Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice

Nature Medicine

Volumn 2, Issue 12, 1996, Pages 1348-1353

  Tian, Jide ^a   Clare Salzler, Michael ^b   Herschenfeld, Alan ^a   Middleton, Blake ^a   Newman, Douglas ^a   Mueller, Regula ^c   Arita, Seiji ^a   Evans, Christopher ^a   Atkinson, Mark A ^b   Mullen, Yoko ^a   Sarvetnick, Nora ^c   Tobin, Allan J ^a   Lehmann, Paul V ^d   Kaufman, Daniel L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE DECARBOXYLASE;

ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DIABETES MELLITUS; HELPER CELL; MOUSE; MOUSE STRAIN; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ADOPTIVE TRANSFER; ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; DIABETES MELLITUS, TYPE 1; DISEASE PROGRESSION; FEMALE; GLUTAMATE DECARBOXYLASE; GRAFT SURVIVAL; INTERFERON TYPE II; INTERLEUKIN-4; INTERLEUKIN-5; ISLETS OF LANGERHANS TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED NOD; PANCREATIN; SELF TOLERANCE; SPLEEN; TH1 CELLS; TH2 CELLS;

ANIMALIA;

EID: 16144361909     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1296-1348     Document Type: Article

References (29)

1. Castano, L. & Eisenbarth, G.S. Type I-diabetes: A chronic autoimmune disease of human, mouse and rat. Annu. Rev. Immunol. 8, 647-679 (1990).
2. Rossini, A.A., Greiner, D.L., Friedman, H.P. & Mordes, J.P. Immunopathogenesis of diabetes mellitus. Diabetes Rev. 1, 43-75 (1993).
3. Bach, J.F. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr. Rev. 15, 516-542 (1994).
4. Kaufman, D.L. et al. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366, 69-72 (1993).
5. Tisch, R. et al. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366, 72-75 (1993)
6. Baekkeskov, S. et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 347, 151-156 (1990).
7. Palmer, J.P. Predicting IDDM: Use of humoral immune markers. Diabetes Rev. 1, 104-115 (1993).
8. Zamvil, S.S. & Steinman, L. The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 8, 579-621 (1990).
9. Fairchild, P.J., Thorpe, C.J., Travers, P.J. & Wraith, D.C. Modulation of the immune response with T-cell epitopes: The ultimate goal for specific immunotherapy of autoimmune disease. Immunology 81, 487-196 (1994).
10. Mosmann, T.R. & Coffman, R.L. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7, 145-173 (1989).
11. Tisch, R. & McDevitt, HO. Antigen-specific immunotherapy: Is it a real possibility to combat T-cell-mediated autoimmunity? Proc. Natl. Acad. Sci. USA 91, 437-438 (1994).
12. Rabinovitch, A. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation? Diabetes 43, 613-621 (1994).
13. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16, 34-38 (1995).
14. Lacy, P.E. Status of islet cell transplantation. Diabetes Rev. 1, 76-92 (1993).
15. Sutherland, D.E.R. Pancreatic transplantation. Diabetes Rev. 1, 152-165 (1993).
16. Forsthuber, T., Yip, H.C. & Lehmann, P.V. Induction of Th1 and Th2 immunity in neonatal mice. Science 271, 1728-1730 (1996).
17. Rapoport, M.J. et al. Interleukin 4 reverses T-cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med. 178, 87-99 (1993).
18. Elias, D. & Cohen, I.R. Peptide therapy for diabetes in NOD mice. Lancet 343, 704-706 (1994).
19. Elliott, J.F. et al. Immunization with the larger isoform of mouse glutamic acid decarboxylase (GAD67) prevents autoimmune diabetes in NOD mice. Diabetes 43, 1494-1499 (1994).
20. Pleau, J.M., Fernandez-Saravia, F., Esling, A., Homo-Delarche, F. & Dardenne, M. Prevention of autoimmune diabetes in nonobese diabetic female mice by treatment with recombinant glutamic acid decarboxylase (GAD65). Clin. Immunol. Immunopathol. 76, 90-95 (1995).
21. Muir, A. et al. Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-γ transcription. J. Clin. Invest. 95, 628-634 (1995).
22. Daniel, D. & Wegmann, D.R. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc. Nat. Acad. Sci. USA 93, 956-960 (1996).
23. Harrison, L.C. et al. Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes. Lancet 341, 1365-1369 (1993).
24. Thai, A-C. & Eisenbarth, G.S. Natural history of IDDM. Diabetes Rev. 1, 1-14 (1993).
25. Tian, J. et al. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J. Exp. Med. 183, 1561-1567 (1996).
26. Lee, D.S., Tian, J., Phan, T. & Kaufman, D.L. Cloning and sequence analysis of a murine cDNA encoding glutamate decarboxylase (GAD65). Biochem. Biophys. Acta 1216, 157-160 (1993).
27. Wicker, L.S., Miller, B.J. & Mullen, Y. Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes 35, 855-860 (1986).
28. Ramsdell, F. & Fowlkes, B.J. Maintenance of in vivo tolerance by persistence of antigen. Science 257, 1130-1134 (1992).
29. Qin, H.Y., Sadelain, M.W., Hitchon, C., Lauzon, J. & Singh, B. Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice. J. Immunol. 150, 2072-2080 (1993).