Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 9, 2012, Pages 1810-1819

  Pradillo, Jesus M ^a   Denes, Adam ^a   Greenhalgh, Andrew D ^a   Boutin, Herve ^a   Drake, Caroline ^a   McColl, Barry W ^a,c   Barton, Eleanor ^a   Proctor, Spencer D ^b   Russell, James C ^b   Rothwell, Nancy J ^a   Allan, Stuart M ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

cerebral ischemia; inflammation; interleukin 1 receptor antagonist; neutroprotection; risk factors; therapy

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVOUS SYSTEM INFLAMMATION; NEUTROPHILIA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; REPERFUSION; TREATMENT OUTCOME;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN ISCHEMIA; CYTOKINES; IMMUNOHISTOCHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; ISCHEMIC ATTACK, TRANSIENT; LYMPHOCYTE ACTIVATION; MAGNETIC RESONANCE IMAGING; MALE; MICROGLIA; NEUROPROTECTIVE AGENTS; NEUTROPHIL INFILTRATION; RATS; RECOMBINANT PROTEINS; REPERFUSION; STROKE; TREATMENT OUTCOME;

EID: 84865965431     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.101     Document Type: Article

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