Prevention and treatment of relapsing autoimmune encephalomyelitis with myelin peptide-coupled splenocytes

Journal of Neuroscience Research

Volumn 45, Issue 4, 1996, Pages 430-438

  Vandenbark, Arthur A ^a,b,c   Vainiene, M ^a,b   Ariail, K ^a   Miller, S D ^d   Offner, H ^a,b  

^a PORTLAND VA MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

autoimmunity; encephalomyelitis; mice; neuroantigens; T cells; tolerance

Indexed keywords

MYELIN PROTEIN;

ACCESSORY CELL; ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; CROSS LINKING; DRUG EFFECT; GENE INDUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RELAPSE; SPLEEN CELL;

AMINO ACID SEQUENCE; ANIMALS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPITOPES; FEMALE; IMMUNE TOLERANCE; IMMUNIZATION; LYMPH NODES; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; MYELIN PROTEINS; MYELIN PROTEOLIPID PROTEIN; PEPTIDE FRAGMENTS; RECURRENCE; SPLEEN; T-LYMPHOCYTES; TIME FACTORS;

EID: 0029760566     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960815)45:4<430::AID-JNR12>3.0.CO;2-4     Document Type: Article

References (42)

1. Bourdette DN, Vandenbark AA, Meshul C, Whitham R, Offner H (1988): Basic protein specific T cell lines that induce experimental autoimmune encephalomyelitis in SJL/J mice: comparison with Lewis rat lines. Cell Immunol 112:351-363.
2. Brown AM, McFarlin DE (1981): Relapsing experimental allergic encephalomyelitis in the SJL/J mouse. Lab Invest 45:278-284.
3. Cross AH, Tuohy VK Raine CS (1993): Development of reactivity to new myelin antigens during chronic relapsing autoimmune demyelination. Cell Immunol 146:261-269.
4. Eylar EH, Brostoff SW, Hashim GA, Caccam J, Bernett P (1971): Basic Al protein of the myelin membrane: the complete amino acid sequence. J Biol Chem 246:5770-5784.
5. Fritz RB, Chou CH, McFarlin DE (1983): Induction of experimental allergic encephalomyelitis in PL/J and (SJL/J × PL/J)F1 mice by myelin basic protein and its peptides: localization of a second encephalitogenic determinant. J Immunol 130:191-194.
6. Fritz RB, Skeen MJ, Chou CH, Zamvil SS (1990): Localization of an encephalitogenic epitope for the SJL mouse in the N-terminal region of myelin basic protein. J Neuroimmunol 26:239-243.
7. Greer JM, Kuchroo VK, Sobel RA, Lees MJ (1992): Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice. J Immunol 149:783-788.
8. Gregorian SK, Clark L, Heber-Katz E, Amento EP, Rostami A (1993): Induction of peripheral tolerance with peptide-specific anergy in experimental autoimmune neuritis. Cell Immunol 150:298-310.
9. Gregorian SK, Rostami A (1994): Delayed-type hypersensitivity response in experimental autoimmune neuritis treated with peptide-coupled spleen cells. J Neuroimmunol 51:69-75.
10. Jenkins MK, Schwartz RH (1987): Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med 165:302-319.
11. + Th 1 but not Th2 cytokine responses. Int Immunol 6:721-730.
12. Kennedy MK, Tan L-J, Dal Canto MC, Miller SD (1990a): Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction. J Immunol 145:117-126.
13. Kennedy MK, Tan L-J, Dal Canto MC, Tuohy VK, Lu Z, Trotter JL, Miller SD (1990b): Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides. J Immunol 144:909-915.
14. Kono DH, Urban JL, Horvath SL, Ando DG, Suavedra RA, Hood L (1988): Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice. J Exp Med 168:213-227.
15. Lehmann PV, Forsthuber T, Miller A, Sercarz EE (1992): Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358:155-157.
16. Malotky MKH, Pope L, Miller SD (1994): Epitope and functional specificity of peripheral tolerance induction in experimental autoimmune encephalomyelitis in adult Lewis rats. J Immunol 153:841-851.
17. McCarron RM, Fallis RJ, McFarlin DE (1990): Alterations in T cell antigen specificity and class II restriction during the course of chronic relapsing experimental allergic encephalomyelitis. J Neuroimmunol 29:73-79.
18. McKenna R, Carter B, Paterson J, Sehon A (1983): The suppression of EAE in Lewis rats by treatment with myelin basic protein-cell conjugates. Cell Immunol 81:391-402.
19. McKenna RM, Carter BG, Sehon AH (1984): Studies on the mechanism of suppression of experimental allergic encephalomyelitis induced by myelin basic protein-cell conjugates. Cell Immunol 88:251-259.
20. McRae BL, Vanderlugt CL, Dal Canto MC, Miller SD (1995): Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. J Exp Med 182:75-85.
21. Miller SD, Wetzig RP, Claman HN (1979): The induction of cell-mediated immunity and tolerance with protein antigens coupled to syngeneic lymphoid cells. J Exp Med 149:758-773.
22. Miller SD, Tan L-J, Pope L, McRae BL, Karpus WJ (1992): Antigen-specific tolerance as a therapy for experimental autoimmune encephalomyelitis. Int Rev Immunol 9:203-222.
23. Miller SD, Karpus WJ (1994): The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases. Immunol Today 15:356-361.
24. Miller SD, McRae BL, Vanderlugt CL, Nikcevich KM, Pope JG, Pope L, Karpus WJ (1995a): Evolution of the T-cell repertoire during the course of experimental immune-mediated demyelinating diseases. Immunol Rev 144:225-244.
25. Miller SD, Vanderlugt CL, Lenschow DJ, Pope JG, Karandikar NJ, Dal Canto MC, Bluestone JA (1995b): Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity 3:739-745.
26. Mokhtarian F, McFarlin DE, Raine CS (1984): Adoptive transfer of myelin basic protein-sensitized T cell produces chronic relapsing demyelinating disease in mice. Nature 309:356-358.
27. Paterson PY, Swanborg RH (1988): Demyelinating diseases of the central and peripheral nervous systems. In Sampler M, Talmage DW, Frank MM, Austen KF, Claman HN (eds): "Immunological Diseases." Boston: Little, Brown & Co., pp 1877-1916.
28. Perry LL, Barzaga-Gilbert E, Trotter JL (1991): T cell sensitization to proteolipid protein in myelin basic protein-induced experimental allergic encephalomyelitis. J Neuroimmunol 33:7-16.
29. Peterson JD, Karpus WJ, Clatch RJ, Miller SD (1993): Split tolerance to TH1 and TH2 cells in tolerance to Theiler's murine encephalomyelitis virus. Eur J Immunol 23:46-55.
30. Pope L, Paterson PY, Miller SD (1992): Antigen-specific inhibition of the adoptive transfer of experimental autoimmune encephalomyelitis in Lewis rats. J Neuroimmunol 37:177-190.
31. Sakai K, Zamvil SS, Mitchell DJ, Lira M, Rothbard JB, Steinman L (1988): Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein. J Neuroimmunol 19:21-32.
32. Schwartz RH (1992): Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71:1065-1068.
33. Strejan GH, St. Louis J (1990): Suppression of experimental allergic encephalomyelitis by MBP-coupled lymphoid cells and by MBP-liposomes: a comparison. Cell Immunol 127:284-298.
34. Tan L-J, Kennedy MK, Dal Canto MC, Miller SD (1991): Successful treatment of paralytic relapses in EAE via neuroantigen-specific tolerance. J Immunol 147:1797-1802.
35. Tan L-J, Kennedy MK, Miller SD (1992): Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction: II. Fine specificity of effector T cell inhibition. J Immunol 148:2748-2755.
36. Tuohy VK, Lu Z, Sobel RA, Laursen RA, Lees MB (1989): Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J Immunol 142:1523-1527.
37. Tuohy VK, Thomas DM (1993): A third encephalitogenic determinant of myelin proteolipid protein (PLP) for SJL/J mice. J Immunol 150:194(Abstr).
38. Vandenbark AA, Vainiene M, Celnik B, Hashim GA, Buenafe A, Offner H (1994): Definition of encephalitogenic and immunodominant epitopes of guinea pig myelin basic protein (Gp-BP) in Lewis rats tolerized neonatally with Gp-BP or Gp-BP peptides. J Immunol 153:852-861.
39. Vandenbark AA, Celnik B, Vainiene M, Miller SD, Offner H (1995): Myelin antigen-coupled splenocytes suppress experimental autoimmune encephalomyelitis in Lewis rats through a partially reversible anergy mechanism. J Immunol 155:5861-5867.
40. Whitham RH, Bourdette DN, Hashim GA, Herndon RM, Ilg RO, Vandenbark AA, Offner H (1991a): Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis. J Immunol 146: 101-107.
41. Whitham RH, Jones RE, Hashim GA, Hoy CM, Wang R-Y, Vandenbark AA, Offner H (1991b): Location of a new encephalitogenic epitope (residues 43-64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL×PL)Fl mice. J Immunol 147:3803-3808.
42. Zamvil SS, Mitchell DJ, Powell MB, Sakai K, Rothbard JB, Steinman L (1988): Multiple discrete encephalitogenic epitopes of the autoantigen myelin basic protein include a determinant for I-E class II-restricted T cells. J Exp Med 168:1181-1186.