Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type I diabetic nephropathy

Free Radical Research

Volumn 42, Issue 4, 2008, Pages 397-404

  Tikoo, Kulbhushan ^a   Singh, Karmveer ^a   Kabra, Dhiraj ^a   Sharma, Vikram ^a   Gaikwad, Anil ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Diabetic nephropathy; H3 phosphorylation; Oxidative stress; p38; p53; Resveratrol; SIR2

Indexed keywords

CREATININE; HISTONE H3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITROGEN; PROTEIN P53; RESVERATROL; SILENT INFORMATION REGULATOR PROTEIN 2; UREA; ANTIOXIDANT; HISTONE; SIRT1 PROTEIN, RAT; SIRTUIN; STILBENE DERIVATIVE; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; DRUG MECHANISM; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NONHUMAN; PROTEIN DEPHOSPHORYLATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RENAL PROTECTION; STREPTOZOCIN DIABETES; UREA NITROGEN BLOOD LEVEL; WESTERN BLOTTING; ANIMAL; CHEMISTRY; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; OXIDATIVE STRESS; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; ANTIOXIDANTS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; HISTONES; MALE; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; SIRTUINS; STILBENES; STREPTOZOCIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 48849086013     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760801998646     Document Type: Article

References (46)

1. Marshall, SM. (2004) Recent advances in diabetic nephropathy. Postgrad Med J, 80, pp. 624-633.
2. Keane, WF and Lyle, PA. (2003) Recent advances in management of type 2 diabetes and nephropathy: Lessons from the RENAAL study. Am J Kidney Dis, 41, pp. S22-S25.
3. Kowluru, RA, Abbas, SN and Odenbach, S. (2004) Reversal of hyperglycemia and diabetic nephropathy: Effect of reinstitution of good metabolic control on oxidative stress in the kidney of diabetic rats. J Diabetes Complications, 18, pp. 282-288.
4. Chan, WH. (2005) Effect of resveratrol on high glucose-induced stress in human leukemia K562 cells. J Cell Biochem, 94, pp. 1267-1279.
5. Kumar, D., Robertson, S. and Burns, KD. (2004) Evidence of apoptosis in human diabetic kidney. Mol Cell Biochem, 259, pp. 67-70.
6. Zhang, W., Khanna, P., Chan, LL, Campbell, G. and Ansari, NH. (1997) Diabetes-induced apoptosis in rat kidney. Biochem Mol Med, 61, pp. 58-62.
7. Evans, JL, Goldfine, ID, Maddux, BA and Grodsky, GM. (2002) Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes. Endocr Rev, 23, pp. 599-622.
8. Susztak, K., Raff, AC, Schiffer, M. and Bottinger, EP. (2006) Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes, 55, pp. 225-233.
9. Adhikary, L., Chow, F., Nikolic-Paterson, DJ, Stambe, C., Dowling, J., Atkins, RC and Tesch, GH. (2004) Abnormal p38 mitogen-activated protein kinase signalling in human and experimental diabetic nephropathy. Diabetologia, 47, pp. 1210-1222.
10. Dong, J., Ramachandiran, S., Tikoo, K., Jia, Z., Lau, SS and Monks, TJ. (2004) EGFR-independent activation of p38 MAPK and EGFR-dependent activation of ERK1/2 are required for ROS-induced renal cell death. Am J Physiol Renal Physiol, 287, pp. F1049-F1058.
11. Labrador, M. and Corces, VG. (2003) Phosphorylation of histone H3 during transcriptional activation depends on promoter structure. Genes Dev, 17, pp. 43-48.
12. Mahadevan, LC, Willis, AC and Barratt, MJ. (1991) Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors. Cell, 65, pp. 775-783.
13. Howitz, KT, Bitterman, KJ, Cohen, HY, Lamming, DW, Lavu, S., Wood, JG, Zipkin, RE, Chung, P., Kisielewski, A., Zhang, LL, Scherer, B. and Sinclair, DA. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature, 425, pp. 191-196.
14. Lamming, DW, Wood, JG and Sinclair, DA. (2004) Small molecules that regulate lifespan: Evidence for xenohormesis. Mol Microbiol, 53, pp. 1003-1009.
15. Viswanathan, M., Kim, SK, Berdichevsky, A. and Guarente, L. (2005) A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev Cell, 9, pp. 605-615.
16. Jarolim, S., Millen, J., Heeren, G., Laun, P., Goldfarb, DS and Breitenbach, M. (2004) A novel assay for replicative lifespan in Saccharomyces cerevisiae. FEMS Yeast Res, 5, pp. 169-177.
17. Baur, JA, Pearson, KJ, Price, NL, Jamieson, HA, Lerin, C., Kalra, A., Prabhu, VV, Allard, JS, Lopez-Lluch, G., Lewis, K., Pistell, PJ, Poosala, S., Becker, KG, Boss, O., Gwinn, D., Wang, M., Ramaswamy, S., Fishbein, KW, Spencer, RG, Lakatta, EG, Couteur, D Le, Shaw, RJ, Navas, P., Puigserver, P., Ingram, DK, de Cabo, R. and Sinclair, DA. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 444, pp. 337-342.
18. Fremont, L. (2000) Biological effects of resveratrol. Life Sci, 66, pp. 663-673.
19. Martinez, J. and Moreno, JJ. (2000) Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production. Biochem Pharmacol, 59, pp. 865-870.
20. Jang, M., Cai, L., Udeani, GO, Slowing, KV, Thomas, CF, Beecher, CW, Fong, HH, Farnsworth, NR, Kinghorn, AD, Mehta, RG, Moon, RC and Pezzuto, JM. (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science, 275, pp. 218-220.
21. Kundu, JK, Shin, YK, Kim, SH and Surh, YJ. (2006) Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity. Carcinogenesis, 27, pp. 1465-1474.
22. Tikoo, K., Tripathi, DN, Kabra, DG, Sharma, V. and Gaikwad, AB. (2007) Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53. FEBS Lett, 581, pp. 1071-1078.
23. Tikoo, K., Bhatt, DK, Gaikwad, AB, Sharma, V. and Kabra, DG. (2007) Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats. FEBS Lett, 4, pp. 2027-2035.
24. Ohkawa, H., Ohishi, N. and Yagi, K. (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 95, pp. 351-358.
25. Paoletti, F. and Mocali, A. (1990) Determination of superoxide dismutase activity by purely chemical system based on NAD(P)H oxidation. Methods Enzymol, 186, pp. 209-220.
26. Tikoo, K., Gupta, S., Hamid, QA, Shah, V., Chatterjee, B. and Ali, Z. (1997) Structure of active chromatin: Isolation and characterization of transcriptionally active chromatin from rat liver. Biochem J, 322, pp. 273-279.
27. Breyer, MD, Bottinger, E., Brosius, FC 3rd, Coffman, TM, Harris, RC, Heilig, CW and Sharma, K. (2005) Mouse models of diabetic nephropathy. J Am Soc Nephrol, 16, pp. 27-45.
28. Makino, H., Tanaka, I., Mukoyama, M., Sugawara, A., Mori, K., Muro, S., Suganami, T., Yahata, K., Ishibashi, R., Ohuchida, S., Maruyama, T., Narumiya, S. and Nakao, K. (2002) Prevention of diabetic nephropathy in rats by prostaglandin E receptor EP1-selective antagonist. J Am Soc Nephrol, 13, pp. 1757-1765.
29. Igarashi, M., Wakasaki, H., Takahara, N., Ishii, H., Jiang, ZY, Yamauchi, T., Kuboki, K., Meier, M., Rhodes, CJ and King, GL. (1999) Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest, 103, pp. 185-195.
30. Keim, AL, Chi, MM and Moley, KH. (2001) Hyperglycemia-induced apoptotic cell death in the mouse blastocyst is dependent on expression of p53. Mol Reprod Dev, 60, pp. 214-224.
31. Fiordaliso, F., Leri, A., Cesselli, D., Limana, F., Safai, B., Nadal-Ginard, B., Anversa, P. and Kajstura, J. (2001) Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death. Diabetes, 50, pp. 2363-2375.
32. Kume, S., Haneda, M., Kanasaki, K., Sugimoto, T., Araki, S., Isono, M., Isshiki, K., Uzu, T., Kashiwagi, A. and Koya, D. (2006) Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation. Free Radic Biol Med, 40, pp. 2175-2182.
33. Cheng, HL, Mostoslavsky, R., Saito, S., Manis, JP, Gu, Y., Patel, P., Bronson, R., Appella, E., Alt, FW and Chua, KF (2003) Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci USA, 100, pp. 10794-10799.
34. Zhong, SP, Ma, WY and Dong, Z. (2000) ERKs and p38 kinases mediate ultraviolet B-induced phosphorylation of histone H3 at serine 10. J Biol Chem, 275, pp. 20980-20984.
35. Li, J., Chen, P., Sinogeeva, N., Gorospe, M., Wersto, RP, Chrest, FJ, Barnes, J. and Liu, Y. (2002) Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells. J Biol Chem, 277, pp. 49504-49510.
36. Aggarwal, BB, Bhardwaj, A., Aggarwal, RS, Seeram, NP, Shishodia, S. and Takada, Y. (2004) Role of resveratrol in prevention and therapy of cancer: Preclinical and clinical studies. Anticancer Res, 24, pp. 2783-2840.
37. Murias, M., Jager, W., Handler, N., Erker, T., Horvath, Z., Szekeres, T., Nohl, H. and Gille, L. (2005) Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: Structure-activity relationship. Biochem Pharmacol, 69, pp. 903-912.
38. Kundu, JK, Shin, YK and Surh, YJ. (2006) Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-kappaB and AP-1 as prime targets. Biochem Pharmacol, 72, pp. 1506-1515.
39. Wyke, SM, Russell, ST and Tisdale, MJ. (2004) Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation. Br J Cancer, 91, pp. 1742-1750.
40. Gehm, BD, Levenson, AS, Liu, H., Lee, EJ, Amundsen, BM, Cushman, M., Jordan, VC and Jameson, JL. (2004) Estrogenic effects of resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors: role of AF-1 and AF-2. J Steroid Biochem Mol Biol, 88, pp. 223-234.
41. Chen, CY, Jang, JH, Li, MH and Surh, YJ. (2005) Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells. Biochem Biophys Res Commun, 331, pp. 993-1000.
42. Fujita, H., Omori, S., Ishikura, K., Hida, M. and Awazu, M. (2004) ERK and p38 mediate high-glucose-induced hypertrophy and TGF-beta expression in renal tubular cells. Am J Physiol Renal Physiol, 286, pp. F120-F126.
43. Wei, Y., Mizzen, CA, Cook, RG, Gorovsky, MA and Allis, CD. (1998) Phosphorylation of histone H3 at serine 10 is correlated with chromosome condensation during mitosis and meiosis in Tetrahymena. Proc Natl Acad Sci USA, 95, pp. 7480-7484.
44. Allison, SJ and Milner, J. (2003) Loss of p53 has site-specific effects on histone H3 modification, including serine 10 phosphorylation important for maintenance of ploidy. Cancer Res, 63, pp. 6674-6679.
45. Hendzel, MJ, Nishioka, WK, Raymond, Y., Allis, CD, Bazett-Jones, DP and Th'ng, JP. (1998) Chromatin condensation is not associated with apoptosis. J Biol Chem, 273, pp. 24470-24478.
46. Kakoki, M., Kizer, CM, Yi, X., Takahashi, N., Kim, HS, Bagnell, CR, Edgell, CJ, Maeda, N., Jennette, JC and Smithies, O. (2006) Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors. J Clin Invest, 116, pp. 1302-1309.