CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

EMBO Reports

Volumn 12, Issue 10, 2011, Pages 1069-1076

  Noriega, Lilia G ^a,c   Feige, Jérôme N ^a,d   Canto, Carles ^a   Yamamoto, Hiroyasu ^a   Yu, Jiujiu ^a   Herman, Mark A ^b   Mataki, Chikage ^a   Kahn, Barbara B ^b   Auwerx, Johan ^a  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

^b HARVARD MEDICAL SCHOOL   (United States)

^c INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

ChREBP; CREB; glucagon; nutrient availability; SIRT1

Indexed keywords

CARBOHYDRATE BINDING PROTEIN; CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; SIRTUIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENERGY; HUMAN; MALE; MOUSE; NONHUMAN; NUTRIENT AVAILABILITY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FASTING; GENE EXPRESSION REGULATION; HEP G2 CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; SIRTUIN 1; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 80053564714     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2011.151     Document Type: Article

References (26)

1. Berry MN, Friend DS (1969) High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. J Cell Biol 43: 506-520
2. Brunet A et al (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303: 2011-2015 (Pubitemid 38393275)
3. Burgess SC, Iizuka K, Jeoung NH, Harris RA, Kashiwaya Y, Veech RL, Kitazume T, Uyeda K (2008) Carbohydrate-response element-binding protein deletion alters substrate utilization producing an energy-deficient liver. J Biol Chem 283: 1670-1678
4. Canto C, Jiang LQ, Deshmukh AS, Mataki C, Coste A, Lagouge M, Zierath JR, Auwerx J (2010) Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab 11: 213-219
5. Champy MF, Selloum M, Piard L, Zeitler V, Caradec C, Chambon P, Auwerx J (2004) Mouse functional genomics requires standardization of mouse handling and housing conditions. Mamm Genome 15: 768-783 (Pubitemid 40012690)
6. Champy MF, Selloum M, Zeitler V, Caradec C, Jung B, Rousseau S, Pouilly L, Sorg T, Auwerx J (2008) Genetic background determines metabolic phenotypes in the mouse. Mamm Genome 19: 318-331
7. Christophe J (1996) Glucagon and its receptor in various tissues. Ann NY Acad Sci 805: 31-42; discussion 42-33
8. Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA (2004) Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305: 390-392 (Pubitemid 38938153)
9. Denechaud PD, Bossard P, Lobaccaro JM, Millatt L, Staels B, Girard J, Postic C (2008) ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver. J Clin Invest 118: 956-964 (Pubitemid 351364603)
10. Feige JN, Auwerx J (2008) Transcriptional targets of sirtuins in the coordination of mammalian physiology. Curr Opin Cell Biol 20: 303-309
11. Ford J, Ahmed S, Allison S, Jiang M, Milner J (2008) JNK2-dependent regulation of SIRT1 protein stability. Cell Cycle 7: 3091-3097
12. Houtkooper RH, Canto C, Wanders RJ, Auwerx J (2010) The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev 31: 194-223
13. Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K (2004) Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci USA 101: 7281-7286 (Pubitemid 38638024)
14. Kanfi Y, Peshti V, Gozlan YM, Rathaus M, Gil R, Cohen HY (2008) Regulation of SIRT1 protein levels by nutrient availability. FEBS Lett 582: 2417-2423
15. Kawaguchi T, Takenoshita M, Kabashima T, Uyeda K (2001) Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein. Proc Natl Acad Sci USA 98: 13710-13715 (Pubitemid 33115963)
16. Liu Y et al (2008) A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456: 269-273
17. Montminy M, Koo SH, Zhang X (2004) The CREB family: key regulators of hepatic metabolism. Ann Endocrinol (Paris) 65: 73-75 (Pubitemid 38590706)
18. Noordeen NA, Khera TK, Sun G, Longbottom ER, Pullen TJ, da Silva Xavier G, Rutter GA, Leclerc I (2009) ChREBP is a negative regulator of ARNT/HIF-1b gene expression in pancreatic islet b-cells. Diabetes 59: 153-160
19. Perilhou A, Tourrel-Cuzin C, Kharroubi I, Henique C, Fauveau V, Kitamura T, Magnan C, Postic C, Prip-Buus C, Vasseur-Cognet M (2008) The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1-and ChREBP-controlled pathways. Mol Cell Biol 28: 6568-6579
20. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434: 113-118 (Pubitemid 40349395)
21. Schwer B, Verdin E (2008) Conserved metabolic regulatory functions of sirtuins. Cell Metab 7: 104-112 (Pubitemid 351168554)
22. Uyeda K, Repa JJ (2006) Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. Cell Metab 4: 107-110 (Pubitemid 44138720)
23. Wang RH, Li C, Deng CX (2010) Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition. Int J Biol Sci 6: 682-690
24. Yamakuchi M, Ferlito M, Lowenstein CJ (2008) miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci USA 105: 13421-13426
25. Yu J, Auwerx J (2010) Protein deacetylation by SIRT1: an emerging key posttranslational modification in metabolic regulation. Pharmacol Res 62: 35-41
26. Zhang Q, Wang SY, Fleuriel C, Leprince D, Rocheleau JV, Piston DW, Goodman RH (2007) Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex. Proc Natl Acad Sci USA 104: 829-833 (Pubitemid 46154696)