Amelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats

Human and Experimental Toxicology

Volumn 34, Issue 1, 2015, Pages 100-113

  Elbe, H ^a   Vardi, N ^a   Esrefoglu, M ^b   Ates, B ^a   Yologlu, S ^a   Taskapan, C ^a  

^a INONU UNIVERSITY   (Turkey)

^b BEZMIALEM VAKIF UNIVERSITY   (Turkey)

Author keywords

diabetic nephropathy; melatonin; quercetin; resveratrol; Streptozotocin; TGF 1

Indexed keywords

CATALASE; CREATININE; GLUCOSE; MALONALDEHYDE; MELATONIN; QUERCETIN; RESVERATROL; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA1; ANTIOXIDANT; GLUCOSE BLOOD LEVEL; GLUTATHIONE; STILBENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASEMENT MEMBRANE; BODY WEIGHT; BRUSH BORDER; CELL INFILTRATION; CELL LOSS; CELL SWELLING; CELL VACUOLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY MASS; MALE; NONHUMAN; RAT; STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHY; UREA NITROGEN BLOOD LEVEL; WISTAR ALBINO GLAXO RAT; ANALYSIS; ANIMAL; BLOOD; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DRUG EFFECTS; KIDNEY; METABOLISM; PATHOLOGY; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS;

ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; BLOOD UREA NITROGEN; CATALASE; CREATININE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; GLUTATHIONE; KIDNEY; MALE; MALONDIALDEHYDE; MELATONIN; QUERCETIN; RATS, WISTAR; STILBENES; SUPEROXIDE DISMUTASE;

EID: 84919667875     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327114531995     Document Type: Article

References (58)

1. Vardi N, Ucar M, Iraz M, et al. Morphological changes of rat endocrine pancreas in experimental diabetes. T Klin J Med Sci. 2003 ; 23: 27-32
2. Militante JD, Lombardini JB, Schaffer SW. The role of taurine in the pathogenesis of the cardiomyopathy of insulin-dependent diabetes mellitus. Cardiovas Res. 2000 ; 46: 393-402
3. Kanter M, Coskun O, Korkmaz A, et al. Effects of Nigella sativa on oxidative stress and β-cell damage in streptozotocin-induced diabetic rats. Anat Rec. 2004 ; 279: 685-691
4. Coskun O, Ocakci A, Bayraktaroglu T, et al. Exercise training prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Tohoku J Exp Med. 2004 ; 203: 145-154
5. Tatsuki R, Satoh K, Yamamoto A, et al. Lipid peroxidation in the pancreas and other organs in streptozotocin diabetic rats. Jpn J Pharmacol. 1997 ; 75: 267-273
6. Rakieten N, Rakieten ML, Nadkarni MV. Studies on the diabetogenic action of streptozotocin. Canc Chemother Rep. 1963 ; 29: 91-98
7. Gurpinar T, Ekerbicer N, Uysal N, et al. The histologic evaluation of atorvastatin and melatonin treatment on oxidative stress and apoptosis of diabetic rat pancreas. Kafkas Univ Vet Fak Derg. 2010 ; 16 (4). 547-552
8. Nishida S. Metabolic effects of melatonin on oxidative stress and diabetes mellitus. Endocrine. 2005 ; 27 (2). 131-135
9. Coldiron AD, Sanders RA, Watkins JB. Effects of combined quercetin and coenzyme Q10 treatment on oxidative stress in normal and diabetic rats. J Biochem Mol Toxicol. 2002 ; 16 (4). 197-202
10. Szkudelski T. Resveratrol-induced inhibition of insulin secretion from rat pancreatic islets: evidence for pivotal role of metabolic disturbances. Am J Physiol Endocrinol Metab. 2007 ; 293: 901-907
11. Yar AS, Menevse S, Alp E, et al. The effects of resveratrol on cyclooxygenase-1 and cyclooxygenase-2 mRNA and protein levels in diabetic rat kidneys. Mol Biol Rep. 2010 ; 37: 2323-2331
12. Border WA, Noble NA. Evidence that TGF-β should be a therapeutic target in diabetic nephropathy. Kidney Int. 1998 ; 54: 1390-1391
13. Flyvbjerg A. Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease. Diabetologia. 2000 ; 43: 1205-1223
14. Sharma K, Jin Y, Guo J, et al. Neutralization of TGF-β by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes. 1996 ; 45: 522-530
15. Lee HS. Pathogenic role of TGF-β in the progression of podocyte diseases. Histol Histopathol. 2011 ; 26: 107-116
16. Buege AJ, Aust SD. Microsomal lipid peroxidation. Methods Enzymol. 1978 ; 52: 302-310
17. Luck H Methods of enzymatic analysis. New York, NY: Verlag Chemie Academic Press ; 1963: 885-888.
18. McCord JM, Fridovich I. Superoxide dismutase: an enzymatic function for erythrocuprein (hemocuprein). J Biol Chem. 1969 ; 244: 6049-6055
19. Theodorus P, Akerboom M, Sies H. Assay of glutathione, glutathione disulfide and glutathione mixed disulfides in biological samples. Methods Enzymol. 1981 ; 77: 373-383
20. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976 ; 72: 248-254
21. Liptakova A, Carsky J, Ulicna O, et al. Influence of β-resorcylidene aminoguanidine on selected metabolic parameters and antioxidant status of rats with diabetes mellitus. Physiol Res. 2002 ; 51: 277-284
22. Vardi N, Iraz M, Gul M, et al. Improving effects of aminoguanidine on the histologic alterations in rat kidneys in diabetes. J Med Sci. 2006 ; 26: 599-606
23. Garman JH, Mulroney S, Manigrasso M, et al. Omega-3 fatty acid rich diet prevents diabetic renal disease. Am J Physiol Renal Physiol. 2009 ; 296: 306-316
24. Lu Q, Yin X-X, Wang J-Y, et al. Effects of Ginkgo biloba on prevention of development of experimental diabetic nephropathy in rats. Acta Pharmacol Sin. 2007 ; 28: 818-828
25. Abo-Salem OM, El-Edel RH, Harisa GEI, et al. Experimental diabetic nephropathy can be prevented by propolis: effect on metabolic disturbances and renal oxidative parameters. Pak J Pharm Sci. 2009 ; 22: 205-210
26. Vardi N, Iraz M, Ozturk F, et al. Improving effects of melatonin on the histologic alterations of rat kidneys induced by experimental diabetes. J Inonu Univ Med Faculty. 2005 ; 12 (3). 145-152
27. Vessal M, Hemmati M, Vasei M. Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comp Biochem Physiol. 2003 ; 135: 357-364
28. Mahesh T, Menon VP. Quercetin allievates oxidative stress in streptozotocin-induced diabetic rats. Phytother Res. 2004 ; 18: 123-127
29. Chang C-C, Chang C-Y, Wu Y-T, et al. Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase. J Biomed Sci. 2011 ; 18: 47
30. Obrosova IG, Fathallah L, Liu E, et al. Early oxidative stress in the diabetic kidney: effect of dl-alpha-lipoic acid. Free Rad Biol Med. 2003 ; 34: 186-195
31. Guneli E, Tugyan K, Ozturk H, et al. Effect of melatonin on testicular damage in streptozotocin-induced diabetes rats. Eur Surg Res. 2008 ; 78: 479-484
32. Andallu B, Varadacharyulu NC. Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats. Clin Chim Acta. 2003 ; 338: 3-10
33. Teoh SL, Latiff AA, Das S. Histological changes in the kidneys of experimental diabetic rats fed with Momordica charantia (bitter gourd) extract. Roman J Morphol Embryol. 2010 ; 51 (1). 91-95
34. Osterby R, Asplund J, Bangstad HJ, et al. Neovascularization at the vascular pole region in diabetic glomerulopathy. Nephrol Dial Transplant. 1999 ; 14: 348-352
35. Shaw KM, Cummings MH Diabetes chronic complications. 2 nd ed. Chichester, UK: Wiley, 2005, pp. 21-22. Chichester, UK: Wiley ; 2005: 21-22.
36. Poretsky L Principles of diabetes mellitus. 2 nd ed. New York, NY: Springer, 2010, pp. 347-351. New York, NY: Springer ; 2010: 347-351.
37. Eddy AA. Experimental insights into the tubulointerstitial disease accompanying primary glomerular lesions. J Am Soc Nephrol. 1996 ; 7: 2494-2508
38. Shankland SJ, Scholey JW. Expression of transforming growth factor-β1 during diabetic renal hypertrophy. Kidney Int. 1994 ; 46: 430-442
39. Tuncdemir M, Ozturk M. The effects of ACE inhibitor and angiotensin receptor blocker on clusterin and apoptosis in the kidney tissue of streptozotocin-diabetic rats. J Mol Hist. 2008 ; 39: 605-616
40. Choi YE, Ahn SK, Lee WT, et al. Soybeans ameliolarate diabetic nephropathy in rats. eCAM. 2010 ; 7 (4). 433-440
41. Moskaug JQ, Carlsen H, Myhrstad M, et al. Moleculer imaging of the biological effects of quercetin and quercetin-rich foods. Mech Ageing Dev. 2004 ; 125: 315-324
42. Edremitlioglu M, Andic MF, Korkut O. Quercetin, a powerful antioxidant bioflavonoid, prevents oxidative damage in different tissues of long-term diabetic rats. Balkan Med J. 2012 ; 29: 49-55
43. Esrefoglu M, Seyhan M, Gul M, et al. Potent therapeutic effect of melatonin on aging skin in pinealectomized rats. J Pineal Res. 2005 ; 39 (3). 231-237
44. Esrefoglu M, Gul M, Ates B, et al. Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis. J Pineal Res. 2006 ; 40 (1). 92-97
45. Cam M, Yavuz O, Guven A, et al. Protective effects of chronic melatonin treatment against renal injury in streptozotocin-induced diabetic rats. J Pineal Res. 2003 ; 35: 212-220
46. Gugliucci A. Glycation as the glucose link to diabetic complication. JAOA. 2000 ; 100 (10). 621-634
47. Yakan B, Esrefoglu M. Deneysel diyabetes mellitusda böbreklerin ince yapisi ve selenyumun düzeltici etkileri. Turkiye Klinikleri. 1995 ; 15: 255-259
48. Osicka TM, Kiriazis Z, Pratt LM, et al. Ramipril and aminoguanidine restore lysosomal processing in streptozotocin diabetic rats. Diabetologia. 2001 ; 44: 230-236
49. Teschner M, Schaefer RM, Svarnas A, et al. Decreased proteinase activity in isolated glomeruli of streptozotocin diabetic rats. Am J Nephrol. 1989 ; 9: 464-469
50. Branton MH, Kopp JB. TGF-β and fibrosis. Microbes Infect. 1999 ; 1: 1349-1365
51. Hill C, Flyvbjerg A, Grønbaek H, et al. The renal expression of transforming growth factor-β isoforms and their receptors in acute and chronic experimental diabetes in rats. Endocrinology. 2000 ; 141: 1196-1208
52. Rocco MV, Chen Y, Goldfarb S, et al. Elevated glucose stimulates TGF-β gene expression and bioactivity in proximal tubule. Kidney Int. 1992 ; 41: 107-114
53. Ha H, Yu M-R, Kim KH. Melatonin and taurine reduce early glomerulopathy in diabetic rats. Free Rad Biol Med. 1999 ; 26: 944-950
54. Kataya HAH, Hamza AA. Red cabbage (Brassica oleracea) ameliorates diabetic nephropathy in rats. eCAM. 2008 ; 5 (3). 281-287
55. Maritim AC, Sanders RA, Watkins JB. Diabetes, oxidative stress and antioxidants: a review. J Biochem Molecular Toxicology. 2003 ; 17: 24-38
56. Kaplowitz N. Mechanism of liver cell injury. J Hepatol. 2000 ; 32: 39-47
57. Maritim AC, Moore BH, Sanders RA, et al. Effects of melatonin on oxidative stress in streptozicin-induced diabetic rats. Int J Toxicol. 1999 ; 18: 161-166
58. Lu-Jia Z, Li-Jing Z International conference on human health and biomedical engineering. 19-22.