Regulatory T cells: Stability revisited

Trends in Immunology

Volumn 32, Issue 7, 2011, Pages 301-306

  Bailey Bucktrout, Samantha L ^a   Bluestone, Jeffrey A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FORKHEAD TRANSCRIPTION FACTOR; INTERLEUKIN 2; TRANSCRIPTION FACTOR FOXP3;

AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL THERAPY; DISEASE COURSE; GRAFT VERSUS HOST REACTION; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; LYMPHOCYTE SUBPOPULATION; NONHUMAN; REGULATORY T LYMPHOCYTE; REVIEW;

ANIMALS; AUTOIMMUNE DISEASES; CELL DIFFERENTIATION; HUMANS; INFLAMMATION; T-LYMPHOCYTES, REGULATORY;

EID: 80955178941     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2011.04.002     Document Type: Review

References (51)

1. Sakaguchi S., et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25) Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995, 155:1151-1164.
2. Asano M., et al. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 1996, 184:387-396.
3. Baecher-Allan C., et al. CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo. Novartis Found Symp. 2003, 252:67-88. discussion 88-91, 106-114.
4. Brunkow M.E., et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 2001, 27:68-73.
5. Fontenot J.D., et al. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 2003, 4:330-336.
6. Hori S., et al. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061.
7. Khattri R., et al. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 2003, 4:337-342.
8. Brusko T.M., et al. Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunol. Rev. 2008, 223:371-390.
9. Bennett C.L., et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 2001, 27:20-21.
10. Wildin R.S., et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat. Genet. 2001, 27:18-20.
11. Pillai V., et al. Transient regulatory T-cells: a state attained by all activated human T-cells. Clin. Immunol. 2007, 123:18-29.
12. Tran D.Q., et al. Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood 2007, 110:2983-2990.
13. Huehn J., et al. Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?. Nat. Rev. Immunol. 2009, 9:83-89.
14. Zheng Y., et al. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 2010, 463:808-812.
15. Miyara M., et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 2009, 30:899-911.
16. Hsieh C.S., et al. Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity 2004, 21:267-277.
17. Zhou X., et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat. Immunol. 2009, 10:1000-1007.
18. Rubtsov Y.P., et al. Stability of the regulatory T cell lineage in vivo. Science 2010, 329:1667-1671.
19. Murai M., et al. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat. Immunol. 2009, 10:1178-1184.
20. Zhou X., et al. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J. Exp. Med. 2008, 205:1983-1991.
21. Rubtsov Y.P., et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 2008, 28:546-558.
22. Wing K., et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008, 322:271-275.
23. Srinivas S., et al. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 2001, 1:4.
24. Luche H., et al. Faithful activation of an extra-bright red fluorescent protein in " knock-in" Cre-reporter mice ideally suited for lineage tracing studies. Eur J. Immunol. 2007, 37:43-53.
25. Sakaguchi S., et al. FOXP3+ regulatory T cells in the human immune system. Nat. Rev. Immunol. 2010, 10:490-500.
26. Schmidt-Supprian M., Rajewsky K. Vagaries of conditional gene targeting. Nat. Immunol. 2007, 8:665-668.
27. Loonstra A., et al. Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:9209-9214.
28. Thornton A.M., et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J. Immunol. 2010, 184:3433-3441.
29. Feuerer M., et al. Genomic definition of multiple ex vivo regulatory T cell subphenotypes. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:5919-5924.
30. Yang X.O., et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 2008, 29:44-56.
31. Yang X.O., et al. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 2007, 282:9358-9363.
32. Ghoreschi K., et al. Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling. Nature 2010, 467:967-971.
33. Pasare C., Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003, 299:1033-1036.
34. Xu L., et al. Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J. Immunol. 2007, 178:6725-6729.
35. Sharma M.D., et al. Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice. Immunity 2010, 33:942-954.
36. Chaudhry A., et al. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 2009, 326:986-991.
37. Wan Y.Y., Flavell R.A. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 2007, 445:766-770.
38. Tang Q., et al. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 2008, 28:687-697.
39. Setoguchi R., et al. Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 2005, 201:723-735.
40. Yamanouchi J., et al. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat. Genet. 2007, 39:329-337.
41. Oldenhove G., et al. Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity 2009, 31:772-786.
42. McClymont S.A., et al. Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J. Immunol. 2011, 186:3918-3926.
43. Komatsu N., et al. Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:1903-1908.
44. Tsuji M., et al. Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science 2009, 323:1488-1492.
45. Duarte J.H., et al. Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions. Eur J. Immunol. 2009, 39:948-955.
46. Almeida A.R., et al. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J. Immunol. 2002, 169:4850-4860.
47. Grinberg-Bleyer Y., et al. Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs. J. Clin. Invest. 2010, 120:4558-4568.
48. Brunstein C.G., et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011, 117:1061-1070.
49. Belkaid Y., Tarbell K. Regulatory T cells in the control of host-microorganism interactions (*). Annu. Rev. Immunol. 2009, 27:551-589.
50. Grainger J.R., et al. Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-beta pathway. J. Exp. Med. 2010, 207:2331-2341.
51. Kohm A.P., et al. Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J. Immunol. 2002, 169:4712-4716.