-
1
-
-
84904999040
-
Histone-acetylation: A link between Alzheimer’s disease and post-traumatic stress disorder?
-
Bahari-Javan S, Sananbenesi F, Fischer A. (2014) Histone-acetylation: a link between Alzheimer’s disease and post-traumatic stress disorder? Front. Neurosci. 8:160
-
(2014)
Front. Neurosci
, vol.8
-
-
Bahari-Javan, S.1
Sananbenesi, F.2
Fischer, A.3
-
2
-
-
84908217408
-
The role of dietary histone deacetylases (HDACs) inhibitors in health and disease
-
Bassett SA, Barnett MP. (2014) The role of dietary histone deacetylases (HDACs) inhibitors in health and disease. Nutrients. 6:4273–301
-
(2014)
Nutrients
, vol.6
, pp. 4273-4301
-
-
Bassett, S.A.1
Barnett, M.P.2
-
3
-
-
84874643841
-
Involvement of p300/CBP and epigenetic histone acetylation in TGF-beta1- mediated gene transcription in mesangial cells
-
Yuan H, et al. (2013) Involvement of p300/CBP and epigenetic histone acetylation in TGF-beta1- mediated gene transcription in mesangial cells. Am. J. Physiol. Renal. Physiol. 304:F601–13
-
(2013)
Am. J. Physiol. Renal. Physiol
, vol.304
, pp. F601-F613
-
-
Yuan, H.1
-
4
-
-
84907998067
-
Novel role of silent information regulator 1 in acute endothelial cell oxidative stress injury
-
Li Y, et al. (2014) Novel role of silent information regulator 1 in acute endothelial cell oxidative stress injury. Biochim. Biophys. Acta. 1842:2246–56
-
(2014)
Biochim. Biophys. Acta
, vol.1842
, pp. 2246-2256
-
-
Li, Y.1
-
5
-
-
84900428277
-
High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy
-
Bugyei-Twum A, et al. (2014) High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy. Cardiovasc. Diabetol. 13:89
-
(2014)
Cardiovasc. Diabetol
, vol.13
-
-
Bugyei-Twum, A.1
-
6
-
-
84907428509
-
Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells
-
Hwang YJ, Song J, Kim HR, Hwang KA. (2014) Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells. BMB Rep. 47:524–9
-
(2014)
BMB Rep
, vol.47
, pp. 524-529
-
-
Hwang, Y.J.1
Song, J.2
Kim, H.R.3
Hwang, K.A.4
-
7
-
-
34547431097
-
Histone deacetylase inhibitors: A novel class of therapeutic agents in diabetic nephropathy
-
Lee HB, Noh H, Seo JY, Yu MR, Ha H. (2007) Histone deacetylase inhibitors: a novel class of therapeutic agents in diabetic nephropathy. Kidney Int. S61–6
-
(2007)
Kidney Int
-
-
Lee, H.B.1
Noh, H.2
Seo, J.Y.3
Yu, M.R.4
Ha, H.5
-
8
-
-
84555195156
-
Nutrient sensing, autophagy, and diabetic nephropathy
-
Kume S, Thomas MC, Koya D. (2012) Nutrient sensing, autophagy, and diabetic nephropathy. Diabetes. 61:23–9
-
(2012)
Diabetes
, vol.61
, pp. 23-29
-
-
Kume, S.1
Thomas, M.C.2
Koya, D.3
-
9
-
-
26244436281
-
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
-
Michishita E, Park JY, Burneskis JM, Barrett JC, Horikawa I. (2005) Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Biol. Cell. 16:4623–35
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 4623-4635
-
-
Michishita, E.1
Park, J.Y.2
Burneskis, J.M.3
Barrett, J.C.4
Horikawa, I.5
-
10
-
-
84870942679
-
Negative regulation of inflammation by SIRT1. Pharmacol
-
Xie J, Zhang X, Zhang L. (2013) Negative regulation of inflammation by SIRT1. Pharmacol. Res. 67:60–7
-
(2013)
Res
, vol.67
, pp. 60-67
-
-
Xie, J.1
Zhang, X.2
Zhang, L.3
-
11
-
-
24344466882
-
DNA methylation and histone modifications: Teaming up to silence genes
-
Fuks F. (2005) DNA methylation and histone modifications: teaming up to silence genes. Curr. Opin. Genet. Dev. 15:490–5
-
(2005)
Curr. Opin. Genet. Dev
, vol.15
, pp. 490-495
-
-
Fuks, F.1
-
12
-
-
84887415137
-
Renal tubular SIRT1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes
-
Hasegawa K, et al. (2013) Renal tubular SIRT1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. Nat. Med. 19:1496–504
-
(2013)
Nat. Med
, vol.19
, pp. 1496-1504
-
-
Hasegawa, K.1
-
13
-
-
0034632829
-
Regulation of chromatin structure by site-specific histone H3 methyltransferases
-
Rea S, et al. (2000) Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature. 406:593–9
-
(2000)
Nature
, vol.406
, pp. 593-599
-
-
Rea, S.1
-
14
-
-
27644589675
-
The diverse functions of histone lysine methylation
-
Martin C, Zhang Y. (2005) The diverse functions of histone lysine methylation. Nat. Rev. Mol. Cell. Biol. 6:838–49
-
(2005)
Nat. Rev. Mol. Cell. Biol
, vol.6
, pp. 838-849
-
-
Martin, C.1
Zhang, Y.2
-
15
-
-
0035913903
-
HSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
-
Vaziri H, et al. (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell. 107:149–59
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
-
16
-
-
3242719545
-
Modulation of NF-kappaBdependent transcription and cell survival by the SIRT1 deacetylase
-
Yeung F, et al. (2004) Modulation of NF-kappaBdependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23:2369–80
-
(2004)
EMBO J
, vol.23
, pp. 2369-2380
-
-
Yeung, F.1
-
17
-
-
38649092744
-
Regulation of protein turnover by acetyltransferases and deacetylases
-
Sadoul K, Boyault C, Pabion M, Khochbin S. (2008) Regulation of protein turnover by acetyltransferases and deacetylases. Biochimie. 90:306–12
-
(2008)
Biochimie
, vol.90
, pp. 306-312
-
-
Sadoul, K.1
Boyault, C.2
Pabion, M.3
Khochbin, S.4
-
20
-
-
84897811327
-
Resveratrol prevention of diabetic nephropathy is associated with the suppression of renal inflammation and mesangial cell proliferation: Possible roles of Akt/NF-kappaB pathway
-
Xu F, et al. (2014) Resveratrol prevention of diabetic nephropathy is associated with the suppression of renal inflammation and mesangial cell proliferation: possible roles of Akt/NF-kappaB pathway. Int. J. Endocrinol. 2014:289327
-
(2014)
Int. J. Endocrinol
-
-
Xu, F.1
-
21
-
-
84891621483
-
Resveratrol attenuates diabetic nephropathy via modulating angiogenesis
-
Wen D, et al. (2013) Resveratrol attenuates diabetic nephropathy via modulating angiogenesis. PLoS One.8:e82336
-
(2013)
Plos One
, vol.8
-
-
Wen, D.1
-
22
-
-
84919667875
-
Amelioration of streptozotocininduced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats
-
Elbe H, et al. (2015) Amelioration of streptozotocininduced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats. Hum. Exp. Toxicol. 34:100–13
-
(2015)
Hum. Exp. Toxicol
, vol.34
, pp. 100-113
-
-
Elbe, H.1
-
23
-
-
84884519280
-
SIRT1 resists advanced glycation end products-induced expressions of fibronectin and TGF-beta1 by activating the Nrf2/ARE pathway in glomerular mesangial cells
-
Huang K, et al. (2013) SIRT1 resists advanced glycation end products-induced expressions of fibronectin and TGF-beta1 by activating the Nrf2/ARE pathway in glomerular mesangial cells. Free Radic. Biol. Med. 65:528–40
-
(2013)
Free Radic. Biol. Med
, vol.65
, pp. 528-540
-
-
Huang, K.1
-
24
-
-
84902523833
-
SIRT1 deletion leads to enhanced inflammation and aggravates endotoxininduced acute kidney injury
-
Gao R, et al. (2014) SIRT1 deletion leads to enhanced inflammation and aggravates endotoxininduced acute kidney injury. PLoS One. 9:e98909
-
(2014)
Plos One
, vol.9
-
-
Gao, R.1
-
25
-
-
33644783770
-
Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy
-
Susztak K, Raff AC, Schiffer M, Bottinger EP. (2006) Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes. 55:225–33
-
(2006)
Diabetes
, vol.55
, pp. 225-233
-
-
Susztak, K.1
Raff, A.C.2
Schiffer, M.3
Bottinger, E.P.4
-
26
-
-
15744400877
-
Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy
-
Susztak K, Ciccone E, McCue P, Sharma K, Bottinger EP. (2005) Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy. PLoS Med. 2:e45
-
(2005)
Plos Med
, vol.2
-
-
Susztak, K.1
Ciccone, E.2
McCue, P.3
Sharma, K.4
Bottinger, E.P.5
-
27
-
-
84867394203
-
Can we target tubular damage to prevent renal function decline in diabetes?
-
Bonventre JV. (2012) Can we target tubular damage to prevent renal function decline in diabetes? Semin. Nephrol. 32:452–62
-
(2012)
Semin. Nephrol
, vol.32
, pp. 452-462
-
-
Bonventre, J.V.1
-
28
-
-
77649099572
-
De novo expression of podocyte proteins in parietal epithelial cells during experimental glomerular disease
-
Ohse T, et al. (2010) De novo expression of podocyte proteins in parietal epithelial cells during experimental glomerular disease. Am. J. Physiol. Renal Physiol. 298:F702–11
-
(2010)
Am. J. Physiol. Renal Physiol
, vol.298
, pp. F702-F711
-
-
Ohse, T.1
-
29
-
-
84863229342
-
De novo expression of podocyte proteins in parietal epithelial cells in experimental aging nephropathy
-
Zhang J, et al. (2012) De novo expression of podocyte proteins in parietal epithelial cells in experimental aging nephropathy. Am. J. Physiol. Renal Physiol. 302:F571–80
-
(2012)
Am. J. Physiol. Renal Physiol
, vol.302
-
-
Zhang, J.1
-
30
-
-
84901045119
-
Expression of tight junction protein claudin-1 in human crescentic glomerulonephritis
-
Koda R, et al. (2014) Expression of tight junction protein claudin-1 in human crescentic glomerulonephritis. Int. J. Nephrol. 2014:598670
-
(2014)
Int. J. Nephrol
-
-
Koda, R.1
-
31
-
-
84924026400
-
Tamoxifen ameliorates renal tubulointerstitial fibrosis by modulation of estrogen receptor alpha-mediated transforming growth factor-beta1/Smad signaling pathway
-
Kim D, et al. (2014) Tamoxifen ameliorates renal tubulointerstitial fibrosis by modulation of estrogen receptor alpha-mediated transforming growth factor-beta1/Smad signaling pathway. Nephrol. Dial. Transplant. 29:2043–53
-
(2014)
Nephrol. Dial. Transplant
, vol.29
, pp. 2043-2053
-
-
Kim, D.1
-
32
-
-
84884805852
-
Knockdown of thioredoxininteracting protein ameliorates high glucoseinduced epithelial to mesenchymal transition in renal tubular epithelial cells
-
Wei J, et al. (2013) Knockdown of thioredoxininteracting protein ameliorates high glucoseinduced epithelial to mesenchymal transition in renal tubular epithelial cells. Cell Signal. 25:2788–96
-
(2013)
Cell Signal
, vol.25
, pp. 2788-2796
-
-
Wei, J.1
-
33
-
-
84892616097
-
Upregulation of mitochondrial Nox4 mediates TGF-beta-induced apoptosis in cultured mouse podocytes
-
Das R, et al. (2014) Upregulation of mitochondrial Nox4 mediates TGF-beta-induced apoptosis in cultured mouse podocytes. Am. J. Physiol. Renal Physiol. 306:F155–67
-
(2014)
Am. J. Physiol. Renal Physiol
, vol.306
, pp. F155-F167
-
-
Das, R.1
-
34
-
-
84882727355
-
Induction of renal fibrotic genes by TGF-beta1 requires EGFR activation, p53 and reactive oxygen species
-
Samarakoon R, et al. (2013) Induction of renal fibrotic genes by TGF-beta1 requires EGFR activation, p53 and reactive oxygen species. Cell Signal. 25:2198–209
-
(2013)
Cell Signal
, vol.25
, pp. 2198-2209
-
-
Samarakoon, R.1
-
35
-
-
48249109924
-
The role of the TGF/Smad signaling pathway in peritoneal fibrosis induced by peritoneal dialysis solutions
-
Yao Q, et al. (2008) The role of the TGF/Smad signaling pathway in peritoneal fibrosis induced by peritoneal dialysis solutions. Nephron Exp. Nephrol. 109:e71–8
-
(2008)
Nephron Exp. Nephrol
, vol.109
-
-
Yao, Q.1
-
36
-
-
84906687076
-
Effect of Smad pathway activation on podocyte cell cycle regulation: An immunohistochemical evaluation
-
Koutroutsos K, et al. (2014) Effect of Smad pathway activation on podocyte cell cycle regulation: an immunohistochemical evaluation. Ren. Fail. 36:1310–6
-
(2014)
Ren. Fail
, vol.36
, pp. 1310-1316
-
-
Koutroutsos, K.1
-
37
-
-
84896711717
-
Resveratrol as a therapeutic agent for renal fibrosis induced by unilateral ureteral obstruction
-
Liang J, Tian S, Han J, Xiong P. (2014) Resveratrol as a therapeutic agent for renal fibrosis induced by unilateral ureteral obstruction. Ren. Fail. 36:285–91
-
(2014)
Ren. Fail
, vol.36
, pp. 285-291
-
-
Liang, J.1
Tian, S.2
Han, J.3
Xiong, P.4
-
38
-
-
77956531086
-
Resveratrol inhibits renal fibrosis in the obstructed kidney: Potential role in deacetylation of Smad3
-
Li J, Qu X, Ricardo SD, Bertram JF, Nikolic-Paterson DJ. (2010) Resveratrol inhibits renal fibrosis in the obstructed kidney: potential role in deacetylation of Smad3. Am. J. Pathol. 177:1065–71
-
(2010)
Am. J. Pathol
, vol.177
, pp. 1065-1071
-
-
Li, J.1
Qu, X.2
Ricardo, S.D.3
Bertram, J.F.4
Nikolic-Paterson, D.J.5
-
39
-
-
84895535457
-
SIRT1 activation ameliorates renal fibrosis by inhibiting the TGF-beta/Smad3 pathway
-
Huang XZ, et al. (2014) SIRT1 activation ameliorates renal fibrosis by inhibiting the TGF-beta/Smad3 pathway. J. Cell. Biochem. 115:996–1005
-
(2014)
J. Cell. Biochem
, vol.115
, pp. 996-1005
-
-
Huang, X.Z.1
-
40
-
-
84876952651
-
SIRT1 suppresses the epithelial- to-mesenchymal transition in cancer metastasis and organ fibrosis
-
Simic P, et al. (2013) SIRT1 suppresses the epithelial- to-mesenchymal transition in cancer metastasis and organ fibrosis. Cell Rep. 3:1175–86
-
(2013)
Cell Rep
, vol.3
, pp. 1175-1186
-
-
Simic, P.1
-
41
-
-
84863011417
-
Apoptosis occurs differentially according to glomerular size in diabetic kidney disease
-
Jung DS, et al. (2012) Apoptosis occurs differentially according to glomerular size in diabetic kidney disease. Nephrology Dialysis Transplantation. 27:259–66
-
(2012)
Nephrology Dialysis Transplantation
, vol.27
, pp. 259-266
-
-
Jung, D.S.1
-
42
-
-
84903866014
-
Down-regulation of PERKATF4- CHOP pathway by astragaloside IV is associated with the inhibition of endoplasmic reticulum stress-induced podocyte apoptosis in diabetic rats
-
Chen Y, et al. (2014) Down-regulation of PERKATF4- CHOP pathway by astragaloside IV is associated with the inhibition of endoplasmic reticulum stress-induced podocyte apoptosis in diabetic rats. Cell Physiol. Biochem. 3:1975–87
-
(2014)
Cell Physiol. Biochem
, vol.3
, pp. 1975-1987
-
-
Chen, Y.1
-
43
-
-
84920270340
-
Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury
-
Peng J, et al. (2015) Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury. Kidney Int. 87:137–50
-
(2015)
Kidney Int
, vol.87
, pp. 137-150
-
-
Peng, J.1
-
44
-
-
84930200910
-
TRB3 mediates renal tubular cell apoptosis associated with proteinuria
-
Wang W, et al. (2015) TRB3 mediates renal tubular cell apoptosis associated with proteinuria. Clin. Exp. Med. 15:167–77
-
(2015)
Clin. Exp. Med
, vol.15
, pp. 167-177
-
-
Wang, W.1
-
45
-
-
84901659445
-
Ubiquitination-dependent CARM1 degradation facilitates Notch1-mediated podocyte apoptosis in diabetic nephropathy
-
Kim D, et al. (2014) Ubiquitination-dependent CARM1 degradation facilitates Notch1-mediated podocyte apoptosis in diabetic nephropathy. Cell Signal. 26:1774–82
-
(2014)
Cell Signal
, vol.26
, pp. 1774-1782
-
-
Kim, D.1
-
46
-
-
84877255276
-
Glomerular cell death and inflammation with high-protein diet and diabetes. Nephrol. Dial
-
Meek RL, et al. (2013) Glomerular cell death and inflammation with high-protein diet and diabetes. Nephrol. Dial. Transplant. 28:1711–20
-
(2013)
Transplant
, vol.28
, pp. 1711-1720
-
-
Meek, R.L.1
-
47
-
-
79961143570
-
SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53
-
Kim DH, et al. (2011) SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53. Am. J. Physiol. Renal Physiol. 301:F427–35
-
(2011)
Am. J. Physiol. Renal Physiol
, vol.301
, pp. F427-F435
-
-
Kim, D.H.1
-
48
-
-
48849086013
-
Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type I diabetic nephropathy
-
Tikoo K, Singh K, Kabra D, Sharma V, Gaikwad A. (2008) Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type I diabetic nephropathy. Free Radic. Res. 42:397–404
-
(2008)
Free Radic. Res
, vol.42
, pp. 397-404
-
-
Tikoo, K.1
Singh, K.2
Kabra, D.3
Sharma, V.4
Gaikwad, A.5
-
49
-
-
33846976509
-
SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation
-
Kume S, et al. (2007) SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. J. Biol. Chem. 282:151–8
-
(2007)
J. Biol. Chem
, vol.282
, pp. 151-158
-
-
Kume, S.1
-
50
-
-
46349096040
-
SIRT1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochem. Biophys. Res
-
Hasegawa K, et al. (2008) SIRT1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochem. Biophys. Res. Commun. 372:51–6
-
(2008)
Commun
, vol.372
, pp. 51-56
-
-
Hasegawa, K.1
-
51
-
-
80051750952
-
Alteration of forkhead box O (Foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus
-
Chuang PY, et al. 2011 Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus. PLoS One. 6:e23566
-
(2011)
Plos One
, vol.6
-
-
Chuang, P.Y.1
-
52
-
-
84875190140
-
Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways
-
Gao F, et al. (2013) Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways. J. Cell. Biochem. 114:1029–38
-
(2013)
J. Cell. Biochem
, vol.114
, pp. 1029-1038
-
-
Gao, F.1
-
53
-
-
35848931880
-
Increased glomerular cell (Podocyte) apoptosis in rats with streptozotocininduced diabetes mellitus: Role in the development of diabetic glomerular disease
-
Menini S, et al. (2007) Increased glomerular cell (podocyte) apoptosis in rats with streptozotocininduced diabetes mellitus: role in the development of diabetic glomerular disease. Diabetologia. 50:2591–9
-
(2007)
Diabetologia
, vol.50
, pp. 2591-2599
-
-
Menini, S.1
-
54
-
-
84884793994
-
Transforming growth factor-beta-induced cross talk between p53 and a microRNA in the pathogenesis of diabetic nephropathy
-
Deshpande SD, et al. (2013) Transforming growth factor-beta-induced cross talk between p53 and a microRNA in the pathogenesis of diabetic nephropathy. Diabetes 62:3151–62
-
(2013)
Diabetes
, vol.62
, pp. 3151-3162
-
-
Deshpande, S.D.1
-
55
-
-
33846105394
-
Apoptosis by cyclosporine in mesangial cells. Transplant
-
Han SY, et al. (2006) Apoptosis by cyclosporine in mesangial cells. Transplant. Proc. 38:2244–6
-
(2006)
Proc
, vol.38
, pp. 2244-2246
-
-
Han, S.Y.1
-
56
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
Luo J, et al. (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell. 107:137–48
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
-
57
-
-
0037093346
-
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
-
Langley E, et al. (2002) Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 21:2383–96
-
(2002)
EMBO J
, vol.21
, pp. 2383-2396
-
-
Langley, E.1
-
58
-
-
58849158388
-
How does SIRT1 affect metabolism, senescence and cancer?
-
Brooks CL, Gu W. (2009) How does SIRT1 affect metabolism, senescence and cancer? Nat. Rev. Cancer. 9:123–8
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 123-128
-
-
Brooks, C.L.1
Gu, W.2
-
60
-
-
84900034723
-
FOXO transcription factors: Their clinical significance and regulation
-
Wang Y, Zhou Y, Graves DT. (2014) FOXO transcription factors: their clinical significance and regulation. Biomed. Res. Int. 2014:925350
-
(2014)
Biomed. Res. Int
-
-
Wang, Y.1
Zhou, Y.2
Graves, D.T.3
-
61
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet A, et al. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science. 303:2011–5
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
-
62
-
-
10844236451
-
Nutrient availability regulates SIRT1 through a forkhead- dependent pathway
-
Nemoto S, Fergusson MM, Finkel T. (2004) Nutrient availability regulates SIRT1 through a forkhead- dependent pathway. Science. 306:2105–8
-
(2004)
Science
, vol.306
, pp. 2105-2108
-
-
Nemoto, S.1
Fergusson, M.M.2
Finkel, T.3
-
63
-
-
84868210978
-
Nrf2-keap1 system versus NFkappaB: The good and the evil in chronic kidney disease?
-
Pedruzzi LM, Stockler-Pinto MB, Leite M Jr, Mafra D. (2012) Nrf2-keap1 system versus NFkappaB: the good and the evil in chronic kidney disease? Biochimie. 94:2461–6
-
(2012)
Biochimie
, vol.94
, pp. 2461-2466
-
-
Pedruzzi, L.M.1
Stockler-Pinto, M.B.2
Leite, M.3
Mafra, D.4
-
64
-
-
84892534814
-
Transcription factor NFkappaB regulates the expression of the histone deacetylase SIRT1
-
Katto J, Engel N, Abbas W, Herbein G, Mahlknecht U. (2013) Transcription factor NFkappaB regulates the expression of the histone deacetylase SIRT1. Clin. Epigenetics. 5:11
-
(2013)
Clin. Epigenetics
, vol.5
-
-
Katto, J.1
Engel, N.2
Abbas, W.3
Herbein, G.4
Mahlknecht, U.5
-
65
-
-
38849199203
-
Shared principles in NF-kappaB signaling
-
Hayden MS, Ghosh S. (2008) Shared principles in NF-kappaB signaling. Cell. 132:344–62
-
(2008)
Cell
, vol.132
, pp. 344-362
-
-
Hayden, M.S.1
Ghosh, S.2
-
66
-
-
84904270853
-
Febuxostat ameliorates diabetic renal injury in a streptozotocin-induced diabetic rat model
-
Lee HJ, et al. (2014) Febuxostat ameliorates diabetic renal injury in a streptozotocin-induced diabetic rat model. Am. J. Nephrol. 40:56–63
-
(2014)
Am. J. Nephrol
, vol.40
, pp. 56-63
-
-
Lee, H.J.1
-
67
-
-
84922267842
-
Markers of endothelial dysfunction and inflammation predict progression of diabetic nephropathy in African Americans with type 1 diabetes
-
Roy MS, Janal MN, Crosby J, Donnelly R. (2015) Markers of endothelial dysfunction and inflammation predict progression of diabetic nephropathy in African Americans with type 1 diabetes. Kidney Int. 87:427–33
-
(2015)
Kidney Int
, vol.87
, pp. 427-433
-
-
Roy, M.S.1
Janal, M.N.2
Crosby, J.3
Donnelly, R.4
-
68
-
-
84908316746
-
Global tolllike receptor 4 knockout results in decreased renal inflammation, fibrosis and podocytopathy
-
Jialal I, Major AM, Devaraj S. (2014) Global tolllike receptor 4 knockout results in decreased renal inflammation, fibrosis and podocytopathy. J. Diabetes Complications. 28:755–61
-
(2014)
J. Diabetes Complications
, vol.28
, pp. 755-761
-
-
Jialal, I.1
Major, A.M.2
Devaraj, S.3
-
69
-
-
84924922747
-
The role of MicroRNAs in diabetic nephropathy
-
Wu H, et al. (2014) The role of MicroRNAs in diabetic nephropathy. J. Diabetes Res. 2014:920134
-
(2014)
J. Diabetes Res
-
-
Wu, H.1
-
70
-
-
84875643469
-
A novel nuclear factor kappaB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates puromycin aminonucleoside-induced nephrosis in mice
-
Shimo T, et al. (2013) A novel nuclear factor kappaB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates puromycin aminonucleoside-induced nephrosis in mice. Am. J. Nephrol. 37:302–9
-
(2013)
Am. J. Nephrol
, vol.37
, pp. 302-309
-
-
Shimo, T.1
-
71
-
-
84865293359
-
Polydatin ameliorates experimental diabetes-induced fibronectin through inhibiting the activation of NF-kappaB signaling pathway in rat glomerular mesangial cells
-
Xie X, et al. (2012) Polydatin ameliorates experimental diabetes-induced fibronectin through inhibiting the activation of NF-kappaB signaling pathway in rat glomerular mesangial cells. Mol. Cell. Endocrinol. 362:183–93
-
(2012)
Mol. Cell. Endocrinol
, vol.362
, pp. 183-193
-
-
Xie, X.1
-
72
-
-
84862528465
-
Tanshinone IIA prevents uric acid nephropathy in rats through NF-kappaB inhibition
-
Wu X, et al. (2012) Tanshinone IIA prevents uric acid nephropathy in rats through NF-kappaB inhibition. Planta. Med. 78:866–73
-
(2012)
Planta. Med
, vol.78
, pp. 866-873
-
-
Wu, X.1
-
73
-
-
84864609051
-
Sodium butyrate decreases the activation of NF-kappaB reducing inflammation inflammation and oxidative damage in the kidney of rats subjected to contrast-induced nephropathy
-
Machado RA, et al. (2012) Sodium butyrate decreases the activation of NF-kappaB reducing inflammation inflammation and oxidative damage in the kidney of rats subjected to contrast-induced nephropathy. Nephrol. Dial. Transplant. 27:3136–40
-
(2012)
Nephrol. Dial. Transplant
, vol.27
, pp. 3136-3140
-
-
Machado, R.A.1
-
74
-
-
67449113506
-
Suppression of NF-kappaB by cyclosporin a and tacrolimus (FK506) via induction of the C/EBP family: Implication for unfolded protein response
-
Du S, et al. (2009) Suppression of NF-kappaB by cyclosporin a and tacrolimus (FK506) via induction of the C/EBP family: implication for unfolded protein response. J. Immunol. 182:7201–11
-
(2009)
J. Immunol
, vol.182
, pp. 7201-7211
-
-
Du, S.1
-
75
-
-
53149100858
-
SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: Regulation of aging via NF-kappaB acetylation?
-
Salminen A, Kauppinen A, Suuronen T, Kaarniranta K. (2008) SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation? Bioessays. 30:939–42
-
(2008)
Bioessays
, vol.30
, pp. 939-942
-
-
Salminen, A.1
Kauppinen, A.2
Suuronen, T.3
Kaarniranta, K.4
-
76
-
-
84862778684
-
SIRT1 overexpression decreases cisplatin-induced acetylation of NF-kappaB p65 subunit and cytotoxicity in renal proximal tubule cells
-
Jung YJ, et al. (2012) SIRT1 overexpression decreases cisplatin-induced acetylation of NF-kappaB p65 subunit and cytotoxicity in renal proximal tubule cells. Biochem. Biophys. Res. Commun. 419:206–10
-
(2012)
Biochem. Biophys. Res. Commun
, vol.419
, pp. 206-210
-
-
Jung, Y.J.1
-
77
-
-
81555225308
-
Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of SIRT1 in diabetic Wistar fatty (Fa/fa) rats: A model of type 2 diabetes
-
Kitada M, Takeda A, Nagai T, Ito H, Kanasaki K, Koya D. (2011) Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of SIRT1 in diabetic Wistar fatty (fa/fa) rats: a model of type 2 diabetes. Exp. Diabetes Res. 2011:908185
-
(2011)
Exp. Diabetes Res
-
-
Kitada, M.1
Takeda, A.2
Nagai, T.3
Ito, H.4
Kanasaki, K.5
Koya, D.6
-
78
-
-
79961125549
-
Tumor necrosis factor alpha-mediated cleavage and inactivation of SIRT1 in human osteoarthritic chondrocytes
-
Dvir-Ginzberg M, et al. (2011) Tumor necrosis factor alpha-mediated cleavage and inactivation of SIRT1 in human osteoarthritic chondrocytes. Arthritis Rheum. 63:2363–73
-
(2011)
Arthritis Rheum
, vol.63
, pp. 2363-2373
-
-
Dvir-Ginzberg, M.1
-
79
-
-
84864678390
-
High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction
-
Chalkiadaki A, Guarente L. (2012) High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell Metab. 16:180–8
-
(2012)
Cell Metab
, vol.16
, pp. 180-188
-
-
Chalkiadaki, A.1
Guarente, L.2
-
80
-
-
0034753236
-
Dual roles for HMGB1: DNA binding and cytokine
-
Czura CJ, Wang H, Tracey KJ. (2001) Dual roles for HMGB1: DNA binding and cytokine. J. Endotoxin Res. 7:315–21
-
(2001)
J. Endotoxin Res
, vol.7
, pp. 315-321
-
-
Czura, C.J.1
Wang, H.2
Tracey, K.J.3
-
82
-
-
0037062934
-
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
-
Scaffidi P, Misteli T, Bianchi ME. (2002) Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature. 418:191–5
-
(2002)
Nature
, vol.418
, pp. 191-195
-
-
Scaffidi, P.1
Misteli, T.2
Bianchi, M.E.3
-
83
-
-
84912097756
-
Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice
-
Karuppagounder V, et al. (2014) Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice. Int. Immunopharmacol. 23:617–23
-
(2014)
Int. Immunopharmacol
, vol.23
, pp. 617-623
-
-
Karuppagounder, V.1
-
84
-
-
84920288890
-
High-mobility group box 1 is a novel deacetylation target of Sirtuin1
-
Rabadi MM, et al. (2015) High-mobility group box 1 is a novel deacetylation target of Sirtuin1. Kidney Int. 87:95–108
-
(2015)
Kidney Int
, vol.87
, pp. 95-108
-
-
Rabadi, M.M.1
-
85
-
-
81055144784
-
Autophagy: Renovation of cells and tissues
-
Mizushima N, Komatsu M. (2011) Autophagy: renovation of cells and tissues. Cell. 147:728–41
-
(2011)
Cell
, vol.147
, pp. 728-741
-
-
Mizushima, N.1
Komatsu, M.2
-
86
-
-
77951157657
-
Calorie restriction enhances cell adaptation to hypoxia through SIRT1-dependent mitochondrial autophagy in mouse aged kidney
-
Kume S, et al. (2010) Calorie restriction enhances cell adaptation to hypoxia through SIRT1-dependent mitochondrial autophagy in mouse aged kidney. J. Clin. Invest. 120:1043–55
-
(2010)
J. Clin. Invest
, vol.120
, pp. 1043-1055
-
-
Kume, S.1
-
87
-
-
77951169411
-
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice
-
Hartleben B, et al. (2010) Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J. Clin. Invest. 120:1084–96
-
(2010)
J. Clin. Invest
, vol.120
, pp. 1084-1096
-
-
Hartleben, B.1
-
88
-
-
77749264299
-
Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury
-
Jiang M, Liu K, Luo J, Dong Z. (2010) Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury. Am. J. Pathol. 176:1181–92
-
(2010)
Am. J. Pathol
, vol.176
, pp. 1181-1192
-
-
Jiang, M.1
Liu, K.2
Luo, J.3
Dong, Z.4
-
89
-
-
79955626606
-
Autophagy protects the proximal tubule from degeneration and acute ischemic injury
-
Kimura T, et al. (2011) Autophagy protects the proximal tubule from degeneration and acute ischemic injury. J. Am. Soc. Nephrol. 22:902–13
-
(2011)
J. Am. Soc. Nephrol
, vol.22
, pp. 902-913
-
-
Kimura, T.1
-
90
-
-
49749120592
-
Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells
-
Periyasamy-Thandavan S, et al. (2008) Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells. Kidney Int. 74:631–40
-
(2008)
Kidney Int
, vol.74
, pp. 631-640
-
-
Periyasamy-Thandavan, S.1
-
91
-
-
77952875466
-
Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo
-
Inoue K, et al. (2010) Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo. Clin. Exp. Nephrol. 14:112–22
-
(2010)
Clin. Exp. Nephrol
, vol.14
, pp. 112-122
-
-
Inoue, K.1
-
92
-
-
84870622028
-
Autophagy protects proximal tubular cells from injury and apoptosis
-
Kaushal GP. (2012) Autophagy protects proximal tubular cells from injury and apoptosis. Kidney Int. 82:1250–3
-
(2012)
Kidney Int
, vol.82
, pp. 1250-1253
-
-
Kaushal, G.P.1
-
93
-
-
41549138483
-
A role for the NAD-dependent deacetylase SIRT1 in the regulation of autophagy
-
Lee IH, et al. (2008) A role for the NAD-dependent deacetylase SIRT1 in the regulation of autophagy. Proc. Natl. Acad. Sci. U. S. A. 105:3374–9
-
(2008)
Proc. Natl. Acad. Sci. U. S. A
, vol.105
, pp. 3374-3379
-
-
Lee, I.H.1
-
94
-
-
84893744708
-
The role of autophagy in the pathogenesis of diabetic nephropathy
-
Yamahara K, et al. (2013) The role of autophagy in the pathogenesis of diabetic nephropathy. J. Diabetes Res. 2013:193757
-
(2013)
J. Diabetes Res
, vol.19
, pp. 2013
-
-
Yamahara, K.1
-
95
-
-
84876117324
-
Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury
-
Fang L, et al. (2013) Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury. PLoS One. 8:e60546
-
(2013)
Plos One
, vol.8
-
-
Fang, L.1
-
96
-
-
66349121718
-
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
-
Bellot G, et al. (2009) Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol. Cell. Biol. 29:2570–81
-
(2009)
Mol. Cell. Biol
, vol.29
, pp. 2570-2581
-
-
Bellot, G.1
-
97
-
-
78650691023
-
Deacetylation of FoxO by SIRT1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes
-
Hariharan N, et al. (2010) Deacetylation of FoxO by SIRT1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes. Circ. Res. 107:1470–82
-
(2010)
Circ. Res
, vol.107
, pp. 1470-1482
-
-
Hariharan, N.1
-
98
-
-
84865145752
-
The effect of resveratrol on FoxO1 expression in kidneys of diabetic nephropathy rats
-
Wu L, Zhang Y, Ma X, Zhang N, Qin G. (2012) The effect of resveratrol on FoxO1 expression in kidneys of diabetic nephropathy rats. Mol. Biol. Rep. 39:9085–93
-
(2012)
Mol. Biol. Rep
, vol.39
, pp. 9085-9093
-
-
Wu, L.1
Zhang, Y.2
Ma, X.3
Zhang, N.4
Qin, G.5
-
99
-
-
84877093032
-
Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol
-
Xia N, et al. (2013) Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol. Nitric Oxide. 32:29–35
-
(2013)
Nitric Oxide
, vol.32
, pp. 29-35
-
-
Xia, N.1
-
100
-
-
67650091375
-
Resveratrol induces mitochondrial biogenesis in endothelial cells
-
Csiszar A, et al. (2009) Resveratrol induces mitochondrial biogenesis in endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 297:H13–20
-
(2009)
Am. J. Physiol. Heart Circ. Physiol
, vol.297
-
-
Csiszar, A.1
-
101
-
-
26844558334
-
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
-
Nisoli E, et al. (2005) Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science. 310:314–7
-
(2005)
Science
, vol.310
, pp. 314-317
-
-
Nisoli, E.1
-
102
-
-
69249136263
-
SIRT1: A novel target to prevent atherosclerosis
-
Yu W, Fu YC, Chen CJ, Wang X, Wang W. (2009) SIRT1: a novel target to prevent atherosclerosis. J. Cell. Biochem. 108:10–3
-
(2009)
J. Cell. Biochem
, vol.108
, pp. 10-13
-
-
Yu, W.1
Fu, Y.C.2
Chen, C.J.3
Wang, X.4
Wang, W.5
-
103
-
-
78650522881
-
Endothelial dysfunction as a potential contributor in diabetic nephropathy
-
Nakagawa T, et al. (2011) Endothelial dysfunction as a potential contributor in diabetic nephropathy. Nat. Rev. Nephrol. 7:36–44
-
(2011)
Nat. Rev. Nephrol
, vol.7
, pp. 36-44
-
-
Nakagawa, T.1
-
104
-
-
33749236623
-
Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice
-
Zhao HJ, et al. (2006) Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. J. Am. Soc. Nephrol. 17:2664–9
-
(2006)
J. Am. Soc. Nephrol
, vol.17
, pp. 2664-2669
-
-
Zhao, H.J.1
-
105
-
-
33846701668
-
Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy
-
Nakagawa T, et al. (2007) Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy. J. Am. Soc. Nephrol. 18:539–50
-
(2007)
J. Am. Soc. Nephrol
, vol.18
, pp. 539-550
-
-
Nakagawa, T.1
-
106
-
-
35549008884
-
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
-
Mattagajasingh I, et al. (2007) SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. U. S. A. 104:14855–60
-
(2007)
Proc. Natl. Acad. Sci. U. S. A
, vol.104
, pp. 14855-14860
-
-
Mattagajasingh, I.1
-
107
-
-
46249095235
-
SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells
-
Miyazaki R, et al. (2008) SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 28:1263–9
-
(2008)
Arterioscler. Thromb. Vasc. Biol
, vol.28
, pp. 1263-1269
-
-
Miyazaki, R.1
-
108
-
-
0033538473
-
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
-
Wu Z, et al. (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 98:115–24
-
(1999)
Cell
, vol.98
, pp. 115-124
-
-
Wu, Z.1
-
109
-
-
33847306780
-
Signaling of mitochondrial biogenesis following oxidant injury
-
Rasbach KA, Schnellmann RG. (2007) Signaling of mitochondrial biogenesis following oxidant injury. J. Biol. Chem. 282:2355–62
-
(2007)
J. Biol. Chem
, vol.282
, pp. 2355-2362
-
-
Rasbach, K.A.1
Schnellmann, R.G.2
-
110
-
-
0033803048
-
Peroxisome proliferatoractivated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
-
Lehman JJ, et al. (2000) Peroxisome proliferatoractivated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J. Clin. Invest. 106:847–56
-
(2000)
J. Clin. Invest
, vol.106
, pp. 847-856
-
-
Lehman, J.J.1
-
111
-
-
84861534662
-
Mitochondrial dysfunction accounts for aldosterone-induced epithelial-tomesenchymal transition of renal proximal tubular epithelial cells
-
Yuan Y, et al. (2012) Mitochondrial dysfunction accounts for aldosterone-induced epithelial-tomesenchymal transition of renal proximal tubular epithelial cells. Free Radic. Biol. Med. 53:30–43
-
(2012)
Free Radic. Biol. Med
, vol.53
, pp. 30-43
-
-
Yuan, Y.1
-
112
-
-
18144411313
-
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC- 1α
-
Nemoto S, Fergusson MM, Finkel T. (2005) SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC- 1α. J. Biol. Chem. 280:16456–60
-
(2005)
J. Biol. Chem
, vol.280
, pp. 16456-16460
-
-
Nemoto, S.1
Fergusson, M.M.2
Finkel, T.3
-
113
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC- 1alpha and SIRT1
-
Rodgers JT, et al. (2005) Nutrient control of glucose homeostasis through a complex of PGC- 1alpha and SIRT1. Nature. 434:113–8
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
-
114
-
-
84866377470
-
Activation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha ameliorates mitochondrial dysfunction and protects podocytes from aldosteroneinduced injury
-
Yuan Y, et al. (2012) Activation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha ameliorates mitochondrial dysfunction and protects podocytes from aldosteroneinduced injury. Kidney Int. 82:771–89
-
(2012)
Kidney Int
, vol.82
, pp. 771-789
-
-
Yuan, Y.1
-
115
-
-
77951049870
-
SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells
-
Funk JA, Odejinmi S, Schnellmann RG. (2010) SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells. J. Pharmacol. Exp. Ther. 333:593–601
-
(2010)
J. Pharmacol. Exp. Ther
, vol.333
, pp. 593-601
-
-
Funk, J.A.1
Odejinmi, S.2
Schnellmann, R.G.3
-
116
-
-
0345491599
-
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
-
Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. (2003) Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol. Cell. Biol. 23:9361–74
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 9361-9374
-
-
Hu, C.J.1
Wang, L.Y.2
Chodosh, L.A.3
Keith, B.4
Simon, M.C.5
-
117
-
-
0037416792
-
HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin
-
Morita M, et al. (2003) HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin. EMBO J. 22:1134–46
-
(2003)
EMBO J
, vol.22
, pp. 1134-1146
-
-
Morita, M.1
-
118
-
-
9444283176
-
Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: Erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells
-
Warnecke C, et al. (2004) Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells. FASEB J. 18:1462–4
-
(2004)
FASEB J
, vol.18
, pp. 1462-1464
-
-
Warnecke, C.1
-
119
-
-
33746655373
-
Hypoxia-inducible factors in the kidney
-
Haase VH. (2006) Hypoxia-inducible factors in the kidney. Am. J. Physiol. Renal Physiol. 291:F271–81
-
(2006)
Am. J. Physiol. Renal Physiol
, vol.291
, pp. F271-F281
-
-
Haase, V.H.1
-
120
-
-
77955499804
-
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxiainducible factor 1alpha
-
Lim JH, Lee YM, Chun YS, Chen J, Kim JE, Park JW. (2010) Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxiainducible factor 1alpha. Mol. Cell. 38:864–78
-
(2010)
Mol. Cell
, vol.38
, pp. 864-878
-
-
Lim, J.H.1
Lee, Y.M.2
Chun, Y.S.3
Chen, J.4
Kim, J.E.5
Park, J.W.6
-
121
-
-
66749129781
-
Regulation of hypoxiainducible factor 2alpha signaling by the stressresponsive deacetylase sirtuin 1
-
Dioum EM, et al. (2009) Regulation of hypoxiainducible factor 2alpha signaling by the stressresponsive deacetylase sirtuin 1. Science. 324:1289–93
-
(2009)
Science
, vol.324
, pp. 1289-1293
-
-
Dioum, E.M.1
-
122
-
-
84893830924
-
Differential roles of SIRT1 in HIF-1alpha and HIF-2alpha mediated hypoxic responses
-
Yoon H, Shin SH, Shin DH, Chun YS, Park JW. (2014) Differential roles of SIRT1 in HIF-1alpha and HIF-2alpha mediated hypoxic responses. Biochem. Biophys. Res. Commun. 444:36–43
-
(2014)
Biochem. Biophys. Res. Commun
, vol.444
, pp. 36-43
-
-
Yoon, H.1
Shin, S.H.2
Shin, D.H.3
Chun, Y.S.4
Park, J.W.5
-
123
-
-
77954488637
-
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
-
Walker AK, et al. (2010) Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 24:1403–17
-
(2010)
Genes Dev
, vol.24
, pp. 1403-1417
-
-
Walker, A.K.1
-
124
-
-
34948883324
-
SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol
-
Li X, et al. (2007) SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol. Cell. 28:91–106
-
(2007)
Cell
, vol.28
, pp. 91-106
-
-
Li, X.1
-
125
-
-
70350606061
-
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
-
Kemper JK, et al. (2009) FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metab. 10:392–404
-
(2009)
Cell Metab
, vol.10
, pp. 392-404
-
-
Kemper, J.K.1
-
126
-
-
36348974168
-
The direct involvement of SIRT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation
-
Zhang J. (2007) The direct involvement of SIRT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation. J. Biol. Chem. 282:34356–64
-
(2007)
J. Biol. Chem
, vol.282
, pp. 34356-34364
-
-
Zhang, J.1
-
127
-
-
84905028707
-
Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy
-
Ponnusamy M, et al. (2014) Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy. J. Pharmacol. Exp. Ther. 350:243–56
-
(2014)
J. Pharmacol. Exp. Ther
, vol.350
, pp. 243-256
-
-
Ponnusamy, M.1
-
128
-
-
80053920774
-
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice
-
Yoshino J, Mills KF, Yoon MJ, Imai S. (2011) Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 14:528–36
-
(2011)
Cell Metab
, vol.14
, pp. 528-536
-
-
Yoshino, J.1
Mills, K.F.2
Yoon, M.J.3
Imai, S.4
-
129
-
-
84905005034
-
Grape seed proanthocyanidin extracts ameliorate podocyte injury by activating peroxisome proliferator-activated receptorgamma coactivator 1alpha in low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats
-
Bao L, et al. (2014) Grape seed proanthocyanidin extracts ameliorate podocyte injury by activating peroxisome proliferator-activated receptorgamma coactivator 1alpha in low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats. Food Funct. 5:1872–80
-
(2014)
Food Funct
, vol.5
, pp. 1872-1880
-
-
Bao, L.1
-
130
-
-
46249100836
-
Tissue-specific regulation of SIRT1 by calorie restriction
-
Chen D, et al. (2008) Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev. 22:1753–7
-
(2008)
Genes Dev
, vol.22
, pp. 1753-1757
-
-
Chen, D.1
-
131
-
-
84906123510
-
Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis
-
Lai CH, et al. (2014) Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis. Age (Dordr). 36:9706
-
(2014)
Age (Dordr)
, vol.36
-
-
Lai, C.H.1
-
132
-
-
84906082309
-
Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy
-
Tikoo K, Lodea S, Karpe PA, Kumar S. (2014) Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy. Biochem. Biophys. Res. Commun. 450:1581–6
-
(2014)
Biochem. Biophys. Res. Commun
, vol.450
, pp. 1581-1586
-
-
Tikoo, K.1
Lodea, S.2
Karpe, P.A.3
Kumar, S.4
-
133
-
-
77952288176
-
Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARalpha in mice. Mol
-
Hayashida S, et al. (2010) Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARalpha in mice. Mol. Cell Biochem. 339:285–92
-
(2010)
Cell Biochem
, vol.339
, pp. 285-292
-
-
Hayashida, S.1
-
134
-
-
80053564714
-
CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
-
Noriega LG, et al. (2011) CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. EMBO Rep. 12:1069–76
-
(2011)
EMBO Rep
, vol.12
, pp. 1069-1076
-
-
Noriega, L.G.1
-
135
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
Motta MC, et al. (2004) Mammalian SIRT1 represses forkhead transcription factors. Cell. 116:551–63
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
-
136
-
-
33644875936
-
Cloning, chromosomal characterization and mapping of the NAD-dependent histone deacetylases gene sirtuin 1
-
Voelter-Mahlknecht S, Mahlknecht U. (2006) Cloning, chromosomal characterization and mapping of the NAD-dependent histone deacetylases gene sirtuin 1. Int. J. Mol. Med. 17:59–67
-
(2006)
Int. J. Mol. Med
, vol.17
, pp. 59-67
-
-
Voelter-Mahlknecht, S.1
Mahlknecht, U.2
-
137
-
-
77954218572
-
Involvement of the p65/RelA subunit of NF-kappaB in TNF-alphainduced SIRT1 expression in vascular smooth muscle cells
-
Zhang HN, et al. (2010) Involvement of the p65/RelA subunit of NF-kappaB in TNF-alphainduced SIRT1 expression in vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 397:569–75
-
(2010)
Biochem. Biophys. Res. Commun
, vol.397
, pp. 569-575
-
-
Zhang, H.N.1
-
138
-
-
84875831763
-
Regulation of TREM2 expression by an NF-small ka, CyrillicB-sensitive miRNA-34a
-
Zhao Y, et al. (2013) Regulation of TREM2 expression by an NF-small ka, CyrillicB-sensitive miRNA-34a. Neuroreport. 24:318–23
-
(2013)
Neuroreport
, vol.24
, pp. 318-323
-
-
Zhao, Y.1
-
139
-
-
84863993239
-
The Epstein-Barr virus (EBV)-induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells
-
Forte E, et al. (2012) The Epstein-Barr virus (EBV)-induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells. J. Virol. 86:6889–98
-
(2012)
J. Virol
, vol.86
, pp. 6889-6898
-
-
Forte, E.1
-
141
-
-
84856347212
-
Transcriptional activation of microRNA-34a by NF-kappa B in human esophageal cancer cells
-
Li J, et al. (2012) Transcriptional activation of microRNA-34a by NF-kappa B in human esophageal cancer cells. BMC Mol. Biol. 13:4
-
(2012)
BMC Mol. Biol
, vol.13
-
-
Li, J.1
-
142
-
-
63449112017
-
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
-
Purushotham A, et al. (2009) Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab. 9:327–38
-
(2009)
Cell Metab
, vol.9
, pp. 327-338
-
-
Purushotham, A.1
-
143
-
-
77953633702
-
PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1
-
Okazaki M, et al. (2010) PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1. Endocr. J. 57:403–13
-
(2010)
Endocr. J
, vol.57
, pp. 403-413
-
-
Okazaki, M.1
-
144
-
-
78649852533
-
SIRT1 is regulated by a PPARγ-SIRT1 negative feedback loop associated with senescence
-
Han L, et al. (2010) SIRT1 is regulated by a PPARγ-SIRT1 negative feedback loop associated with senescence. Nucleic Acids Res. 38:7458–71
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 7458-7471
-
-
Han, L.1
-
145
-
-
67349276169
-
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
-
Canto C, et al. (2009) AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 458:1056–60
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Canto, C.1
-
146
-
-
84863622561
-
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMPactivated protein kinase
-
Nin V, et al. (2012) Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMPactivated protein kinase. J. Biol. Chem. 287:23489–501
-
(2012)
J. Biol. Chem
, vol.287
, pp. 23489-23501
-
-
Nin, V.1
-
147
-
-
50649112638
-
SIRT1 regulates hepatocyte lipid metabolism through activating AMPactivated protein kinase
-
Hou X, et al. (2008) SIRT1 regulates hepatocyte lipid metabolism through activating AMPactivated protein kinase. J. Biol. Chem. 283:20015–26
-
(2008)
J. Biol. Chem
, vol.283
, pp. 20015-20026
-
-
Hou, X.1
-
148
-
-
55549096745
-
SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1: Possible role in AMP-activated protein kinase activation
-
Lan F, Cacicedo JM, Ruderman N, Ido Y. (2008) SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1: possible role in AMP-activated protein kinase activation. J. Biol. Chem. 283:27628–35
-
(2008)
J. Biol. Chem
, vol.283
, pp. 27628-27635
-
-
Lan, F.1
Cacicedo, J.M.2
Ruderman, N.3
Ido, Y.4
-
149
-
-
41649094992
-
SIRT1 acts as a nutrientsensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity
-
Narala SR, et al. (2008) SIRT1 acts as a nutrientsensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity. Mol. Biol. Cell. 19:1210–9
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 1210-1219
-
-
Narala, S.R.1
-
150
-
-
80052908737
-
MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating SIRT1
-
Zhu H, et al. (2011) MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating SIRT1. Cardiovasc. Res. 92:75–84
-
(2011)
Cardiovasc. Res
, vol.92
, pp. 75-84
-
-
Zhu, H.1
-
151
-
-
79959343572
-
The controversial links among calorie restriction, SIRT1, and resveratrol
-
Hu Y, Liu J, Wang J, Liu Q. (2011) The controversial links among calorie restriction, SIRT1, and resveratrol. Free Radic. Biol. Med. 51:250–6
-
(2011)
Free Radic. Biol. Med
, vol.51
, pp. 250-256
-
-
Hu, Y.1
Liu, J.2
Wang, J.3
Liu, Q.4
-
152
-
-
0035914304
-
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
-
Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL. (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J. Biol. Chem. 276:38837–43
-
(2001)
J. Biol. Chem
, vol.276
, pp. 38837-38843
-
-
Grozinger, C.M.1
Chao, E.D.2
Blackwell, H.E.3
Moazed, D.4
Schreiber, S.L.5
-
154
-
-
28144438533
-
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors
-
Mai A, et al. (2005) Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J. Med. Chem. 48:7789–95.
-
(2005)
J. Med. Chem
, vol.48
, pp. 7789-7795
-
-
Mai, A.1
|