Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice

American Journal of Pathology

Volumn 181, Issue 2, 2012, Pages 616-625

  Medeiros, Rodrigo ^a,b   Kitazawa, Masashi ^a,b   Chabrier, Meredith A ^a,b   Cheng, David ^a,b   Baglietto Vargas, David ^a,b   Kling, Andreas ^c   Moeller, Achim ^c   Green, Kim N ^a,b   Laferla, Frank M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ABBOTT GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

A 705253; ABC TRANSPORTER; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE; BETA SECRETASE 1; CALPAIN; CYCLIN DEPENDENT KINASE 5; DETERGENT; ENZYME INHIBITOR; N (1 BENZYL 2 CARBAMOYL 2 OXOETHYL) 2 [2 (4 DIETHYLAMINOMETHYLPHENYL) ETHEN 1 YL] BENZAMIDE; NOOTROPIC AGENT; TAU PROTEIN; THIOFLAVINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; COGNITIVE DEFECT; CONTROLLED STUDY; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; SYNAPTIC INHIBITION;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; ATP-BINDING CASSETTE TRANSPORTERS; BENZAMIDES; COGNITION; CYCLIN-DEPENDENT KINASE 5; ENZYME ACTIVATION; GLYCOPROTEINS; HUMANS; INFLAMMATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVOUS SYSTEM; PHOSPHORYLATION; TAU PROTEINS;

EID: 84864140992     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.04.020     Document Type: Article

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