-
1
-
-
84871839739
-
Immune-mediated disease genetics: The shared basis of pathogenesis
-
Cotsapas C, Hafler DA. Immune-mediated disease genetics: The shared basis of pathogenesis. Trends Immunol. 2013;34(1): 22-26.
-
(2013)
Trends Immunol
, vol.34
, Issue.1
, pp. 22-26
-
-
Cotsapas, C.1
Hafler, D.A.2
-
2
-
-
0037648405
-
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
-
Ueda H, et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature. 2003;423(6939): 506-511.
-
(2003)
Nature
, vol.423
, Issue.6939
, pp. 506-511
-
-
Ueda, H.1
-
3
-
-
34347341846
-
Robust associations of four new chromosome regions from genomewide analyses of type 1 diabetes
-
Todd JA, et al. Robust associations of four new chromosome regions from genomewide analyses of type 1 diabetes. Nat Genet. 2007;39(7): 857-864.
-
(2007)
Nat Genet
, vol.39
, Issue.7
, pp. 857-864
-
-
Todd, J.A.1
-
4
-
-
84969213492
-
Genomewide association study of 14,000 cases of seven common diseases and 3,000 controls
-
Consortium WTCC. Genomewide association study of 14,000 cases of seven common diseases and 3,000 controls. Nature. 2007;447(7145): 661-683.
-
(2007)
Nature
, vol.447
, Issue.7145
, pp. 661-683
-
-
Wtcc, C.1
-
5
-
-
18244421874
-
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTRIDDM2 susceptibility locus for type 1 diabetes
-
Pugliese A, et al. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTRIDDM2 susceptibility locus for type 1 diabetes. Nat Genet. 1997;15(3): 293-297.
-
(1997)
Nat Genet
, vol.15
, Issue.3
, pp. 293-297
-
-
Pugliese, A.1
-
6
-
-
0042667153
-
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis
-
Suzuki A. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet. 2003;34(4): 395-402.
-
(2003)
Nat Genet
, vol.34
, Issue.4
, pp. 395-402
-
-
Suzuki, A.1
-
8
-
-
0028238201
-
Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide
-
Wucherpfennig KW, et al. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J Immunol. 1994;152(11): 5581-5592.
-
(1994)
J Immunol
, vol.152
, Issue.11
, pp. 5581-5592
-
-
Wucherpfennig, K.W.1
-
9
-
-
39149094629
-
Insulin as an autoantigen in NOD/human diabetes
-
Zhang L, Nakayama M, Eisenbarth GS. Insulin as an autoantigen in NOD/human diabetes. Curr Opin Immunol. 2008;20(1): 111-118.
-
(2008)
Curr Opin Immunol
, vol.20
, Issue.1
, pp. 111-118
-
-
Zhang, L.1
Nakayama, M.2
Eisenbarth, G.S.3
-
10
-
-
0036312395
-
Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects
-
Reijonen H, et al. Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects. Diabetes. 2002;51(5): 1375-1382.
-
(2002)
Diabetes
, vol.51
, Issue.5
, pp. 1375-1382
-
-
Reijonen, H.1
-
11
-
-
84874253445
-
Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults
-
Su LF, Kidd BA, Han A, Kotzin JJ, Davis MM. Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults. Immunity. 2013;38(2): 373-383.
-
(2013)
Immunity
, vol.38
, Issue.2
, pp. 373-383
-
-
Su, L.F.1
Kidd, B.A.2
Han, A.3
Kotzin, J.J.4
Davis, M.M.5
-
12
-
-
79954459308
-
Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/B7 family
-
Bour-Jordan H, Esensten JH, Martinez-Llordella M, Penaranda C, Stumpf M, Bluestone JA. Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/B7 family. Immunol Rev. 2011;241(1): 180-205.
-
(2011)
Immunol Rev
, vol.241
, Issue.1
, pp. 180-205
-
-
Bour-Jordan, H.1
Esensten, J.H.2
Martinez-Llordella, M.3
Penaranda, C.4
Stumpf, M.5
Bluestone, J.A.6
-
13
-
-
79954551032
-
Mechanisms of tolerance
-
Bluestone JA. Mechanisms of tolerance. Immunol Rev. 2011;241(1): 5-19.
-
(2011)
Immunol Rev
, vol.241
, Issue.1
, pp. 5-19
-
-
Bluestone, J.A.1
-
14
-
-
74049164847
-
Regulatory T cells exert checks and balances on self tolerance and autoimmunity
-
Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol. 2010;11(1): 7-13.
-
(2010)
Nat Immunol
, vol.11
, Issue.1
, pp. 7-13
-
-
Wing, K.1
Sakaguchi, S.2
-
15
-
-
47249124078
-
Human regulatory T cells: Role in autoimmune disease and therapeutic opportunities
-
Brusko TM, Putnam AL, Bluestone JA. Human regulatory T cells: Role in autoimmune disease and therapeutic opportunities. Immunol Rev. 2008;223: 371-390.
-
(2008)
Immunol Rev
, vol.223
, pp. 371-390
-
-
Brusko, T.M.1
Putnam, A.L.2
Bluestone, J.A.3
-
16
-
-
77954141914
-
FOXP3+ regulatory T cells in the human immune system
-
Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol. 2010;10(7): 490-500.
-
(2010)
Nat Rev Immunol
, vol.10
, Issue.7
, pp. 490-500
-
-
Sakaguchi, S.1
Miyara, M.2
Costantino, C.M.3
Hafler, D.A.4
-
17
-
-
0035167967
-
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
-
Bennett CL, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet. 2001; 27(1): 20-21.
-
(2001)
Nat Genet
, vol.27
, Issue.1
, pp. 20-21
-
-
Bennett, C.L.1
-
18
-
-
0037385330
-
Foxp3 programs the development and function of CD4(+)CD25(+) regulatory T cells
-
Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4(+)CD25(+) regulatory T cells. Nat Immunol. 2003;4(4): 330-336.
-
(2003)
Nat Immunol
, vol.4
, Issue.4
, pp. 330-336
-
-
Fontenot, J.D.1
Gavin, M.A.2
Rudensky, A.Y.3
-
19
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299(5609): 1057-1061.
-
(2003)
Science
, vol.299
, Issue.5609
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
20
-
-
33847125247
-
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
-
Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature. 2007;445(7129): 766-770.
-
(2007)
Nature
, vol.445
, Issue.7129
, pp. 766-770
-
-
Wan, Y.Y.1
Flavell, R.A.2
-
21
-
-
33846485153
-
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
-
Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol. 2007;8(2): 191-197.
-
(2007)
Nat Immunol
, vol.8
, Issue.2
, pp. 191-197
-
-
Kim, J.M.1
Rasmussen, J.P.2
Rudensky, A.Y.3
-
22
-
-
0037112047
-
Projection of an immunological self shadow within the thymus by the aire protein
-
Anderson MS, et al. Projection of an immunological self shadow within the thymus by the aire protein. Science. 2002;298(5597): 1395-1401.
-
(2002)
Science
, vol.298
, Issue.5597
, pp. 1395-1401
-
-
Anderson, M.S.1
-
23
-
-
0037383758
-
Aire regulates negative selection of organ-specific T cells
-
Liston A, Lesage S, Wilson J, Peltonen L, Goodnow CC. Aire regulates negative selection of organ-specific T cells. Nat Immunol. 2003;4(4): 350-354.
-
(2003)
Nat Immunol
, vol.4
, Issue.4
, pp. 350-354
-
-
Liston, A.1
Lesage, S.2
Wilson, J.3
Peltonen, L.4
Goodnow, C.C.5
-
24
-
-
79953097064
-
Aire and T cell development
-
Anderson MS, Su MA. Aire and T cell development. Curr Opin Immunol. 2011;23(2): 198-206.
-
(2011)
Curr Opin Immunol
, vol.23
, Issue.2
, pp. 198-206
-
-
Anderson, M.S.1
Su, M.A.2
-
25
-
-
33747662305
-
Autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy
-
Perheentupa J. Autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy. J Clin Endocrinol Metab. 2006;91(8): 2843-2850.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, Issue.8
, pp. 2843-2850
-
-
Perheentupa, J.1
-
26
-
-
84861212351
-
Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection
-
Taniguchi RT, et al. Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc Natl Acad Sci U S A. 2012;109(20): 7847-7852.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, Issue.20
, pp. 7847-7852
-
-
Taniguchi, R.T.1
-
27
-
-
34548151158
-
An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus
-
Giraud M, et al. An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nature. 2007;448(7156): 934-937.
-
(2007)
Nature
, vol.448
, Issue.7156
, pp. 934-937
-
-
Giraud, M.1
-
28
-
-
0031018819
-
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
-
Vafiadis P, et al. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet. 1997;15(3): 289-292.
-
(1997)
Nat Genet
, vol.15
, Issue.3
, pp. 289-292
-
-
Vafiadis, P.1
-
29
-
-
35748941369
-
Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
-
Gray D, Abramson J, Benoist C, Mathis D. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med. 2007;204(11): 2521-2528.
-
(2007)
J Exp Med
, vol.204
, Issue.11
, pp. 2521-2528
-
-
Gray, D.1
Abramson, J.2
Benoist, C.3
Mathis, D.4
-
30
-
-
84885854982
-
Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population
-
Metzger TC, et al. Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population. Cell Rep. 2013; 5(1): 166-179.
-
(2013)
Cell Rep
, vol.5
, Issue.1
, pp. 166-179
-
-
Metzger, T.C.1
-
31
-
-
84907336905
-
Adult thymus contains FoxN1(-) epithelial stem cells that are bipotent for medullary and cortical thymic epithelial lineages
-
Ucar A, et al. Adult thymus contains FoxN1(-) epithelial stem cells that are bipotent for medullary and cortical thymic epithelial lineages. Immunity. 2014;41(2): 257-269.
-
(2014)
Immunity
, vol.41
, Issue.2
, pp. 257-269
-
-
Ucar, A.1
-
32
-
-
84908356419
-
Multilineage potential and self-renewal define an epithelial progenitor cell population in the adult thymus
-
Wong K, et al. Multilineage potential and self-renewal define an epithelial progenitor cell population in the adult thymus. Cell Rep. 2014;8(4): 1198-1209.
-
(2014)
Cell Rep
, vol.8
, Issue.4
, pp. 1198-1209
-
-
Wong, K.1
-
33
-
-
84858795036
-
Rank signaling links the development of invariant gammadelta T cell progenitors and Aire(+) medullary epithelium
-
Roberts NA, et al. Rank signaling links the development of invariant gammadelta T cell progenitors and Aire(+) medullary epithelium. Immunity. 2012;36(3): 427-437.
-
(2012)
Immunity
, vol.36
, Issue.3
, pp. 427-437
-
-
Roberts, N.A.1
-
34
-
-
34250336454
-
RANK signals from CD4(+)3(-) inducer cells regulate development of Aireexpressing epithelial cells in the thymic medulla
-
Rossi SW, et al. RANK signals from CD4(+)3(-) inducer cells regulate development of Aireexpressing epithelial cells in the thymic medulla. J Exp Med. 2007;204(6): 1267-1272.
-
(2007)
J Exp Med
, vol.204
, Issue.6
, pp. 1267-1272
-
-
Rossi, S.W.1
-
35
-
-
44849090702
-
Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input
-
White AJ, et al. Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input. Eur J Immunol. 2008;38(4): 942-947.
-
(2008)
Eur J Immunol
, vol.38
, Issue.4
, pp. 942-947
-
-
White, A.J.1
-
36
-
-
0033136325
-
Generation of functional thymocytes in the human adult
-
Jamieson BD, et al. Generation of functional thymocytes in the human adult. Immunity. 1999;10(5): 569-575.
-
(1999)
Immunity
, vol.10
, Issue.5
, pp. 569-575
-
-
Jamieson, B.D.1
-
37
-
-
0034636053
-
Identification of a human recent thymic emigrant phenotype
-
McFarland RD, Douek DC, Koup RA, Picker LJ. Identification of a human recent thymic emigrant phenotype. Proc Natl Acad Sci U S A. 2000;97(8): 4215-4220.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, Issue.8
, pp. 4215-4220
-
-
McFarland, R.D.1
Douek, D.C.2
Koup, R.A.3
Picker, L.J.4
-
38
-
-
70449470318
-
Structural alterations in peptide-MHC recognition by self-reactive T cell receptors
-
Wucherpfennig KW, Call MJ, Deng L, Mariuzza R. Structural alterations in peptide-MHC recognition by self-reactive T cell receptors. Curr Opin Immunol. 2009;21(6): 590-595.
-
(2009)
Curr Opin Immunol
, vol.21
, Issue.6
, pp. 590-595
-
-
Wucherpfennig, K.W.1
Call, M.J.2
Deng, L.3
Mariuzza, R.4
-
39
-
-
18244392426
-
Unconventional topology of self peptide- major histocompatibility complex binding by a human autoimmune T cell receptor
-
Hahn M, Nicholson MJ, Pyrdol J, Wucherpfennig KW. Unconventional topology of self peptide- major histocompatibility complex binding by a human autoimmune T cell receptor. Nat Immunol. 2005;6(5): 490-496.
-
(2005)
Nat Immunol
, vol.6
, Issue.5
, pp. 490-496
-
-
Hahn, M.1
Nicholson, M.J.2
Pyrdol, J.3
Wucherpfennig, K.W.4
-
40
-
-
84857189975
-
Structural basis for the killing of human β cells by CD8+ T cells in type 1 diabetes
-
Bulek AM, et al. Structural basis for the killing of human β cells by CD8+ T cells in type 1 diabetes. Nat Immunol. 2012;13(3): 283-289.
-
(2012)
Nat Immunol
, vol.13
, Issue.3
, pp. 283-289
-
-
Bulek, A.M.1
-
41
-
-
80053628904
-
Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse
-
Crawford F, et al. Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc Natl Acad Sci U S A. 2011;108(40): 16729-16734.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.40
, pp. 16729-16734
-
-
Crawford, F.1
-
42
-
-
77954643719
-
Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register
-
Stadinski BD, Zhang L, Crawford F, Marrack P, Eisenbarth GS, Kappler JW. Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. Proc Natl Acad Sci U S A. 2010;107(24): 10978-10983.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.24
, pp. 10978-10983
-
-
Stadinski, B.D.1
Zhang, L.2
Crawford, F.3
Marrack, P.4
Eisenbarth, G.S.5
Kappler, J.W.6
-
43
-
-
84907901062
-
Autoreactive T cells specific for insulin B: 11-23 recognize a low-Affinity peptide register in human subjects with autoimmune diabetes
-
Yang J, et al. Autoreactive T cells specific for insulin B: 11-23 recognize a low-Affinity peptide register in human subjects with autoimmune diabetes. Proc Natl Acad Sci U S A. 2014;111(41): 14840-14845.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, Issue.41
, pp. 14840-14845
-
-
Yang, J.1
-
44
-
-
84855476371
-
Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion
-
Mohan JF, Petzold SJ, Unanue ER. Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion. J Exp Med. 2011;208(12): 2375-2383.
-
(2011)
J Exp Med
, vol.208
, Issue.12
, pp. 2375-2383
-
-
Mohan, J.F.1
Petzold, S.J.2
Unanue, E.R.3
-
45
-
-
84875625575
-
A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins important in autoimmunity
-
Mohan JF, Unanue ER. A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins important in autoimmunity. Mol Immunol. 2013; 55(2): 166-168.
-
(2013)
Mol Immunol
, vol.55
, Issue.2
, pp. 166-168
-
-
Mohan, J.F.1
Unanue, E.R.2
-
46
-
-
76949098835
-
Chromogranin A is an autoantigen in type 1 diabetes
-
Stadinski BD, et al. Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol. 2010;11(3): 225-231.
-
(2010)
Nat Immunol
, vol.11
, Issue.3
, pp. 225-231
-
-
Stadinski, B.D.1
-
47
-
-
26644468528
-
Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-Associated MHC class II molecule
-
Li Y, Huang Y, Lue J, Quandt JA, Martin R, Mariuzza RA. Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-Associated MHC class II molecule. EMBO J. 2005;24(17): 2968-2979.
-
(2005)
EMBO J
, vol.24
, Issue.17
, pp. 2968-2979
-
-
Li, Y.1
Huang, Y.2
Lue, J.3
Quandt, J.A.4
Martin, R.5
Mariuzza, R.A.6
-
48
-
-
0036337673
-
Structural snapshot of aberrant antigen presentation linked to autoimmunity: The immunodominant epitope of MBP complexed with I-Au
-
He XL, Radu C, Sidney J, Sette A, Ward ES, Garcia KC. Structural snapshot of aberrant antigen presentation linked to autoimmunity: The immunodominant epitope of MBP complexed with I-Au. Immunity. 2002;17(1): 83-94.
-
(2002)
Immunity
, vol.17
, Issue.1
, pp. 83-94
-
-
He, X.L.1
Radu, C.2
Sidney, J.3
Sette, A.4
Ward, E.S.5
Garcia, K.C.6
-
49
-
-
84906661993
-
Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes
-
McGinty JW, Chow IT, Greenbaum C, Odegard J, Kwok WW, James EA. Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes. Diabetes. 2014;63(9): 3033-3040.
-
(2014)
Diabetes
, vol.63
, Issue.9
, pp. 3033-3040
-
-
McGinty, J.W.1
Chow, I.T.2
Greenbaum, C.3
Odegard, J.4
Kwok, W.W.5
James, E.A.6
-
50
-
-
84930398461
-
A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells
-
Knight RR, et al. A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells. Clin Exp Immunol. 2015;179(1): 100-107.
-
(2015)
Clin Exp Immunol
, vol.179
, Issue.1
, pp. 100-107
-
-
Knight, R.R.1
-
51
-
-
73249145617
-
Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
-
Wegner N. Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. Immunol Rev. 2010;233(1): 34-54.
-
(2010)
Immunol Rev
, vol.233
, Issue.1
, pp. 34-54
-
-
Wegner, N.1
-
52
-
-
84874518327
-
On the perils of poor editing: Regulation of peptide loading by HLADQ and H2-A molecules associated with celiac disease and type 1 diabetes
-
Busch R, De Riva A, Hadjinicolaou AV, Jiang W, Hou T, Mellins ED. On the perils of poor editing: Regulation of peptide loading by HLADQ and H2-A molecules associated with celiac disease and type 1 diabetes. Expert Rev Mol Med. 2012;14: E15.
-
(2012)
Expert Rev Mol Med
, vol.14
, pp. e15
-
-
Busch, R.1
De Riva, A.2
Hadjinicolaou, A.V.3
Jiang, W.4
Hou, T.5
Mellins, E.D.6
-
53
-
-
65749120321
-
Intraclonal competition limits the fate determination of regulatory T cells in the thymus
-
Bautista JL, et al. Intraclonal competition limits the fate determination of regulatory T cells in the thymus. Nat Immunol. 2009;10(6): 610-617.
-
(2009)
Nat Immunol
, vol.10
, Issue.6
, pp. 610-617
-
-
Bautista, J.L.1
-
54
-
-
84901487911
-
Positive and negative selection of the T cell repertoire: What thymocytes see (and don't see
-
Klein L, Kyewski B, Allen PM, Hogquist KA. Positive and negative selection of the T cell repertoire: What thymocytes see (and don't see). Nat Rev Immunol. 2014;14(6): 377-391.
-
(2014)
Nat Rev Immunol
, vol.14
, Issue.6
, pp. 377-391
-
-
Klein, L.1
Kyewski, B.2
Allen, P.M.3
Hogquist, K.A.4
-
55
-
-
84907982768
-
Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus
-
Perry JS, et al. Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus. Immunity. 2014;41(3): 414-426.
-
(2014)
Immunity
, vol.41
, Issue.3
, pp. 414-426
-
-
Perry, J.S.1
-
56
-
-
34248598295
-
Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
-
Aschenbrenner K, et al. Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat Immunol. 2007;8(4): 351-358.
-
(2007)
Nat Immunol
, vol.8
, Issue.4
, pp. 351-358
-
-
Aschenbrenner, K.1
-
57
-
-
84874745221
-
Aire-dependent thymic development of tumor-Associated regulatory T cells
-
Malchow S, et al. Aire-dependent thymic development of tumor-Associated regulatory T cells. Science. 2013;339(6124): 1219-1224.
-
(2013)
Science
, vol.339
, Issue.6124
, pp. 1219-1224
-
-
Malchow, S.1
-
58
-
-
23844558032
-
The cellular mechanism of Aire control of T cell tolerance
-
Anderson MS, Venanzi ES, Chen Z, Berzins SP, Benoist C, Mathis D. The cellular mechanism of Aire control of T cell tolerance. Immunity. 2005;23(2): 227-239.
-
(2005)
Immunity
, vol.23
, Issue.2
, pp. 227-239
-
-
Anderson, M.S.1
Venanzi, E.S.2
Chen, Z.3
Berzins, S.P.4
Benoist, C.5
Mathis, D.6
-
59
-
-
0036838536
-
Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis
-
Kohm AP, Carpentier PA, Anger HA, Miller SD. Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J Immunol. 2002;169(9): 4712-4716.
-
(2002)
J Immunol
, vol.169
, Issue.9
, pp. 4712-4716
-
-
Kohm, A.P.1
Carpentier, P.A.2
Anger, H.A.3
Miller, S.D.4
-
60
-
-
0037446531
-
Cutting edge: Cure of colitis by CD4+CD25+ regulatory T cells
-
Mottet C, Uhlig HH, Powrie F. Cutting edge: Cure of colitis by CD4+CD25+ regulatory T cells. J Immunol. 2003;170(8): 3939-3943.
-
(2003)
J Immunol
, vol.170
, Issue.8
, pp. 3939-3943
-
-
Mottet, C.1
Uhlig, H.H.2
Powrie, F.3
-
61
-
-
0033682056
-
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
-
Salomon B, et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 2000;12(4): 431-440.
-
(2000)
Immunity
, vol.12
, Issue.4
, pp. 431-440
-
-
Salomon, B.1
-
62
-
-
20944444896
-
Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells
-
You S, et al. Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells. Diabetes. 2005;54(5): 1415-1422.
-
(2005)
Diabetes
, vol.54
, Issue.5
, pp. 1415-1422
-
-
You, S.1
-
63
-
-
84874099546
-
In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling
-
Schneider A, et al. In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling. Sci Transl Med. 2013;5(170): 170ra115.
-
(2013)
Sci Transl Med
, vol.5
, Issue.170
, pp. 170ra115
-
-
Schneider, A.1
-
64
-
-
84892474632
-
Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells
-
Schenten D, et al. Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells. Immunity. 2014;40(1): 78-90.
-
(2014)
Immunity
, vol.40
, Issue.1
, pp. 78-90
-
-
Schenten, D.1
-
65
-
-
9644270396
-
Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells
-
Bour-Jordan H, Salomon BL, Thompson HL, Szot GL, Bernhard MR, Bluestone JA. Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells. J Clin Invest. 2004;114(7): 979-987.
-
(2004)
J Clin Invest
, vol.114
, Issue.7
, pp. 979-987
-
-
Bour-Jordan, H.1
Salomon, B.L.2
Thompson, H.L.3
Szot, G.L.4
Bernhard, M.R.5
Bluestone, J.A.6
-
66
-
-
78649897032
-
Human regulatory T cells in autoimmune diseases
-
Cvetanovich GL, Hafler DA. Human regulatory T cells in autoimmune diseases. Curr Opin Immunol. 2010;22(6): 753-760.
-
(2010)
Curr Opin Immunol
, vol.22
, Issue.6
, pp. 753-760
-
-
Cvetanovich, G.L.1
Hafler, D.A.2
-
67
-
-
78649526238
-
Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases
-
Buckner JH. Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases. Nat Rev Immunol. 2010;10(12): 849-859.
-
(2010)
Nat Rev Immunol
, vol.10
, Issue.12
, pp. 849-859
-
-
Buckner, J.H.1
-
68
-
-
77449143100
-
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects
-
Long SA, et al. Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes. 2010;59(2): 407-415.
-
(2010)
Diabetes
, vol.59
, Issue.2
, pp. 407-415
-
-
Long, S.A.1
-
69
-
-
79952280031
-
An autoimmune-Associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells
-
Long SA, et al. An autoimmune-Associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells. Genes Immun. 2011;12(2): 116-125.
-
(2011)
Genes Immun
, vol.12
, Issue.2
, pp. 116-125
-
-
Long, S.A.1
-
70
-
-
84893466383
-
Multiple autoimmune-Associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients
-
Cerosaletti K, et al. Multiple autoimmune-Associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients. PLoS One. 2013;8(12): E83811.
-
(2013)
PLoS One
, vol.8
, Issue.12
, pp. e83811
-
-
Cerosaletti, K.1
-
71
-
-
33745817085
-
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
-
Liu W, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med. 2006;203(7): 1701-1711.
-
(2006)
J Exp Med
, vol.203
, Issue.7
, pp. 1701-1711
-
-
Liu, W.1
-
72
-
-
62749201002
-
Expansion of human regulatory T-cells from patients with type 1 diabetes
-
Putnam AL, et al. Expansion of human regulatory T-cells from patients with type 1 diabetes. Diabetes. 2009;58(3): 652-662.
-
(2009)
Diabetes
, vol.58
, Issue.3
, pp. 652-662
-
-
Putnam, A.L.1
-
73
-
-
84860317093
-
Type 1 diabetes-Associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function
-
Garg G, et al. Type 1 diabetes-Associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function. J Immunol. 2012;188(9): 4644-4653.
-
(2012)
J Immunol
, vol.188
, Issue.9
, pp. 4644-4653
-
-
Garg, G.1
-
74
-
-
12144249838
-
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
-
Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, Tree TI. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes. 2005;54(1): 92-99.
-
(2005)
Diabetes
, vol.54
, Issue.1
, pp. 92-99
-
-
Lindley, S.1
Dayan, C.M.2
Bishop, A.3
Roep, B.O.4
Peakman, M.5
Tree, T.I.6
-
75
-
-
51049120236
-
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity
-
Zhou X, et al. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med. 2008;205(9): 1983-1991.
-
(2008)
J Exp Med
, vol.205
, Issue.9
, pp. 1983-1991
-
-
Zhou, X.1
-
76
-
-
43049174722
-
Central role of defective interleukin- 2 production in the triggering of islet autoimmune destruction
-
Tang Q, et al. Central role of defective interleukin- 2 production in the triggering of islet autoimmune destruction. Immunity. 2008;28(5): 687-697.
-
(2008)
Immunity
, vol.28
, Issue.5
, pp. 687-697
-
-
Tang, Q.1
-
77
-
-
4143066714
-
Recognition of the peripheral self by naturally arising CD25+CD4+ T cell receptors
-
Hsieh CS, Liang Y, Tyznik AJ, Self SG, Liggitt D, Rudensky AY. Recognition of the peripheral self by naturally arising CD25+CD4+ T cell receptors. Immunity. 2004;21(2): 267-277.
-
(2004)
Immunity
, vol.21
, Issue.2
, pp. 267-277
-
-
Hsieh, C.S.1
Liang, Y.2
Tyznik, A.J.3
Self, S.G.4
Liggitt, D.5
Rudensky, A.Y.6
-
78
-
-
0035320679
-
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist selfpeptide
-
Jordan MS, et al. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist selfpeptide. Nat Immunol. 2001;2(4): 301-306.
-
(2001)
Nat Immunol
, vol.2
, Issue.4
, pp. 301-306
-
-
Jordan, M.S.1
-
79
-
-
84875427488
-
Regulatory T cells: Recommendations to simplify the nomenclature
-
Abbas AK, et al. Regulatory T cells: Recommendations to simplify the nomenclature. Nat Immunol. 2013;14(4): 307-308.
-
(2013)
Nat Immunol
, vol.14
, Issue.4
, pp. 307-308
-
-
Abbas, A.K.1
-
80
-
-
0037364804
-
Natural versus adaptive regulatory T cells
-
Bluestone JA, Abbas AK. Natural versus adaptive regulatory T cells. Nat Rev Immunol. 2003;3(3): 253-257.
-
(2003)
Nat Rev Immunol
, vol.3
, Issue.3
, pp. 253-257
-
-
Bluestone, J.A.1
Abbas, A.K.2
-
81
-
-
84883679673
-
Peripherally induced tregs - role in immune homeostasis and autoimmunity
-
Yadav M, Stephan S, Bluestone JA. Peripherally induced tregs - role in immune homeostasis and autoimmunity. Front Immunol. 2013;4: 232.
-
(2013)
Front Immunol
, vol.4
, pp. 232
-
-
Yadav, M.1
Stephan, S.2
Bluestone, J.A.3
-
82
-
-
0036345337
-
Origin of regulatory T cells with known specificity for antigen
-
Apostolou I, Sarukhan A, Klein L, Von Boehmer H. Origin of regulatory T cells with known specificity for antigen. Nat Immunol. 2002;3(8): 756-763.
-
(2002)
Nat Immunol
, vol.3
, Issue.8
, pp. 756-763
-
-
Apostolou, I.1
Sarukhan, A.2
Klein, L.3
Von Boehmer, H.4
-
83
-
-
79955541353
-
Strength of TCR-peptide/MHC interactions and in vivo T cell responses
-
Corse E, Gottschalk RA, Allison JP. Strength of TCR-peptide/MHC interactions and in vivo T cell responses. J Immunol. 2011;186(9): 5039-5045.
-
(2011)
J Immunol
, vol.186
, Issue.9
, pp. 5039-5045
-
-
Corse, E.1
Gottschalk, R.A.2
Allison, J.P.3
-
84
-
-
34547788180
-
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β and retinoic acid-dependent mechanism
-
Coombes JL, et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β and retinoic acid-dependent mechanism. J Exp Med. 2007;204(8): 1757-1764.
-
(2007)
J Exp Med
, vol.204
, Issue.8
, pp. 1757-1764
-
-
Coombes, J.L.1
-
85
-
-
33748448717
-
Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
-
Li MO, Sanjabi S, Flavell RA. Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity. 2006;25(3): 455-471.
-
(2006)
Immunity
, vol.25
, Issue.3
, pp. 455-471
-
-
Li, M.O.1
Sanjabi, S.2
Flavell, R.A.3
-
86
-
-
34547757390
-
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
-
Sun CM, et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med. 2007;204(8): 1775-1785.
-
(2007)
J Exp Med
, vol.204
, Issue.8
, pp. 1775-1785
-
-
Sun, C.M.1
-
87
-
-
34447503805
-
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
-
Mucida D, et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science. 2007;317(5835): 256-260.
-
(2007)
Science
, vol.317
, Issue.5835
, pp. 256-260
-
-
Mucida, D.1
-
88
-
-
80054020840
-
Peripheral education of the immune system by colonic commensal microbiota
-
Lathrop SK, et al. Peripheral education of the immune system by colonic commensal microbiota. Nature. 2011;478(7368): 250-254.
-
(2011)
Nature
, vol.478
, Issue.7368
, pp. 250-254
-
-
Lathrop, S.K.1
-
89
-
-
84881477044
-
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
-
Atarashi K, et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature. 2013;500(7461): 232-236.
-
(2013)
Nature
, vol.500
, Issue.7461
, pp. 232-236
-
-
Atarashi, K.1
-
90
-
-
84890550163
-
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
-
Arpaia N, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013;504(7480): 451-455.
-
(2013)
Nature
, vol.504
, Issue.7480
, pp. 451-455
-
-
Arpaia, N.1
-
91
-
-
84890564250
-
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
-
Furusawa Y, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013;504(7480): 446-450.
-
(2013)
Nature
, vol.504
, Issue.7480
, pp. 446-450
-
-
Furusawa, Y.1
-
92
-
-
84883679673
-
Peripherally induced tregs - role in immune homeostasis and autoimmunity
-
Yadav M, Stephan S, Bluestone JA. Peripherally induced tregs - role in immune homeostasis and autoimmunity. Front Immunol. 2013;4: 232.
-
(2013)
Front Immunol
, vol.4
, pp. 232
-
-
Yadav, M.1
Stephan, S.2
Bluestone, J.A.3
-
93
-
-
65449136307
-
A central role for induced regulatory T cells in tolerance induction in experimental colitis
-
Haribhai D, et al. A central role for induced regulatory T cells in tolerance induction in experimental colitis. J Immunol. 2009;182(6): 3461-3468.
-
(2009)
J Immunol
, vol.182
, Issue.6
, pp. 3461-3468
-
-
Haribhai, D.1
-
94
-
-
79960453738
-
A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity
-
Haribhai D, et al. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity. 2011;35(1): 109-122.
-
(2011)
Immunity
, vol.35
, Issue.1
, pp. 109-122
-
-
Haribhai, D.1
-
95
-
-
84862777225
-
Extrathymically generated regulatory T cells control mucosal TH2 inflammation
-
Josefowicz SZ, et al. Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature. 2012;482(7385): 395-399.
-
(2012)
Nature
, vol.482
, Issue.7385
, pp. 395-399
-
-
Josefowicz, S.Z.1
-
96
-
-
84867901322
-
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
-
Yadav M, et al. Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J Exp Med. 2012;209(10): 1713-1722.
-
(2012)
J Exp Med
, vol.209
, Issue.10
, pp. 1713-1722
-
-
Yadav, M.1
-
97
-
-
33747099523
-
Origin and T cell receptor diversity of Foxp3+CD4+ CD25+ T cells
-
Pacholczyk R, Ignatowicz H, Kraj P, Ignatowicz L. Origin and T cell receptor diversity of Foxp3+CD4+ CD25+ T cells. Immunity. 2006;25(2): 249-259.
-
(2006)
Immunity
, vol.25
, Issue.2
, pp. 249-259
-
-
Pacholczyk, R.1
Ignatowicz, H.2
Kraj, P.3
Ignatowicz, L.4
-
98
-
-
33645102841
-
An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
-
Hsieh CS, Zheng Y, Liang Y, Fontenot JD, Rudensky AY. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat Immunol. 2006;7(4): 401-410.
-
(2006)
Nat Immunol
, vol.7
, Issue.4
, pp. 401-410
-
-
Hsieh, C.S.1
Zheng, Y.2
Liang, Y.3
Fontenot, J.D.4
Rudensky, A.Y.5
-
99
-
-
34249814016
-
Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells
-
Wong J, Obst R, Correia-Neves M, Losyev G, Mathis D, Benoist C. Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells. J Immunol. 2007;178(11): 7032-7041.
-
(2007)
J Immunol
, vol.178
, Issue.11
, pp. 7032-7041
-
-
Wong, J.1
Obst, R.2
Correia-Neves, M.3
Losyev, G.4
Mathis, D.5
Benoist, C.6
-
100
-
-
25144452923
-
Continuous control of autoimmune disease by antigen- dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node
-
Samy ET, Parker LA, Sharp CP, Tung KS. Continuous control of autoimmune disease by antigen- dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node. J Exp Med. 2005;202(6): 771-781.
-
(2005)
J Exp Med
, vol.202
, Issue.6
, pp. 771-781
-
-
Samy, E.T.1
Parker, L.A.2
Sharp, C.P.3
Tung, K.S.4
-
101
-
-
0033103668
-
Peripheral autoantigen induces regulatory T cells that prevent autoimmunity
-
Seddon B, Mason D. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. J Exp Med. 1999;189(5): 877-882.
-
(1999)
J Exp Med
, vol.189
, Issue.5
, pp. 877-882
-
-
Seddon, B.1
Mason, D.2
-
102
-
-
69049107358
-
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
-
Zhou X, et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol. 2009;10(9): 1000-1007.
-
(2009)
Nat Immunol
, vol.10
, Issue.9
, pp. 1000-1007
-
-
Zhou, X.1
-
104
-
-
65549088243
-
IL-17-producing human peripheral regulatory T cells retain suppressive function
-
Beriou G, et al. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood. 2009;113(18): 4240-4249.
-
(2009)
Blood
, vol.113
, Issue.18
, pp. 4240-4249
-
-
Beriou, G.1
-
105
-
-
63849183918
-
Identification of IL-17-producing FOXP3+ regulatory T cells in humans
-
Voo KS, et al. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A. 2009;106(12): 4793-4798.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.12
, pp. 4793-4798
-
-
Voo, K.S.1
-
106
-
-
84891838421
-
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
-
Komatsu N, et al. Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat Med. 2014;20(1): 62-68.
-
(2014)
Nat Med
, vol.20
, Issue.1
, pp. 62-68
-
-
Komatsu, N.1
-
107
-
-
77957371028
-
Stability of the regulatory T cell lineage in vivo
-
Rubtsov YP, et al. Stability of the regulatory T cell lineage in vivo. Science. 2010;329(5999): 1667-1671.
-
(2010)
Science
, vol.329
, Issue.5999
, pp. 1667-1671
-
-
Rubtsov, Y.P.1
-
108
-
-
84857416489
-
Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells
-
Miyao T, et al. Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity. 2012;36(2): 262-275.
-
(2012)
Immunity
, vol.36
, Issue.2
, pp. 262-275
-
-
Miyao, T.1
-
109
-
-
84887512828
-
Self-Antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response
-
Bailey-Bucktrout SL, et al. Self-Antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response. Immunity. 2013;39(5): 949-962.
-
(2013)
Immunity
, vol.39
, Issue.5
, pp. 949-962
-
-
Bailey-Bucktrout, S.L.1
-
110
-
-
79955028001
-
Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes
-
McClymont SA, et al. Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J Immunol. 2011;186(7): 3918-3926.
-
(2011)
J Immunol
, vol.186
, Issue.7
, pp. 3918-3926
-
-
McClymont, S.A.1
-
111
-
-
79958134797
-
Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease
-
Dominguez-Villar M, Baecher-Allan CM, Hafler DA. Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease. Nat Med. 2011;17(6): 673-675.
-
(2011)
Nat Med
, vol.17
, Issue.6
, pp. 673-675
-
-
Dominguez-Villar, M.1
Baecher-Allan, C.M.2
Hafler, D.A.3
-
112
-
-
33847153417
-
Foxp3-dependent programme of regulatory T-cell differentiation
-
Gavin MA, et al. Foxp3-dependent programme of regulatory T-cell differentiation. Nature. 2007;445(7129): 771-775.
-
(2007)
Nature
, vol.445
, Issue.7129
, pp. 771-775
-
-
Gavin, M.A.1
-
113
-
-
65349151316
-
Regulating the regulators: Costimulatory signals control the homeostasis and function of regulatory T cells
-
Bour-Jordan H, Bluestone JA. Regulating the regulators: Costimulatory signals control the homeostasis and function of regulatory T cells. Immunol Rev. 2009;229(1): 41-66.
-
(2009)
Immunol Rev
, vol.229
, Issue.1
, pp. 41-66
-
-
Bour-Jordan, H.1
Bluestone, J.A.2
-
114
-
-
0141920662
-
Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells
-
Tang Q, et al. Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J Immunol. 2003;171(7): 3348.
-
(2003)
J Immunol
, vol.171
, Issue.7
, pp. 3348
-
-
Tang, Q.1
-
115
-
-
65549145814
-
Control of regulatory T cell lineage commitment and maintenance
-
Josefowicz SZ, Rudensky A. Control of regulatory T cell lineage commitment and maintenance. Immunity. 2009;30(5): 616-625.
-
(2009)
Immunity
, vol.30
, Issue.5
, pp. 616-625
-
-
Josefowicz, S.Z.1
Rudensky, A.2
-
116
-
-
79954486763
-
Regulatory T cells and Foxp3
-
Rudensky AY. Regulatory T cells and Foxp3. Immunol Rev. 2011;241(1): 260-268.
-
(2011)
Immunol Rev
, vol.241
, Issue.1
, pp. 260-268
-
-
Rudensky, A.Y.1
-
117
-
-
78650668123
-
Cutting edge: Mechanisms of IL-2-dependent maintenance of functional regulatory T cells
-
Barron L, et al. Cutting edge: Mechanisms of IL-2-dependent maintenance of functional regulatory T cells. J Immunol. 2010;185(11): 6426-6430.
-
(2010)
J Immunol
, vol.185
, Issue.11
, pp. 6426-6430
-
-
Barron, L.1
-
118
-
-
84908123494
-
Continuous requirement for the TCR in regulatory T cell function
-
Levine AG, Arvey A, Jin W, Rudensky AY. Continuous requirement for the TCR in regulatory T cell function. Nat Immunol. 2014;15(11): 1070-1078.
-
(2014)
Nat Immunol
, vol.15
, Issue.11
, pp. 1070-1078
-
-
Levine, A.G.1
Arvey, A.2
Jin, W.3
Rudensky, A.Y.4
-
119
-
-
79954559096
-
T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells
-
Cheng G, Yu A, Malek TR. T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells. Immunol Rev. 2011;241(1): 63-76.
-
(2011)
Immunol Rev
, vol.241
, Issue.1
, pp. 63-76
-
-
Cheng, G.1
Yu, A.2
Malek, T.R.3
-
120
-
-
34548755672
-
DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells
-
Baron U, et al. DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. Eur J Immunol. 2007;37(9): 2378-2389.
-
(2007)
Eur J Immunol
, vol.37
, Issue.9
, pp. 2378-2389
-
-
Baron, U.1
-
121
-
-
33846980131
-
Epigenetic control of the foxp3 locus in regulatory T cells
-
Floess S, et al. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol. 2007;5(2): E38.
-
(2007)
PLoS Biol
, vol.5
, Issue.2
, pp. e38
-
-
Floess, S.1
-
122
-
-
49649107703
-
DNA methylation controls Foxp3 gene expression
-
Polansky JK, et al. DNA methylation controls Foxp3 gene expression. Eur J Immunol. 2008;38(6): 1654-1663.
-
(2008)
Eur J Immunol
, vol.38
, Issue.6
, pp. 1654-1663
-
-
Polansky, J.K.1
-
123
-
-
84908403082
-
Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus
-
Feng Y, Arvey A, Chinen T, van der Veeken J, Gasteiger G, Rudensky AY. Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus. Cell. 2014;158(4): 749-763.
-
(2014)
Cell
, vol.158
, Issue.4
, pp. 749-763
-
-
Feng, Y.1
Arvey, A.2
Chinen, T.3
Van Der Veeken, J.4
Gasteiger, G.5
Rudensky, A.Y.6
-
124
-
-
84908401913
-
Function of a Foxp3 cis-element in protecting regulatory T cell identity
-
Li X, Liang Y, LeBlanc M, Benner C, Zheng Y. Function of a Foxp3 cis-element in protecting regulatory T cell identity. Cell. 2014;158(4): 734-748.
-
(2014)
Cell
, vol.158
, Issue.4
, pp. 734-748
-
-
Li, X.1
Liang, Y.2
LeBlanc, M.3
Benner, C.4
Zheng, Y.5
-
125
-
-
84868596823
-
Current and future immunomodulation strategies to restore tolerance in autoimmune diseases
-
Bluestone JA, Bour-Jordan H. Current and future immunomodulation strategies to restore tolerance in autoimmune diseases. Cold Spring Harb Perspect Biol. 2012;4(11): A007542.
-
(2012)
Cold Spring Harb Perspect Biol
, vol.4
, Issue.11
, pp. a007542
-
-
Bluestone, J.A.1
Bour-Jordan, H.2
-
126
-
-
33747448103
-
Mechanisms of antibody immunotherapy on clonal islet reactive T cells
-
van de Linde P, et al. Mechanisms of antibody immunotherapy on clonal islet reactive T cells. Hum Immunol. 2006;67(4): 264-273.
-
(2006)
Hum Immunol
, vol.67
, Issue.4
, pp. 264-273
-
-
Van De Linde, P.1
-
127
-
-
39449126502
-
The Foxp3+ regulatory T cell: A jack of all trades, master of regulation
-
Tang Q, Bluestone JA. The Foxp3+ regulatory T cell: A jack of all trades, master of regulation. Nat Immunol. 2008;9(3): 239-244.
-
(2008)
Nat Immunol
, vol.9
, Issue.3
, pp. 239-244
-
-
Tang, Q.1
Bluestone, J.A.2
-
128
-
-
84875432419
-
Type 1 diabetes: Translating mechanistic observations into effective clinical outcomes
-
Herold KC, Vignali DA, Cooke A, Bluestone JA. Type 1 diabetes: Translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol. 2013;13(4): 243-256.
-
(2013)
Nat Rev Immunol
, vol.13
, Issue.4
, pp. 243-256
-
-
Herold, K.C.1
Vignali, D.A.2
Cooke, A.3
Bluestone, J.A.4
-
129
-
-
85056050903
-
Polyclonal anti-T-cell therapy for type 1 diabetes mellitus of recent onset
-
Saudek F, Havrdova T, Boucek P, Karasova L, Novota P, Skibova J. Polyclonal anti-T-cell therapy for type 1 diabetes mellitus of recent onset. Rev Diabet Stud. 2004;1(2): 80-88.
-
(2004)
Rev Diabet Stud
, vol.1
, Issue.2
, pp. 80-88
-
-
Saudek, F.1
Havrdova, T.2
Boucek, P.3
Karasova, L.4
Novota, P.5
Skibova, J.6
-
130
-
-
40749153195
-
Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation
-
Simon G, et al. Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation. Diabetes. 2008;57(2): 405-414.
-
(2008)
Diabetes
, vol.57
, Issue.2
, pp. 405-414
-
-
Simon, G.1
-
131
-
-
43549114342
-
Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro
-
Feng X, et al. Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro. Blood. 2008;111(7): 3675-3683.
-
(2008)
Blood
, vol.111
, Issue.7
, pp. 3675-3683
-
-
Feng, X.1
-
132
-
-
33749259809
-
A novel mechanism of action for anti-thymocyte globulin: Induction of CD4+CD25+Foxp3+ regulatory T cells
-
Lopez M, Clarkson MR, Albin M, Sayegh MH, Najafian N. A novel mechanism of action for anti-thymocyte globulin: Induction of CD4+CD25+Foxp3+ regulatory T cells. J Am Soc Nephrol. 2006;17(10): 2844-2853.
-
(2006)
J Am Soc Nephrol
, vol.17
, Issue.10
, pp. 2844-2853
-
-
Lopez, M.1
Clarkson, M.R.2
Albin, M.3
Sayegh, M.H.4
Najafian, N.5
-
133
-
-
84887624109
-
Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial
-
Gitelman SE, et al. Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial. Lancet Diabetes Endocrinol. 2013;1(4): 306-316.
-
(2013)
Lancet Diabetes Endocrinol
, vol.1
, Issue.4
, pp. 306-316
-
-
Gitelman, S.E.1
-
134
-
-
84920413163
-
Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes
-
Haller MJ, et al. Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes. J Clin Invest. 2015;125(1): 448-455.
-
(2015)
J Clin Invest
, vol.125
, Issue.1
, pp. 448-455
-
-
Haller, M.J.1
-
135
-
-
49949152047
-
Recurrence of autoreactive antigen-specific CD4+ T cells in autoimmune diabetes after pancreas transplantation
-
Laughlin E, Burke G, Pugliese A, Falk B, Nepom G. Recurrence of autoreactive antigen-specific CD4+ T cells in autoimmune diabetes after pancreas transplantation. Clin Immunol. 2008;128(1): 23-30.
-
(2008)
Clin Immunol
, vol.128
, Issue.1
, pp. 23-30
-
-
Laughlin, E.1
Burke, G.2
Pugliese, A.3
Falk, B.4
Nepom, G.5
-
136
-
-
77951168859
-
Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells
-
Vendrame F, et al. Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells. Diabetes. 2010;59(4): 947-957.
-
(2010)
Diabetes
, vol.59
, Issue.4
, pp. 947-957
-
-
Vendrame, F.1
-
137
-
-
84890285333
-
Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation
-
Jones JL, et al. Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation. Proc Natl Acad Sci U S A. 2013;110(50): 20200-20205.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.50
, pp. 20200-20205
-
-
Jones, J.L.1
-
138
-
-
84880849711
-
Immune status following alemtuzumab treatment in human CD52 transgenic mice
-
Turner MJ, et al. Immune status following alemtuzumab treatment in human CD52 transgenic mice. J Neuroimmunol. 2013;261(1): 29-36.
-
(2013)
J Neuroimmunol
, vol.261
, Issue.1
, pp. 29-36
-
-
Turner, M.J.1
-
139
-
-
84890400796
-
Differential reconstitution of T cell subsets following immunodepleting treatment with alemtuzumab (anti-CD52 monoclonal antibody) in patients with relapsing-remitting multiple sclerosis
-
Zhang X, et al. Differential reconstitution of T cell subsets following immunodepleting treatment with alemtuzumab (anti-CD52 monoclonal antibody) in patients with relapsing-remitting multiple sclerosis. J Immunol. 2013;191(12): 5867-5874.
-
(2013)
J Immunol
, vol.191
, Issue.12
, pp. 5867-5874
-
-
Zhang, X.1
-
140
-
-
84921047834
-
Alemtuzumab in the treatment of multiple sclerosis: Key clinical trial results and considerations for use
-
Havrdova E, Horakova D, Kovarova I. Alemtuzumab in the treatment of multiple sclerosis: Key clinical trial results and considerations for use. Ther Adv Neurol Disord. 2015;8(1): 31-45.
-
(2015)
Ther Adv Neurol Disord
, vol.8
, Issue.1
, pp. 31-45
-
-
Havrdova, E.1
Horakova, D.2
Kovarova, I.3
-
141
-
-
34447329553
-
Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis
-
Chamian F, et al. Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis. J Transl Med. 2007;5: 27.
-
(2007)
J Transl Med
, vol.5
, pp. 27
-
-
Chamian, F.1
-
142
-
-
67650506103
-
Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates
-
Weaver TA, et al. Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates. Nat Med. 2009;15(7): 746-749.
-
(2009)
Nat Med
, vol.15
, Issue.7
, pp. 746-749
-
-
Weaver, T.A.1
-
143
-
-
0142182716
-
CD4+ T-cell-directed antibody responses are maintained in patients with psoriasis receiving alefacept: Results of a randomized study
-
Gottlieb AB, et al. CD4+ T-cell-directed antibody responses are maintained in patients with psoriasis receiving alefacept: Results of a randomized study. J Am Acad Dermatol. 2003;49(5): 816-825.
-
(2003)
J Am Acad Dermatol
, vol.49
, Issue.5
, pp. 816-825
-
-
Gottlieb, A.B.1
-
144
-
-
0038824717
-
Alefacept therapy produces remission for patients with chronic plaque psoriasis
-
Krueger GG, Ellis CN. Alefacept therapy produces remission for patients with chronic plaque psoriasis. Br J Dermatol. 2003;148(4): 784-788.
-
(2003)
Br J Dermatol
, vol.148
, Issue.4
, pp. 784-788
-
-
Krueger, G.G.1
Ellis, C.N.2
-
145
-
-
0035954670
-
Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes
-
Ellis CN, Krueger GG, Alefacept Clinical Study G. Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes. N Engl J Med. 2001;345(4): 248-255.
-
(2001)
N Engl J Med
, vol.345
, Issue.4
, pp. 248-255
-
-
Ellis, C.N.1
Krueger, G.G.2
-
146
-
-
84887621720
-
Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double- blind, placebo-controlled phase 2 trial
-
Rigby MR, et al. Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double- blind, placebo-controlled phase 2 trial. Lancet Diabetes Endocrinol. 2013;1(4): 284-294.
-
(2013)
Lancet Diabetes Endocrinol
, vol.1
, Issue.4
, pp. 284-294
-
-
Rigby, M.R.1
-
147
-
-
67649933375
-
Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years
-
Herold KC, et al. Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years. Clin Immunol. 2009;132(2): 166-173.
-
(2009)
Clin Immunol
, vol.132
, Issue.2
, pp. 166-173
-
-
Herold, K.C.1
-
148
-
-
84887052291
-
Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: Metabolic and immunologic features at baseline identify a subgroup of responders
-
Herold KC, et al. Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: Metabolic and immunologic features at baseline identify a subgroup of responders. Diabetes. 2013;62(11): 3766-3774.
-
(2013)
Diabetes
, vol.62
, Issue.11
, pp. 3766-3774
-
-
Herold, K.C.1
-
149
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
Herold KC, et al. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med. 2002;346(22): 1692-1698.
-
(2002)
N Engl J Med
, vol.346
, Issue.22
, pp. 1692-1698
-
-
Herold, K.C.1
-
150
-
-
20544443927
-
Insulin needs after CD3-Antibody therapy in new-onset type 1 diabetes
-
Keymeulen B, et al. Insulin needs after CD3-Antibody therapy in new-onset type 1 diabetes. N Engl J Med. 2005;352(25): 2598-2608.
-
(2005)
N Engl J Med
, vol.352
, Issue.25
, pp. 2598-2608
-
-
Keymeulen, B.1
-
151
-
-
0141796312
-
TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
-
Belghith M, Bluestone JA, Barriot S, Megret J, Bach JF, Chatenoud L. TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med. 2003;9(9): 1202-1208.
-
(2003)
Nat Med
, vol.9
, Issue.9
, pp. 1202-1208
-
-
Belghith, M.1
Bluestone, J.A.2
Barriot, S.3
Megret, J.4
Bach, J.F.5
Chatenoud, L.6
-
152
-
-
0037314237
-
Activation of human T cells by FcR nonbinding anti- CD3 mAb, hOKT3?1(Ala-Ala)
-
Herold KC, Burton JB, Francois F, Poumian- Ruiz E, Glandt M, Bluestone JA. Activation of human T cells by FcR nonbinding anti- CD3 mAb, hOKT3?1(Ala-Ala). J Clin Invest. 2003;111(3): 409-418.
-
(2003)
J Clin Invest
, vol.111
, Issue.3
, pp. 409-418
-
-
Herold, K.C.1
Burton, J.B.2
Francois, F.3
Poumian- Ruiz, E.4
Glandt, M.5
Bluestone, J.A.6
-
153
-
-
80051931752
-
Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells
-
Penaranda C, Tang Q, Bluestone JA. Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. J Immunol. 2011;187(4): 2015-2022.
-
(2011)
J Immunol
, vol.187
, Issue.4
, pp. 2015-2022
-
-
Penaranda, C.1
Tang, Q.2
Bluestone, J.A.3
-
154
-
-
33744990181
-
Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+CD25- LAP+ T cells
-
Ochi H, et al. Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+CD25- LAP+ T cells. Nat Med. 2006;12(6): 627-635.
-
(2006)
Nat Med
, vol.12
, Issue.6
, pp. 627-635
-
-
Ochi, H.1
-
155
-
-
85044009966
-
Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients
-
Waldron-Lynch F, et al. Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients. Sci Transl Med. 2012;4(118): 118ra112.
-
(2012)
Sci Transl Med
, vol.4
, Issue.118
, pp. 118ra112
-
-
Waldron-Lynch, F.1
-
156
-
-
0029033375
-
Reversal of acute experimental autoimmune encephalomyelitis and prevention of relapses by treatment with a myelin basic protein peptide analogue modified to form long-lived peptide-MHC complexes
-
Samson MF, Smilek DE. Reversal of acute experimental autoimmune encephalomyelitis and prevention of relapses by treatment with a myelin basic protein peptide analogue modified to form long-lived peptide-MHC complexes. J Immunol. 1995;155(5): 2737-2746.
-
(1995)
J Immunol
, vol.155
, Issue.5
, pp. 2737-2746
-
-
Samson, M.F.1
Smilek, D.E.2
-
157
-
-
0025995510
-
A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis
-
Smilek DE, Wraith DC, Hodgkinson S, Dwivedy S, Steinman L, McDevitt HO. A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 1991;88(21): 9633-9637.
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, Issue.21
, pp. 9633-9637
-
-
Smilek, D.E.1
Wraith, D.C.2
Hodgkinson, S.3
Dwivedy, S.4
Steinman, L.5
McDevitt, H.O.6
-
158
-
-
16144361909
-
Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice
-
Tian J, et al. Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice. Nat Med. 1996;2(12): 1348-1353.
-
(1996)
Nat Med
, vol.2
, Issue.12
, pp. 1348-1353
-
-
Tian, J.1
-
159
-
-
0025837184
-
Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin
-
Zhang ZJ, Davidson L, Eisenbarth G, Weiner HL. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc Natl Acad Sci U S A. 1991;88(22): 10252-10256.
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, Issue.22
, pp. 10252-10256
-
-
Zhang, Z.J.1
Davidson, L.2
Eisenbarth, G.3
Weiner, H.L.4
-
160
-
-
78651374710
-
GAD-Alum treatment induces GAD65-specific CD4+CD25highFOXP3+ cells in type 1 diabetic patients
-
Hjorth M, Axelsson S, Ryden A, Faresjo M, Ludvigsson J, Casas R. GAD-Alum treatment induces GAD65-specific CD4+CD25highFOXP3+ cells in type 1 diabetic patients. Clin Immunol. 2011;138(1): 117-126.
-
(2011)
Clin Immunol
, vol.138
, Issue.1
, pp. 117-126
-
-
Hjorth, M.1
Axelsson, S.2
Ryden, A.3
Faresjo, M.4
Ludvigsson, J.5
Casas, R.6
-
161
-
-
77952243765
-
Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy
-
Orban T, et al. Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy. J Autoimmun. 2010;34(4): 408-415.
-
(2010)
J Autoimmun
, vol.34
, Issue.4
, pp. 408-415
-
-
Orban, T.1
-
162
-
-
12144289938
-
Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis
-
Prakken BJ, et al. Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2004;101(12): 4228-4233.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.12
, pp. 4228-4233
-
-
Prakken, B.J.1
-
163
-
-
58149302798
-
Proinsulin peptide immunotherapy in type 1 diabetes: Report of a firstin- man Phase I safety study
-
Thrower SL, et al. Proinsulin peptide immunotherapy in type 1 diabetes: Report of a firstin- man Phase I safety study. Clin Exp Immunol. 2009;155(2): 156-165.
-
(2009)
Clin Exp Immunol
, vol.155
, Issue.2
, pp. 156-165
-
-
Thrower, S.L.1
-
164
-
-
0029760566
-
Prevention and treatment of relapsing autoimmune encephalomyelitis with myelin peptide-coupled splenocytes
-
Vandenbark AA, Vainiene M, Ariail K, Miller SD, Offner H. Prevention and treatment of relapsing autoimmune encephalomyelitis with myelin peptide-coupled splenocytes. J Neurosci Res. 1996;45(4): 430-438.
-
(1996)
J Neurosci Res
, vol.45
, Issue.4
, pp. 430-438
-
-
Vandenbark, A.A.1
Vainiene, M.2
Ariail, K.3
Miller, S.D.4
Offner, H.5
-
165
-
-
33751552197
-
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway
-
Fife BT, et al. Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway. J Exp Med. 2006;203(12): 2737-2747.
-
(2006)
J Exp Med
, vol.203
, Issue.12
, pp. 2737-2747
-
-
Fife, B.T.1
-
166
-
-
33846681640
-
Multi-peptide coupled-cell tolerance ameliorates ongoing relapsing EAE associated with multiple pathogenic autoreactivities
-
Smith CE, Miller SD. Multi-peptide coupled-cell tolerance ameliorates ongoing relapsing EAE associated with multiple pathogenic autoreactivities. J Autoimmunity. 2006;27(4): 218-231.
-
(2006)
J Autoimmunity
, vol.27
, Issue.4
, pp. 218-231
-
-
Smith, C.E.1
Miller, S.D.2
-
167
-
-
79953172219
-
Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach
-
Niens M, Grier AE, Marron M, Kay TW, Greiner DL, Serreze DV. Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach. Diabetes. 2011;60(4): 1229-1236.
-
(2011)
Diabetes
, vol.60
, Issue.4
, pp. 1229-1236
-
-
Niens, M.1
Grier, A.E.2
Marron, M.3
Kay, T.W.4
Greiner, D.L.5
Serreze, D.V.6
-
168
-
-
84880559839
-
Antigen-specific tolerance by autologous myelin peptide-coupled cells: A phase 1 trial in multiple sclerosis
-
Lutterotti A, et al. Antigen-specific tolerance by autologous myelin peptide-coupled cells: A phase 1 trial in multiple sclerosis. Sci Transl Med. 2013;5(188): 188ra175.
-
(2013)
Sci Transl Med
, vol.5
, Issue.188
, pp. 188ra175
-
-
Lutterotti, A.1
-
169
-
-
84878836808
-
Mechanism of oral tolerance induction to therapeutic proteins
-
Wang X, et al. Mechanism of oral tolerance induction to therapeutic proteins. Adv Drug Deliv Rev. 2013;65(6): 759-773.
-
(2013)
Adv Drug Deliv Rev
, vol.65
, Issue.6
, pp. 759-773
-
-
Wang, X.1
-
170
-
-
18144391496
-
Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial - Type 1
-
Skyler JS, et al. Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial - Type 1. Diabetes care. 2005;28(5): 1068-1076.
-
(2005)
Diabetes care
, vol.28
, Issue.5
, pp. 1068-1076
-
-
Skyler, J.S.1
-
171
-
-
84891488474
-
The IL-2/IL-2R system: From basic science to therapeutic applications to enhance immune regulation
-
Bayer AL, Pugliese A, Malek TR. The IL-2/IL-2R system: From basic science to therapeutic applications to enhance immune regulation. Immunol Res. 2013;57(1): 197-209.
-
(2013)
Immunol Res
, vol.57
, Issue.1
, pp. 197-209
-
-
Bayer, A.L.1
Pugliese, A.2
Malek, T.R.3
-
172
-
-
77956257716
-
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
-
Grinberg-Bleyer Y, et al. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med. 2010;207(9): 1871.
-
(2010)
J Exp Med
, vol.207
, Issue.9
, pp. 1871
-
-
Grinberg-Bleyer, Y.1
-
173
-
-
84887625676
-
Low-dose interleukin 2 in patients with type 1 diabetes: A phase 1/2 randomised, double-blind, placebo-controlled trial
-
Hartemann A, et al. Low-dose interleukin 2 in patients with type 1 diabetes: A phase 1/2 randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2013;1(4): 295-305.
-
(2013)
Lancet Diabetes Endocrinol
, vol.1
, Issue.4
, pp. 295-305
-
-
Hartemann, A.1
-
174
-
-
33645465526
-
Selective stimulation of T cell subsets with antibody-cytokine immune complexes
-
Boyman O, Kovar M, Rubinstein MP, Surh CD, Sprent J. Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science. 2006;311(5769): 1924-1927.
-
(2006)
Science
, vol.311
, Issue.5769
, pp. 1924-1927
-
-
Boyman, O.1
Kovar, M.2
Rubinstein, M.P.3
Surh, C.D.4
Sprent, J.5
-
175
-
-
84887343555
-
Limitations of IL-2 and rapamycin in immunotherapy of type 1 diabetes
-
Baeyens A, et al. Limitations of IL-2 and rapamycin in immunotherapy of type 1 diabetes. Diabetes. 2013;62(9): 3120-3131.
-
(2013)
Diabetes
, vol.62
, Issue.9
, pp. 3120-3131
-
-
Baeyens, A.1
-
176
-
-
20444373376
-
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
-
Battaglia M, Stabilini A, Roncarolo MG. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood. 2005;105(12): 4743-4748.
-
(2005)
Blood
, vol.105
, Issue.12
, pp. 4743-4748
-
-
Battaglia, M.1
Stabilini, A.2
Roncarolo, M.G.3
-
177
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe GM, et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity. 2009;30(6): 832-844.
-
(2009)
Immunity
, vol.30
, Issue.6
, pp. 832-844
-
-
Delgoffe, G.M.1
-
178
-
-
79952985551
-
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
-
Delgoffe GM, et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol. 2011;12(4): 295-303.
-
(2011)
Nat Immunol
, vol.12
, Issue.4
, pp. 295-303
-
-
Delgoffe, G.M.1
-
179
-
-
84865478468
-
Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs beta-cell function
-
Long SA, et al. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs beta-cell function. Diabetes. 2012;61(9): 2340-2348.
-
(2012)
Diabetes
, vol.61
, Issue.9
, pp. 2340-2348
-
-
Long, S.A.1
-
180
-
-
84862776988
-
Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
-
Levin AM, et al. Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Nature. 2012;484(7395): 529-533.
-
(2012)
Nature
, vol.484
, Issue.7395
, pp. 529-533
-
-
Levin, A.M.1
-
181
-
-
27944505913
-
Structure of the quaternary complex of interleukin-2 with its a, β, and ?c receptors
-
Wang X, Rickert M, Garcia KC. Structure of the quaternary complex of interleukin-2 with its a, β, and ?c receptors. Science. 2005;310(5751): 1159-1163.
-
(2005)
Science
, vol.310
, Issue.5751
, pp. 1159-1163
-
-
Wang, X.1
Rickert, M.2
Garcia, K.C.3
-
182
-
-
84887194102
-
Regulatory T-cell therapy in transplantation: Moving to the clinic
-
Tang Q, Bluestone JA. Regulatory T-cell therapy in transplantation: Moving to the clinic. Cold Spring Harb Perspect Med. 2013;3(11): A015552.
-
(2013)
Cold Spring Harb Perspect Med
, vol.3
, Issue.11
, pp. a015552
-
-
Tang, Q.1
Bluestone, J.A.2
-
183
-
-
5144222918
-
Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells
-
Bluestone JA, Tang Q. Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells. Proc Natl Acad Sci U S A. 2004;101(suppl 2): 14622-14626.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 14622-14626
-
-
Bluestone, J.A.1
Tang, Q.2
-
184
-
-
2942642383
-
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
-
Tang Q, et al. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med. 2004;199(11): 1455-1465.
-
(2004)
J Exp Med
, vol.199
, Issue.11
, pp. 1455-1465
-
-
Tang, Q.1
-
185
-
-
33746214867
-
Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells
-
Scalapino KJ, Tang Q, Bluestone JA, Bonyhadi ML, Daikh DI. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. J Immunol. 2006;177(3): 1451-1459.
-
(2006)
J Immunol
, vol.177
, Issue.3
, pp. 1451-1459
-
-
Scalapino, K.J.1
Tang, Q.2
Bluestone, J.A.3
Bonyhadi, M.L.4
Daikh, D.I.5
-
186
-
-
40449117736
-
In vitro expansion improves in vivo regulation by CD4+CD25+ regulatory T cells
-
Chai JG, Coe D, Chen D, Simpson E, Dyson J, Scott D. In vitro expansion improves in vivo regulation by CD4+CD25+ regulatory T cells. J Immunol. 2008;180(2): 858-869.
-
(2008)
J Immunol
, vol.180
, Issue.2
, pp. 858-869
-
-
Chai, J.G.1
Coe, D.2
Chen, D.3
Simpson, E.4
Dyson, J.5
Scott, D.6
-
187
-
-
84886786872
-
Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation
-
Putnam AL, et al. Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation. Am J Transplant. 2013;13(11): 3010-3020.
-
(2013)
Am J Transplant
, vol.13
, Issue.11
, pp. 3010-3020
-
-
Putnam, A.L.1
-
188
-
-
84899144218
-
Therapy of type 1 diabetes with CD4(+)CD25(high)CD127- regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up
-
Marek-Trzonkowska N, et al. Therapy of type 1 diabetes with CD4(+)CD25(high)CD127- regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up. Clin Immunol. 2014;153(1): 23-30.
-
(2014)
Clin Immunol
, vol.153
, Issue.1
, pp. 23-30
-
-
Marek-Trzonkowska, N.1
-
189
-
-
32644459908
-
Antigen-specific regulatory T cells - ex vivo expansion and therapeutic potential
-
Masteller EL, Tang Q, Bluestone JA. Antigen-specific regulatory T cells - ex vivo expansion and therapeutic potential. Semin Immunol. 2006;18(2): 103-110.
-
(2006)
Semin Immunol
, vol.18
, Issue.2
, pp. 103-110
-
-
Masteller, E.L.1
Tang, Q.2
Bluestone, J.A.3
-
190
-
-
14944371830
-
Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytes
-
Mekala DJ, Geiger TL. Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytes. Blood. 2005;105(5): 2090-2092.
-
(2005)
Blood
, vol.105
, Issue.5
, pp. 2090-2092
-
-
Mekala, D.J.1
Geiger, T.L.2
-
191
-
-
77955380678
-
Human antigen-specific regulatory T cells generated by T cell receptor gene transfer
-
Brusko TM, et al. Human antigen-specific regulatory T cells generated by T cell receptor gene transfer. PLoS One. 2010;5(7): E11726.
-
(2010)
PLoS One
, vol.5
, Issue.7
, pp. e11726
-
-
Brusko, T.M.1
-
192
-
-
65249120858
-
Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen- specific chimeric receptor
-
Elinav E, Adam N, Waks T, Eshhar Z. Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen- specific chimeric receptor. Gastroenterology. 2009;136(5): 1721-1731.
-
(2009)
Gastroenterology
, vol.136
, Issue.5
, pp. 1721-1731
-
-
Elinav, E.1
Adam, N.2
Waks, T.3
Eshhar, Z.4
-
193
-
-
70249108787
-
Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity
-
Hombach AA, Kofler D, Rappl G, Abken H. Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity. Gene Ther. 2009;16(9): 1088-1096.
-
(2009)
Gene Ther
, vol.16
, Issue.9
, pp. 1088-1096
-
-
Hombach, A.A.1
Kofler, D.2
Rappl, G.3
Abken, H.4
-
194
-
-
43749113383
-
Tolerance strategies for stem-cell-based therapies
-
Chidgey AP, Layton D, Trounson A, Boyd RL. Tolerance strategies for stem-cell-based therapies. Nature. 2008;453(7193): 330-337.
-
(2008)
Nature
, vol.453
, Issue.7193
, pp. 330-337
-
-
Chidgey, A.P.1
Layton, D.2
Trounson, A.3
Boyd, R.L.4
-
195
-
-
31044435204
-
Long-term acceptance of fully allogeneic cardiac grafts by cotransplantation of vascularized thymus in miniature swine
-
Nobori S, et al. Long-term acceptance of fully allogeneic cardiac grafts by cotransplantation of vascularized thymus in miniature swine. Transplantation. 2006;81(1): 26-35.
-
(2006)
Transplantation
, vol.81
, Issue.1
, pp. 26-35
-
-
Nobori, S.1
-
196
-
-
84881120386
-
Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development
-
Parent AV, et al. Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development. Cell Stem Cell. 2013;13(2): 219-229.
-
(2013)
Cell Stem Cell
, vol.13
, Issue.2
, pp. 219-229
-
-
Parent, A.V.1
-
197
-
-
84881123537
-
Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo
-
Sun X, et al. Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo. Cell Stem Cell. 2013;13(2): 230-236.
-
(2013)
Cell Stem Cell
, vol.13
, Issue.2
, pp. 230-236
-
-
Sun, X.1
-
198
-
-
41849151748
-
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
-
Kroon E, et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol. 2008;26(4): 443-452.
-
(2008)
Nat Biotechnol
, vol.26
, Issue.4
, pp. 443-452
-
-
Kroon, E.1
-
199
-
-
84924977469
-
Tolerance induction and reversal of diabetes in mice transplanted with human embryonic stem cell-derived pancreatic endoderm
-
Szot GL, et al. Tolerance induction and reversal of diabetes in mice transplanted with human embryonic stem cell-derived pancreatic endoderm. Cell Stem Cell. 2015;16(2): 148-157.
-
(2015)
Cell Stem Cell
, vol.16
, Issue.2
, pp. 148-157
-
-
Szot, G.L.1
-
200
-
-
84900462616
-
Restoring the balance: Immunotherapeutic combinations for autoimmune disease
-
Smilek DE, Ehlers MR, Nepom GT. Restoring the balance: Immunotherapeutic combinations for autoimmune disease. Dis Model Mech. 2014;7(5): 503-513.
-
(2014)
Dis Model Mech
, vol.7
, Issue.5
, pp. 503-513
-
-
Smilek, D.E.1
Ehlers, M.R.2
Nepom, G.T.3
|