Arctigenin protects focal cerebral ischemia-reperfusion rats through inhibiting neuroinflammation

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 11, 2012, Pages 2004-2009

  Tao, Fan ^a   Wei, Long Jiang ^a   Jian, Zhu ^a   Yu, Feng Zhang ^a  

^a Nanjing Traditional Chinese Medcine University   (China)

Author keywords

Anti inflammation; Apoptosis; Arctigenin; Ischemic stroke

Indexed keywords

ARCTIGENIN; CYTOKINE; INTERLEUKIN 1BETA; PLACEBO; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL ACTIVATION; CEREBROVASCULAR ACCIDENT; CYTOKINE RELEASE; DOSE RESPONSE; DRUG INHIBITION; DRUG ISOLATION; DRUG MEGADOSE; INFLAMMATORY CELL; LOW DRUG DOSE; MALE; MENTAL PERFORMANCE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL INHIBITION; NERVOUS SYSTEM INFLAMMATION; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SCORING SYSTEM; TREATMENT DURATION; TREATMENT RESPONSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; ARCTIUM; FURANS; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; INTERLEUKIN-1BETA; LIGNANS; MACROPHAGES; MALE; MICROGLIA; NEUROPROTECTIVE AGENTS; PHYTOTHERAPY; RATS; RATS, SPRAGUE-DAWLEY; SEEDS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84869229018     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00463     Document Type: Article

References (26)

1. WHO. Definitive atlas on global heart disease and stroke epidemic. Indian J. Med. Sci., 58, 405-406 (2004).
2. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, Ferguson TB, Ford E, Furie K, Gillespie C, Go A, Greenlund K, Haase N, Hailpern S, Ho PM, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott MM, Meigs J, Mozaffarian D, Mussolino M, Nichol G, Roger VL, Rosamond W, Sacco R, Sorlie P, Roger VL, Thom T, Wasserthiel-Smoller S, Wong ND, Wylie-Rosett J, American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics - 2010 update: a report from The American Heart Association. Circulation, 121, e46-e215 (2010).
3. Planas AM, Gorina R, Chamorro A. Signalling pathways mediating inflammatory responses in brain ischaemia. Biochem. Soc. Trans., 34, 1267-1270 (2006).
4. Wang Q, Tang XN, Yenari MA. The inflammatory response in stroke. J. Neuroimmunol., 184, 53-68 (2007).
5. Lai AY, Todd KG. Microglia in cerebral ischemia: molecular actions and interactions. Can. J. Physiol. Pharmacol., 84, 49-59 (2006).
6. Hosomi N, Ban CR, Naya T, Takahashi T, Guo P, Song XY, Kohno M. Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia. J. Cereb. Blood Flow Metab., 25, 959-967 (2005).
7. Gehrmann J, Matsumoto Y, Kreutzberg GW. Microglia: intrinsic immuneffector cell of the brain. Brain Res. Brain Res. Rev., 20, 269-287 (1995).
8. Guo ZH, Li F, Wang WZ. The mechanisms of brain ischemic insult and potential protective interventions. Neurosci. Bull., 25, 139-152 (2009).
9. Miyazawa M, Yagi N, Taguchi K. Inhibitory compounds of alpha glucosidase activity from Arctium lappa L. J. Oleo Sci., 54, 589-594 (2005).
10. Tamayo C, Richardson MA, Diamond S, Skoda I. The chemistry and biological activity of herbs used in Flor-Essence herbal tonic and Essiac. Phytother. Res., 14, 1-14 (2000).
11. Pereira JV, Bergamo DC, Pereira JO, França SC, Pietro RC, Silva-Sousa YT. Antimicrobial activity of Arctium lappa constituents against microorganisms commonly found in endodontic infections. Braz. Dent. J., 16, 192-196 (2005).
12. Zhang ZX, Liu ZQ, Liang QC. Effect of fructus compound preparation on expression of caspase-3 following focal cerebral ischemia-repefusion in rats. Heilongjiang Med. J., 23, 48-49 (2010).
13. Zhao F, Wang L, Liu K. In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway. J. Ethnopharmacol., 122, 457-462 (2009).
14. Cho MK, Park JW, Jang YP, Kim YC, Kim SG. Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-κBα phosphorylation and of p65 nuclear translocation in macrophages. Int. Immunopharmacol., 2, 105-116 (2002).
15. Huang SL, Yu RT, Gong J, Feng Y, Dai YL, Hu F, Hu YH, Tao YD, Leng Y. Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice. Diabetologia, 55, 1469-1481 (2012).
16. Park JH, Hong YJ, Moon E, Kim SA, Kim SY. Forsythiae fructus and its active component, arctigenin, provide neuroprotection by inhibiting neuroinflammation. Biomol. ther., 19, 425-430 (2011).
17. Han BH, Kang YH, Yang HO, Man KP. A butyrolactone lignin dimmer from Arctium lappa. Phytochemistry, 37, 1161-1163 (1994).
18. Takasaki M, Konoshima T, Komatsu K, Tokuda H, Nishino H. Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa. Cancer Lett., 158, 53-59 (2000).
19. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke, 20, 84-91 (1989).
20. Lee IA, Joh EH, Kim DH. Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice. Planta Med., 11, 1525-1527 (2011).
21. Joshi CN, Jain SK, Murthy PS. An optimized triphenyltetrazolium chloride method for identification of cerebral infarcts. Brain Res. Brain Res. Protoc., 13, 11-17 (2004).
22. Loh KP, Qi J, Tan BK, Liu XH, Wei BG, Zhu YZ. Leonurine protects middle cerebral artery occluded rats through antioxidant effect and regulation of mitochondrial function. Stroke, 41, 2661-2668 (2010).
23. Qi J, Hong ZY, Xin H, Zhu YZ. Neuroprotective effects of leonurine on ischemia/reperfusion-induced mitochondrial dysfunctions in rat cerebral cortex. Biol. Pharm. Bull., 33, 1958-1964 (2010).
24. Kleinig TJ, Vink R. Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options. Curr. Opin. Neurol., 22, 294-301 (2009).
25. Danton GH, Dietrich WD. Inflammatory mechanisms after ischemia and stroke. J. Neuropathol. Exp. Neurol., 62, 127-136 (2003).
26. Lambertsen KL, Meldgaard M, Ladeby x, Finsen B. A quantitative study of microglial-macrophage synthesis of tumor necrosis factor during acute and late focal cerebral ischemia in mice. J. Cereb. Blood Flow Metab., 25, 119-135 (2005).