growth factor receptor-mediated Stat3 signaling blocks apoptosis in head and neck cancer. Laryngoscope 2000; 110: 868-74.
    • (2000) Laryngoscope , vol.110 , pp. 868-874
    • Grandis, J.R.1    Zeng, Q.2    Drenning, S.D.3
  • 54
    • 0037124102 scopus 로고    scopus 로고
    • Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines
    • Li L, Shaw PE. Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines. J Biol Chem 2002; 277: 17397-405.
    • (2002) J. Biol. Chem. , vol.277 , pp. 17397-17405
    • Li, L.1    Shaw, P.E.2
  • 55
    • 0035042611 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
    • Yoshikawa H, Matsubara K, Qian G-S, Jackson P, Groopman JD, Manning JE, et al. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet 2001; 28: 29-35.
    • (2001) Nat. Genet. , vol.28 , pp. 29-35
    • Yoshikawa, H.1    Matsubara, K.2    Qian, G.-S.3    Jackson, P.4    Groopman, J.D.5    Manning, J.E.6
  • 56
    • 0037112367 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 in human prostate tumors and cell lines: Direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells
    • Mora LB, Buettner R, Seigne J, Diaz J, Ahmad N, Garcia R, et al. Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Res 2002; 62: 6659-66.
    • (2002) Cancer Res. , vol.62 , pp. 6659-6666
    • Mora, L.B.1    Buettner, R.2    Seigne, J.3    Diaz, J.4    Ahmad, N.5    Garcia, R.6
  • 57
    • 0036093058 scopus 로고    scopus 로고
    • Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival
    • Benekli M, Xia Z, Donohue KA, Ford LA, Pixley LA, Baer MR, et al. Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival. Blood 2002; 99: 252-7.
    • (2002) Blood , vol.99 , pp. 252-257
    • Benekli, M.1    Xia, Z.2    Donohue, K.A.3    Ford, L.A.4    Pixley, L.A.5    Baer, M.R.6
  • 58
    • 0032499801 scopus 로고    scopus 로고
    • Three-dimensional structure of the Stat3beta homodimer bound to DNA
    • Becker S, Groner B, Muller CW. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 1998; 94: 145-51.
    • (1998) Nature , vol.94 , pp. 145-151
    • Becker, S.1    Groner, B.2    Muller, C.W.3
  • 60
    • 0035977055 scopus 로고    scopus 로고
    • Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation
    • Turkson J, Ryan D, Kim JS, Zhang Y, Chen Z, Haura E, et al. Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J Biol Chem 2001; 276: 45443-55.
    • (2001) J. Biol. Chem. , vol.276 , pp. 45443-45455
    • Turkson, J.1    Ryan, D.2    Kim, J.S.3    Zhang, Y.4    Chen, Z.5    Haura, E.6
  • 62
    • 0043175471 scopus 로고    scopus 로고
    • Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor
    • Shao H, Cheng HY, Cook RG, Tweardy DJ. Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. Cancer Res 2003; 63: 3923-30.
    • (2003) Cancer Res. , vol.63 , pp. 3923-3930
    • Shao, H.1    Cheng, H.Y.2    Cook, R.G.3    Tweardy, D.J.4
  • 63
    • 0037507282 scopus 로고    scopus 로고
    • Characterization of phosphopeptide motifs specific for the Src homology 2 domains of signal transducer and activator of transcription 1 (STAT1) and STAT3
    • Wiederkehr-Adam M, Ernst P, Muller K, Bieck E, Gombert FO, Ottl J, et al. Characterization of phosphopeptide motifs specific for the Src homology 2 domains of signal transducer and activator of transcription 1 (STAT1) and STAT3. J Biol Chem 2003; 278: 16117-28.
    • (2003) J. Biol. Chem. , vol.278 , pp. 16117-16128
    • Wiederkehr-Adam, M.1    Ernst, P.2    Muller, K.3    Bieck, E.4    Gombert, F.O.5    Ottl, J.6
  • 64
    • 2442618276 scopus 로고    scopus 로고
    • Structural requirements for signal transduction and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif
    • In Press
    • Shao H, Xu X, Mastrangelo MA, Jing N, Cook RG, Legge GD, et al. Structural requirements for signal transduction and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif. J Biol Chem 2004; In Press.
    • (2004) J. Biol. Chem.
    • Shao, H.1    Xu, X.2    Mastrangelo, M.A.3    Jing, N.4    Cook, R.G.5    Legge, G.D.6
  • 65
    • 0037163125 scopus 로고    scopus 로고
    • Identification of both positive and negative domains within EGF receptor COOH-terminal region for STAT activation
    • Xia L, Wang L, Chung AS, Ivanov SS, Ling MY, Dragoi AM, et al. Identification of both positive and negative domains within EGF receptor COOH-terminal region for STAT activation. J Biol Chem 2002; 277: 30716-23.
    • (2002) J. Biol. Chem. , vol.277 , pp. 30716-30723
    • Xia, L.1    Wang, L.2    Chung, A.S.3    Ivanov, S.S.4    Ling, M.Y.5    Dragoi, A.M.6
  • 66
    • 0344984245 scopus 로고    scopus 로고
    • Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells
    • Jing N, Li Y, Xu X, Sha W, Li P, Feng L et al. Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA Cell Biol 2003; 22: 685-696.
    • (2003) DNA Cell Biol. , vol.22 , pp. 685-696
    • Jing, N.1    Li, Y.2    Xu, X.3    Sha, W.4    Li, P.5    Feng, L.6
  • 67
    • 4644325545 scopus 로고    scopus 로고
    • G-quartet oligonucleotides: A new class of Stat3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis
    • Jing N, Li Y, Xiong W, Jing L, Tweardy DJ. G-quartet oligonucleotides: a new class of Stat3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer Res 2004; 64: 6603-6609.
    • (2004) Cancer Res. , vol.64 , pp. 6603-6609
    • Jing, N.1    Li, Y.2    Xiong, W.3    Jing, L.4    Tweardy, D.J.5
  • 70
    • 0033106168 scopus 로고    scopus 로고
    • Transcriptional regulation of the cyclin D1 promoter by STAT5: Its involvement in cytokine-dependent growth of hematopoietic cells
    • Matsumura I, Kitamura T, Wakao H, Tanaka H, Hashimoto K, Albanese C, et al. Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells. EMBO J 1999; 118: 1367-77.
    • (1999) EMBO J. , vol.118 , pp. 1367-1377
    • Matsumura, I.1    Kitamura, T.2    Wakao, H.3    Tanaka, H.4    Hashimoto, K.5    Albanese, C.6
  • 71
    • 0033199236 scopus 로고    scopus 로고
    • STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells
    • Nosaka T, Kawashima T, Misawa K, Ikuta K, Mui AL-F, Kitamura T. STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO J 1999; 18: 4754-65.
    • (1999) EMBO J. , vol.18 , pp. 4754-4765
    • Nosaka, T.1    Kawashima, T.2    Misawa, K.3    Ikuta, K.4    Mui, A.L.-F.5    Kitamura, T.6
  • 73
    • 0037960023 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells
    • Friedrichsen BN, Richter HE, Hansen JA, Rhodes CJ, Nielsen JH, Billestrup N, et al. Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells. Mol Endocrinol 2003; 17: 945-58.
    • (2003) Mol. Endocrinol. , vol.17 , pp. 945-958
    • Friedrichsen, B.N.1    Richter, H.E.2    Hansen, J.A.3    Rhodes, C.J.4    Nielsen, J.H.5    Billestrup, N.6
  • 74
    • 0030793345 scopus 로고    scopus 로고
    • Functionally distinct isoforms of STAT5 are generated by protein processing
    • Azam M, Lee C. Strehlow I, Schindler C. Functionally distinct isoforms of STAT5 are generated by protein processing. Immunity 1997; 6: 691-701.
    • (1997) Immunity , vol.6 , pp. 691-701
    • Azam, M.1    Lee, C.2    Strehlow, I.3    Schindler, C.4
  • 76
    • 0029197427 scopus 로고
    • Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements
    • Ripperger JA, Fritz S, Richter K, Hocke GM, Lottspeich F, Fey GH. Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements. J Biol Chem 1995; 270: 29998-30006.
    • (1995) J. Biol. Chem. , vol.270 , pp. 29998-30006
    • Ripperger, J.A.1    Fritz, S.2    Richter, K.3    Hocke, G.M.4    Lottspeich, F.5    Fey, G.H.6
  • 78
    • 0031573141 scopus 로고    scopus 로고
    • Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients
    • Chai SK, Nichols GL, Rothman P. Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients. J Immunol 1997; 159: 4720-8.
    • (1997) J. Immunol. , vol.159 , pp. 4720-7428
    • Chai, S.K.1    Nichols, G.L.2    Rothman, P.3
  • 79
    • 0029810923 scopus 로고    scopus 로고
    • Constitutive activation of Stat5 by the BCR-ABL oncogene in chronic myelogenous leukemia
    • Shuai K, Hallpern J, ten Hoeve J, Rao X, Sawyers CL. Constitutive activation of Stat5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene 1996; 13: 247-54.
    • (1996) Oncogene , vol.13 , pp. 247-254
    • Shuai, K.1    Hallpern, J.2    ten Hoeve, J.3    Rao, X.4    Sawyers, C.L.5
  • 80
    • 0036190076 scopus 로고    scopus 로고
    • Constitutive activation of STAT3 and STAT5 is induced by leukemic fusion proteins with protein tyrosine kinase activity and is sufficient for transformation of hematopoietic precursor cells
    • Spiekermann K, Pau M, Schwab R, Schmieja K, Franzrahe S, Hiddemann W. Constitutive activation of STAT3 and STAT5 is induced by leukemic fusion proteins with protein tyrosine kinase activity and is sufficient for transformation of hematopoietic precursor cells. Exp Hematol 2002; 30: 262-71.
    • (2002) Exp. Hematol. , vol.30 , pp. 262-271
    • Spiekermann, K.1    Pau, M.2    Schwab, R.3    Schmieja, K.4    Franzrahe, S.5    Hiddemann, W.6
  • 81
    • 0030451722 scopus 로고    scopus 로고
    • Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
    • Nakao M, Yokota S, Iwai T, Kaneko H, Horiike S, Kashima K, et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia Leukemia 1996; 10: 1911-8.
    • (1996) Leukemia , vol.10 , pp. 1911-1918
    • Nakao, M.1    Yokota, S.2    Iwai, T.3    Kaneko, H.4    Horiike, S.5    Kashima, K.6
  • 82
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa F, Towatari M, Kiyoi H, Tanimoto M, Kitamura T, Saito H, et al. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene 2000; 19: 624-31.
    • (2000) Oncogene , vol.19 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3    Tanimoto, M.4    Kitamura, T.5    Saito, H.6
  • 83
    • 0035203382 scopus 로고    scopus 로고
    • Regulation of constitutive Stat5 phosphorylation in acute myeloid leukemia blasts
    • Birkenkamp KU, Geugien M, Lemmink HH, Kruijer W, Vellenga E. Regulation of constitutive Stat5 phosphorylation in acute myeloid leukemia blasts. Leukemia 2001; 15: 1923-31.
    • (2001) Leukemia , vol.15 , pp. 1923-1931
    • Birkenkamp, K.U.1    Geugien, M.2    Lemmink, H.H.3    Kruijer, W.4    Vellenga, E.5
  • 84
    • 0034554796 scopus 로고    scopus 로고
    • Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
    • Mizuki M, Fenski R, Halfter H, Matsumura I, Schmidt R, Muller C, et al. Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood 2000; 96: 3907-14.
    • (2000) Blood , vol.96 , pp. 3907-3914
    • Mizuki, M.1    Fenski, R.2    Halfter, H.3    Matsumura, I.4    Schmidt, R.5    Muller, C.6
  • 85
    • 0031836964 scopus 로고    scopus 로고
    • Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation
    • Onishi M, Nosaka T, Misawa K, Mui AL-F, Gorman D, McMahon M, et al. Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation. Mol Cell Biol 1998; 18: 3871-9.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 3871-3879
    • Onishi, M.1    Nosaka, T.2    Misawa, K.3    Mui, A.L.-F.4    Gorman, D.5    McMahon, M.6
  • 86
    • 0033639119 scopus 로고    scopus 로고
    • Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2
    • Schwaller J, Parganas E, Wang D, Cain D, Aster JC, Williams IR, et al. Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2. Mol Cell 2000; 6: 693-704.
    • (2000) Mol. Cell , vol.6 , pp. 693-704
    • Schwaller, J.1    Parganas, E.2    Wang, D.3    Cain, D.4    Aster, J.C.5    Williams, I.R.6
  • 87
    • 0142219889 scopus 로고    scopus 로고
    • Constitutive activation of Stat5b contributes to carcinogenesis in vivo
    • Xi S, Zhang Q, Gooding WE, Smithgall TE, Grandis JR. Constitutive activation of Stat5b contributes to carcinogenesis in vivo. Cancer Res 2003; 63: 6763-71.
    • (2003) Cancer Res. , vol.63 , pp. 6763-6771
    • Xi, S.1    Zhang, Q.2    Gooding, W.E.3    Smithgall, T.E.4    Grandis, J.R.5
  • 88
    • 0034653929 scopus 로고    scopus 로고
    • STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells
    • Sillaber C, Gesbert F, Frank DA, Sattler M, Griffin JD. STAT5 activation contributes to growth and viability in Bcr/Abl-transformed. cells. Blood 2000; 95: 2118-25.
    • (2000) Blood , vol.95 , pp. 2118-2125
    • Sillaber, C.1    Gesbert, F.2    Frank, D.A.3    Sattler, M.4    Griffin, J.D.5
  • 89
    • 0022644806 scopus 로고
    • A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes
    • Singh H, Sen R, Baltimore D, Sharp PA. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature 1986; 319: 154-8.
    • (1986) Nature , vol.319 , pp. 154-158
    • Singh, H.1    Sen, R.2    Baltimore, D.3    Sharp, P.A.4
  • 91
    • 0037496130 scopus 로고    scopus 로고
    • Transducing signals from antigen receptors to nuclear factor κB
    • Ruland J, Mak TW. Transducing signals from antigen receptors to nuclear factor κB. Immunol Rev 2003; 193: 93-100.
    • (2003) Immunol. Rev. , vol.193 , pp. 93-100
    • Ruland, J.1    Mak, T.W.2
  • 92
    • 0029059060 scopus 로고
    • Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappaB
    • Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappaB. Nature 1995; 376: 167-70.
    • (1995) Nature , vol.376 , pp. 167-170
    • Beg, A.A.1    Sha, W.C.2    Bronson, R.T.3    Ghosh, S.4    Baltimore, D.5
  • 93
    • 0033596124 scopus 로고    scopus 로고
    • Aberrant rel/rfkb genes and activity in human cancer
    • Rayet B, Gelinas C. Aberrant rel/rfkb genes and activity in human cancer. Oncogene 1999; 18.
    • (1999) Oncogene , pp. 18
    • Rayet, B.1    Gelinas, C.2
  • 94
    • 0034092559 scopus 로고    scopus 로고
    • Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells
    • Kordes U, Krappmann D, Heissmeyer V, Ludwig WD, Scheidereit C. Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells. Leukemia 2000; 14: 399-402.
    • (2000) Leukemia , vol.14 , pp. 399-402
    • Kordes, U.1    Krappmann, D.2    Heissmeyer, V.3    Ludwig, W.D.4    Scheidereit, C.5
  • 95
    • 0028986985 scopus 로고
    • The spontaneous expression of interleukin-1 beta and interleukin-6 is associated with spontaneous expression of AP-1 and NF-kappaB transcription factor in acute myeloblastic leukemia cells
    • Dokter WH, Tuyt L, Sierdsema SJ, Esseling MT, Vellenga E. The spontaneous expression of interleukin-1 beta and interleukin-6 is associated with spontaneous expression of AP-1 and NF-kappaB transcription factor in acute myeloblastic leukemia cells. Leukemia 1995; 9: 425-32.
    • (1995) Leukemia , vol.9 , pp. 425-432
    • Dokter, W.H.1    Tuyt, L.2    Sierdsema, S.J.3    Esseling, M.T.4    Vellenga, E.5
  • 96
    • 0035886024 scopus 로고    scopus 로고
    • Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells
    • Guzman ML, Neering SJ, Upchurch D, Grimes B, Howard DS, Rizzieri DA, et al. Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood 2001; 98: 2301-7.
    • (2001) Blood , vol.98 , pp. 2301-2307
    • Guzman, M.L.1    Neering, S.J.2    Upchurch, D.3    Grimes, B.4    Howard, D.S.5    Rizzieri, D.A.6
  • 97
    • 0030006437 scopus 로고    scopus 로고
    • High-level nuclear NF-κB and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells
    • Bargou RC, Leng C, Krappmann D, Emmerich F, Mapara MY, Bommert K, et al. High-level nuclear NF-κB and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells. Blood 1996; 87: 4340-7.
    • (1996) Blood , vol.87 , pp. 4340-4347
    • Bargou, R.C.1    Leng, C.2    Krappmann, D.3    Emmerich, F.4    Mapara, M.Y.5    Bommert, K.6
  • 98
    • 0033611588 scopus 로고    scopus 로고
    • Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells
    • Krappmann D, Emmerich F, Kordes U, Scharschmidt E, Dorken B, Scheideref C. Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells. Oncogene 1999; 18: 943-53.
    • (1999) Oncogene , vol.18 , pp. 943-953
    • Krappmann, D.1    Emmerich, F.2    Kordes, U.3    Scharschmidt, E.4    Dorken, B.5    Scheideref, C.6
  • 99
    • 0033587084 scopus 로고    scopus 로고
    • Mutations in the IκBα gene in Hodgkin's disease suggest a tumor suppressor role for IkappaBalpha
    • Cabannes E, Khan G, Aillet F, Jarrett RF, Hay RT. Mutations in the IκBα gene in Hodgkin's disease suggest a tumor suppressor role for IkappaBalpha. Oncogene 1999; 18: 3063-70.
    • (1999) Oncogene , vol.18 , pp. 3063-3070
    • Cabannes, E.1    Khan, G.2    Aillet, F.3    Jarrett, R.F.4    Hay, R.T.5
  • 100
    • 0032559888 scopus 로고    scopus 로고
    • Defective IkappaBalpha in Hodgkin cell lines with constitutively active NF-kappaB
    • Wood KM, Roff M, Hay RT. Defective IkappaBalpha in Hodgkin cell lines with constitutively active NF-kappaB. Oncogene 1998; 16: 2131-9.
    • (1998) Oncogene , vol.16 , pp. 2131-2139
    • Wood, K.M.1    Roff, M.2    Hay, R.T.3
  • 102
    • 0032943591 scopus 로고    scopus 로고
    • The nuclcar factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
    • Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary KR, Chiao PJ. The nuclcar factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 1999; 5: 119-27.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 119-127
    • Wang, W.1    Abbruzzese, J.L.2    Evans, D.B.3    Larry, L.4    Cleary, K.R.5    Chiao, P.J.6
  • 103
    • 0035963273 scopus 로고    scopus 로고
    • Constitutive activation of nuclear factor-κB prevents TRAIL-induced apoptosis in reveal cancer cells
    • Oya M, Ohtsubo M, Takayanagi A, Tachibana ME, Shimuzi N, Murai M. Constitutive activation of nuclear factor-κB prevents TRAIL-induced apoptosis in reveal cancer cells. Oncogene 2001; 20: 3888-96.
    • (2001) Oncogene , vol.20 , pp. 3888-3896
    • Oya, M.1    Ohtsubo, M.2    Takayanagi, A.3    Tachibana, M.E.4    Shimuzi, N.5    Murai, M.6
  • 105
    • 0030747827 scopus 로고    scopus 로고
    • Enhanced degradation of I-KappaB alpha contributes to endogenous activation of NF-kappaB in Hs294T melanoma cells
    • Shattuck-Brandt RL, Richmond A. Enhanced degradation of I-KappaB alpha contributes to endogenous activation of NF-kappaB in Hs294T melanoma cells. Cancer Res 1997; 57: 3032-9.
    • (1997) Cancer Res. , vol.57 , pp. 3032-3039
    • Shattuck-Brandt, R.L.1    Richmond, A.2
  • 106
    • 0028172914 scopus 로고
    • Disruption of I kappa B alpha regulation by antisense RNA expression leads to malignant transformation
    • Beauparlant P, Kwan I, Bitar R, Chou P, Koromilas AE, Sonenberg N, et al. Disruption of I kappa B alpha regulation by antisense RNA expression leads to malignant transformation. Oncogene 1994; 9: 3189-97.
    • (1994) Oncogene , vol.9 , pp. 3189-3197
    • Beauparlant, P.1    Kwan, I.2    Bitar, R.3    Chou, P.4    Koromilas, A.E.5    Sonenberg, N.6
  • 107
    • 0033596126 scopus 로고    scopus 로고
    • Diverse agents act at multiple levels to inhibit the Rel/NF-κB signal transduction pathway
    • Epinat J-C, Gilmore TD. Diverse agents act at multiple levels to inhibit the Rel/NF-κB signal transduction pathway. Oncogene 1999; 18: 6896-909.
    • (1999) Oncogene , vol.18 , pp. 6896-6909
    • Epinat, J.-C.1    Gilmore, T.D.2
  • 109
    • 6544264325 scopus 로고    scopus 로고
    • Intratumoral injection of oligonucleotides to the NFκB binding site inhibits cachexia in a mouse tumor model
    • Kawamura I, Morishita R, Tomita N, Lacey E, Aketa M, Tsujimoto S, et al. Intratumoral injection of oligonucleotides to the NFκB binding site inhibits cachexia in a mouse tumor model. Gene Ther 1999; 6: 91-7.
    • (1999) Gene Ther. , vol.6 , pp. 91-97
    • Kawamura, I.1    Morishita, R.2    Tomita, N.3    Lacey, E.4    Aketa, M.5    Tsujimoto, S.6
  • 110
    • 0034949959 scopus 로고    scopus 로고
    • Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice
    • Kawamura I, Morishita R, Tsujimoto S, Manda T, Tomoi M, Tomita N, et al. Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice. Gene Ther 2001; 8: 905-12.
    • (2001) Gene Ther. , vol.8 , pp. 905-912
    • Kawamura, I.1    Morishita, R.2    Tsujimoto, S.3    Manda, T.4    Tomoi, M.5    Tomita, N.6
  • 111
    • 0030873289 scopus 로고    scopus 로고
    • Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF-κB site
    • Galien R, Garcia T. Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF-κB site. Nucleic Acids Res 1997; 25: 2424-9.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 2424-2429
    • Galien, R.1    Garcia, T.2
  • 112
    • 0029147741 scopus 로고
    • Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappaB and C/EBP beta
    • Stein B, Yang MN. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappaB and C/EBP beta. Mol Cell Biol 1995; 15: 4971-9.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 4971-4979
    • Stein, B.1    Yang, M.N.2
  • 113
    • 0031916865 scopus 로고    scopus 로고
    • Cross-talk between nuclear factor-κB and the steroid hormone receptors: Mechanisms of mutual antagonism
    • McKay LI, Cidlowski JA. Cross-talk between nuclear factor-κB and the steroid hormone receptors: mechanisms of mutual antagonism. Mol Endocrinol 1998; 12: 45-56.
    • (1998) Mol. Endocrinol. , vol.12 , pp. 45-56
    • McKay, L.I.1    Cidlowski, J.A.2
  • 114
    • 0028107237 scopus 로고
    • Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor
    • Ray A, Prefontaine K. Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc Natl Acad Sci USA 1994; 91: 752-6.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 752-756
    • Ray, A.1    Prefontaine, K.2
  • 115
    • 0029006149 scopus 로고
    • Inhibition of nuclear translocaiion of transcription factor NF-kappaB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
    • Lin YZ, Yao SY, Veach RA, Torgerson TR, Hawiger J. Inhibition of nuclear translocaiion of transcription factor NF-kappaB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J Biol Chem 1995; 270: 14255-8.
    • (1995) J. Biol. Chem. , vol.270 , pp. 14255-14258
    • Lin, Y.Z.1    Yao, S.Y.2    Veach, R.A.3    Torgerson, T.R.4    Hawiger, J.5
  • 116
    • 0036624741 scopus 로고    scopus 로고
    • Biologic sequelae of nuclear factor-κB blockade an multiple myeloma: Therapeutic applications
    • Mitsiades N, Mitsiades CS, Poulaki V, Chauhan D, Richardson PG, Hideshima T, et al. Biologic sequelae of nuclear factor-κB blockade an multiple myeloma: therapeutic applications. Blood 2002; 99: 4079-86.
    • (2002) Blood , vol.99 , pp. 4079-4086
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3    Chauhan, D.4    Richardson, P.G.5    Hideshima, T.6
  • 117
    • 18844465632 scopus 로고    scopus 로고
    • Constitutive nuclear factor-κB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells
    • Bargou RC, Emmerich F, Krappmann D, Bommert K, Mapara MY, Arnold W, et al. Constitutive nuclear factor-κB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J Clin Invest 1997; 100: 2961-9.
    • (1997) J. Clin. Invest. , vol.100 , pp. 2961-2969
    • Bargou, R.C.1    Emmerich, F.2    Krappmann, D.3    Bommert, K.4    Mapara, M.Y.5    Arnold, W.6
  • 118
    • 0032905030 scopus 로고    scopus 로고
    • Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB
    • Wang C-Y, Cusack JC, Jr., Liu R, Baldwin AS, Jr. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB. Nat Med 1999; 5: 412-7.
    • (1999) Nat. Med. , vol.5 , pp. 412-417
    • Wang, C.-Y.1    Cusack Jr., J.C.2    Liu, R.3    Baldwin Jr., A.S.4
  • 119
    • 0035300479 scopus 로고    scopus 로고
    • The proteosome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
    • Hideshima T, Richardson P, Chauhan D, Palombella VJ, Elliott PJ, Adams J, et al. The proteosome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 2001; 61: 3071-6.
    • (2001) Cancer Res. , vol.61 , pp. 3071-3076
    • Hideshima, T.1    Richardson, P.2    Chauhan, D.3    Palombella, V.J.4    Elliott, P.J.5    Adams, J.6
  • 121
    • 0035933772 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB activity by thalidomide through suppression of IkappaB kinase activity
    • Keifer JA, Guttridge DC, Ashburner BP, Baldwin AS, Jr. Inhibition of NF-kappaB activity by thalidomide through suppression of IkappaB kinase activity. J Biol Chem 2001; 276: 22382-7.
    • (2001) J. Biol. Chem. , vol.276 , pp. 22382-22387
    • Keifer, J.A.1    Guttridge, D.C.2    Ashburner, B.P.3    Baldwin Jr., A.S.4
  • 122
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-κB system: A treasure trove for drug development
    • Karin M, Yamamoto Y, Wang QM. The IKK NF-κB system: A treasure trove for drug development. Nat Rev Drug Disc 2004; 3: 17-26.
    • (2004) Nat. Rev. Drug Disc. , vol.3 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 123
    • 0033776536 scopus 로고    scopus 로고
    • Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
    • Ohh M, Park CW, Ivan V, Hoffman MA, Kim TY, Huang LE, et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2000; 2: 423-7.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 423-427
    • Ohh, M.1    Park, C.W.2    Ivan, V.3    Hoffman, M.A.4    Kim, T.Y.5    Huang, L.E.6
  • 124
    • 0027210562 scopus 로고
    • General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
    • Wang GL, Semenza GL. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA 1993; 90: 4304-8.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4304-4308
    • Wang, G.L.1    Semenza, G.L.2
  • 125
    • 0036710591 scopus 로고    scopus 로고
    • Signal transduction to hypoxia-indueible factor 1
    • Semenza GL. Signal transduction to hypoxia-indueible factor 1. Biochem Pharmacol 2002; 64: 993-8.
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 993-998
    • Semenza, G.L.1
  • 126
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1α expression by the epidermis growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu M-M, et al. Modulation of hypoxia-inducible factor 1α expression by the epidermis growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000; 60: 1541-5.
    • (2000) Cancer Res. , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.-M.6
  • 127
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-indueible factor 1α (HIF-1α) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. HER2 (neu) signaling increases the rate of hypoxia-indueible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 2001; 21: 2995-4004.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 2995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 128
    • 0034282553 scopus 로고    scopus 로고
    • The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1α
    • Sodhi A, Mortaner S, Patel V, Zohar M, Bais C, Mesri EA, et al. The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1α. Cancer Res 2000; 60: 4873-80.
    • (2000) Cancer Res. , vol.60 , pp. 4873-4880
    • Sodhi, A.1    Mortaner, S.2    Patel, V.3    Zohar, M.4    Bais, C.5    Mesri, E.A.6
  • 129
    • 0032725554 scopus 로고    scopus 로고
    • p42/p44 Mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
    • Richard DE, Berra E, Gothie E, Roux D, Pouyssegur J. p42/p44 Mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J Biol Chem 1999; 274: 32631-7.
    • (1999) J. Biol. Chem. , vol.274 , pp. 32631-32637
    • Richard, D.E.1    Berra, E.2    Gothie, E.3    Roux, D.4    Pouyssegur, J.5
  • 130
    • 0037064010 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphotidylinositoi 3-kinase signaling in colon cancer cells
    • Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphotidylinositoi 3-kinase signaling in colon cancer cells. J Biol Chem 2002; 277: 38205-11.
    • (2002) J. Biol. Chem. , vol.277 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3    Jung, Y.D.4    Ellis, L.M.5    Semenza, G.L.6
  • 131
    • 0034282388 scopus 로고    scopus 로고
    • Nonhypoxic pathway mediates the induction of hypoxia-inducible factor Iα in vascular smooth muscle cells
    • Richard DE, Berra E, Pouyssegur J. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor Iα in vascular smooth muscle cells. J Biol Chem 2000; 275: 26765-71.
    • (2000) J. Biol. Chem. , vol.275 , pp. 26765-26771
    • Richard, D.E.1    Berra, E.2    Pouyssegur, J.3
  • 132
    • 0030659531 scopus 로고    scopus 로고
    • V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
    • Jiang B-H, Agani F, Passaniti A, Semenza GL. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res 1997; 57: 5328-35.
    • (1997) Cancer Res. , vol.57 , pp. 5328-5335
    • Jiang, B.-H.1    Agani, F.2    Passaniti, A.3    Semenza, G.L.4
  • 133
    • 0029681850 scopus 로고    scopus 로고
    • Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression
    • Mazure NM, Chen EY, Yeh P, Ladercute KR, Giaccia AJ. Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Res 1996; 56: 3436-40.
    • (1996) Cancer Res. , vol.56 , pp. 3436-3440
    • Mazure, N.M.1    Chen, E.Y.2    Yeh, P.3    Ladercute, K.R.4    Giaccia, A.J.5
  • 134
    • 0037131271 scopus 로고    scopus 로고
    • Role of prolyl hydroxylation in oncogenically stabilized hypoxia inducible factor-1α
    • Chan DA, Sutphin PD, Denko NC, Giaccia AJ. Role of prolyl hydroxylation in oncogenically stabilized hypoxia inducible factor-1α. J Biol Chem 2002; 277: 40112-7.
    • (2002) J. Biol. Chem. , vol.277 , pp. 40112-40117
    • Chan, D.A.1    Sutphin, P.D.2    Denko, N.C.3    Giaccia, A.J.4
  • 135
    • 0034925041 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1
    • Jiang B-H, Jiang G, Zheng JZ, Lu Z, Hunter T, Vogt PK. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ 2001; 12: 363-9.
    • (2001) Cell Growth Differ. , vol.12 , pp. 363-369
    • Jiang, B.-H.1    Jiang, G.2    Zheng, J.Z.3    Lu, Z.4    Hunter, T.5    Vogt, P.K.6
  • 136
    • 0033954247 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
    • Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q, et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α. Genes Dev 2000; 14: 34-44.
    • (2000) Genes Dev. , vol.14 , pp. 34-44
    • Ravi, R.1    Mookerjee, B.2    Bhujwalla, Z.M.3    Sutter, C.H.4    Artemov, D.5    Zeng, Q.6
  • 137
    • 0037189542 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
    • Lu H, Forbes RA, Verma A. Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 2002; 277: 23111-5.
    • (2002) J. Biol. Chem. , vol.277 , pp. 23111-23115
    • Lu, H.1    Forbes, R.A.2    Verma, A.3
  • 138
    • 0033566693 scopus 로고    scopus 로고
    • Reciprocal positive regulation of hypoxia-inducible factor 1α and insulin-like growth factor 2
    • Feldser D, Agani F, Iyer NV, Pak B, Perreira G, Semenza GL. Reciprocal positive regulation of hypoxia-inducible factor 1α and insulin-like growth factor 2. Cancer Res 1999; 59: 3915-8.
    • (1999) Cancer Res. , vol.59 , pp. 3915-3918
    • Feldser, D.1    Agani, F.2    Iyer, N.V.3    Pak, B.4    Perreira, G.5    Semenza, G.L.6
  • 139
    • 0242581718 scopus 로고    scopus 로고
    • Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in (VHL-/-) renal cell carcinoma cells
    • Gunaratnam L, Morley M, Franovic A, de Paulsen N, Mekhail K, Parolin DAE, et al. Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in (VHL-/-) renal cell carcinoma cells. J Biol Chem 2003; 278: 44966-74.
    • (2003) J. Biol. Chem. , vol.278 , pp. 44966-44974
    • Gunaratnam, L.1    Morley, M.2    Franovic, A.3    de Paulsen, N.4    Mekhail, K.5    Parolin, D.A.E.6
  • 140
    • 0034100836 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-I mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)
    • Caniggia I, Mostachfi H, Winter J, Gassmann M, Lye SJ, Kuliszewski M, et al. Hypoxia-inducible factor-I mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J Clin Invest 2000; 105: 577-87.
    • (2000) J. Clin. Invest. , vol.105 , pp. 577-587
    • Caniggia, I.1    Mostachfi, H.2    Winter, J.3    Gassmann, M.4    Lye, S.J.5    Kuliszewski, M.6
  • 141
    • 0042830775 scopus 로고    scopus 로고
    • Increased growth factor production in a human prostatic stromal cell culture model caused by hypoxia
    • Berger AP, Kofler K, Bektic J, Rogatsch H, Steiner H, Bartsch G, et al. Increased growth factor production in a human prostatic stromal cell culture model caused by hypoxia. Prostate 2003; 57: 57-65.
    • (2003) Prostate , vol.57 , pp. 57-65
    • Berger, A.P.1    Kofler, K.2    Bektic, J.3    Rogatsch, H.4    Steiner, H.5    Bartsch, G.6
  • 142
    • 0035852630 scopus 로고    scopus 로고
    • Role of transforming growth factor-alpha in von Hippel-Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis
    • de Paulsen N, Brychzy A, Fournier MC, Klausner RD, Gnarra JR, Pause et al.. Role of transforming growth factor-alpha in von Hippel-Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proc Natl Acad Sci USA 2001; 98: 1387-92.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 1387-1392
    • de Paulsen, N.1    Brychzy, A.2    Fournier, M.C.3    Klausner, R.D.4    Gnarra, J.R.5    Pause, A.6
  • 143
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
    • Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, et al. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res 1999; 59: 5830-5.
    • (1999) Cancer Res. , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3    Lim, M.4    Hilton, D.A.5    Zagzag, D.6
  • 144
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000; 157: 411-21.
    • (2000) Am. J. Pathol. , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3    Maxwell, P.H.4    Pugh, C.W.5    Ratcliffe, P.J.6
  • 145
    • 0035394516 scopus 로고    scopus 로고
    • Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas
    • Wiesener MS, Munchenhagen PM, Berger I, Morgan NV, Roigas J, Schwiertz A, et al. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas. Cancer Res 2001; 61: 5215-22.
    • (2001) Cancer Res. , vol.61 , pp. 5215-5222
    • Wiesener, M.S.1    Munchenhagen, P.M.2    Berger, I.3    Morgan, N.V.4    Roigas, J.5    Schwiertz, A.6
  • 146
    • 0034676331 scopus 로고    scopus 로고
    • Upregulation of Hypoxia-inducible factors HIF-Ialpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
    • Krieg M, Haas R, Brauch H, Acker T, Flamme I, Plate KH. Upregulation of Hypoxia-inducible factors HIF-Ialpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 2000; 19: 5435-43.
    • (2000) Oncogene , vol.19 , pp. 5435-5443
    • Krieg, M.1    Haas, R.2    Brauch, H.3    Acker, T.4    Flamme, I.5    Plate, K.H.6
  • 148
    • 0036278899 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer
    • Schindl M, Schoppmann SF, Samonigg H, Hausmaninger H, Kwasny W, Gnant M, et al. Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer. Ciin Cancer Res 2002; 8: 1831-7.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1831-1837
    • Schindl, M.1    Schoppmann, S.F.2    Samonigg, H.3    Hausmaninger, H.4    Kwasny, W.5    Gnant, M.6
  • 150
    • 0035395098 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1alpha in oligodendrogliomas: Its impact on prognosis and on neoangiogenesis
    • Birner P, Gatterbauer B, Oberhuber G, Schindl M, Rossler K, Prodinger A, et al. Expression of hypoxia-inducible factor-1alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis. Cancer 2001; 92: 165-71.
    • (2001) Cancer , vol.92 , pp. 165-171
    • Birner, P.1    Gatterbauer, B.2    Oberhuber, G.3    Schindl, M.4    Rossler, K.5    Prodinger, A.6
  • 151
    • 0034282518 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
    • Birner P, Schind M, Obermair A, Breitenecker G, Oberhuber G. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 2000; 60: 4693-6.
    • (2000) Cancer Res. , vol.60 , pp. 4693-4696
    • Birner, P.1    Schind, M.2    Obermair, A.3    Breitenecker, G.4    Oberhuber, G.5
  • 152
    • 0035300410 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
    • Aebersold DM, Burri P, Beer KT, Laissue J, Djonov V, Greiner RH, et al. Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 2001; 61: 2911-6.
    • (2001) Cancer Res. , vol.61 , pp. 2911-2916
    • Aebersold, D.M.1    Burri, P.2    Beer, K.T.3    Laissue, J.4    Djonov, V.5    Greiner, R.H.6
  • 153
    • 0035418621 scopus 로고    scopus 로고
    • Constitutive expression of hypoxia-inducible factor-1α renders pancreatic cancer cells resistant to all induced by hypoxia and nutrient deprivation
    • Akakura N, Kobayashi M, Horiuchi I, Suzuki A, Wang J, Chen J, et al. Constitutive expression of hypoxia-inducible factor-1α renders pancreatic cancer cells resistant to all induced by hypoxia and nutrient deprivation. Cancer Res 2001; 6: 6548-54.
    • (2001) Cancer Res. , vol.6 , pp. 6548-6554
    • Akakura, N.1    Kobayashi, M.2    Horiuchi, I.3    Suzuki, A.4    Wang, J.5    Chen, J.6
  • 154
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev 2003; 3: 721-32.
    • (2003) Nat. Rev. , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 156
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1α is required for solid tumor formation and embryonic vascularization
    • Ryan HE, Lo J, Johnson RS. HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J 1998; 17: 3005-15.
    • (1998) EMBO J. , vol.17 , pp. 3005-3015
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 157
    • 0035003528 scopus 로고    scopus 로고
    • Gene transfer of antisense hypoxia inducible factor-1α enhances the therapeutic efficacy of cancer immunotherapy
    • Sun X, Kanwar JR, Leung E, Lehnert K, Wang D, Krissansen GW. Gene transfer of antisense hypoxia inducible factor-1α enhances the therapeutic efficacy of cancer immunotherapy. Gene Ther 2001; 8: 638-45.
    • (2001) Gene Ther. , vol.8 , pp. 638-645
    • Sun, X.1    Kanwar, J.R.2    Leung, E.3    Lehnert, K.4    Wang, D.5    Krissansen, G.W.6
  • 159
    • 0344608877 scopus 로고    scopus 로고
    • Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism
    • Chen J, Zhao S, Nakada K, Kuge Y, Tamaki N, Okada F, et al. Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol 2003; 162: 1283-91.
    • (2003) Am. J. Pathol. , vol.162 , pp. 1283-1291
    • Chen, J.1    Zhao, S.2    Nakada, K.3    Kuge, Y.4    Tamaki, N.5    Okada, F.6
  • 160
    • 0034529914 scopus 로고    scopus 로고
    • Suppression of tumor growth through disruption of hypoxia-inducible transcription
    • Kung AL, Warg S, Klco JM, Kaelin WG Jr, Livingston DM. Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat Med 2000; 6: 1335-40.
    • (2000) Nat. Med. , vol.6 , pp. 1335-1340
    • Kung, A.L.1    Warg, S.2    Klco, J.M.3    Kaelin Jr., W.G.4    Livingston, D.M.5
  • 162
    • 0036682284 scopus 로고    scopus 로고
    • Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
    • Rapisarda A, Uranchimeg B, Scudiero DA, Selby M, Sausville EA, Shoemaker RN, et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res 2002; 62: 4316-24.
    • (2002) Cancer Res. , vol.62 , pp. 4316-4324
    • Rapisarda, A.1    Uranchimeg, B.2    Scudiero, D.A.3    Selby, M.4    Sausville, E.A.5    Shoemaker, R.N.6
  • 163
    • 0141761369 scopus 로고    scopus 로고
    • Renaissance of the biologically active vitamin A derivatives:
    • Brtko J, Thalhamer J. Renaissance of the biologically active vitamin A derivatives: established and novel directed therapies for cancer and the chemoprevention. Curr Pharm Design 2003; 9(25): 2067-77.
    • (2003) Curr. Pharm. Design , vol.9 , Issue.25 , pp. 2067-2077
    • Brtko, J.1    Thalhamer, J.2
  • 164
    • 1642286962 scopus 로고    scopus 로고
    • Modulating the hypoxia-inducible factor signaling pathway: Applications from cardiovascular disease to cancer
    • Hewitson KS, McNeill LA, Schofield CJ. Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer. Curr Pharm Design 2004; 10(8): 821-33.
    • (2004) Curr. Pharm. Design , vol.10 , Issue.8 , pp. 821-833
    • Hewitson, K.S.1    McNeill, L.A.2    Schofield, C.J.3
  • 165
    • 0037278475 scopus 로고    scopus 로고
    • Protein kinases and the hypoxia-inducible factor-1, two switches in angiogenesis
    • Mazure NM, Brahimi-Horn MC, Pouyssegur J. Protein kinases and the hypoxia-inducible factor-1, two switches in angiogenesis. Curr Pharm Design 2003; 9(7): 531-41.
    • (2003) Curr. Pharm. Design , vol.9 , Issue.7 , pp. 531-541
    • Mazure, N.M.1    Brahimi-Horn, M.C.2    Pouyssegur, J.3


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