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Volumn , Issue , 2014, Pages 199-244

Neuroinflammation and immune regulation in ischemic stroke: Identification of new pharmacological targets

Author keywords

Adaptive immunity; C Reactive protein; Cerebral ischemia; Danger associated molecular pattern molecules (DAMPs); Hypothermia; Innate immunity; Neuroinflammation

Indexed keywords


EID: 84929859709     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4939-1071-7_11     Document Type: Chapter
Times cited : (2)

References (254)
  • 1
    • 62149101015 scopus 로고    scopus 로고
    • Global variation in stroke burden and mortality: Estimates from monitoring, surveillance, and modelling
    • Johnston SC, Mendis S, Mathers CD. Global variation in stroke burden and mortality: estimates from monitoring, surveillance, and modelling. Lancet Neurol. 2009;8:345-54.
    • (2009) Lancet Neurol. , vol.8 , pp. 345-354
    • Johnston, S.C.1    Mendis, S.2    Mathers, C.D.3
  • 3
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke
    • Group TNIoNDaSr-PSS. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581-7.
    • (1995) N Engl J Med. , vol.333 , pp. 1581-1587
    • Group TNIoNDaSr-PSS1
  • 4
    • 79952073474 scopus 로고    scopus 로고
    • Timeliness of tissue-type plasminogen activator therapy in acute ischemic stroke: Patient characteristics, hospital factors, and outcomes associated with door-to-needle times within 60 minutes
    • Fonarow GC, Smith EE, Saver JL, Reeves MJ, Bhatt DL, Grau-Sepulveda MV, et al. Timeliness of tissue-type plasminogen activator therapy in acute ischemic stroke: patient characteristics, hospital factors, and outcomes associated with door-to-needle times within 60 minutes. Circulation. 2011;123:750-8.
    • (2011) Circulation. , vol.123 , pp. 750-758
    • Fonarow, G.C.1    Smith, E.E.2    Saver, J.L.3    Reeves, M.J.4    Bhatt, D.L.5    Grau-Sepulveda, M.V.6
  • 5
    • 0142137232 scopus 로고    scopus 로고
    • Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator
    • Wang X, Lee SR, Arai K, Tsuji K, Rebeck GW, Lo EH. Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med. 2003;9:1313-7.
    • (2003) Nat Med. , vol.9 , pp. 1313-1317
    • Wang, X.1    Lee, S.R.2    Arai, K.3    Tsuji, K.4    Rebeck, G.W.5    Lo, E.H.6
  • 6
    • 0034746189 scopus 로고    scopus 로고
    • The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling
    • Nicole O, Docagne F, Ali C, Margaill I, Carmeliet P, MacKenzie ET, et al. The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling. Nat Med. 2001;7:59-64.
    • (2001) Nat Med. , vol.7 , pp. 59-64
    • Nicole, O.1    Docagne, F.2    Ali, C.3    Margaill, I.4    Carmeliet, P.5    Mackenzie, E.T.6
  • 7
    • 34249845166 scopus 로고    scopus 로고
    • Neurotoxic effects of exogenous recombinant tissue-type plasminogen activator on the normal rat brain
    • Goto H, Fujisawa H, Oka F, Nomura S, Kajiwara K, Kato S, et al. Neurotoxic effects of exogenous recombinant tissue-type plasminogen activator on the normal rat brain. J Neurotrauma. 2007;24:745-52.
    • (2007) J Neurotrauma. , vol.24 , pp. 745-752
    • Goto, H.1    Fujisawa, H.2    Oka, F.3    Nomura, S.4    Kajiwara, K.5    Kato, S.6
  • 8
    • 84863869837 scopus 로고    scopus 로고
    • Neuroinflammation and cerebrovascular disease in old age: A translational medicine perspective
    • Di Napoli M, Shah IM. Neuroinflammation and cerebrovascular disease in old age: A translational medicine perspective. J Aging Res. 2011;2011:857484.
    • (2011) J Aging Res. , vol.2011 , pp. 857484
    • Di Napoli, M.1    Shah, I.M.2
  • 9
    • 78049420136 scopus 로고    scopus 로고
    • Brain protection: Maybe yes, maybe no
    • Moskowitz MA. Brain protection: maybe yes, maybe no. Stroke. 2010;41:S85-6.
    • (2010) Stroke. , vol.41 , pp. S85-S86
    • Moskowitz, M.A.1
  • 10
    • 78149253585 scopus 로고    scopus 로고
    • Acute anti-inflammatory approaches to ischemic stroke
    • del Zoppo GJ. Acute anti-inflammatory approaches to ischemic stroke. Ann N Y Acad Sci. 2010;1207:143-8.
    • (2010) Ann N y Acad Sci. , vol.1207 , pp. 143-148
    • Del Zoppo, G.J.1
  • 11
    • 80055022198 scopus 로고    scopus 로고
    • Stroke research at a crossroad: Asking the brain for directions
    • Iadecola C, Anrather J. Stroke research at a crossroad: asking the brain for directions. Nat Neurosci. 2011;14:1363-8.
    • (2011) Nat Neurosci. , vol.14 , pp. 1363-1368
    • Iadecola, C.1    Anrather, J.2
  • 12
    • 33747158504 scopus 로고    scopus 로고
    • Potential new risk factors for ischemic stroke: What is their potential?
    • Hankey GJ. Potential new risk factors for ischemic stroke: what is their potential? Stroke. 2006;37:2181-8.
    • (2006) Stroke. , vol.37 , pp. 2181-2188
    • Hankey, G.J.1
  • 13
    • 20444381235 scopus 로고    scopus 로고
    • Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: A statement for health care professionals from the CRP pooling project members
    • Di Napoli M, Schwaninger M, Cappelli R, Ceccarelli E, Di Gianfilippo G, Donati C, et al. Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: A statement for health care professionals from the CRP pooling project members. Stroke. 2005;36:1316-29.
    • (2005) Stroke. , vol.36 , pp. 1316-1329
    • Di Napoli, M.1    Schwaninger, M.2    Cappelli, R.3    Ceccarelli, E.4    Di Gianfilippo, G.5    Donati, C.6
  • 14
    • 79956319051 scopus 로고    scopus 로고
    • Progress and challenges in translating the biology of atherosclerosis
    • Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011;473:317-25.
    • (2011) Nature. , vol.473 , pp. 317-325
    • Libby, P.1    Ridker, P.M.2    Hansson, G.K.3
  • 15
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. Inflammation in atherosclerosis. Nature. 2002;420:868-74.
    • (2002) Nature. , vol.420 , pp. 868-874
    • Libby, P.1
  • 16
    • 25444522479 scopus 로고    scopus 로고
    • Role of angiogenesis in cardiovascular disease: A critical appraisal
    • Khurana R, Simons M, Martin JF, Zachary IC. Role of angiogenesis in cardiovascular disease: A critical appraisal. Circulation. 2005;112:1813-24.
    • (2005) Circulation. , vol.112 , pp. 1813-1824
    • Khurana, R.1    Simons, M.2    Martin, J.F.3    Zachary, I.C.4
  • 17
    • 84864958466 scopus 로고    scopus 로고
    • Cerebral hypoperfusion and cognitive impairment: The pathogenic role of vascular oxidative stress
    • Liu H, Zhang J. Cerebral hypoperfusion and cognitive impairment: The pathogenic role of vascular oxidative stress. Int J Neurosci. 2012;122:494-9.
    • (2012) Int J Neurosci. , vol.122 , pp. 494-499
    • Liu, H.1    Zhang, J.2
  • 18
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • Hawkins BT, Davis TP. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev. 2005;57:173-85.
    • (2005) Pharmacol Rev. , vol.57 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 19
    • 77956231757 scopus 로고    scopus 로고
    • The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia
    • Iadecola C. The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropathol. 2010;120:287-96.
    • (2010) Acta Neuropathol. , vol.120 , pp. 287-296
    • Iadecola, C.1
  • 20
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimer's disease
    • Iadecola C. Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci. 2004;5:347-60.
    • (2004) Nat Rev Neurosci. , vol.5 , pp. 347-360
    • Iadecola, C.1
  • 21
    • 77955174671 scopus 로고    scopus 로고
    • Prolonged, 24-h delayed peripheral inflammation increases short-and long-term functional impairment and histopathological damage after focal ischemia in the rat
    • Langdon KD, Maclellan CL, Corbett D. Prolonged, 24-h delayed peripheral inflammation increases short-and long-term functional impairment and histopathological damage after focal ischemia in the rat. J Cereb Blood Flow Metab. 2010;30:1450-9.
    • (2010) J Cereb Blood Flow Metab. , vol.30 , pp. 1450-1459
    • Langdon, K.D.1    Maclellan, C.L.2    Corbett, D.3
  • 22
    • 65249138162 scopus 로고    scopus 로고
    • Monocytes are major players in the prognosis and risk of infection after acute stroke
    • Urra X, Cervera A, Obach V, Climent N, Planas AM, Chamorro A. Monocytes are major players in the prognosis and risk of infection after acute stroke. Stroke. 2009;40:1262-8.
    • (2009) Stroke. , vol.40 , pp. 1262-1268
    • Urra, X.1    Cervera, A.2    Obach, V.3    Climent, N.4    Planas, A.M.5    Chamorro, A.6
  • 23
    • 77955346640 scopus 로고    scopus 로고
    • Chronic systemic infection exacerbates ischemic brain damage via a ccl5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice
    • Denes A, Humphreys N, Lane TE, Grencis R, Rothwell N. Chronic systemic infection exacerbates ischemic brain damage via a ccl5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice. J Neurosci. 2010;30:10086-95.
    • (2010) J Neurosci. , vol.30 , pp. 10086-10095
    • Denes, A.1    Humphreys, N.2    Lane, T.E.3    Grencis, R.4    Rothwell, N.5
  • 24
    • 84883818276 scopus 로고    scopus 로고
    • Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection
    • Dhungana H, Malm T, Denes A, Valonen P, Wojciechowski S, Magga J, et al. Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection. Aging Cell. 2013;12:842-50.
    • (2013) Aging Cell. , vol.12 , pp. 842-850
    • Dhungana, H.1    Malm, T.2    Denes, A.3    Valonen, P.4    Wojciechowski, S.5    Magga, J.6
  • 25
    • 84866705875 scopus 로고    scopus 로고
    • Modelling neuroinflammation in vitro: A tool to test the potential neuroprotective effect of anti-inflammatory agents
    • Gresa-Arribas N, Vieitez C, Dentesano G, Serratosa J, Saura J, Sola C. Modelling neuroinflammation in vitro: A tool to test the potential neuroprotective effect of anti-inflammatory agents. PLoS One. 2012;7:e45227.
    • (2012) PLoS One. , vol.7 , pp. e45227
    • Gresa-Arribas, N.1    Vieitez, C.2    Dentesano, G.3    Serratosa, J.4    Saura, J.5    Sola, C.6
  • 26
    • 82055164124 scopus 로고    scopus 로고
    • Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood-brain barrier damage and brain oedema independently of infarct size
    • Denes A, Ferenczi S, Kovacs KJ. Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood-brain barrier damage and brain oedema independently of infarct size. J Neuroinflammation. 2011;8:164.
    • (2011) J Neuroinflammation. , vol.8 , pp. 164
    • Denes, A.1    Ferenczi, S.2    Kovacs, K.J.3
  • 28
    • 62949210528 scopus 로고    scopus 로고
    • Stroke-associated infection is an independent risk factor for poor outcome after acute ischemic stroke: Data from the Netherlands stroke survey
    • Vermeij FH, Scholte op Reimer WJ, de Man P, van Oostenbrugge RJ, Franke CL, de Jong G, et al. Stroke-associated infection is an independent risk factor for poor outcome after acute ischemic stroke: data from the Netherlands stroke survey. Cerebrovasc Dis. 2009;27: 465-71.
    • (2009) Cerebrovasc Dis. , vol.27 , pp. 465-471
    • Vermeij, F.H.1    Scholte Op Reimer, W.J.2    De Man, P.3    Van Oostenbrugge, R.J.4    Franke, C.L.5    De Jong, G.6
  • 29
    • 84874631229 scopus 로고    scopus 로고
    • Immunological biomarkers improve the accuracy of clinical risk models of infection in the acute phase of ischemic stroke
    • Salat D, Penalba A, Garcia-Berrocoso T, Campos-Martorell M, Flores A, Pagola J, et al. Immunological biomarkers improve the accuracy of clinical risk models of infection in the acute phase of ischemic stroke. Cerebrovasc Dis. 2013;35:220-7.
    • (2013) Cerebrovasc Dis. , vol.35 , pp. 220-227
    • Salat, D.1    Penalba, A.2    Garcia-Berrocoso, T.3    Campos-Martorell, M.4    Flores, A.5    Pagola, J.6
  • 30
    • 77958037487 scopus 로고    scopus 로고
    • Current and emerging treatments for acute stroke: Relationships with infection
    • Smith CJ, Tyrrell PJ. Current and emerging treatments for acute stroke: relationships with infection. Infect Disord Drug Targets. 2010;10:112-21.
    • (2010) Infect Disord Drug Targets. , vol.10 , pp. 112-121
    • Smith, C.J.1    Tyrrell, P.J.2
  • 31
    • 78649908826 scopus 로고    scopus 로고
    • Common infections and the risk of stroke
    • Grau AJ, Urbanek C, Palm F. Common infections and the risk of stroke. Nat Rev Neurol. 2010;6:681-94.
    • (2010) Nat Rev Neurol. , vol.6 , pp. 681-694
    • Grau, A.J.1    Urbanek, C.2    Palm, F.3
  • 33
    • 77958053182 scopus 로고    scopus 로고
    • Infectious burden: A new risk factor and treatment target for atherosclerosis
    • Elkind MS. Infectious burden: A new risk factor and treatment target for atherosclerosis. Infect Disord Drug Targets. 2010;10:84-90.
    • (2010) Infect Disord Drug Targets. , vol.10 , pp. 84-90
    • Elkind, M.S.1
  • 35
    • 79959956679 scopus 로고    scopus 로고
    • Hospitalization for infection and risk of acute ischemic stroke: The cardiovascular health study
    • Elkind MS, Carty CL, O'Meara ES, Lumley T, Lefkowitz D, Kronmal RA, et al. Hospitalization for infection and risk of acute ischemic stroke: The cardiovascular health study. Stroke. 2011;42:1851-6.
    • (2011) Stroke. , vol.42 , pp. 1851-1856
    • Elkind, M.S.1    Carty, C.L.2    O'Meara, E.S.3    Lumley, T.4    Lefkowitz, D.5    Kronmal, R.A.6
  • 36
    • 33244488507 scopus 로고    scopus 로고
    • Do common infections cause stroke?
    • Elkind MS, Cole JW. Do common infections cause stroke? Semin Neurol. 2006;26:88-99.
    • (2006) Semin Neurol. , vol.26 , pp. 88-99
    • Elkind, M.S.1    Cole, J.W.2
  • 37
    • 33846154602 scopus 로고    scopus 로고
    • Why now? Moving from stroke risk factors to stroke triggers
    • Elkind MS. Why now? Moving from stroke risk factors to stroke triggers. Curr Opin Neurol. 2007;20:51-7.
    • (2007) Curr Opin Neurol. , vol.20 , pp. 51-57
    • Elkind, M.S.1
  • 38
    • 58749106299 scopus 로고    scopus 로고
    • Associations of inflammatory and haemostatic biomarkers with poor outcome in acute ischaemic stroke
    • Welsh P, Barber M, Langhorne P, Rumley A, Lowe GD, Stott DJ. Associations of inflammatory and haemostatic biomarkers with poor outcome in acute ischaemic stroke. Cerebrovasc Dis. 2009;27:247-53.
    • (2009) Cerebrovasc Dis. , vol.27 , pp. 247-253
    • Welsh, P.1    Barber, M.2    Langhorne, P.3    Rumley, A.4    Lowe, G.D.5    Stott, D.J.6
  • 39
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: An integrated view
    • Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 1999;22:391-7.
    • (1999) Trends Neurosci. , vol.22 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 41
    • 77955487488 scopus 로고    scopus 로고
    • The science of stroke: Mechanisms in search of treatments
    • Moskowitz MA, Lo EH, Iadecola C. The science of stroke: mechanisms in search of treatments. Neuron. 2010;67:181-98.
    • (2010) Neuron. , vol.67 , pp. 181-198
    • Moskowitz, M.A.1    Lo, E.H.2    Iadecola, C.3
  • 42
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: From mechanisms to translation
    • Iadecola C, Anrather J. The immunology of stroke: from mechanisms to translation. Nat Med. 2011;17:796-808.
    • (2011) Nat Med. , vol.17 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 44
    • 0043071539 scopus 로고    scopus 로고
    • Cerebral microvessel responses to focal ischemia
    • del Zoppo GJ, Mabuchi T. Cerebral microvessel responses to focal ischemia. J Cereb Blood Flow Metab. 2003;23:879-94.
    • (2003) J Cereb Blood Flow Metab. , vol.23 , pp. 879-894
    • Del Zoppo, G.J.1    Mabuchi, T.2
  • 45
    • 0034053099 scopus 로고    scopus 로고
    • Pathophysiology of ischaemia-reperfusion injury
    • Carden DL, Granger DN. Pathophysiology of ischaemia-reperfusion injury. J Pathol. 2000;190:255-66.
    • (2000) J Pathol. , vol.190 , pp. 255-266
    • Carden, D.L.1    Granger, D.N.2
  • 47
    • 78149276162 scopus 로고    scopus 로고
    • Platelet-leukocyte interactions link inflammatory and thromboembolic events in ischemic stroke
    • Franks ZG, Campbell RA, Weyrich AS, Rondina MT. Platelet-leukocyte interactions link inflammatory and thromboembolic events in ischemic stroke. Ann N Y Acad Sci. 2010; 1207:11-7.
    • (2010) Ann N y Acad Sci. , vol.1207 , pp. 11-17
    • Franks, Z.G.1    Campbell, R.A.2    Weyrich, A.S.3    Rondina, M.T.4
  • 48
    • 2442664421 scopus 로고    scopus 로고
    • Inflammatory responses to ischemia and reperfusion in the cerebral microcirculation
    • Ishikawa M, Zhang JH, Nanda A, Granger DN. Inflammatory responses to ischemia and reperfusion in the cerebral microcirculation. Front Biosci. 2004;9:1339-47.
    • (2004) Front Biosci. , vol.9 , pp. 1339-1347
    • Ishikawa, M.1    Zhang, J.H.2    Nanda, A.3    Granger, D.N.4
  • 49
    • 34447116875 scopus 로고    scopus 로고
    • The phosphorylation state of ENOS modulates vascular reactivity and outcome of cerebral ischemia in vivo
    • Atochin DN, Wang A, Liu VW, Critchlow JD, Dantas AP, Looft-Wilson R, et al. The phosphorylation state of ENOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. J Clin Invest. 2007;117:1961-7.
    • (2007) J Clin Invest. , vol.117 , pp. 1961-1967
    • Atochin, D.N.1    Wang, A.2    Liu, V.W.3    Critchlow, J.D.4    Dantas, A.P.5    Looft-Wilson, R.6
  • 50
    • 0025947863 scopus 로고
    • Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons
    • del Zoppo GJ, Schmid-Schonbein GW, Mori E, Copeland BR, Chang CM. Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke. 1991;22:1276-83.
    • (1991) Stroke. , vol.22 , pp. 1276-1283
    • Del Zoppo, G.J.1    Schmid-Schonbein, G.W.2    Mori, E.3    Copeland, B.R.4    Chang, C.M.5
  • 51
    • 0032981648 scopus 로고    scopus 로고
    • Adhesion molecule expression and regulation on cells of the central nervous system
    • Lee SJ, Benveniste EN. Adhesion molecule expression and regulation on cells of the central nervous system. J Neuroimmunol. 1999;98:77-88.
    • (1999) J Neuroimmunol. , vol.98 , pp. 77-88
    • Lee, S.J.1    Benveniste, E.N.2
  • 52
    • 77954482190 scopus 로고    scopus 로고
    • Leukocyte recruitment and ischemic brain injury
    • Yilmaz G, Granger DN. Leukocyte recruitment and ischemic brain injury. Neuromolecular Med. 2010;12:193-204.
    • (2010) Neuromolecular Med. , vol.12 , pp. 193-204
    • Yilmaz, G.1    Granger, D.N.2
  • 53
    • 84860907056 scopus 로고    scopus 로고
    • Brain-immune interactions and ischemic stroke: Clinical implications
    • Kamel H, Iadecola C. Brain-immune interactions and ischemic stroke: clinical implications. Arch Neurol. 2012;69:576-81.
    • (2012) Arch Neurol. , vol.69 , pp. 576-581
    • Kamel, H.1    Iadecola, C.2
  • 54
    • 73449115641 scopus 로고    scopus 로고
    • The blood-brain and the blood-cerebrospinalfluid barriers: Function and dysfunction
    • Engelhardt B, Sorokin L. The blood-brain and the blood-cerebrospinalfluid barriers: function and dysfunction. Semin Immunopathol. 2009;31:497-511.
    • (2009) Semin Immunopathol. , vol.31 , pp. 497-511
    • Engelhardt, B.1    Sorokin, L.2
  • 55
    • 77950517721 scopus 로고    scopus 로고
    • Mast cells as early responders in the regulation of acute blood-brain barrier changes after cerebral ischemia and hemorrhage
    • Lindsberg PJ, Strbian D, Karjalainen-Lindsberg ML. Mast cells as early responders in the regulation of acute blood-brain barrier changes after cerebral ischemia and hemorrhage. J Cereb Blood Flow Metab. 2010;30:689-702.
    • (2010) J Cereb Blood Flow Metab. , vol.30 , pp. 689-702
    • Lindsberg, P.J.1    Strbian, D.2    Karjalainen-Lindsberg, M.L.3
  • 57
    • 33846380363 scopus 로고    scopus 로고
    • Perivascular production and action of proinflammatory cytokines in brain pathology
    • Konsman JP, Drukarch B, VanDam AM. Perivascular production and action of proinflammatory cytokines in brain pathology. Clin Sci (Lond). 2007;112:1-25.
    • (2007) Clin Sci (Lond). , vol.112 , pp. 1-25
    • Konsman, J.P.1    Drukarch, B.2    Vandam, A.M.3
  • 58
    • 0030729296 scopus 로고    scopus 로고
    • Global forebrain ischemia results in differential cellular expression of interleukin-1beta (IL-1beta) and its receptor at mRNA and protein level
    • Sairanen TR, Lindsberg PJ, Brenner M, Siren AL. Global forebrain ischemia results in differential cellular expression of interleukin-1beta (IL-1beta) and its receptor at mRNA and protein level. J Cereb Blood Flow Metab. 1997;17:1107-20.
    • (1997) J Cereb Blood Flow Metab. , vol.17 , pp. 1107-1120
    • Sairanen, T.R.1    Lindsberg, P.J.2    Brenner, M.3    Siren, A.L.4
  • 59
    • 69749101241 scopus 로고    scopus 로고
    • Turn-over of meningeal and perivascular macrophages in the brain of MCP-1-, CCR-2-or double knockout mice
    • Schilling M, Strecker JK, Ringelstein EB, Kiefer R, Schabitz WR. Turn-over of meningeal and perivascular macrophages in the brain of MCP-1-, CCR-2-or double knockout mice. Exp Neurol. 2009;219:583-5.
    • (2009) Exp Neurol. , vol.219 , pp. 583-585
    • Schilling, M.1    Strecker, J.K.2    Ringelstein, E.B.3    Kiefer, R.4    Schabitz, W.R.5
  • 60
    • 52449112645 scopus 로고    scopus 로고
    • Blood cell-derived rantes mediates cerebral microvascular dysfunction, inflammation, and tissue injury after focal ischemia-reperfusion
    • Terao S, Yilmaz G, Stokes KY, Russell J, Ishikawa M, Kawase T, et al. Blood cell-derived rantes mediates cerebral microvascular dysfunction, inflammation, and tissue injury after focal ischemia-reperfusion. Stroke. 2008;39:2560-70.
    • (2008) Stroke. , vol.39 , pp. 2560-2570
    • Terao, S.1    Yilmaz, G.2    Stokes, K.Y.3    Russell, J.4    Ishikawa, M.5    Kawase, T.6
  • 63
    • 34548266197 scopus 로고    scopus 로고
    • Cortical spreading depression releases ATP into the extracellular space and purinergic receptor activation contributes to the induction of ischemic tolerance
    • Schock SC, Munyao N, Yakubchyk Y, Sabourin LA, Hakim AM, Ventureyra EC, et al. Cortical spreading depression releases ATP into the extracellular space and purinergic receptor activation contributes to the induction of ischemic tolerance. Brain Res. 2007;1168: 129-38.
    • (2007) Brain Res. , vol.1168 , pp. 129-138
    • Schock, S.C.1    Munyao, N.2    Yakubchyk, Y.3    Sabourin, L.A.4    Hakim, A.M.5    Ventureyra, E.C.6
  • 64
    • 46449134214 scopus 로고    scopus 로고
    • Purinergic signalling and disorders of the central nervous system
    • Burnstock G. Purinergic signalling and disorders of the central nervous system. Nat Rev Drug Discov. 2008;7:575-90.
    • (2008) Nat Rev Drug Discov. , vol.7 , pp. 575-590
    • Burnstock, G.1
  • 65
    • 34848843543 scopus 로고    scopus 로고
    • Neurotransmitter receptors on microglia
    • Pocock JM, Kettenmann H. Neurotransmitter receptors on microglia. Trends Neurosci. 2007;30:527-35.
    • (2007) Trends Neurosci. , vol.30 , pp. 527-535
    • Pocock, J.M.1    Kettenmann, H.2
  • 66
    • 33751314506 scopus 로고    scopus 로고
    • Regulation of mast cells by beta-agonists
    • Peachell P. Regulation of mast cells by beta-agonists. Clin Rev Allergy Immunol. 2006; 31:131-42.
    • (2006) Clin Rev Allergy Immunol. , vol.31 , pp. 131-142
    • Peachell, P.1
  • 68
    • 57149094857 scopus 로고    scopus 로고
    • Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress
    • Sparkman NL, Johnson RW. Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress. Neuroimmunomodulation. 2008;15:323-30.
    • (2008) Neuroimmunomodulation. , vol.15 , pp. 323-330
    • Sparkman, N.L.1    Johnson, R.W.2
  • 69
    • 41149118513 scopus 로고    scopus 로고
    • How dying cells alert the immune system to danger
    • Kono H, Rock KL. How dying cells alert the immune system to danger. Nat Rev Immunol. 2008;8:279-89.
    • (2008) Nat Rev Immunol. , vol.8 , pp. 279-289
    • Kono, H.1    Rock, K.L.2
  • 70
    • 33749261659 scopus 로고    scopus 로고
    • Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation
    • Bours MJ, Swennen EL, Di Virgilio F, Cronstein BN, Dagnelie PC. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006;112:358-404.
    • (2006) Pharmacol Ther. , vol.112 , pp. 358-404
    • Bours, M.J.1    Swennen, E.L.2    Di Virgilio, F.3    Cronstein, B.N.4    Dagnelie, P.C.5
  • 71
    • 59349116736 scopus 로고    scopus 로고
    • Toll-like receptor signaling in endogenous neuroprotection and stroke
    • Marsh BJ, Williams-Karnesky RL, Stenzel-Poore MP. Toll-like receptor signaling in endogenous neuroprotection and stroke. Neuroscience. 2009;158:1007-20.
    • (2009) Neuroscience. , vol.158 , pp. 1007-1020
    • Marsh, B.J.1    Williams-Karnesky, R.L.2    Stenzel-Poore, M.P.3
  • 72
    • 84856181466 scopus 로고    scopus 로고
    • Dysregulated neuronal-microglial cross-talk during aging, stress and inflammation
    • Jurgens HA, Johnson RW. Dysregulated neuronal-microglial cross-talk during aging, stress and inflammation. Exp Neurol. 2012;233:40-8.
    • (2012) Exp Neurol. , vol.233 , pp. 40-48
    • Jurgens, H.A.1    Johnson, R.W.2
  • 73
    • 0345381021 scopus 로고    scopus 로고
    • Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage
    • Chapman GA, Moores K, Harrison D, Campbell CA, Stewart BR, Strijbos PJ. Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage. J Neurosci. 2000;20:RC87.
    • (2000) J Neurosci. , vol.20 , pp. RC87
    • Chapman, G.A.1    Moores, K.2    Harrison, D.3    Campbell, C.A.4    Stewart, B.R.5    Strijbos, P.J.6
  • 74
    • 80051759671 scopus 로고    scopus 로고
    • ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels
    • Orellana JA, Froger N, Ezan P, Jiang JX, Bennett MV, Naus CC, et al. ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels. J Neurochem. 2011;118:826-40.
    • (2011) J Neurochem. , vol.118 , pp. 826-840
    • Orellana, J.A.1    Froger, N.2    Ezan, P.3    Jiang, J.X.4    Bennett, M.V.5    Naus, C.C.6
  • 75
    • 80155123520 scopus 로고    scopus 로고
    • Hypoxia induced amoeboid microglial cell activation in postnatal rat brain is mediated by ATP receptor p2x4
    • Li F, Wang L, Li JW, Gong M, He L, Feng R, et al. Hypoxia induced amoeboid microglial cell activation in postnatal rat brain is mediated by ATP receptor p2x4. BMC Neurosci. 2011;12:111.
    • (2011) BMC Neurosci. , vol.12 , pp. 111
    • Li, F.1    Wang, L.2    Li, J.W.3    Gong, M.4    He, L.5    Feng, R.6
  • 76
    • 79955473647 scopus 로고    scopus 로고
    • Anti-high mobility group box-1 monoclonal antibody protects the blood-brain barrier from ischemia-induced disruption in rats
    • Zhang J, Takahashi HK, Liu K, Wake H, Liu R, Maruo T, et al. Anti-high mobility group box-1 monoclonal antibody protects the blood-brain barrier from ischemia-induced disruption in rats. Stroke. 2011;42:1420-8.
    • (2011) Stroke. , vol.42 , pp. 1420-1428
    • Zhang, J.1    Takahashi, H.K.2    Liu, K.3    Wake, H.4    Liu, R.5    Maruo, T.6
  • 77
    • 79551627378 scopus 로고    scopus 로고
    • Hmbg1 mediates ischemiareperfusion injury by TRIF-adaptor independent toll-like receptor 4 signaling
    • Yang QW, Lu FL, Zhou Y, Wang L, Zhong Q, Lin S, et al. Hmbg1 mediates ischemiareperfusion injury by TRIF-adaptor independent toll-like receptor 4 signaling. J Cereb Blood Flow Metab. 2011;31:593-605.
    • (2011) J Cereb Blood Flow Metab. , vol.31 , pp. 593-605
    • Yang, Q.W.1    Lu, F.L.2    Zhou, Y.3    Wang, L.4    Zhong, Q.5    Lin, S.6
  • 79
    • 84875631644 scopus 로고    scopus 로고
    • Hmgb1 and leukocyte migration during trauma and sterile inflammation
    • Venereau E, Schiraldi M, Uguccioni M, Bianchi ME. Hmgb1 and leukocyte migration during trauma and sterile inflammation. Mol Immunol. 2013;55:76-82.
    • (2013) Mol Immunol. , vol.55 , pp. 76-82
    • Venereau, E.1    Schiraldi, M.2    Uguccioni, M.3    Bianchi, M.E.4
  • 81
    • 34247166592 scopus 로고    scopus 로고
    • Expression of CD200 by macrophage-like cells in ischemic core of rat brain after transient middle cerebral artery occlusion
    • Matsumoto H, Kumon Y, Watanabe H, Ohnishi T, Takahashi H, Imai Y, et al. Expression of CD200 by macrophage-like cells in ischemic core of rat brain after transient middle cerebral artery occlusion. Neurosci Lett. 2007;418:44-8.
    • (2007) Neurosci Lett. , vol.418 , pp. 44-48
    • Matsumoto, H.1    Kumon, Y.2    Watanabe, H.3    Ohnishi, T.4    Takahashi, H.5    Imai, Y.6
  • 82
    • 52549109505 scopus 로고    scopus 로고
    • Role of cx3cr1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse
    • Denes A, Ferenczi S, Halasz J, Kornyei Z, Kovacs KJ. Role of cx3cr1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse. J Cereb Blood Flow Metab. 2008;28:1707-21.
    • (2008) J Cereb Blood Flow Metab. , vol.28 , pp. 1707-1721
    • Denes, A.1    Ferenczi, S.2    Halasz, J.3    Kornyei, Z.4    Kovacs, K.J.5
  • 83
    • 80755127243 scopus 로고    scopus 로고
    • Cx3cl1 is neuroprotective in permanent focal cerebral ischemia in rodents
    • Cipriani R, Villa P, Chece G, Lauro C, Paladini A, Micotti E, et al. Cx3cl1 is neuroprotective in permanent focal cerebral ischemia in rodents. J Neurosci. 2011;31:16327-35.
    • (2011) J Neurosci. , vol.31 , pp. 16327-16335
    • Cipriani, R.1    Villa, P.2    Chece, G.3    Lauro, C.4    Paladini, A.5    Micotti, E.6
  • 84
    • 84876486923 scopus 로고    scopus 로고
    • Cx3cr1 deficiency induces an early protective inflammatory environment in ischemic mice
    • Fumagalli S, Perego C, Ortolano F, De Simoni MG. Cx3cr1 deficiency induces an early protective inflammatory environment in ischemic mice. Glia. 2013;61:827-42.
    • (2013) Glia. , vol.61 , pp. 827-842
    • Fumagalli, S.1    Perego, C.2    Ortolano, F.3    De Simoni, M.G.4
  • 85
    • 65349101724 scopus 로고    scopus 로고
    • The multiple roles of the innate immune system in the regulation of apoptosis and inflammation in the brain
    • Griffiths MR, Gasque P, Neal JW. The multiple roles of the innate immune system in the regulation of apoptosis and inflammation in the brain. J Neuropathol Exp Neurol. 2009;68: 217-26.
    • (2009) J Neuropathol Exp Neurol. , vol.68 , pp. 217-226
    • Griffiths, M.R.1    Gasque, P.2    Neal, J.W.3
  • 86
    • 84861999263 scopus 로고    scopus 로고
    • Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain
    • Shichita T, Hasegawa E, Kimura A, Morita R, Sakaguchi R, Takada I, et al. Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Nat Med. 2012;18:911-7.
    • (2012) Nat Med. , vol.18 , pp. 911-917
    • Shichita, T.1    Hasegawa, E.2    Kimura, A.3    Morita, R.4    Sakaguchi, R.5    Takada, I.6
  • 87
    • 84880447788 scopus 로고    scopus 로고
    • Innate immune regulation by toll-like receptors in the brain
    • Mallard C. Innate immune regulation by toll-like receptors in the brain. ISRN Neurol. 2012;2012:701950.
    • (2012) ISRN Neurol. , vol.2012 , pp. 701950
    • Mallard, C.1
  • 88
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science. 2005;308:1314-8.
    • (2005) Science. , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 89
    • 0027343511 scopus 로고
    • Bone marrow derived elements and resident microglia in brain inflammation
    • Lassmann H, Schmied M, Vass K, Hickey WF. Bone marrow derived elements and resident microglia in brain inflammation. Glia. 1993;7:19-24.
    • (1993) Glia. , vol.7 , pp. 19-24
    • Lassmann, H.1    Schmied, M.2    Vass, K.3    Hickey, W.F.4
  • 90
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science. 2010;330:841-5.
    • (2010) Science. , vol.330 , pp. 841-845
    • Ginhoux, F.1    Greter, M.2    Leboeuf, M.3    Nandi, S.4    See, P.5    Gokhan, S.6
  • 91
    • 0035784701 scopus 로고    scopus 로고
    • Immune surveillance of mouse brain perivascular spaces by blood-borne macrophages
    • Bechmann I, Priller J, Kovac A, Bontert M, Wehner T, Klett FF, et al. Immune surveillance of mouse brain perivascular spaces by blood-borne macrophages. Eur J Neurosci. 2001;14: 1651-8.
    • (2001) Eur J Neurosci. , vol.14 , pp. 1651-1658
    • Bechmann, I.1    Priller, J.2    Kovac, A.3    Bontert, M.4    Wehner, T.5    Klett, F.F.6
  • 92
    • 26644452073 scopus 로고    scopus 로고
    • Macrophage polarization comes of age
    • Mantovani A, Sica A, Locati M. Macrophage polarization comes of age. Immunity. 2005;23:344-6.
    • (2005) Immunity. , vol.23 , pp. 344-346
    • Mantovani, A.1    Sica, A.2    Locati, M.3
  • 93
    • 56549122816 scopus 로고    scopus 로고
    • Mast cells: Multifaceted immune cells with diverse roles in health and disease
    • Rao KN, Brown MA. Mast cells: multifaceted immune cells with diverse roles in health and disease. Ann N Y Acad Sci. 2008;1143:83-104.
    • (2008) Ann N y Acad Sci. , vol.1143 , pp. 83-104
    • Rao, K.N.1    Brown, M.A.2
  • 94
    • 0037475144 scopus 로고    scopus 로고
    • Migration of enhanced greenfluorescent protein expressing bone marrow-derived microglia/ macrophage into the mouse brain following permanent focal ischemia
    • Tanaka R, Komine-Kobayashi M, Mochizuki H, Yamada M, Furuya T, Migita M, et al. Migration of enhanced greenfluorescent protein expressing bone marrow-derived microglia/ macrophage into the mouse brain following permanent focal ischemia. Neuroscience. 2003;117:531-9.
    • (2003) Neuroscience. , vol.117 , pp. 531-539
    • Tanaka, R.1    Komine-Kobayashi, M.2    Mochizuki, H.3    Yamada, M.4    Furuya, T.5    Migita, M.6
  • 96
    • 0036347321 scopus 로고    scopus 로고
    • Dendritic cells and dendritic-like microglia in focal cortical ischemia of the mouse brain
    • Reichmann G, Schroeter M, Jander S, Fischer HG. Dendritic cells and dendritic-like microglia in focal cortical ischemia of the mouse brain. J Neuroimmunol. 2002;129:125-32.
    • (2002) J Neuroimmunol. , vol.129 , pp. 125-132
    • Reichmann, G.1    Schroeter, M.2    Jander, S.3    Fischer, H.G.4
  • 97
    • 78649375771 scopus 로고    scopus 로고
    • Neutrophils, from marrow to microbes
    • Borregaard N. Neutrophils, from marrow to microbes. Immunity. 2010;33:657-70.
    • (2010) Immunity. , vol.33 , pp. 657-670
    • Borregaard, N.1
  • 99
    • 70549086665 scopus 로고    scopus 로고
    • Transient decrease in circulating dendritic cell precursors after acute stroke: Potential recruitment into the brain
    • Yilmaz A, Fuchs T, Dietel B, Altendorf R, Cicha I, Stumpf C, et al. Transient decrease in circulating dendritic cell precursors after acute stroke: potential recruitment into the brain. Clin Sci (Lond). 2010;118:147-57.
    • (2010) Clin Sci (Lond). , vol.118 , pp. 147-157
    • Yilmaz, A.1    Fuchs, T.2    Dietel, B.3    Altendorf, R.4    Cicha, I.5    Stumpf, C.6
  • 100
    • 0026929035 scopus 로고
    • Drainage of brain extracellularfluid into blood and deep cervical lymph and its immunological significance
    • Cserr HF, Harling-Berg CJ, Knopf PM. Drainage of brain extracellularfluid into blood and deep cervical lymph and its immunological significance. Brain Pathol. 1992;2:269-76.
    • (1992) Brain Pathol. , vol.2 , pp. 269-276
    • Cserr, H.F.1    Harling-Berg, C.J.2    Knopf, P.M.3
  • 102
    • 59349084695 scopus 로고    scopus 로고
    • Sensitization and tolerization to brain antigens in stroke
    • Becker KJ. Sensitization and tolerization to brain antigens in stroke. Neuroscience. 2009;158:1090-7.
    • (2009) Neuroscience. , vol.158 , pp. 1090-1097
    • Becker, K.J.1
  • 103
    • 0037830589 scopus 로고    scopus 로고
    • Adoptive transfer of myelin basic protein-tolerized splenocytes to naive animals reduces infarct size: A role for lymphocytes in ischemic brain injury?
    • Becker K, Kindrick D, McCarron R, Hallenbeck J, Winn R. Adoptive transfer of myelin basic protein-tolerized splenocytes to naive animals reduces infarct size: A role for lymphocytes in ischemic brain injury? Stroke. 2003;34:1809-15.
    • (2003) Stroke. , vol.34 , pp. 1809-1815
    • Becker, K.1    Kindrick, D.2    McCarron, R.3    Hallenbeck, J.4    Winn, R.5
  • 107
    • 77952557777 scopus 로고    scopus 로고
    • Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation
    • Kleinschnitz C, Schwab N, Kraft P, Hagedorn I, Dreykluft A, Schwarz T, et al. Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation. Blood. 2010;115:3835-42.
    • (2010) Blood. , vol.115 , pp. 3835-3842
    • Kleinschnitz, C.1    Schwab, N.2    Kraft, P.3    Hagedorn, I.4    Dreykluft, A.5    Schwarz, T.6
  • 108
    • 68349160698 scopus 로고    scopus 로고
    • Pivotal role of cerebral interleukin-17-producing gammadeltat cells in the delayed phase of ischemic brain injury
    • Shichita T, Sugiyama Y, Ooboshi H, Sugimori H, Nakagawa R, Takada I, et al. Pivotal role of cerebral interleukin-17-producing gammadeltat cells in the delayed phase of ischemic brain injury. Nat Med. 2009;15:946-50.
    • (2009) Nat Med. , vol.15 , pp. 946-950
    • Shichita, T.1    Sugiyama, Y.2    Ooboshi, H.3    Sugimori, H.4    Nakagawa, R.5    Takada, I.6
  • 109
    • 59649123881 scopus 로고    scopus 로고
    • Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke
    • Liesz A, Suri-Payer E, Veltkamp C, Doerr H, Sommer C, Rivest S, et al. Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med. 2009;15:192-9.
    • (2009) Nat Med. , vol.15 , pp. 192-199
    • Liesz, A.1    Suri-Payer, E.2    Veltkamp, C.3    Doerr, H.4    Sommer, C.5    Rivest, S.6
  • 111
    • 33646454450 scopus 로고    scopus 로고
    • Role of T lymphocytes and interferongamma in ischemic stroke
    • Yilmaz G, Arumugam TV, Stokes KY, Granger DN. Role of T lymphocytes and interferongamma in ischemic stroke. Circulation. 2006;113:2105-12.
    • (2006) Circulation. , vol.113 , pp. 2105-2112
    • Yilmaz, G.1    Arumugam, T.V.2    Stokes, K.Y.3    Granger, D.N.4
  • 112
    • 51549101179 scopus 로고    scopus 로고
    • Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury
    • Sandhir R, Onyszchuk G, Berman NE. Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury. Exp Neurol. 2008;213:372-80.
    • (2008) Exp Neurol. , vol.213 , pp. 372-380
    • Sandhir, R.1    Onyszchuk, G.2    Berman, N.E.3
  • 113
    • 64649100658 scopus 로고    scopus 로고
    • Age and neuroinflammation: A lifetime of psychoneuroimmune consequences
    • Godbout JP, Johnson RW. Age and neuroinflammation: A lifetime of psychoneuroimmune consequences. Immunol Allergy Clin North Am. 2009;29:321-37.
    • (2009) Immunol Allergy Clin North Am. , vol.29 , pp. 321-337
    • Godbout, J.P.1    Johnson, R.W.2
  • 114
    • 84871778200 scopus 로고    scopus 로고
    • Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice
    • Tanaka Y, Matsuwaki T, Yamanouchi K, Nishihara M. Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice. Neuroscience. 2013;231:49-60.
    • (2013) Neuroscience. , vol.231 , pp. 49-60
    • Tanaka, Y.1    Matsuwaki, T.2    Yamanouchi, K.3    Nishihara, M.4
  • 115
    • 0038016402 scopus 로고    scopus 로고
    • Accelerated glial reactivity to stroke in aged rats correlates with reduced functional recovery
    • Badan I, Buchhold B, Hamm A, Gratz M, Walker LC, Platt D, et al. Accelerated glial reactivity to stroke in aged rats correlates with reduced functional recovery. J Cereb Blood Flow Metab. 2003;23:845-54.
    • (2003) J Cereb Blood Flow Metab. , vol.23 , pp. 845-854
    • Badan, I.1    Buchhold, B.2    Hamm, A.3    Gratz, M.4    Walker, L.C.5    Platt, D.6
  • 116
    • 84871896555 scopus 로고    scopus 로고
    • Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled cortical impact model
    • Acosta SA, Tajiri N, Shinozuka K, Ishikawa H, Grimmig B, Diamond D, et al. Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled cortical impact model. PLoS One. 2013;8:e53376.
    • (2013) PLoS One. , vol.8 , pp. e53376
    • Acosta, S.A.1    Tajiri, N.2    Shinozuka, K.3    Ishikawa, H.4    Grimmig, B.5    Diamond, D.6
  • 117
    • 53149110451 scopus 로고    scopus 로고
    • Glial responses, neuron death and lesion resolution after intracerebral hemorrhage in young vs
    • Wasserman JK, Yang H, Schlichter LC. Glial responses, neuron death and lesion resolution after intracerebral hemorrhage in young vs. aged rats. Eur J Neurosci. 2008;28:1316-28.
    • (2008) Aged Rats. Eur J Neurosci. , vol.28 , pp. 1316-1328
    • Wasserman, J.K.1    Yang, H.2    Schlichter, L.C.3
  • 118
    • 78649329486 scopus 로고    scopus 로고
    • Defects in cytokine-mediated neuroprotective glial responses to excitotoxic hippocampal injury in senescence-accelerated mouse
    • Hasegawa-Ishii S, Takei S, Inaba M, Umegaki H, Chiba Y, Furukawa A, et al. Defects in cytokine-mediated neuroprotective glial responses to excitotoxic hippocampal injury in senescence-accelerated mouse. Brain Behav Immun. 2011;25:83-100.
    • (2011) Brain Behav Immun. , vol.25 , pp. 83-100
    • Hasegawa-Ishii, S.1    Takei, S.2    Inaba, M.3    Umegaki, H.4    Chiba, Y.5    Furukawa, A.6
  • 119
    • 70450170095 scopus 로고    scopus 로고
    • Aging exacerbates intracerebral hemorrhageinduced brain injury
    • Lee JC, Cho GS, Choi BO, Kim HC, Kim WK. Aging exacerbates intracerebral hemorrhageinduced brain injury. J Neurotrauma. 2009;26:1567-76.
    • (2009) J Neurotrauma. , vol.26 , pp. 1567-1576
    • Lee, J.C.1    Cho, G.S.2    Choi, B.O.3    Kim, H.C.4    Kim, W.K.5
  • 121
    • 84897035369 scopus 로고    scopus 로고
    • Upregulation of axon guidance molecules in the adult central nervous system of Nogo-A knockout mice restricts neuronal growth and regeneration
    • Kempf A, Montani L, Petrinovic MM, Schroeter A, Weinmann O, Patrignani A, et al. Upregulation of axon guidance molecules in the adult central nervous system of Nogo-A knockout mice restricts neuronal growth and regeneration. Eur J Neurosci. 2013;38: 3567-79.
    • (2013) Eur J Neurosci. , vol.38 , pp. 3567-3579
    • Kempf, A.1    Montani, L.2    Petrinovic, M.M.3    Schroeter, A.4    Weinmann, O.5    Patrignani, A.6
  • 122
    • 42649098547 scopus 로고    scopus 로고
    • Microglial degeneration in the aging brain-bad news for neurons?
    • Streit WJ, Miller KR, Lopes KO, Njie E. Microglial degeneration in the aging brain-bad news for neurons? Front Biosci. 2008;13:3423-38.
    • (2008) Front Biosci. , vol.13 , pp. 3423-3438
    • Streit, W.J.1    Miller, K.R.2    Lopes, K.O.3    Njie, E.4
  • 123
    • 60149098421 scopus 로고    scopus 로고
    • Debris clearance by microglia: An essential link between degeneration and regeneration
    • Neumann H, Kotter MR, Franklin RJ. Debris clearance by microglia: an essential link between degeneration and regeneration. Brain. 2009;132:288-95.
    • (2009) Brain. , vol.132 , pp. 288-295
    • Neumann, H.1    Kotter, M.R.2    Franklin, R.J.3
  • 124
    • 84880626992 scopus 로고    scopus 로고
    • Microglial aging in the healthy CNS: Phenotypes, drivers, and rejuvenation
    • Wong WT. Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation. Front Cell Neurosci. 2013;7:22.
    • (2013) Front Cell Neurosci. , vol.7 , pp. 22
    • Wong, W.T.1
  • 125
    • 30644476095 scopus 로고    scopus 로고
    • Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation
    • Kotter MR, Li WW, Zhao C, Franklin RJ. Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation. J Neurosci. 2006;26:328-32.
    • (2006) J Neurosci. , vol.26 , pp. 328-332
    • Kotter, M.R.1    Li, W.W.2    Zhao, C.3    Franklin, R.J.4
  • 126
    • 25644434410 scopus 로고    scopus 로고
    • Enhancing central nervous system remyelination in multiple sclerosis
    • Dubois-Dalcq M, Ffrench-Constant C, Franklin RJ. Enhancing central nervous system remyelination in multiple sclerosis. Neuron. 2005;48:9-12.
    • (2005) Neuron. , vol.48 , pp. 9-12
    • Dubois-Dalcq, M.1    Ffrench-Constant, C.2    Franklin, R.J.3
  • 127
    • 84865339274 scopus 로고    scopus 로고
    • Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions
    • Clarner T, Diederichs F, Berger K, Denecke B, Gan L, van der Valk P, et al. Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions. Glia. 2012;60:1468-80.
    • (2012) Glia. , vol.60 , pp. 1468-1480
    • Clarner, T.1    Diederichs, F.2    Berger, K.3    Denecke, B.4    Gan, L.5    Van Der Valk, P.6
  • 128
    • 84889841717 scopus 로고    scopus 로고
    • Motor axon regeneration and muscle reinnervation in young adult and aged animals
    • Kang H, Lichtman JW. Motor axon regeneration and muscle reinnervation in young adult and aged animals. J Neurosci. 2013;33:19480-91.
    • (2013) J Neurosci. , vol.33 , pp. 19480-19491
    • Kang, H.1    Lichtman, J.W.2
  • 129
    • 33644931322 scopus 로고    scopus 로고
    • Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system
    • Chari DM, Zhao C, Kotter MR, Blakemore WF, Franklin RJ. Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system. J Neurosci Res. 2006;83:594-605.
    • (2006) J Neurosci Res. , vol.83 , pp. 594-605
    • Chari, D.M.1    Zhao, C.2    Kotter, M.R.3    Blakemore, W.F.4    Franklin, R.J.5
  • 130
    • 84883454794 scopus 로고    scopus 로고
    • M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
    • Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh JM, Shadrach JL, et al. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat Neurosci. 2013;16:1211-8.
    • (2013) Nat Neurosci. , vol.16 , pp. 1211-1218
    • Miron, V.E.1    Boyd, A.2    Zhao, J.W.3    Yuen, T.J.4    Ruckh, J.M.5    Shadrach, J.L.6
  • 131
    • 84875874620 scopus 로고    scopus 로고
    • Microglia-derived TNFalpha induces apoptosis in neural precursor cells via transcriptional activation of the bcl-2 family member puma
    • Guadagno J, Xu X, Karajgikar M, Brown A, Cregan SP. Microglia-derived TNFalpha induces apoptosis in neural precursor cells via transcriptional activation of the bcl-2 family member puma. Cell Death Dis. 2013;4:e538.
    • (2013) Cell Death Dis. , vol.4 , pp. e538
    • Guadagno, J.1    Xu, X.2    Karajgikar, M.3    Brown, A.4    Cregan, S.P.5
  • 133
    • 0037532616 scopus 로고    scopus 로고
    • An early and sustained peripheral inflammatory response in acute ischaemic stroke: Relationships with infection and atherosclerosis
    • Emsley HC, Smith CJ, Gavin CM, Georgiou RF, Vail A, Barberan EM, et al. An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis. J Neuroimmunol. 2003;139:93-101.
    • (2003) J Neuroimmunol. , vol.139 , pp. 93-101
    • Emsley, H.C.1    Smith, C.J.2    Gavin, C.M.3    Georgiou, R.F.4    Vail, A.5    Barberan, E.M.6
  • 134
    • 2642581809 scopus 로고    scopus 로고
    • Peak plasma interleukin-6 and other peripheral markers of inflammation in thefirst week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome
    • Smith CJ, Emsley HC, Gavin CM, Georgiou RF, Vail A, Barberan EM, et al. Peak plasma interleukin-6 and other peripheral markers of inflammation in thefirst week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. BMC Neurol. 2004;4:2.
    • (2004) BMC Neurol. , vol.4 , pp. 2
    • Smith, C.J.1    Emsley, H.C.2    Gavin, C.M.3    Georgiou, R.F.4    Vail, A.5    Barberan, E.M.6
  • 135
    • 65549135642 scopus 로고    scopus 로고
    • Blood markers for the prognosis of ischemic stroke: A systematic review
    • Whiteley W, Chong WL, Sengupta A, Sandercock P. Blood markers for the prognosis of ischemic stroke: A systematic review. Stroke. 2009;40:e380-9.
    • (2009) Stroke. , vol.40 , pp. e380-e389
    • Whiteley, W.1    Chong, W.L.2    Sengupta, A.3    Sandercock, P.4
  • 136
    • 33646682844 scopus 로고    scopus 로고
    • Poststroke C-reactive protein is a powerful prognostic tool among candidates for thrombolysis
    • Montaner J, Fernandez-Cadenas I, Molina CA, Ribo M, Huertas R, Rosell A, et al. Poststroke C-reactive protein is a powerful prognostic tool among candidates for thrombolysis. Stroke. 2006;37:1205-10.
    • (2006) Stroke. , vol.37 , pp. 1205-1210
    • Montaner, J.1    Fernandez-Cadenas, I.2    Molina, C.A.3    Ribo, M.4    Huertas, R.5    Rosell, A.6
  • 137
    • 26444439079 scopus 로고    scopus 로고
    • Associations of inflammatory and hemostatic variables with the risk of recurrent stroke
    • Woodward M, Lowe GD, Campbell DJ, Colman S, Rumley A, Chalmers J, et al. Associations of inflammatory and hemostatic variables with the risk of recurrent stroke. Stroke. 2005;36:2143-7.
    • (2005) Stroke. , vol.36 , pp. 2143-2147
    • Woodward, M.1    Lowe, G.D.2    Campbell, D.J.3    Colman, S.4    Rumley, A.5    Chalmers, J.6
  • 138
    • 0141819133 scopus 로고    scopus 로고
    • C-Reactive protein predicts further ischemic events infirst-ever transient ischemic attack or stroke patients with intracranial large-artery occlusive disease
    • Arenillas JF, Alvarez-Sabin J, Molina CA, Chacon P, Montaner J, Rovira A, et al. C-Reactive protein predicts further ischemic events infirst-ever transient ischemic attack or stroke patients with intracranial large-artery occlusive disease. Stroke. 2003;34:2463-8.
    • (2003) Stroke. , vol.34 , pp. 2463-2468
    • Arenillas, J.F.1    Alvarez-Sabin, J.2    Molina, C.A.3    Chacon, P.4    Montaner, J.5    Rovira, A.6
  • 139
    • 0035067998 scopus 로고    scopus 로고
    • C-Reactive protein in ischemic stroke: An independent prognostic factor
    • Di Napoli M, Papa F, Bocola V. C-Reactive protein in ischemic stroke: an independent prognostic factor. Stroke. 2001;32:917-24.
    • (2001) Stroke. , vol.32 , pp. 917-924
    • Di Napoli, M.1    Papa, F.2    Bocola, V.3
  • 141
    • 0036792815 scopus 로고    scopus 로고
    • Prognostic relevance of early serial C-reactive protein measurements afterfirst ischemic stroke
    • Winbeck K, Poppert H, Etgen T, Conrad B, Sander D. Prognostic relevance of early serial C-reactive protein measurements afterfirst ischemic stroke. Stroke. 2002;33:2459-64.
    • (2002) Stroke. , vol.33 , pp. 2459-2464
    • Winbeck, K.1    Poppert, H.2    Etgen, T.3    Conrad, B.4    Sander, D.5
  • 142
    • 33747193259 scopus 로고    scopus 로고
    • Serum C-reactive protein concentration and genotype in relation to ischemic stroke subtype
    • Ladenvall C, Jood K, Blomstrand C, Nilsson S, Jern C, Ladenvall P. Serum C-reactive protein concentration and genotype in relation to ischemic stroke subtype. Stroke. 2006;37:2018-23.
    • (2006) Stroke. , vol.37 , pp. 2018-2023
    • Ladenvall, C.1    Jood, K.2    Blomstrand, C.3    Nilsson, S.4    Jern, C.5    Ladenvall, P.6
  • 143
    • 8344247671 scopus 로고    scopus 로고
    • Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats
    • Gill R, Kemp JA, Sabin C, Pepys MB. Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats. J Cereb Blood Flow Metab. 2004;24:1214-8.
    • (2004) J Cereb Blood Flow Metab. , vol.24 , pp. 1214-1218
    • Gill, R.1    Kemp, J.A.2    Sabin, C.3    Pepys, M.B.4
  • 145
    • 40749120506 scopus 로고    scopus 로고
    • Acute ischaemic stroke and infection: Recent and emerging concepts
    • Emsley HC, Hopkins SJ. Acute ischaemic stroke and infection: recent and emerging concepts. Lancet Neurol. 2008;7:341-53.
    • (2008) Lancet Neurol. , vol.7 , pp. 341-353
    • Emsley, H.C.1    Hopkins, S.J.2
  • 146
    • 33846583388 scopus 로고    scopus 로고
    • Stroke-induced immunodepression: Experimental evidence and clinical relevance
    • Dirnagl U, Klehmet J, Braun JS, Harms H, Meisel C, Ziemssen T, et al. Stroke-induced immunodepression: experimental evidence and clinical relevance. Stroke. 2007;38:770-3.
    • (2007) Stroke. , vol.38 , pp. 770-773
    • Dirnagl, U.1    Klehmet, J.2    Braun, J.S.3    Harms, H.4    Meisel, C.5    Ziemssen, T.6
  • 147
    • 33947515643 scopus 로고    scopus 로고
    • Infection after acute ischemic stroke: A manifestation of brain-induced immunodepression
    • Chamorro A, Urra X, Planas AM. Infection after acute ischemic stroke: A manifestation of brain-induced immunodepression. Stroke. 2007;38:1097-103.
    • (2007) Stroke. , vol.38 , pp. 1097-1103
    • Chamorro, A.1    Urra, X.2    Planas, A.M.3
  • 150
    • 79955480642 scopus 로고    scopus 로고
    • Autonomic shift and increased susceptibility to infections after acute intracerebral hemorrhage
    • Sykora M, Diedler J, Poli S, Rizos T, Turcani P, Veltkamp R, et al. Autonomic shift and increased susceptibility to infections after acute intracerebral hemorrhage. Stroke. 2011;42: 1218-23.
    • (2011) Stroke. , vol.42 , pp. 1218-1223
    • Sykora, M.1    Diedler, J.2    Poli, S.3    Rizos, T.4    Turcani, P.5    Veltkamp, R.6
  • 155
    • 84873019070 scopus 로고    scopus 로고
    • Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature
    • Kleinschnitz C, Kraft P, Dreykluft A, Hagedorn I, Gobel K, Schuhmann MK, et al. Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood. 2013;121:679-91.
    • (2013) Blood. , vol.121 , pp. 679-691
    • Kleinschnitz, C.1    Kraft, P.2    Dreykluft, A.3    Hagedorn, I.4    Gobel, K.5    Schuhmann, M.K.6
  • 156
    • 33947526469 scopus 로고    scopus 로고
    • Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production
    • Emsley HC, Smith CJ, Gavin CM, Georgiou RF, Vail A, Barberan EM, et al. Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production. BMC Neurol. 2007;7:5.
    • (2007) BMC Neurol. , vol.7 , pp. 5
    • Emsley, H.C.1    Smith, C.J.2    Gavin, C.M.3    Georgiou, R.F.4    Vail, A.5    Barberan, E.M.6
  • 157
    • 0042886941 scopus 로고    scopus 로고
    • Stroke-induced immunodefi-ciency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation
    • Prass K, Meisel C, Hoflich C, Braun J, Halle E, Wolf T, et al. Stroke-induced immunodefi-ciency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med. 2003;198: 725-36.
    • (2003) J Exp Med. , vol.198 , pp. 725-736
    • Prass, K.1    Meisel, C.2    Hoflich, C.3    Braun, J.4    Halle, E.5    Wolf, T.6
  • 159
    • 28044470484 scopus 로고    scopus 로고
    • Monitoring temporary immunodepression byflow cytometric measurement of monocytic HLA-DR expression: A multicenter standardized study
    • Docke WD, Hoflich C, Davis KA, Rottgers K, Meisel C, Kiefer P, et al. Monitoring temporary immunodepression byflow cytometric measurement of monocytic HLA-DR expression: A multicenter standardized study. Clin Chem. 2005;51:2341-7.
    • (2005) Clin Chem. , vol.51 , pp. 2341-2347
    • Docke, W.D.1    Hoflich, C.2    Davis, K.A.3    Rottgers, K.4    Meisel, C.5    Kiefer, P.6
  • 160
    • 59349116941 scopus 로고    scopus 로고
    • Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression
    • Offner H, Vandenbark AA, Hurn PD. Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression. Neuroscience. 2009;158:1098-111.
    • (2009) Neuroscience. , vol.158 , pp. 1098-1111
    • Offner, H.1    Vandenbark, A.A.2    Hurn, P.D.3
  • 161
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare C, Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science. 2003;299:1033-6.
    • (2003) Science. , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 162
    • 0141463763 scopus 로고    scopus 로고
    • Inflammatory mechanisms associated with brain damage induced by kainic acid with special reference to the interleukin-1 system
    • Oprica M, Eriksson C, Schultzberg M. Inflammatory mechanisms associated with brain damage induced by kainic acid with special reference to the interleukin-1 system. J Cell Mol Med. 2003;7:127-40.
    • (2003) J Cell Mol Med. , vol.7 , pp. 127-140
    • Oprica, M.1    Eriksson, C.2    Schultzberg, M.3
  • 163
    • 66449111088 scopus 로고    scopus 로고
    • Reflex control of immunity
    • Tracey KJ. Reflex control of immunity. Nat Rev Immunol. 2009;9:418-28.
    • (2009) Nat Rev Immunol. , vol.9 , pp. 418-428
    • Tracey, K.J.1
  • 164
    • 84862806229 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression
    • Smith CJ, Emsley HC, Udeh CT, Vail A, Hoadley ME, Rothwell NJ, et al. Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression. Cytokine. 2012;58:384-9.
    • (2012) Cytokine. , vol.58 , pp. 384-389
    • Smith, C.J.1    Emsley, H.C.2    Udeh, C.T.3    Vail, A.4    Hoadley, M.E.5    Rothwell, N.J.6
  • 165
    • 0037734003 scopus 로고    scopus 로고
    • Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice
    • Turnbull AV, Prehar S, Kennedy AR, Little RA, Hopkins SJ. Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice. Endocrinology. 2003;144:1894-906.
    • (2003) Endocrinology. , vol.144 , pp. 1894-1906
    • Turnbull, A.V.1    Prehar, S.2    Kennedy, A.R.3    Little, R.A.4    Hopkins, S.J.5
  • 168
    • 84878526769 scopus 로고    scopus 로고
    • Superiority of preventive antibiotic treatment compared with standard treatment of poststroke pneumonia in experimental stroke: A bed to bench approach
    • Hetze S, Engel O, Romer C, Mueller S, Dirnagl U, Meisel C, et al. Superiority of preventive antibiotic treatment compared with standard treatment of poststroke pneumonia in experimental stroke: A bed to bench approach. J Cereb Blood Flow Metab. 2013;33:846-54.
    • (2013) J Cereb Blood Flow Metab. , vol.33 , pp. 846-854
    • Hetze, S.1    Engel, O.2    Romer, C.3    Mueller, S.4    Dirnagl, U.5    Meisel, C.6
  • 170
    • 34848857092 scopus 로고    scopus 로고
    • Minocycline treatment in acute stroke: An open-label, evaluator-blinded study
    • Lampl Y, Boaz M, Gilad R, Lorberboym M, Dabby R, Rapoport A, et al. Minocycline treatment in acute stroke: an open-label, evaluator-blinded study. Neurology. 2007;69:1404-10.
    • (2007) Neurology. , vol.69 , pp. 1404-1410
    • Lampl, Y.1    Boaz, M.2    Gilad, R.3    Lorberboym, M.4    Dabby, R.5    Rapoport, A.6
  • 172
    • 34848842158 scopus 로고    scopus 로고
    • The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention
    • Sheldon AL, Robinson MB. The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention. Neurochem Int. 2007;51:333-55.
    • (2007) Neurochem Int. , vol.51 , pp. 333-355
    • Sheldon, A.L.1    Robinson, M.B.2
  • 173
    • 20944443639 scopus 로고    scopus 로고
    • Glucocorticoid receptor antagonists: New tools to investigate disorders characterized by cortisol hypersecretion
    • Peeters BW, Tonnaer JA, Groen MB, Broekkamp CL, van der Voort HA, Schoonen WG, et al. Glucocorticoid receptor antagonists: new tools to investigate disorders characterized by cortisol hypersecretion. Stress. 2004;7:233-41.
    • (2004) Stress. , vol.7 , pp. 233-241
    • Peeters, B.W.1    Tonnaer, J.A.2    Groen, M.B.3    Broekkamp, C.L.4    Van Der Voort, H.A.5    Schoonen, W.G.6
  • 174
    • 33645744014 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases in delayed cortical responses after stroke
    • Zhao BQ, Wang S, Kim HY, Storrie H, Rosen BR, Mooney DJ, et al. Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med. 2006;12:441-5.
    • (2006) Nat Med. , vol.12 , pp. 441-445
    • Zhao, B.Q.1    Wang, S.2    Kim, H.Y.3    Storrie, H.4    Rosen, B.R.5    Mooney, D.J.6
  • 175
    • 78549283981 scopus 로고    scopus 로고
    • Novel lipid mediators promote resolution of acute inflammation: Impact of aspirin and statins
    • Spite M, Serhan CN. Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins. Circ Res. 2010;107:1170-84.
    • (2010) Circ Res. , vol.107 , pp. 1170-1184
    • Spite, M.1    Serhan, C.N.2
  • 176
    • 77950365906 scopus 로고    scopus 로고
    • Nonresolving inflammation
    • Nathan C, Ding A. Nonresolving inflammation. Cell. 2010;140:871-82.
    • (2010) Cell. , vol.140 , pp. 871-882
    • Nathan, C.1    Ding, A.2
  • 177
    • 77956255766 scopus 로고    scopus 로고
    • Find-me and eat-me signals in apoptotic cell clearance: Progress and conundrums
    • Ravichandran KS. Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums. J Exp Med. 2010;207:1807-17.
    • (2010) J Exp Med. , vol.207 , pp. 1807-1817
    • Ravichandran, K.S.1
  • 178
    • 4744355622 scopus 로고    scopus 로고
    • Cxcr3-dependent microglial recruitment is essential for dendrite loss after brain lesion
    • Rappert A, Bechmann I, Pivneva T, Mahlo J, Biber K, Nolte C, et al. Cxcr3-dependent microglial recruitment is essential for dendrite loss after brain lesion. J Neurosci. 2004;24:8500-9.
    • (2004) J Neurosci. , vol.24 , pp. 8500-8509
    • Rappert, A.1    Bechmann, I.2    Pivneva, T.3    Mahlo, J.4    Biber, K.5    Nolte, C.6
  • 180
    • 33645023639 scopus 로고    scopus 로고
    • Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: The role of T regulatory cells
    • Taylor A, Verhagen J, Blaser K, Akdis M, Akdis CA. Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: The role of T regulatory cells. Immunology. 2006;117:433-42.
    • (2006) Immunology. , vol.117 , pp. 433-442
    • Taylor, A.1    Verhagen, J.2    Blaser, K.3    Akdis, M.4    Akdis, C.A.5
  • 181
    • 33847111695 scopus 로고    scopus 로고
    • The neuropoietic cytokine family in development, plasticity, disease and injury
    • Bauer S, Kerr BJ, Patterson PH. The neuropoietic cytokine family in development, plasticity, disease and injury. Nat Rev Neurosci. 2007;8:221-32.
    • (2007) Nat Rev Neurosci. , vol.8 , pp. 221-232
    • Bauer, S.1    Kerr, B.J.2    Patterson, P.H.3
  • 182
    • 33748978368 scopus 로고    scopus 로고
    • Growth factors and stroke
    • Greenberg DA, Jin K. Growth factors and stroke. NeuroRx. 2006;3:458-65.
    • (2006) NeuroRx. , vol.3 , pp. 458-465
    • Greenberg, D.A.1    Jin, K.2
  • 183
    • 72749103747 scopus 로고    scopus 로고
    • Translating the frontiers of brain repair to treatments: Starting not to break the rules
    • Carmichael ST. Translating the frontiers of brain repair to treatments: starting not to break the rules. Neurobiol Dis. 2010;37:237-42.
    • (2010) Neurobiol Dis. , vol.37 , pp. 237-242
    • Carmichael, S.T.1
  • 184
    • 0037155051 scopus 로고    scopus 로고
    • Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse
    • Zhang ZG, Zhang L, Jiang Q, Chopp M. Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse. Circ Res. 2002;90:284-8.
    • (2002) Circ Res. , vol.90 , pp. 284-288
    • Zhang, Z.G.1    Zhang, L.2    Jiang, Q.3    Chopp, M.4
  • 185
    • 33847785649 scopus 로고    scopus 로고
    • Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain
    • Lalancette-Hebert M, Gowing G, Simard A, Weng YC, Kriz J. Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain. J Neurosci. 2007;27: 2596-605.
    • (2007) J Neurosci. , vol.27 , pp. 2596-2605
    • Lalancette-Hebert, M.1    Gowing, G.2    Simard, A.3    Weng, Y.C.4    Kriz, J.5
  • 186
    • 0036205888 scopus 로고    scopus 로고
    • Correlation of vegf and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia
    • Zhang ZG, Zhang L, Tsang W, Soltanian-Zadeh H, Morris D, Zhang R, et al. Correlation of vegf and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia. J Cereb Blood Flow Metab. 2002;22:379-92.
    • (2002) J Cereb Blood Flow Metab. , vol.22 , pp. 379-392
    • Zhang, Z.G.1    Zhang, L.2    Tsang, W.3    Soltanian-Zadeh, H.4    Morris, D.5    Zhang, R.6
  • 187
    • 35448929084 scopus 로고    scopus 로고
    • Neutrophil depletion decreases vegfinduced focal angiogenesis in the mature mouse brain
    • Hao Q, Chen Y, Zhu Y, Fan Y, Palmer D, Su H, et al. Neutrophil depletion decreases vegfinduced focal angiogenesis in the mature mouse brain. J Cereb Blood Flow Metab. 2007;27:1853-60.
    • (2007) J Cereb Blood Flow Metab. , vol.27 , pp. 1853-1860
    • Hao, Q.1    Chen, Y.2    Zhu, Y.3    Fan, Y.4    Palmer, D.5    Su, H.6
  • 188
    • 2642569472 scopus 로고    scopus 로고
    • Neuroprotection of ischemic brain by vascular endothelial growth factor is critically dependent on proper dosage and may be compromised by angiogenesis
    • Manoonkitiwongsa PS, Schultz RL, McCreery DB, Whitter EF, Lyden PD. Neuroprotection of ischemic brain by vascular endothelial growth factor is critically dependent on proper dosage and may be compromised by angiogenesis. J Cereb Blood Flow Metab. 2004;24: 693-702.
    • (2004) J Cereb Blood Flow Metab. , vol.24 , pp. 693-702
    • Manoonkitiwongsa, P.S.1    Schultz, R.L.2    McCreery, D.B.3    Whitter, E.F.4    Lyden, P.D.5
  • 189
    • 0033797255 scopus 로고    scopus 로고
    • Vegf enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain
    • Zhang ZG, Zhang L, Jiang Q, Zhang R, Davies K, Powers C, et al. Vegf enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest. 2000; 106:829-38.
    • (2000) J Clin Invest. , vol.106 , pp. 829-838
    • Zhang, Z.G.1    Zhang, L.2    Jiang, Q.3    Zhang, R.4    Davies, K.5    Powers, C.6
  • 190
    • 78649339985 scopus 로고    scopus 로고
    • An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke
    • Li S, Overman JJ, Katsman D, Kozlov SV, Donnelly CJ, Twiss JL, et al. An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke. Nat Neurosci. 2010;13:1496-504.
    • (2010) Nat Neurosci. , vol.13 , pp. 1496-1504
    • Li, S.1    Overman, J.J.2    Katsman, D.3    Kozlov, S.V.4    Donnelly, C.J.5    Twiss, J.L.6
  • 191
    • 78650230589 scopus 로고    scopus 로고
    • Perturbed cellular response to brain injury during aging
    • Popa-Wagner A, Buga AM, Kokaia Z. Perturbed cellular response to brain injury during aging. Ageing Res Rev. 2011;10:71-9.
    • (2011) Ageing Res Rev. , vol.10 , pp. 71-79
    • Popa-Wagner, A.1    Buga, A.M.2    Kokaia, Z.3
  • 195
    • 80052330506 scopus 로고    scopus 로고
    • Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease
    • Biron KE, Dickstein DL, Gopaul R, Jefferies WA. Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease. PLoS One. 2011;6:e23789.
    • (2011) PLoS One. , vol.6 , pp. e23789
    • Biron, K.E.1    Dickstein, D.L.2    Gopaul, R.3    Jefferies, W.A.4
  • 196
    • 84867572251 scopus 로고    scopus 로고
    • Characteristic clinical presentation and CSF biomarker pattern in cerebral small vessel disease
    • Wallin A, Ohrfelt A, Bjerke M. Characteristic clinical presentation and CSF biomarker pattern in cerebral small vessel disease. J Neurol Sci. 2012;322:192-6.
    • (2012) J Neurol Sci. , vol.322 , pp. 192-196
    • Wallin, A.1    Ohrfelt, A.2    Bjerke, M.3
  • 198
    • 79251614754 scopus 로고    scopus 로고
    • Triflusal reduces cerebral ischemia induced inflammation in a combined mouse model of Alzheimer's disease and stroke
    • Whitehead SN, Massoni E, Cheng G, Hachinski VC, Cimino M, Balduini W, et al. Triflusal reduces cerebral ischemia induced inflammation in a combined mouse model of Alzheimer's disease and stroke. Brain Res. 2010;1366:246-56.
    • (2010) Brain Res. , vol.1366 , pp. 246-256
    • Whitehead, S.N.1    Massoni, E.2    Cheng, G.3    Hachinski, V.C.4    Cimino, M.5    Balduini, W.6
  • 199
    • 34247338117 scopus 로고    scopus 로고
    • Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1-and neutrophil-dependent mechanisms
    • McColl BW, Rothwell NJ, Allan SM. Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1-and neutrophil-dependent mechanisms. J Neurosci. 2007;27:4403-12.
    • (2007) J Neurosci. , vol.27 , pp. 4403-4412
    • McColl, B.W.1    Rothwell, N.J.2    Allan, S.M.3
  • 202
    • 77953648503 scopus 로고    scopus 로고
    • A critical assessment of edaravone acute ischemic stroke efficacy trials: Is edaravone an effective neuroprotective therapy?
    • Lapchak PA. A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy? Expert Opin Pharmacother. 2010;11:1753-63.
    • (2010) Expert Opin Pharmacother. , vol.11 , pp. 1753-1763
    • Lapchak, P.A.1
  • 207
    • 0035940577 scopus 로고    scopus 로고
    • Use of anti-icam-1 therapy in ischemic stroke: Results of the enlimomab acute stroke trial
    • Investigators EAST. Use of anti-icam-1 therapy in ischemic stroke: results of the enlimomab acute stroke trial. Neurology. 2001;57:1428-34.
    • (2001) Neurology. , vol.57 , pp. 1428-1434
    • Investigators EAST1
  • 208
    • 0035164475 scopus 로고    scopus 로고
    • Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody: A bedside-to-bench study
    • Furuya K, Takeda H, Azhar S, McCarron RM, Chen Y, Ruetzler CA, et al. Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody: A bedside-to-bench study. Stroke. 2001;32:2665-74.
    • (2001) Stroke. , vol.32 , pp. 2665-2674
    • Furuya, K.1    Takeda, H.2    Azhar, S.3    McCarron, R.M.4    Chen, Y.5    Ruetzler, C.A.6
  • 209
    • 84865965431 scopus 로고    scopus 로고
    • Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats
    • Pradillo JM, Denes A, Greenhalgh AD, Boutin H, Drake C, McColl BW, et al. Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats. J Cereb Blood Flow Metab. 2012;32:1810-9.
    • (2012) J Cereb Blood Flow Metab. , vol.32 , pp. 1810-1819
    • Pradillo, J.M.1    Denes, A.2    Greenhalgh, A.D.3    Boutin, H.4    Drake, C.5    McColl, B.W.6
  • 211
    • 39849105534 scopus 로고    scopus 로고
    • Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinalfluid of patients following subarachnoid haemorrhage
    • Gueorguieva I, Clark SR, McMahon CJ, Scarth S, Rothwell NJ, Tyrrell PJ, et al. Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinalfluid of patients following subarachnoid haemorrhage. Br J Clin Pharmacol. 2008;65:317-25.
    • (2008) Br J Clin Pharmacol. , vol.65 , pp. 317-325
    • Gueorguieva, I.1    Clark, S.R.2    McMahon, C.J.3    Scarth, S.4    Rothwell, N.J.5    Tyrrell, P.J.6
  • 212
    • 84884502741 scopus 로고    scopus 로고
    • Intravenous minocycline in acute stroke: A randomized, controlled pilot study and meta-analysis
    • Kohler E, Prentice DA, Bates TR, Hankey GJ, Claxton A, van Heerden J, et al. Intravenous minocycline in acute stroke: A randomized, controlled pilot study and meta-analysis. Stroke. 2013;44:2493-9.
    • (2013) Stroke. , vol.44 , pp. 2493-2499
    • Kohler, E.1    Prentice, D.A.2    Bates, T.R.3    Hankey, G.J.4    Claxton, A.5    Van Heerden, J.6
  • 213
    • 84876281980 scopus 로고    scopus 로고
    • Remote limb preconditioning and postconditioning: Will it translate into a promising treatment for acute stroke?
    • Hess DC, Hoda MN, Bhatia K. Remote limb preconditioning and postconditioning: will it translate into a promising treatment for acute stroke? Stroke. 2013;44:1191-7.
    • (2013) Stroke. , vol.44 , pp. 1191-1197
    • Hess, D.C.1    Hoda, M.N.2    Bhatia, K.3
  • 214
    • 33745763116 scopus 로고    scopus 로고
    • Cerebral preconditioning and ischaemic tolerance
    • Gidday JM. Cerebral preconditioning and ischaemic tolerance. Nat Rev Neurosci. 2006;7:437-48.
    • (2006) Nat Rev Neurosci. , vol.7 , pp. 437-448
    • Gidday, J.M.1
  • 217
    • 0033898859 scopus 로고    scopus 로고
    • Increase in endogenous brain superoxide dismutase as a potential mechanism of lipopolysaccharide-induced brain ischemic tolerance
    • Bordet R, Deplanque D, Maboudou P, Puisieux F, Pu Q, Robin E, et al. Increase in endogenous brain superoxide dismutase as a potential mechanism of lipopolysaccharide-induced brain ischemic tolerance. J Cereb Blood Flow Metab. 2000;20:1190-6.
    • (2000) J Cereb Blood Flow Metab. , vol.20 , pp. 1190-1196
    • Bordet, R.1    Deplanque, D.2    Maboudou, P.3    Puisieux, F.4    Pu, Q.5    Robin, E.6
  • 219
    • 8344267480 scopus 로고    scopus 로고
    • Inhibition of toll-like receptor and cytokine signaling-A unifying theme in ischemic tolerance
    • Kariko K, Weissman D, Welsh FA. Inhibition of toll-like receptor and cytokine signaling-A unifying theme in ischemic tolerance. J Cereb Blood Flow Metab. 2004;24:1288-304.
    • (2004) J Cereb Blood Flow Metab. , vol.24 , pp. 1288-1304
    • Kariko, K.1    Weissman, D.2    Welsh, F.A.3
  • 220
    • 68549089184 scopus 로고    scopus 로고
    • Systemic lipopolysaccharide protects the brain from ischemic injury by reprogramming the response of the brain to stroke: A critical role for IRF3
    • Marsh B, Stevens SL, Packard AE, Gopalan B, Hunter B, Leung PY, et al. Systemic lipopolysaccharide protects the brain from ischemic injury by reprogramming the response of the brain to stroke: A critical role for IRF3. J Neurosci. 2009;29:9839-49.
    • (2009) J Neurosci. , vol.29 , pp. 9839-9849
    • Marsh, B.1    Stevens, S.L.2    Packard, A.E.3    Gopalan, B.4    Hunter, B.5    Leung, P.Y.6
  • 221
    • 0035399856 scopus 로고    scopus 로고
    • Activation of the nuclear factorkappaB is a key event in brain tolerance
    • Blondeau N, Widmann C, Lazdunski M, Heurteaux C. Activation of the nuclear factorkappaB is a key event in brain tolerance. J Neurosci. 2001;21:4668-77.
    • (2001) J Neurosci. , vol.21 , pp. 4668-4677
    • Blondeau, N.1    Widmann, C.2    Lazdunski, M.3    Heurteaux, C.4
  • 222
    • 34447128135 scopus 로고    scopus 로고
    • Neurovascular protection by ischemic tolerance: Role of nitric oxide and reactive oxygen species
    • Kunz A, Park L, Abe T, Gallo EF, Anrather J, Zhou P, et al. Neurovascular protection by ischemic tolerance: role of nitric oxide and reactive oxygen species. J Neurosci. 2007;27:7083-93.
    • (2007) J Neurosci. , vol.27 , pp. 7083-7093
    • Kunz, A.1    Park, L.2    Abe, T.3    Gallo, E.F.4    Anrather, J.5    Zhou, P.6
  • 223
    • 0029974018 scopus 로고    scopus 로고
    • Interleukin-1 mediates induction of tolerance to global ischemia in gerbil hippocampal ca1 neurons
    • Ohtsuki T, Ruetzler CA, Tasaki K, Hallenbeck JM. Interleukin-1 mediates induction of tolerance to global ischemia in gerbil hippocampal ca1 neurons. J Cereb Blood Flow Metab. 1996;16:1137-42.
    • (1996) J Cereb Blood Flow Metab. , vol.16 , pp. 1137-1142
    • Ohtsuki, T.1    Ruetzler, C.A.2    Tasaki, K.3    Hallenbeck, J.M.4
  • 225
    • 33846600939 scopus 로고    scopus 로고
    • A novel immune-based therapy for stroke induces neuroprotection and supports neurogenesis
    • Ziv Y, Finkelstein A, Geffen Y, Kipnis J, Smirnov I, Shpilman S, et al. A novel immune-based therapy for stroke induces neuroprotection and supports neurogenesis. Stroke. 2007;38: 774-82.
    • (2007) Stroke. , vol.38 , pp. 774-782
    • Ziv, Y.1    Finkelstein, A.2    Geffen, Y.3    Kipnis, J.4    Smirnov, I.5    Shpilman, S.6
  • 226
    • 33846966636 scopus 로고    scopus 로고
    • A brief history of t(h)17, thefirst major revision in the t(h)1/t(h)2 hypothesis of T cell-mediated tissue damage
    • Steinman L. A brief history of t(h)17, thefirst major revision in the t(h)1/t(h)2 hypothesis of T cell-mediated tissue damage. Nat Med. 2007;13:139-45.
    • (2007) Nat Med. , vol.13 , pp. 139-145
    • Steinman, L.1
  • 227
    • 59349090559 scopus 로고    scopus 로고
    • Boosting T-cell immunity as a therapeutic approach for neurodegenerative conditions: The role of innate immunity
    • Schwartz M, London A, Shechter R. Boosting T-cell immunity as a therapeutic approach for neurodegenerative conditions: The role of innate immunity. Neuroscience. 2009;158: 1133-42.
    • (2009) Neuroscience. , vol.158 , pp. 1133-1142
    • Schwartz, M.1    London, A.2    Shechter, R.3
  • 228
    • 78650819783 scopus 로고    scopus 로고
    • Brain cooling-stimulated angiogenesis and neurogenesis attenuated traumatic brain injury in rats
    • Kuo JR, Lo CJ, Chang CP, Lin HJ, Lin MT, Chio CC. Brain cooling-stimulated angiogenesis and neurogenesis attenuated traumatic brain injury in rats. J Trauma. 2010;69:1467-72.
    • (2010) J Trauma. , vol.69 , pp. 1467-1472
    • Kuo, J.R.1    Lo, C.J.2    Chang, C.P.3    Lin, H.J.4    Lin, M.T.5    Chio, C.C.6
  • 231
    • 1342347268 scopus 로고    scopus 로고
    • Regional brain cooling induced by vascular saline infusion into ischemic territory reduces brain inflammation in stroke
    • Luan X, Li J, McAllister 2nd JP, Diaz FG, Clark JC, Fessler RD, et al. Regional brain cooling induced by vascular saline infusion into ischemic territory reduces brain inflammation in stroke. Acta Neuropathol. 2004;107:227-34.
    • (2004) Acta Neuropathol. , vol.107 , pp. 227-234
    • Luan, X.1    Li, J.2    McAllister, I.I.J.P.3    Diaz, F.G.4    Clark, J.C.5    Fessler, R.D.6
  • 232
    • 34247577553 scopus 로고    scopus 로고
    • Different degrees of hypothermia after experimental stroke: Short-and long-term outcome
    • Kollmar R, Blank T, Han JL, Georgiadis D, Schwab S. Different degrees of hypothermia after experimental stroke: short-and long-term outcome. Stroke. 2007;38:1585-9.
    • (2007) Stroke. , vol.38 , pp. 1585-1589
    • Kollmar, R.1    Blank, T.2    Han, J.L.3    Georgiadis, D.4    Schwab, S.5
  • 233
  • 235
    • 84864549499 scopus 로고    scopus 로고
    • Prolonged gaseous hypothermia prevents the upregulation of phagocytosis-specific protein annexin 1 and causes low-amplitude EEG activity in the aged rat brain after cerebral ischemia
    • Joseph C, Buga AM, Vintilescu R, Balseanu AT, Moldovan M, Junker H, et al. Prolonged gaseous hypothermia prevents the upregulation of phagocytosis-specific protein annexin 1 and causes low-amplitude EEG activity in the aged rat brain after cerebral ischemia. J Cereb Blood Flow Metab. 2012;32:1632-42.
    • (2012) J Cereb Blood Flow Metab. , vol.32 , pp. 1632-1642
    • Joseph, C.1    Buga, A.M.2    Vintilescu, R.3    Balseanu, A.T.4    Moldovan, M.5    Junker, H.6
  • 236
    • 2542457495 scopus 로고    scopus 로고
    • Inflammatory caspases: Linking an intracellular innate immune system to autoinflammatory diseases
    • Martinon F, Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell. 2004;117:561-74.
    • (2004) Cell. , vol.117 , pp. 561-574
    • Martinon, F.1    Tschopp, J.2
  • 237
    • 33750288937 scopus 로고    scopus 로고
    • Apoptosis and caspases regulate death and inflammation in sepsis
    • Hotchkiss RS, Nicholson DW. Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol. 2006;6:813-22.
    • (2006) Nat Rev Immunol. , vol.6 , pp. 813-822
    • Hotchkiss, R.S.1    Nicholson, D.W.2
  • 238
    • 67650070650 scopus 로고    scopus 로고
    • Normobaric hyperoxia reduces the neurovascular complications associated with delayed tissue plasminogen activator treatment in a rat model of focal cerebral ischemia
    • Liu W, Hendren J, Qin XJ, Liu KJ. Normobaric hyperoxia reduces the neurovascular complications associated with delayed tissue plasminogen activator treatment in a rat model of focal cerebral ischemia. Stroke. 2009;40:2526-31.
    • (2009) Stroke. , vol.40 , pp. 2526-2531
    • Liu, W.1    Hendren, J.2    Qin, X.J.3    Liu, K.J.4
  • 239
    • 79951847407 scopus 로고    scopus 로고
    • Annexin a1 is a new functional linker between actinfilaments and phagosomes during phagocytosis
    • Patel DM, Ahmad SF, Weiss DG, Gerke V, Kuznetsov SA. Annexin a1 is a new functional linker between actinfilaments and phagosomes during phagocytosis. J Cell Sci. 2011;124: 578-88.
    • (2011) J Cell Sci. , vol.124 , pp. 578-588
    • Patel, D.M.1    Ahmad, S.F.2    Weiss, D.G.3    Gerke, V.4    Kuznetsov, S.A.5
  • 241
    • 0035136510 scopus 로고    scopus 로고
    • Neutrophil interaction with inflamed postcapillary venule endothelium alters annexin 1 expression
    • Oliani SM, Paul-Clark MJ, Christian HC, Flower RJ, Perretti M. Neutrophil interaction with inflamed postcapillary venule endothelium alters annexin 1 expression. Am J Pathol. 2001;158:603-15.
    • (2001) Am J Pathol. , vol.158 , pp. 603-615
    • Oliani, S.M.1    Paul-Clark, M.J.2    Christian, H.C.3    Flower, R.J.4    Perretti, M.5
  • 243
    • 84863531193 scopus 로고    scopus 로고
    • Time-dependent effects of hypothermia on microglial activation and migration
    • Seo JW, Kim JH, Seo M, Han HS, Park J, Suk K. Time-dependent effects of hypothermia on microglial activation and migration. J Neuroinflammation. 2012;9:164.
    • (2012) J Neuroinflammation. , vol.9 , pp. 164
    • Seo, J.W.1    Kim, J.H.2    Seo, M.3    Han, H.S.4    Park, J.5    Suk, K.6
  • 244
    • 67149143154 scopus 로고    scopus 로고
    • Clinical application of therapeutic hypothermia in stroke
    • Liu L, Yenari MA. Clinical application of therapeutic hypothermia in stroke. Neurol Res. 2009;31:331-5.
    • (2009) Neurol Res. , vol.31 , pp. 331-335
    • Liu, L.1    Yenari, M.A.2
  • 245
    • 78650793697 scopus 로고    scopus 로고
    • Intravenous hydrogen sulfide does not induce hypothermia or improve survival from hemorrhagic shock in pigs
    • Drabek T, Kochanek PM, Stezoski J, Wu X, Bayir H, Morhard RC, et al. Intravenous hydrogen sulfide does not induce hypothermia or improve survival from hemorrhagic shock in pigs. Shock. 2011;35:67-73.
    • (2011) Shock. , vol.35 , pp. 67-73
    • Drabek, T.1    Kochanek, P.M.2    Stezoski, J.3    Wu, X.4    Bayir, H.5    Morhard, R.C.6
  • 246
    • 80053602560 scopus 로고    scopus 로고
    • Local mild hypothermia with thrombolysis for acute ischemic stroke within a 6-h window
    • Bi M, Ma Q, Zhang S, Li J, Zhang Y, Lin L, et al. Local mild hypothermia with thrombolysis for acute ischemic stroke within a 6-h window. Clin Neurol Neurosurg. 2011;113:768-73.
    • (2011) Clin Neurol Neurosurg. , vol.113 , pp. 768-773
    • Bi, M.1    Ma, Q.2    Zhang, S.3    Li, J.4    Zhang, Y.5    Lin, L.6
  • 247
    • 84877975754 scopus 로고    scopus 로고
    • The multifunctional anti-inflammatory drugs used in the therapy of Alzheimer's disease
    • Shi S, Wang Z, Qiao Z. The multifunctional anti-inflammatory drugs used in the therapy of Alzheimer's disease. Curr Med Chem. 2013;20:2583-8.
    • (2013) Curr Med Chem. , vol.20 , pp. 2583-2588
    • Shi, S.1    Wang, Z.2    Qiao, Z.3
  • 248
    • 84861314593 scopus 로고    scopus 로고
    • Aspirin, steroidal and non-steroidal antiinflammatory drugs for the treatment of Alzheimer's disease
    • Jaturapatporn D, Isaac MG, McCleery J, Tabet N. Aspirin, steroidal and non-steroidal antiinflammatory drugs for the treatment of Alzheimer's disease. Cochrane Database Syst Rev. 2012;2, CD006378.
    • (2012) Cochrane Database Syst Rev. , vol.2 , pp. CD006378
    • Jaturapatporn, D.1    Isaac, M.G.2    McCleery, J.3    Tabet, N.4
  • 249
  • 250
    • 84864140992 scopus 로고    scopus 로고
    • Calpain inhibitor a-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xtgad mice
    • Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, et al. Calpain inhibitor a-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xtgad mice. Am J Pathol. 2012;181:616-25.
    • (2012) Am J Pathol. , vol.181 , pp. 616-625
    • Medeiros, R.1    Kitazawa, M.2    Chabrier, M.A.3    Cheng, D.4    Baglietto-Vargas, D.5    Kling, A.6
  • 251
    • 84870456663 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate prevents systemic inflammation-induced memory deficiency and amyloidogenesis via its antineuroinflammatory properties
    • Lee YJ, Choi DY, Yun YP, Han SB, Oh KW, Hong JT. Epigallocatechin-3-gallate prevents systemic inflammation-induced memory deficiency and amyloidogenesis via its antineuroinflammatory properties. J Nutr Biochem. 2013;24:298-310.
    • (2013) J Nutr Biochem. , vol.24 , pp. 298-310
    • Lee, Y.J.1    Choi, D.Y.2    Yun, Y.P.3    Han, S.B.4    Oh, K.W.5    Hong, J.T.6
  • 252
    • 84869229018 scopus 로고    scopus 로고
    • Arctigenin protects focal cerebral ischemia-reperfusion rats through inhibiting neuroinflammation
    • Fan T, Jiang WL, Zhu J, Feng ZY. Arctigenin protects focal cerebral ischemia-reperfusion rats through inhibiting neuroinflammation. Biol Pharm Bull. 2012;35:2004-9.
    • (2012) Biol Pharm Bull. , vol.35 , pp. 2004-2009
    • Fan, T.1    Jiang, W.L.2    Zhu, J.3    Feng, Z.Y.4
  • 253
    • 84871577272 scopus 로고    scopus 로고
    • Ameliorative effects of telmisartan on the inflammatory response and impaired spatial memory in a rat model of Alzheimer's disease incorporating additional cerebrovascular disease factors
    • Shindo T, Takasaki K, Uchida K, Onimura R, Kubota K, Uchida N, et al. Ameliorative effects of telmisartan on the inflammatory response and impaired spatial memory in a rat model of Alzheimer's disease incorporating additional cerebrovascular disease factors. Biol Pharm Bull. 2012;35:2141-7.
    • (2012) Biol Pharm Bull. , vol.35 , pp. 2141-2147
    • Shindo, T.1    Takasaki, K.2    Uchida, K.3    Onimura, R.4    Kubota, K.5    Uchida, N.6
  • 254
    • 84867370380 scopus 로고    scopus 로고
    • Beneficial effect of antibodies against beta-secretase cleavage site of app on Alzheimer's-like pathology in triple-transgenic mice
    • Rabinovich-Nikitin I, Rakover IS, Becker M, Solomon B. Beneficial effect of antibodies against beta-secretase cleavage site of app on Alzheimer's-like pathology in triple-transgenic mice. PLoS One. 2012;7:e46650.
    • (2012) PLoS One. , vol.7 , pp. e46650
    • Rabinovich-Nikitin, I.1    Rakover, I.S.2    Becker, M.3    Solomon, B.4


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