Regulation of TREM2 expression by an NF-kB-sensitive miRNA-34a

NeuroReport

Volumn 24, Issue 6, 2013, Pages 318-323

  Zhao, Yuhai ^a   Bhattacharjee, Surjyadipta ^a   Jones, Brandon M ^a   Dua, Prerna ^c   Alexandrov, Peter N ^d   Hill, James M ^a,b   Lukiw, Walter J ^a,b  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LOUISIANA STATE UNIVERSITY   (United States)

^d INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

Alzheimer's disease; amyloidosis; hippocampal CA1; innate immune response; microglial cells; miRNA 34a; NF kB; phagocytosis; TREM2

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEMBRANE RECEPTOR; MICRORNA 34A; NUCLEOTIDE; PROTEIN TRIGGERING RECEPTOR EXPRESSED IN MYELOID CELLS 2; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; AGED; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EPIGENETICS; HIPPOCAMPAL CA1 REGION; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; NERVE DEGENERATION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

3' UNTRANSLATED REGIONS; ALZHEIMER DISEASE; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELLS, CULTURED; DATA INTERPRETATION, STATISTICAL; DOWN-REGULATION; EPIGENESIS, GENETIC; HIPPOCAMPUS; INFLAMMATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C3H; MICROGLIA; MICRORNAS; NF-KAPPA B; PHAGOCYTOSIS; QUALITY CONTROL; RECEPTORS, IMMUNOLOGIC;

EID: 84875831763     PISSN: 09594965     EISSN: 1473558X     Source Type: Journal    
DOI: 10.1097/WNR.0b013e32835fb6b0     Document Type: Article

References (24)

1. Lukiw WJ, Bhattacharjee S, Dua P, Alexandrov PN. Common micro RNAs (miRNAs) target complement factor H (CFH) regulation in Alzheimer's disease (AD) and in age-related macular degeneration (AMD). Int J Biochem Mol Biol 2012; 3:105-116.
2. Saijo K, Crotti A, Glass CK. Regulation of microglia activation and deactivation by nuclear receptors. Glia 2013; 61:104-111.
3. Aiyaz M, Lupton MK, Proitsi P, Powell JF, Lovestone S. Complement activation as a biomarker for Alzheimer's disease. Immunobiology 2012; 217:204-215.
4. Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005; 308: 1314-1318. (Pubitemid 40746128)
5. Schmid CD, Sautkulis LN, Danielson PE, Cooper J, Hasel KW, Hilbush BS, et al. Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia. J Neurochem 2002; 83: 1309-1320. (Pubitemid 35477470)
6. Neumann H, Takahashi K. Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis. J Neuroimmunol 2007; 184:92-99. (Pubitemid 46365993)
7. Guerreiro R,Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, et al. TREM2 Variants in Alzheimer's Disease. N Engl J Med 2013; 368:117-127.
8. Li J, Wang K, Chen X, Meng H, Song M, Wang Y, et al. Transcriptional activation of microRNA-34a by NF-kB in human cancer cells. BMC Mol Biol 2012; 13:4.
9. Lukiw WJ, Zhao Y, Cui JG. An NF-kB-sensitive miRNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J Biol Chem 2008; 283:31315-31322.
10. Soreq H, Wolf Y. NeurimmiRs: microRNAs in the neuroimmune interface. Trends Mol Med 2011; 17:548-555.
11. Cui JG, Li YY, Zhao Y, Bhattacharjee S, Lukiw WJ. Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kB in stressed human astroglial cells and in Alzheimer disease. J Biol Chem 2010; 285:38951-38960.
12. Lukiw WJ. NF-kB-regulated micro RNAs (miRNAs) in primary human brain cells. Exp Neurol 2012; 235:484-490.
13. Veremeyko T, Starossom SC, Weiner HL, Ponomarev ED. Detection of miRNAs in microglia by real-time PCR in normal CNS and during neuroinflammation. J Vis Exp 2012. doi:pii: 4097. 10.3791/4097.
14. Lukiw WJ, Alexandrov PN. Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimer's disease (AD) brain. Mol Neurobiol 2012; 46:11-19.
15. Hirrlinger J, Resch A, Gutterer JM, Dringen R. Oligodendroglial cells in culture effectively dispose of exogenous hydrogen peroxide: comparison with cultured neurons, astroglial and microglial cells. J Neurochem 2002; 82:635-644. (Pubitemid 34831501)
16. Giulian D, Baker TJ. Characterization of ameboid microglia isolated from developing mammalian brain. J Neurosci 1986; 6:2163-2178. (Pubitemid 16043659)
17. Lukiw WJ. Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. NeuroReport 2007; 18:297-300.
18. Li YY, Cui JG, Dua P, Pogue AI, Bhattacharjee S, Lukiw WJ. Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells. Neurosci Lett 2011; 499:109-113.
19. Lukiw WJ, Alexandrov PN, Zhao Y, Hill JM, Bhattacharjee S. Spreading of Alzheimer's disease inflammatory signaling through soluble micro-RNA. NeuroReport 2012; 23:621-626.
20. TREM2 gene expression data. Available at: http://www.genecards.org/ cgibin/ carddisp.pl?gene=TREM2.
21. Qin B, Yang H, Xiao B. Role of microRNAs in endothelial inflammation and senescence. Mol Biol Rep 2012; 39:4509-4518.
22. Sonkoly E, Sta° hle M, Pivarcsi A. MiRNAs and immunity: novel players in the regulation of normal immune function and inflammation. Semin Cancer Biol 2008; 18:131-140.
23. Colangelo V, Schurr J, Ball MJ, Pelaez RP, Bazan NG, Lukiw WJ. Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. J Neurosci Res 2002; 70: 462-473. (Pubitemid 35222383)
24. Schulte LN, Westermann AJ, Vogel J. Differential activation and functional specialization of miR-146 and miR-155 in innate immune sensing. Nucleic Acids Res 2013; 41:542-553.