Apoptosis occurs differentially according to glomerular size in diabetic kidney disease

Nephrology Dialysis Transplantation

Volumn 27, Issue 1, 2012, Pages 259-266

  Jung, Dong Sub ^a   Lee, Sun Ha ^a   Kwak, Seung Jae ^a   Li, Jin Ji ^a,b   Kim, Do Hee ^a   Nam, Bo Young ^a   Kang, Hye Young ^a   Chang, Tae Ik ^a   Park, Jung Tak ^a   Han, Seung Hyeok ^a   Yoo, Tae Hyun ^a   Kang, Shin Wook ^a  

^a Yonsei University College of Medicine   (South Korea)

^b YANBIAN UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Akt; apoptosis; cyclin dependent kinase inhibitors; diabetic nephropathy; glomerular size

Indexed keywords

CASPASE 3; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; FIBRONECTIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53; SMAD3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; GLOMERULAR STRUCTURE; KIDNEY HYPERTROPHY; KIDNEY SIZE; MALE; NONHUMAN; PODOCYTE; POROSITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASE 3; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; FLUORESCENT ANTIBODY TECHNIQUE; KIDNEY GLOMERULUS; MALE; PHOSPHORYLATION; PODOCYTES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84863011417     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfr301     Document Type: Article

References (50)

1. Saikumar P, Dong Z, Mikhailov V et al. Apoptosis: definition, mechanisms, and relevance to disease. Am J Med 1999; 107: 489-506 (Pubitemid 29528339)
2. Shimizu A, Masuda Y, Kitamura H et al. Apoptosis in progressive crescentic glomerulonephritis. Lab Invest 1996; 74: 941-951 (Pubitemid 26152663)
3. Kitamura H, Shimizu A, Masuda Y et al. Apoptosis in glomerular endothelial cells during the development of glomerulosclerosis in the remnant-kidney model. Exp Nephrol 1998; 6: 328-336 (Pubitemid 28338192)
4. Dalla Vestra M, Saller A, Mauer M et al. Role of mesangial expansion in the pathogenesis of diabetic nephropathy. J Nephrol 2001; 14 (Suppl 4): S51-S57
5. Susztak K, Raff AC, Schiffer M et al. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 2006; 55: 225-233 (Pubitemid 43343319)
6. Verzola D, Gandolfo MT, Ferrario F et al. Apoptosis in the kidneys of patients with type ii diabetic nephropathy. Kidney Int 2007; 72: 1262-1272 (Pubitemid 350059668)
7. Osterby R. Glomerular structural changes in type 1 (insulin-dependent) diabetes mellitus: causes, consequences, and prevention. Diabetologia 1992; 35: 803-812
8. Adler S. Structure-function relationships associated with extracellular matrix alterations in diabetic glomerulopathy. J Am Soc Nephrol 1994; 5: 1165-1172 (Pubitemid 24977097)
9. Baumgartl HJ, Sigl G, Banholzer P et al. On the prognosis of IDDM patients with large kidneys. Nephrol Dial Transplant 1998; 13: 630-634 (Pubitemid 28119043)
10. Young BA, Johnson RJ, Alpers CE et al. Cellular events in the evolution of experimental diabetic nephropathy. Kidney Int 1995; 47: 935-944
11. Hoffman BB, Sharma K, Ziyadeh FN. Potential role of TGF-b in diabetic nephropathy. Miner Electrolyte Metab 1998; 24: 190-196 (Pubitemid 28098191)
12. Leehey DJ, Singh AK, Alavi N et al. Role of angiotensin II in diabetic nephropathy. Kidney Int 2000; 77 (Suppl 77): S93-S98
13. Manning BD, Cantley LC. Akt/PKB signaling: navigating downstream. Cell 2007; 129: 1261-1274 (Pubitemid 46962095)
14. Takahashi T, Taniguchi T, Konishi H et al. Activation of Akt/protein kinase B after stimulation with angiotensin II in vascular smooth muscle cells. Am J Physiol 1999. 276: H1927-H1934 (Pubitemid 29323476)
15. Mahimainathan L, Das F, Venkatesan B et al. Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN. Diabetes 2006; 55: 2115-2125 (Pubitemid 44509987)
16. Chuang TD, Guh JY, Chiou SJ et al. Phosphoinositide 3-kinase is required for high glucose-induced hypertrophy and p21WAF1 expression in LLC-PK1 cells. Kidney Int 2007; 71: 867-874
17. Song P, Wu Y, Xu J et al. Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner. Circulation 2007; 116: 1585-1595 (Pubitemid 47511422)
18. Kattla JJ, Carew RM, Heljic M et al. Protein kinase B/Akt activity is involved in renal TGF-b1-driven epithelial-mesenchymal transition in vitro and in vivo. Am J Physiol Renal Physiol 2008; 295: F215-F225
19. Gorin Y, Block K, Hernandez J et al. Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. J Biol Chem 2005; 280: 39616-39626 (Pubitemid 41713921)
20. Nagai K, Matsubara T, Mima A et al. Gas6 induces Akt/mTOR-mediated mesangial hypertrophy in diabetic nephropathy. Kidney Int 2005; 68: 552-561 (Pubitemid 43323110)
21. Tejada T, Catanuto P, Ijaz A et al. Failure to phosphorylate Akt in podocytes from mice with early diabetic nephropathy promotes cell death. Kidney Int 2008; 73: 1385-1393 (Pubitemid 351770481)
22. Rane MJ, Song Y, Jin S et al. Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy. Am J Physiol Renal Physiol 2010; 298: F49-F61
23. Gambara V, Mecca G, Remuzzi G et al. Heterogeneous nature of renal lesions in type II diabetes. J Am Soc Nephrol 1993; 3: 1458-1466
24. Dalla Vestra M, Saller A, Bortoloso E et al. Structural involvement in type 1 and type 2 diabetic nephropathy. Diabetes Metab 2000; 26 (Suppl 4): 8-14 (Pubitemid 30618351)
25. Toyota E, Ogasawara Y, Fujimoto K et al. Global heterogeneity of glomerular volume distribution in early diabetic nephropathy. Kidney Int 2004; 66: 855-861 (Pubitemid 38982031)
26. Kim JJ, Li JJ, Jung DS et al. Differential expression of nephrin according to glomerular size in early diabetic kidney disease. J Am Soc Nephrol 2007; 18: 2303-2310
27. St Croix B, Florenes VA, Rak JW et al. Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents. Nat Med 1996; 2: 1204-1210 (Pubitemid 26375403)
28. Wang YA, Elson A, Leder P. Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice. Proc Natl Acad Sci USA 1997; 94: 14590-14595 (Pubitemid 28041418)
29. Wolf G, Schroeder R, Ziyadeh FN et al. High glucose stimulates expression of p27Kip1 in cultured mouse mesangial cells: relationship to hypertrophy. Am J Physiol 1997; 273: F348-F356
30. Kuan CJ, Al-Douahji M, Shankland SJ. The cyclin kinase inhibitor p21WAF1, CIP1 is increased in experimental diabetic nephropathy: potential role in glomerular hypertrophy. J Am Soc Nephrol 1998; 9: 986-993
31. Wolf G, Schroeder R, Thaiss F et al. Glomerular expression of p27Kip1 in diabetic db/db mouse: role of hyperglycemia. Kidney Int 1998; 53: 869-879 (Pubitemid 28155659)
32. Hiromura K, Pippin JW, Fero ML et al. Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27(Kip1). J Clin Invest 1999; 103: 597-604 (Pubitemid 29122412)
33. Li B, Yao J, Kawamura K et al. Real-time observation of glomerular hemodynamic changes in diabetic rats: effects of insulin and ARB. Kidney Int 2004; 66: 1939-1948 (Pubitemid 41094318)
34. Basgen JM, Nicholas SB, Mauer M et al. Comparison of methods for counting cells in the mouse glomerulus. Nephron Exp Nephrol 2006; 103: e139-e148 (Pubitemid 44114507)
35. Wolf G. New insights into the pathophysiology of diabetic nephrop-athy: from haemodynamics to molecular pathology. Eur J Clin Invest 2004; 34: 785-796 (Pubitemid 39657924)
36. Wolf G. Cell cycle regulation in diabetic nephropathy. Kidney Int Suppl 2000; 77: S59-S66
37. Steffes MW, Schmidt D, McCrery R et al. Glomerular cell number in normal subjects and in type 1 diabetic patients. Kidney Int 2001; 59: 2104-2113 (Pubitemid 32467602)
38. Pagtalunan ME, Miller PL, Jumping-Eagle S et al. Podocyte loss and progressive glomerular injury in type II diabetes. J Clin Invest 1997; 99: 342-348 (Pubitemid 27053474)
39. Shankland SJ. The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int 2006; 69: 2131-2147 (Pubitemid 43882099)
40. Menini S, Iacobini C, Oddi G et al. Increased glomerular cell (podo-cyte) apoptosis in rats with streptozotocin-induced diabetes mellitus: role in the development of diabetic glomerular disease. Diabetologia 2007; 50: 2591-2599 (Pubitemid 350060642)
41. Wolf G, Wenzel U, Ziyadeh FN et al. Angiotensin converting-enzyme inhibitor treatment reduces glomerular p16INK4 and p27Kip1 expression in diabetic BBdp rats. Diabetologia 1999; 42: 1425-1432 (Pubitemid 30012314)
42. Xu ZG, Yoo TH, Ryu DR et al. Angiotensin II receptor blocker inhibits p27Kip1 expression in glucose-stimulated podocytes and in diabetic glomeruli. Kidney Int 2005; 67: 944-952
43. Cormack-Aboud FC, Brinkkoetter PT, Pippin JW et al. Rosuvastatin protects against podocyte apoptosis in vitro. Nephrol Dial Transplant 2009; 24: 404-412
44. Marshall CB, Krofft RD, Pippin JW et al. The CDK-inhibitor p21 is pro-survival in adriamycin-induced podocyte injury, in vitro and in vivo. Am J Physiol Renal Physiol 2010; 298: F1140-F1151
45. Sakaguchi M, Isono M, Isshiki K et al. Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice. Biochem Biophys Res Commun 2006; 340: 296-301 (Pubitemid 41827680)
46. Ino H, Chiba T. Cyclin-dependent kinase 4 and cyclin D1 are required for excitotoxin-induced neuronal cell death in vivo. J Neurosci 2001; 21: 6086-6094 (Pubitemid 32737742)
47. Rao HV, Thirumangalakudi L, Desmond P et al. Cyclin D1, cdk4, and Bim are involved in thrombin-induced apoptosis in cultured cortical neurons. J Neurochem 2007; 101: 498-505 (Pubitemid 46525281)
48. Féliers D, Meredith AF, Riley DJ. Activation of cyclin D1-cdk4 and Cdk4-directed phosphorylation of RB protein in diabetic mesangial hypertrophy. Diabetes 2002; 51: 3290-3299 (Pubitemid 35246976)
49. Cip1 expression in glomerular mesangial cells: an investigation of the intracellular signaling pathway and cell-cycle progression. J Cell Biochem 2006; 98: 208-220
50. Rahimi RA, Leof EB. TGF-b signaling: a tale of two responses. J Cell Biochem 2007; 102: 593-608 (Pubitemid 47557414)