Cellular immunodepression preceding infectious complications after acute ischemic stroke in humans

Cerebrovascular Diseases

Volumn 25, Issue 1-2, 2008, Pages 50-58

  Haeusler, Karl Georg ^a,b   Schmidt, Wolf U H ^a   Föhring, Fabian ^a   Meisel, Christian ^a   Helms, Thomas ^a   Jungehulsing, G Jan ^a,b   Nolte, Christian H ^a,b   Schmolke, Katrin ^a   Wegner, Brigitte ^a   Meisel, Andreas ^a,b   Dirnagl, Ulrich ^a,b   Villringer, Arno ^a,b   Volk, Hans Dieter ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Center for Clinical Research   (Germany)

Author keywords

Infection; Inflammation; Ischemia; Leukocytes; Magnetic resonance imaging

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; EX VIVO STUDY; FEMALE; HOSPITAL INFECTION; HUMAN; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOASSAY; LABORATORY TEST; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MONOCYTE; MORBIDITY; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTION; PRIORITY JOURNAL; RISK FACTOR;

AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; CASE-CONTROL STUDIES; COHORT STUDIES; CROSS INFECTION; FEMALE; HUMANS; IMMUNE TOLERANCE; IMMUNITY, CELLULAR; INCIDENCE; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; STROKE;

EID: 39349105381     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000111499     Document Type: Article

References (40)

1. Davenport RJ, Dennis MS, Wellwood I, Warlow CP: Complications after acute stroke. Stroke 1996;27:415-420.
2. Vargas M, Horcajada JP, Obach V, Revilla M, Cervera A, Torres F, Planas AM, Mensa J, Chamorro A: Clinical consequences of infection in patients with acute stroke: is it prime time for further antibiotic trials? Stroke 2006;37:461-465.
3. Katzan IL, Cebul RD, Husak SH, Dawson NV, Baker DW: The effect of pneumonia on mortality among patients hospitalized for acute stroke. Neurology 2003;60:620-625.
4. Heuschmann PU, Kolominsky-Rabas PL, Misselwitz B, Hermanek P, Leffmann C, Janzen RW, Rother J, Buecker-Nott HJ, Berger K: Predictors of in-hospital mortality and attributable risks of death after ischemic stroke. Arch Intern Med 2004;164:1761-1768.
5. Johnston KC, Li JY, Lyden PD, Hanson SK, Feasby TE, Adams RJ, Faught RE Jr, Haley EC Jr: Medical and neurological complications of ischemic stroke: experience from the RANTTAS trial. RANTTAS Investigators. Stroke 1998;29:447-453.
6. Hilker R, Poetter C, Findeisen N, Sobesky J, Jacobs A, Neveling M, Heiss WD: Nosocomial pneumonia after acute stroke: implications for neurological intensive care medicine. Stroke 2003;34:975-981.
7. Chamorro A, Urra X, Planas AM: Infection after acute ischemic stroke: a manifestation of brain-induced immunodepression. Stroke 2007;38:1097-1103.
8. Grau AJ, Buggle F, Schnitzler P, Spiel M, Lichy C, Hacke W: Fever and infection early after ischemic stroke. J Neurol Sci 1999;171:115-120.
9. Langhorne P, Stott DJ, Robertson L, MacDonald J, Jones L, McAlpine C, Dick F, Taylor GS, Murray G: Medical complications after stroke: a multicenter study. Stroke 2000;31:1223-1229.
10. Weimar C, Roth MP, Zillessen G, Glahn J, Wimmer ML, Busse O, Haberl RL, Diener HC: Complications following acute ischemic stroke. Eur Neurol 2002;48:133-140.
11. Aslanyan S, Weir CJ, Diener HC, Kaste M, Lees KR: Pneumonia and urinary tract infection after acute ischaemic stroke: a tertiary analysis of the GAIN International trial. Eur J Neurol 2004;11:49-53.
12. Gastmeier P, Kampf G, Wischnewski N, Hauer T, Schulgen G, Schumacher M, Daschner F, Ruden H: Prevalence of nosocomial infections in representative German hospitals. J Hosp Infect 1998;38:37-49.
13. Nakagawa T, Sekizawa K, Nakajoh K, Tanji H, Arai H, Sasaki H: Silent cerebral infarction: a potential risk for pneumonia in the elderly. J Intern Med 2000;247:255-259.
14. Marik PE: Aspiration pneumonitis and aspiration pneumonia. N Engl J Med 2001;344:665-671.
15. Perry L, Love CP: Screening for dysphagia and aspiration in acute stroke: a systematic review. Dysphagia 2001;16:7-18.
16. Prass K, Braun JS, Dirnagl U, Meisel C, Meisel A: Stroke propagates bacterial aspiration to pneumonia in a model of cerebral ischemia. Stroke 2006;37:2607-2612.
17. Meisel C, Schwab JM, Prass K, Meisel A, Dirnagl U: Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci 2005;6:775-786.
18. Czlonkowska A, Cyrta B, Korlak J: Immunological observations on patients with acute cerebral vascular disease. J Neurol Sci 1979;43:455-464.
19. Prass K, Meisel C, Hoflich C, Braun J, Halle E, Wolf T, Ruscher K, Victorov IV, Priller J, Dirnagl U, Volk HD, Meisel A: Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med 2003;198:725-736.
20. Chamorro A, Amaro S, Vargas M, Obach V, Cervera A, Gomez-Choco M, Torres F, Planas AM: Catecholamines, infection, and death in acute ischemic stroke. J Neurol Sci 2007;15;252:29-35.
21. Hacke W, Kaste M, Bogousslavsky J, Brainin M, Chamorro A, Lees K, Leys D, Kwiecinski H, Toni P, Langhorne P, Diener C, Hennerici M, Ferro J, Sivenius J, Gunnar N, Bath P, Olsen TS, Gugging M, European Stroke Initiative Executive Committee and the EUSI Writing Committee: European Stroke Initiative recommendations for stroke management - update 2003. Cerebrovasc Dis 2003;16:311-337.
22. Myrianthefs PM, Kalafati M, Samara I, Baltopoulos GJ: Nosocomial pneumonia. Crit Care Nurs Q 2004;27:241-257.
23. Daniels SK, Brailey K, Priestly DH, Herrington LR, Weisberg LA, Foundas AL: Aspiration in patients with acute stroke. Arch Phys Med 1998;79:14-19.
24. Strohmeyer JC, Blume C, Meisel C, Doecke WD, Hummel M, Hoeflich C, Thiele K, Unbehaun A, Hetzer R, Volk HD: Standardized immune monitoring for the prediction of infections after cardiopulmonary bypass surgery in risk patients. Cytometry B Clin Cytom 2003;53:54-62.
25. Brott T, Adams HP Jr, Olinger CP, Marler JR, Barsan WG, Biller J, Spilker J, Holleran R, Eberle R, Hertzberg V, Rorick M, Moomaw CJ, Walker M: Measurements of acute cerebral infarction: a clinical examination scale. Stroke 1989;20:864-870.
26. Adams HP, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE III: Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial. Stroke 1993;24:35-41.
27. Beamer NB, Coull BM, Clark WM, Hazel JS, Silberger JR: Interleukin-6 and interleukin-1 receptor antagonist in acute stroke. Ann Neurol 1995;37:800-805.
28. Bartosik-Psujek H, Belniak E, Stelmasiak Z: Markers of inflammation in cerebral ischemia. J Neurol Sci 2003;24:279-280.
29. Chamorro A, Obach V, Vila N, Revilla M, Cervera A, Ascaso C: Comparison of the acute-phase response in patients with ischemic stroke treated with high-dose heparin or aspirin. J Neurol Sci 2000;178:17-22.
30. Asadullah K, Woiciechowsky C, Docke WD, Egerer K, Kox WJ, Vogel S, Sterry W, Volk HD: Very low monocytic HLA-DR expression indicates high risk of infection - immunomonitoring for patients after neurosurgery and patients during high dose steroid therapy. Eur J Emerg Med 1995;2:184-190.
31. Döcke WD, Randow F, Syrbe U, Krausch D, Asadullah K, Reinke P, Volk HD, Kox W: Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 1997;3:678-681.
32. Neveu PJ: Asymmetrical brain modulation of the immune response. Brain Res Rev 1992;17:101-107.
33. Kalra L, Yu G, Wilson K, Roots P: Medical complications during stroke rehabilitation. Stroke 1995;26:990-994.
34. Pinto AN, Melo TP, Lourenco ME, Leandro MJ, Brazio A, Carvalho L, Franco AS, Ferro JM: Can a clinical classification of stroke predict complications and treatments during hospitalization? Cerebrovasc Dis 1998;8:204-209.
35. Chamorro A, Amaro S, Vargas M, Obach V, Cervera A, Torres F, Planas AM: Interleukin 10, monocytes and increased risk of early infection in ischaemic stroke. J Neurol Neurosurg Psychiatry 2006;77:1279-1281.
36. Martino R, Foley N, Bhogal S, Diamant N, Speechley M, Teasell R: Dysphagia after stroke: incidence, diagnosis, and pulmonary complications. Stroke 2005;36:2756-2763.
37. Zaremba J, Skrobanski P, Losy J: Tumour necrosis factor-alpha is increased in the cerebrospinal fluid and serum of ischaemic stroke patients and correlates with the volume of evolving brain infarct. Biomed Pharmacother 2001;55:258-263.
38. Meisel C, Prass K, Braun J, Victorov I, Wolf T, Megow D, Halle E, Volk HD, Dirnagl U, Meisel A: Preventive antibacterial treatment improves the general medical and neurological outcome in a mouse model of stroke. Stroke 2004;35:2-6.
39. Chamorro A, Horcajada JP, Obach V, Vargas M, Revilla M, Torres F, Cervera A, Planas AM, Mensa J: The early systemic prophylaxis of infection after stroke study: a randomized clinical trial. Stroke 2005;36:1495-1500.
40. Woiciechowsky C, Schoning B, Cobanov J, Lanksch WR, Volk HD, Docke WD: Early IL-6 plasma concentrations correlate with severity of brain injury and pneumonia in brain-injured patients. J Trauma 2002;52:339-345.